Marcel Kool

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. doi request reprint Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition
    Marcel Kool
    Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, 69121 Heidelberg, Germany Electronic address
    Cancer Cell 25:393-405. 2014
  2. pmc Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas
    Marcel Kool
    Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Acta Neuropathol 123:473-84. 2012
  3. doi request reprint Biological and clinical heterogeneity of MYCN-amplified medulloblastoma
    Andrey Korshunov
    Department of Neuropathology, University of Heidelberg, Heidelberg, Germany
    Acta Neuropathol 123:515-27. 2012
  4. doi request reprint Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas
    Sebastian Bender
    Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany Department of Pediatric Oncology, Hematology, and Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany
    Cancer Cell 24:660-72. 2013
  5. pmc Medulloblastomics: the end of the beginning
    Paul A Northcott
    Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, Heidelberg 69120, Germany
    Nat Rev Cancer 12:818-34. 2012
  6. pmc Dissecting the genomic complexity underlying medulloblastoma
    David T W Jones
    Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, Heidelberg 69120, Germany
    Nature 488:100-5. 2012
  7. pmc LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR)
    Andrey Korshunov
    Clinical Cooperation Unit Neuropathology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Acta Neuropathol 124:875-81. 2012
  8. pmc Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity
    Andrey Korshunov
    Clinical Cooperation Unit Neuropathology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Acta Neuropathol 128:279-89. 2014
  9. doi request reprint MicroRNA-182 promotes leptomeningeal spread of non-sonic hedgehog-medulloblastoma
    Alfa H C Bai
    Division of Molecular Genetics B060, German Cancer Research Center DKFZ, Heidelberg, Germany
    Acta Neuropathol 123:529-38. 2012
  10. pmc Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
    David T W Jones
    Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Nat Genet 45:927-32. 2013

Detail Information

Publications22

  1. doi request reprint Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition
    Marcel Kool
    Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, 69121 Heidelberg, Germany Electronic address
    Cancer Cell 25:393-405. 2014
    ..Functional assays in different SHH-MB xenograft models demonstrated that SHH-MBs harboring a PTCH1 mutation were responsive to SMO inhibition, whereas tumors harboring an SUFU mutation or MYCN amplification were primarily resistant. ..
  2. pmc Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas
    Marcel Kool
    Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Acta Neuropathol 123:473-84. 2012
    ..Results from these analyses will form the basis for prospective multi-center studies and will have an impact on how the different subgroups of medulloblastoma will be treated in the future...
  3. doi request reprint Biological and clinical heterogeneity of MYCN-amplified medulloblastoma
    Andrey Korshunov
    Department of Neuropathology, University of Heidelberg, Heidelberg, Germany
    Acta Neuropathol 123:515-27. 2012
    ....
  4. doi request reprint Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas
    Sebastian Bender
    Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany Department of Pediatric Oncology, Hematology, and Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany
    Cancer Cell 24:660-72. 2013
    ....
  5. pmc Medulloblastomics: the end of the beginning
    Paul A Northcott
    Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, Heidelberg 69120, Germany
    Nat Rev Cancer 12:818-34. 2012
    ..These data are currently making their way into clinical trials as we seek to integrate conventional and molecularly targeted therapies...
  6. pmc Dissecting the genomic complexity underlying medulloblastoma
    David T W Jones
    Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, Heidelberg 69120, Germany
    Nature 488:100-5. 2012
    ..These findings enhance our understanding of the genomic complexity and heterogeneity underlying medulloblastoma, and provide several potential targets for new therapeutics, especially for Group 3 and 4 patients...
  7. pmc LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR)
    Andrey Korshunov
    Clinical Cooperation Unit Neuropathology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Acta Neuropathol 124:875-81. 2012
    ..In summary, we established LIN28A immunohistochemistry as a highly sensitive and specific, rapid, inexpensive diagnostic tool for routine pathological verification of ETMR...
  8. pmc Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity
    Andrey Korshunov
    Clinical Cooperation Unit Neuropathology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Acta Neuropathol 128:279-89. 2014
    ....
  9. doi request reprint MicroRNA-182 promotes leptomeningeal spread of non-sonic hedgehog-medulloblastoma
    Alfa H C Bai
    Division of Molecular Genetics B060, German Cancer Research Center DKFZ, Heidelberg, Germany
    Acta Neuropathol 123:529-38. 2012
    ..We therefore reason that targeted inhibition of miR-182 may prevent leptomeningeal spread in patients with non-SHH-MB...
  10. pmc Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
    David T W Jones
    Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Nat Genet 45:927-32. 2013
    ..Our findings thus identify new potential therapeutic targets in distinct subsets of pilocytic astrocytoma and childhood glioblastoma. ..
  11. doi request reprint Nestin expression identifies ependymoma patients with poor outcome
    Till Milde
    Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Heidelberg, Germany
    Brain Pathol 22:848-60. 2012
    ..In summary, our data implicate nestin as a useful novel marker for intracranial ependymoma risk stratification easily implementable in routine diagnostics...
  12. doi request reprint HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment
    Till Milde
    Clinical Cooperation Unit Pediatric Oncology G340, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    J Neurooncol 110:335-48. 2012
    ..In summary, our data indicate that HD-MB03 is a suitable preclinical model for Group 3 medulloblastoma, and HDACis could represent a therapeutic option for this subgroup...
  13. doi request reprint Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system
    Christian Koelsche
    Department of Neuropathology, Institute of Pathology, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany
    Acta Neuropathol 126:907-15. 2013
    ..0001), but inversely associated with loss of ATRX expression (p < 0.0001) and IDH1/IDH2 mutations (p < 0.0001). TERT promoter mutations are typically found in adult patients and occur in a highly tumor type-associated distribution...
  14. doi request reprint The role of chromatin remodeling in medulloblastoma
    David T W Jones
    Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Brain Pathol 23:193-9. 2013
    ..The mechanisms by which these chromatin remodelers are dysregulated in MB, and the consequences both for future basic research and for translation to the clinic, will be examined here...
  15. doi request reprint Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations
    David E Reuss
    Department of Neuropathology, Institute of Pathology, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany
    Acta Neuropathol 125:351-8. 2013
    ..In conclusion, our findings suggest an essential contribution of combined KLF4 K409Q and TRAF7 mutations in the genesis of secretory meningioma and demonstrate a role for TRAF7 alterations in other non-NF2 meningiomas...
  16. pmc Coverage bias and sensitivity of variant calling for four whole-genome sequencing technologies
    Nora Rieber
    Division of Theoretical Bioinformatics, German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 8:e66621. 2013
    ..It indicates application areas that call for a specific sequencing platform and disallow other platforms. This helps to identify the proper sequencing platform for whole genome studies with different application scopes...
  17. doi request reprint Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma
    Dominik Sturm
    Division of Pediatric Neurooncology, German Cancer Research Center DKFZ Heidelberg, 69120 Heidelberg, Germany
    Cancer Cell 22:425-37. 2012
    ..We also demonstrate that the two H3F3A mutations give rise to GBMs in separate anatomic compartments, with differential regulation of transcription factors OLIG1, OLIG2, and FOXG1, possibly reflecting different cellular origins...
  18. pmc Hypermutation of the inactive X chromosome is a frequent event in cancer
    Natalie Jäger
    Division of Theoretical Bioinformatics, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Cell 155:567-81. 2013
    ..Our data suggest that hypermutation of the inactive X chromosome is an early and frequent feature of tumorigenesis resulting from DNA replication stress in aberrantly proliferating cells...
  19. pmc Histone deacetylase 10 promotes autophagy-mediated cell survival
    Ina Oehme
    Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center DKFZ, D 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 110:E2592-601. 2013
    ..Moreover, these results propose a promising way to considerably improve treatment response in the neuroblastoma patient subgroup with the poorest outcome. ..
  20. ncbi request reprint Brain Tumor Epidemiology - A Hub within Multidisciplinary Neuro-oncology. Report on the 15th Brain Tumor Epidemiology Consortium (BTEC) Annual Meeting, Vienna, 2014
    Adelheid Woehrer
    Institute of Neurology, Medical University of Vienna, Austria, Department of Pediatrics, Section of Hematology Oncology, Baylor College of Medicine, Houston, TX, USA, Department of Biomedical Imaging and Image Guided Therapy, Medical University of Vienna, Austria, Department of Neurosurgery, CHU Montpellier, France, Service of Neurology, Hospital Clinic, University of Barcelona, Spain, German Cancer Research Center DKFZ, Heidelberg, Germany, Division of Child Neurology, Department of Neurology, Stanford University, CA, USA, SwissCore, Brussels, Belgium, Erasmus MC, Rotterdam, The Netherlands, Central Brain Tumor Registry of the US, Hinsdale, IL, USA, Department of Epidemiology and Biostatistics, Department of Neurological Surgery, University of California, San Francisco, Department of Epidemiology, University of California, Los Angeles, CA, Brown School Master of Public Health Program, Washington University in St Louis, MO, Division of Hematology Oncology, The Vontz Center for Molecular Studies, University of Cincinnati, OH, Department of Neurology, The Mayo Clinic, Rochester, MN, USA Division of Pediatric Hematology Oncology, Japan
    Clin Neuropathol 34:40-6. 2015
    ..Several concrete action plans evolved for the group to move forward until next year's meeting, which will be held at the Mayo Clinic at Rochester, MN, USA. ..
  21. doi request reprint Molecular diagnostics of CNS embryonal tumors
    Stefan M Pfister
    German Cancer Research Center, Heidelberg, Germany
    Acta Neuropathol 120:553-66. 2010
    ....