Manfred Koegl

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. ncbi request reprint Computer-assisted generation of a protein-interaction database for nuclear receptors
    Sylvie Albert
    LION bioscience AG, 69123 Heidelberg, Germany
    Mol Endocrinol 17:1555-67. 2003
  2. ncbi request reprint A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors
    Michael Albers
    PheneX Pharmaceuticals AG, 67056 Ludwigshafen, Germany and Department of Vascular and Metabolic Diseases, F Hoffmann La Roche AG, 4070 Basel, Switzerland
    J Biol Chem 281:4920-30. 2006
  3. pmc Ubiquitin-interaction motifs of RAP80 are critical in its regulation of estrogen receptor alpha
    Jun Yan
    Cell Biology Section, Division of Intramural Research, National Institute of Enironmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 35:1673-86. 2007
  4. ncbi request reprint Panning for SNuRMs: using cofactor profiling for the rational discovery of selective nuclear receptor modulators
    Claus Kremoser
    PheneX Pharmaceuticals AG, Gebaeude J542N, Werksgelaende BASF, D 67056 Ludwigshafen, Germany
    Drug Discov Today 12:860-9. 2007
  5. doi request reprint Improving yeast two-hybrid screening systems
    Manfred Koegl
    Translational Research, and Genomics and Proteomics Core Facilities, German Cancer Research Center, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
    Brief Funct Genomic Proteomic 6:302-12. 2007
  6. pmc The EHEC-host interactome reveals novel targets for the translocated intimin receptor
    Sonja Blasche
    Genomics and Proteomics Core Facilities, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Sci Rep 4:7531. 2014
  7. doi request reprint Analysis of protein-protein interactions using LUMIER assays
    Sonja Blasche
    Genomics and Proteomics Core Facility, German Cancer Research Center, Heidelberg, Germany
    Methods Mol Biol 1064:17-27. 2013
  8. ncbi request reprint Automated yeast two-hybrid screening for nuclear receptor-interacting proteins
    Michael Albers
    PheneX Pharmaceuticals AG, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
    Mol Cell Proteomics 4:205-13. 2005
  9. pmc Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol
    Kerstin Otte
    LION bioscience AG, 69120 Heidelberg, Germany
    Mol Cell Biol 23:864-72. 2003

Collaborators

  • Peter Uetz
  • Stefan Wuchty
  • Patrick Aloy
  • Arnaud Ceol
  • Michael Albers
  • Sonja Blasche
  • Claus Kremoser
  • Ulrich Deuschle
  • Ingo Kober
  • Jun Yan
  • Carmen Kaiser
  • Harald Kranz
  • Kerstin Otte
  • Sylvie Albert
  • M Alexander Schmidt
  • Frank Schwarz
  • Gabriella Siszler
  • Roman Hauser
  • Theresia Stradal
  • Stefan Arens
  • Anton M Jetten
  • Yong Sik Kim
  • Xiao Ping Yang
  • Thomas P Burris
  • Beatrix Blume
  • Matthew B Wright
  • Thomas Schlueter
  • Martin Klink
  • Rainer Kern
  • Jörg Suckow
  • Bernhard Haubold
  • David Jackson
  • Sylvain Gaudan
  • Zaccharias Cheruvallath
  • Harald Kirsch
  • Bettina Huhse
  • Dietrich Rebholz-Schuhmann
  • Svante Paabo
  • Bettina Remmel
  • Paul Thompson
  • Michael Hoefer
  • Georg Casari
  • Heidrun Knigge
  • Jan Mous
  • Hartmut Voss
  • Asuncion Delgado
  • Andreas Raetsch

Detail Information

Publications9

  1. ncbi request reprint Computer-assisted generation of a protein-interaction database for nuclear receptors
    Sylvie Albert
    LION bioscience AG, 69123 Heidelberg, Germany
    Mol Endocrinol 17:1555-67. 2003
    ..The data set obtained serves as a source for information on NR interactions, as well as a reference data set for the improvement of advanced text-mining methods...
  2. ncbi request reprint A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors
    Michael Albers
    PheneX Pharmaceuticals AG, 67056 Ludwigshafen, Germany and Department of Vascular and Metabolic Diseases, F Hoffmann La Roche AG, 4070 Basel, Switzerland
    J Biol Chem 281:4920-30. 2006
    ..Our data show how competitive binding of coactivators and corepressors can explain the tissue-specific behavior of partial agonists and open up new routes to a rational design of partial agonists for LXRs...
  3. pmc Ubiquitin-interaction motifs of RAP80 are critical in its regulation of estrogen receptor alpha
    Jun Yan
    Cell Biology Section, Division of Intramural Research, National Institute of Enironmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 35:1673-86. 2007
    ..These data indicate that the UIMs in RAP80 are critical for the function of RAP80. Our study identifies ERalpha as a new RAP80-interacting protein and suggests that RAP80 may be an important modulator of ERalpha activity...
  4. ncbi request reprint Panning for SNuRMs: using cofactor profiling for the rational discovery of selective nuclear receptor modulators
    Claus Kremoser
    PheneX Pharmaceuticals AG, Gebaeude J542N, Werksgelaende BASF, D 67056 Ludwigshafen, Germany
    Drug Discov Today 12:860-9. 2007
    ..Hence, systematic cofactor profiling is advancing into an approach for the rationally guided identification of selective NR modulators (SNuRMs) with improved therapeutic ratio...
  5. doi request reprint Improving yeast two-hybrid screening systems
    Manfred Koegl
    Translational Research, and Genomics and Proteomics Core Facilities, German Cancer Research Center, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
    Brief Funct Genomic Proteomic 6:302-12. 2007
    ....
  6. pmc The EHEC-host interactome reveals novel targets for the translocated intimin receptor
    Sonja Blasche
    Genomics and Proteomics Core Facilities, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Sci Rep 4:7531. 2014
    ..In particular, we observed that EspJ is connected to the microtubule system while EspY1 appears to be involved in apoptosis/cell cycle regulation. ..
  7. doi request reprint Analysis of protein-protein interactions using LUMIER assays
    Sonja Blasche
    Genomics and Proteomics Core Facility, German Cancer Research Center, Heidelberg, Germany
    Methods Mol Biol 1064:17-27. 2013
    ..This protocol is ideal for miniaturization of the assay on microtiter plates and supports a throughput of several hundred interaction tests per week. ..
  8. ncbi request reprint Automated yeast two-hybrid screening for nuclear receptor-interacting proteins
    Michael Albers
    PheneX Pharmaceuticals AG, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany
    Mol Cell Proteomics 4:205-13. 2005
    ....
  9. pmc Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol
    Kerstin Otte
    LION bioscience AG, 69120 Heidelberg, Germany
    Mol Cell Biol 23:864-72. 2003
    ....