Susanne Klaus

Summary

Affiliation: German Institute of Human Nutrition
Country: Germany

Publications

  1. pmc Activation of AMPKα2 is not crucial for mitochondrial uncoupling-induced metabolic effects but required to maintain skeletal muscle integrity
    Mario Ost
    German Institute of Human Nutrition DIfE Potsdam Rehbruecke, Nuthetal, Germany
    PLoS ONE 9:e94689. 2014
  2. pmc Dietary effects on body composition, glucose metabolism, and longevity are modulated by skeletal muscle mitochondrial uncoupling in mice
    Susanne Keipert
    Group of Energy Metabolism, German Institute of Human Nutrition, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Aging Cell 10:122-36. 2011
  3. doi request reprint Skeletal muscle uncoupling-induced longevity in mice is linked to increased substrate metabolism and induction of the endogenous antioxidant defense system
    S Keipert
    German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    Am J Physiol Endocrinol Metab 304:E495-506. 2013
  4. ncbi request reprint Dissociation of obesity and insulin resistance in transgenic mice with skeletal muscle expression of uncoupling protein 1
    Yvonne Katterle
    German Institute of Human Nutrition in Potsdam Rehbruecke, Group of Energy Metabolism, Nuthetal, Germany
    Physiol Genomics 32:352-9. 2008
  5. doi request reprint Comparison of high-protein diets and leucine supplementation in the prevention of metabolic syndrome and related disorders in mice
    Anne Freudenberg
    German Institute of Human Nutrition in Potsdam Rehbruecke DIfE, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    J Nutr Biochem 23:1524-30. 2012
  6. ncbi request reprint Tissue-specific response to interstitial angiotensin II in humans
    Michael Boschmann
    German Institute of Human Nutrition, Department of Biochemistry and Physiology of Nutrition, Potsdam, Germany
    Hypertension 41:37-41. 2003
  7. ncbi request reprint Long-term dietary high protein intake up-regulates tissue specific gene expression of uncoupling proteins 1 and 2 in rats
    Klaus J Petzke
    German Institute of Human Nutrition, Potsdam Rehbrücke DIfE, 14558 Nuthetal, Germany
    Eur J Nutr 44:414-21. 2005
  8. ncbi request reprint Expression of uncoupling protein 1 in skeletal muscle decreases muscle energy efficiency and affects thermoregulation and substrate oxidation
    Susanne Klaus
    German Institute of Human Nutrition Potsdam Rehbruecke, Group of Energy Metabolism, Nuthetal, Germany
    Physiol Genomics 21:193-200. 2005
  9. ncbi request reprint Norepinephrine transporter function and autonomic control of metabolism
    Michael Boschmann
    German Institute of Human Nutrition, 14558 Potsdam, Germany
    J Clin Endocrinol Metab 87:5130-7. 2002
  10. ncbi request reprint Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine
    Susanne Keipert
    German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    Am J Physiol Endocrinol Metab 306:E469-82. 2014

Collaborators

Detail Information

Publications28

  1. pmc Activation of AMPKα2 is not crucial for mitochondrial uncoupling-induced metabolic effects but required to maintain skeletal muscle integrity
    Mario Ost
    German Institute of Human Nutrition DIfE Potsdam Rehbruecke, Nuthetal, Germany
    PLoS ONE 9:e94689. 2014
    ..But strikingly, activation of AMPKα2 seems crucial for maintaining SM function, integrity and the ability to compensate chronic metabolic stress induced by SM mitochondrial uncoupling. ..
  2. pmc Dietary effects on body composition, glucose metabolism, and longevity are modulated by skeletal muscle mitochondrial uncoupling in mice
    Susanne Keipert
    Group of Energy Metabolism, German Institute of Human Nutrition, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Aging Cell 10:122-36. 2011
    ....
  3. doi request reprint Skeletal muscle uncoupling-induced longevity in mice is linked to increased substrate metabolism and induction of the endogenous antioxidant defense system
    S Keipert
    German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    Am J Physiol Endocrinol Metab 304:E495-506. 2013
    ..This stress induction in turn increases the endogenous antioxidant defense system and redox signaling. Altogether, our data argue for an adaptive role of reactive species as essential signaling molecules for health and longevity...
  4. ncbi request reprint Dissociation of obesity and insulin resistance in transgenic mice with skeletal muscle expression of uncoupling protein 1
    Yvonne Katterle
    German Institute of Human Nutrition in Potsdam Rehbruecke, Group of Energy Metabolism, Nuthetal, Germany
    Physiol Genomics 32:352-9. 2008
    ..Rather it can lead to a "healthy" obese phenotype by preserving insulin sensitivity and a high metabolic flexibility, thus protecting from the development of obesity associated disturbances of glucose homeostasis...
  5. doi request reprint Comparison of high-protein diets and leucine supplementation in the prevention of metabolic syndrome and related disorders in mice
    Anne Freudenberg
    German Institute of Human Nutrition in Potsdam Rehbruecke DIfE, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    J Nutr Biochem 23:1524-30. 2012
    ..Leucine supplementation had no effect on liver lipogenesis and white fat lipolysis compared to AP. It is concluded that the essential amino acid leucine is able to mimic part but not all beneficial metabolic effects of HP diets...
  6. ncbi request reprint Tissue-specific response to interstitial angiotensin II in humans
    Michael Boschmann
    German Institute of Human Nutrition, Department of Biochemistry and Physiology of Nutrition, Potsdam, Germany
    Hypertension 41:37-41. 2003
    ..However, interstitial angiotensin II modulates lipid and carbohydrate metabolism in a tissue specific fashion. Thus, the physiology of interstitial angiotensin II cannot be predicted from intravascular studies...
  7. ncbi request reprint Long-term dietary high protein intake up-regulates tissue specific gene expression of uncoupling proteins 1 and 2 in rats
    Klaus J Petzke
    German Institute of Human Nutrition, Potsdam Rehbrücke DIfE, 14558 Nuthetal, Germany
    Eur J Nutr 44:414-21. 2005
    ..We hypothesized that the dietary protein level can affect gene expression of uncoupling protein (UCP) homologues which is suggested to be involved in thermogenesis, substrate oxidation, and energy expenditure...
  8. ncbi request reprint Expression of uncoupling protein 1 in skeletal muscle decreases muscle energy efficiency and affects thermoregulation and substrate oxidation
    Susanne Klaus
    German Institute of Human Nutrition Potsdam Rehbruecke, Group of Energy Metabolism, Nuthetal, Germany
    Physiol Genomics 21:193-200. 2005
    ..At Tas below thermoneutrality, this puts increasing energy demands on the animals, whereas at thermoneutrality most differences in energy metabolism are not apparent any more...
  9. ncbi request reprint Norepinephrine transporter function and autonomic control of metabolism
    Michael Boschmann
    German Institute of Human Nutrition, 14558 Potsdam, Germany
    J Clin Endocrinol Metab 87:5130-7. 2002
    ..This effect cannot be explained by increased systemic or adipose tissue norepinephrine concentrations. Instead, NET inhibition may sensitize adipose tissue to beta-adrenergic stimulation...
  10. ncbi request reprint Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine
    Susanne Keipert
    German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    Am J Physiol Endocrinol Metab 306:E469-82. 2014
    ..These results confirm muscle as an important endocrine regulator of whole body metabolism. ..
  11. ncbi request reprint Increasing the protein:carbohydrate ratio in a high-fat diet delays the development of adiposity and improves glucose homeostasis in mice
    Susanne Klaus
    German Institute of Human Nutrition, Potsdam Rehbruecke, Group of Energy Metabolism, Nuthetal
    J Nutr 135:1854-8. 2005
    ..However, glucose homeostasis was improved in LC mice, indicating that a combination of high fat and high CHO is responsible for the development of metabolic syndrome-related traits in mice...
  12. doi request reprint Body weight and energy homeostasis was not affected in C57BL/6 mice fed high whey protein or leucine-supplemented low-fat diets
    Anne Noatsch
    German Institute of Human Nutrition in Potsdam Rehbruecke DIfE, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Eur J Nutr 50:479-88. 2011
    ..Leucine is suggested to act as nutrient signal of high-protein diets regulating pathways associated with an alleviation of metabolic syndrome parameters. However, the subject remains controversial...
  13. doi request reprint Dietary L-leucine and L-alanine supplementation have similar acute effects in the prevention of high-fat diet-induced obesity
    Anne Freudenberg
    German Institute of Human Nutrition in Potsdam Rehbruecke, DIFE, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Amino Acids 44:519-28. 2013
    ....
  14. doi request reprint UCP1 ectopically expressed in murine muscle displays native function and mitigates mitochondrial superoxide production
    Susanne Keipert
    German Institute of Human Nutrition, Group of Energy Metabolism, 14558 Nuthetal, Germany
    Biochim Biophys Acta 1797:324-30. 2010
    ..Our study confirms native behaviour of UCP1 in skeletal muscle and demonstrates beneficial effects on prevention of mitochondrial reactive oxygen species production which may reduce age-related deleterious processes...
  15. doi request reprint Effects of long-term soluble vs. insoluble dietary fiber intake on high-fat diet-induced obesity in C57BL/6J mice
    Frank Isken
    Department of Clinical Nutrition, German Institute of Human Nutrition, Potsdam Rehbruecke, Nuthetal 14558, Germany
    J Nutr Biochem 21:278-84. 2010
    ..Soluble fiber intake with increased SCFA production significantly contributed to digested energy, thereby potentially outweighing the well known short-term beneficial effects of soluble fiber consumption...
  16. ncbi request reprint Short-term, high fat feeding-induced changes in white adipose tissue gene expression are highly predictive for long-term changes
    Anja Voigt
    Group of Energy Metabolism, German Institute of Human Nutrition in Potsdam, Nuthetal, Germany
    Mol Nutr Food Res 57:1423-34. 2013
    ..We aimed to evaluate the predictability of short-term (5 days) changes in epididymal white adipose tissue (eWAT) gene expression for long-term (12 weeks) changes induced by high-fat diet (HFD) feeding...
  17. doi request reprint Absence of intestinal microbiota does not protect mice from diet-induced obesity
    Christine K Fleissner
    Group of Physiology of Energy Metabolism, German Institute of Human Nutrition Potsdam Rehbrucke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Br J Nutr 104:919-29. 2010
    ....
  18. ncbi request reprint cis-9,trans-11 and trans-10,cis-12 CLA affect lipid metabolism differently in primary white and brown adipocytes of Djungarian hamsters
    Cornelia C Metges
    German Institute of Human Nutrition, 14558 Bergholz Rehbrucke, Germany
    Lipids 38:1133-42. 2003
    ..The opposite effects of c9,t11-CLA and t10,c12-CLA are evident in both WAT and BAT cultures; however, brown adipocytes seem to be more susceptible to CLA treatment...
  19. ncbi request reprint Adipose tissue as a regulator of energy balance
    Susanne Klaus
    German Institute of Human Nutrition in Potsdam DIfE, Arthur Scheunert Allee 114 116, 14558 Bergholz Rehbrucke, Germany
    Curr Drug Targets 5:241-50. 2004
    ....
  20. ncbi request reprint The novel antiobesic HMR1426 reduces food intake without affecting energy expenditure in rats
    Sylvia Ortmann
    Group of Energy Metabolism, German Institute of Human Nutrition in Potsdam, Nuthetal, Germany
    Obes Res 12:1290-7. 2004
    ..To determine the effect of acute and chronic administration of a new food intake-reducing compound (HMR1426) with novel mode of action (retardation of gastric emptying) on body weight development, food intake, and energy metabolism in rats...
  21. ncbi request reprint Prenatal high protein exposure decreases energy expenditure and increases adiposity in young rats
    Maren Daenzer
    Department Biochemistry and Physiology of Nutrition, German Institute of Human Nutrition, 14558 Bergholz Rehbrucke, Germany
    J Nutr 132:142-4. 2002
    ..05). Postnatal HP alone had no significant effect on body composition or metabolic rate. These results indicate that in utero exposure to a high protein level reprograms body weight and energy homeostasis...
  22. ncbi request reprint In vivo response to alpha(1)-adrenoreceptor stimulation in human white adipose tissue
    Michael Boschmann
    German Institute of Human Nutrition, Potsdam, Germany
    Obes Res 10:555-8. 2002
    ..Recent studies in rats suggest an important effect of alpha(1)-adrenoreceptor stimulation on glucose uptake in white adipocytes. It is not known if alpha(1)-adrenoreceptor stimulation elicits similar metabolic effects in humans...
  23. pmc Beyond the role of dietary protein and amino acids in the prevention of diet-induced obesity
    Klaus J Petzke
    German Institute of Human Nutrition in Potsdam Rehbruecke DIfE, Arthur Scheunert Allee 114 116, Nuthetal 14558, Germany
    Int J Mol Sci 15:1374-91. 2014
    ..Research in this field can provide important information to justify dietary recommendations and strategies in promoting long-term weight loss and may help to reduce health problems associated with the comorbidities of obesity. ..
  24. pmc Augmenting energy expenditure by mitochondrial uncoupling: a role of AMP-activated protein kinase
    Susanne Klaus
    German Institute of Human Nutrition, Arthur Scheunert Allee 114 116, 14558, Nuthetal, Germany
    Genes Nutr 7:369-86. 2012
    ....
  25. ncbi request reprint Intestinal microbiota and obesity
    Michael Blaut
    Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558, Nuthetal, Germany
    Handb Exp Pharmacol 209:251-73. 2012
    ..In conclusion, there is ample evidence for a role of gut microbiota in the development of obesity in rodents. However, the magnitude of its contribution to human obesity is still unknown...
  26. pmc Increased fat-free body mass and no adverse effects on blood lipid concentrations 4 weeks after additional meat consumption in comparison with an exclusion of meat in the diet of young healthy women
    Klaus J Petzke
    Group of Stable Isotopes and of Energy Metabolism, German Institute of Human Nutrition in Potsdam Rehbruecke DIfE, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    J Nutr Metab 2011:210930. 2011
    ..Conclusions. Additional meat intake can increase FFM without adverse effects on blood lipid concentrations. Long-term studies are required. Urinary excretion of 3-methylhistidine could represent a biomarker for meat protein consumption...
  27. ncbi request reprint Weight per se influences body mass regulation differently in male and female mice
    Petra Wiedmer
    German Institute of Human Nutrition, Arthur Scheunert Allee, Bergholz Rehbruecke, Germany
    J Gravit Physiol 9:P189-90. 2002
    ..We conclude that the coupling of EI and EE seems to be tighter in females than in males in order to keep a stable BM...
  28. pmc Reduced postprandial energy expenditure and increased exogenous fat oxidation in young woman after ingestion of test meals with a low protein content
    Klaus J Petzke
    Group of Stable Isotopes and of Energy Metabolism, German Institute of Human Nutrition in Potsdam Rehbruecke DIfE, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Nutr Metab (Lond) 5:25. 2008
    ..We tested the hypothesis whether low protein content in single meals may induce lower values of energy expenditure (EE) and fat oxidation (FO) as compared to adequate protein content...