S Klaus

Summary

Affiliation: German Institute of Human Nutrition
Country: Germany

Publications

  1. ncbi Gene expression profiling of adipose tissue: individual, depot-dependent, and sex-dependent variabilities
    Susanne Klaus
    German Institute of Human Nutrition in Potsdam, Bergholz Rehbrücke, Germany
    Nutrition 20:115-20. 2004
  2. ncbi Adipose tissue as a regulator of energy balance
    Susanne Klaus
    German Institute of Human Nutrition in Potsdam DIfE, Arthur Scheunert Allee 114 116, 14558 Bergholz Rehbrucke, Germany
    Curr Drug Targets 5:241-50. 2004
  3. ncbi Expression of uncoupling protein 1 in skeletal muscle decreases muscle energy efficiency and affects thermoregulation and substrate oxidation
    Susanne Klaus
    German Institute of Human Nutrition Potsdam Rehbruecke, Group of Energy Metabolism, Nuthetal, Germany
    Physiol Genomics 21:193-200. 2005
  4. ncbi Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation
    S Klaus
    Group of Energy Metabolism, German Institute of Human Nutrition in Potsdam, Nuthetal, Germany
    Int J Obes (Lond) 29:615-23. 2005
  5. ncbi Increasing the protein:carbohydrate ratio in a high-fat diet delays the development of adiposity and improves glucose homeostasis in mice
    Susanne Klaus
    German Institute of Human Nutrition, Potsdam Rehbruecke, Group of Energy Metabolism, Nuthetal
    J Nutr 135:1854-8. 2005
  6. doi Impairment of fat oxidation under high- vs. low-glycemic index diet occurs before the development of an obese phenotype
    F Isken
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Am J Physiol Endocrinol Metab 298:E287-95. 2010
  7. ncbi In situ metabolic and hemodynamic response to dexfenfluramine in white adipose tissue of rats
    M Boschmann
    German Institute of Human Nutrition, Potsdam, Germany
    Ann Nutr Metab 45:24-9. 2001
  8. doi Acute effects of epigallocatechin gallate from green tea on oxidation and tissue incorporation of dietary lipids in mice fed a high-fat diet
    M Friedrich
    German Institute of Human Nutrition in Potsdam Rehbruecke, Group of Energy Metabolism, Arthur Scheunert Allee 114 116, Nuthetal, Germany
    Int J Obes (Lond) 36:735-43. 2012
  9. ncbi Metabolic and hemodynamic response of adipose tissue to angiotensin II
    M Boschmann
    Department of Biochemistry and Physiology of Nutrition, German Institute of Human Nutrition, Potsdam, Germany
    Obes Res 9:486-91. 2001
  10. ncbi Development of diabetes in obese, insulin-resistant mice: essential role of dietary carbohydrate in beta cell destruction
    H S Jürgens
    Department of Pharmacology, German Institute of Human Nutrition, Potsdam Rehbrucke, Arthur Scheunert Allee 114 116, 14558, Nuthetal, Germany
    Diabetologia 50:1481-9. 2007

Collaborators

Detail Information

Publications40

  1. ncbi Gene expression profiling of adipose tissue: individual, depot-dependent, and sex-dependent variabilities
    Susanne Klaus
    German Institute of Human Nutrition in Potsdam, Bergholz Rehbrücke, Germany
    Nutrition 20:115-20. 2004
  2. ncbi Adipose tissue as a regulator of energy balance
    Susanne Klaus
    German Institute of Human Nutrition in Potsdam DIfE, Arthur Scheunert Allee 114 116, 14558 Bergholz Rehbrucke, Germany
    Curr Drug Targets 5:241-50. 2004
    ....
  3. ncbi Expression of uncoupling protein 1 in skeletal muscle decreases muscle energy efficiency and affects thermoregulation and substrate oxidation
    Susanne Klaus
    German Institute of Human Nutrition Potsdam Rehbruecke, Group of Energy Metabolism, Nuthetal, Germany
    Physiol Genomics 21:193-200. 2005
    ..At Tas below thermoneutrality, this puts increasing energy demands on the animals, whereas at thermoneutrality most differences in energy metabolism are not apparent any more...
  4. ncbi Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation
    S Klaus
    Group of Energy Metabolism, German Institute of Human Nutrition in Potsdam, Nuthetal, Germany
    Int J Obes (Lond) 29:615-23. 2005
    ..To examine the antiobesity effect of epigallocatechin gallate (EGCG), a green tea bioactive polyphenol in a mouse model of diet-induced obesity...
  5. ncbi Increasing the protein:carbohydrate ratio in a high-fat diet delays the development of adiposity and improves glucose homeostasis in mice
    Susanne Klaus
    German Institute of Human Nutrition, Potsdam Rehbruecke, Group of Energy Metabolism, Nuthetal
    J Nutr 135:1854-8. 2005
    ..However, glucose homeostasis was improved in LC mice, indicating that a combination of high fat and high CHO is responsible for the development of metabolic syndrome-related traits in mice...
  6. doi Impairment of fat oxidation under high- vs. low-glycemic index diet occurs before the development of an obese phenotype
    F Isken
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Am J Physiol Endocrinol Metab 298:E287-95. 2010
    ..Early onset and significantly impaired fatty acid oxidation preceded these changes, thereby indicating a potentially causal involvement...
  7. ncbi In situ metabolic and hemodynamic response to dexfenfluramine in white adipose tissue of rats
    M Boschmann
    German Institute of Human Nutrition, Potsdam, Germany
    Ann Nutr Metab 45:24-9. 2001
    ..e., lowered blood lipids and fat mass of DF-treated obese subjects...
  8. doi Acute effects of epigallocatechin gallate from green tea on oxidation and tissue incorporation of dietary lipids in mice fed a high-fat diet
    M Friedrich
    German Institute of Human Nutrition in Potsdam Rehbruecke, Group of Energy Metabolism, Arthur Scheunert Allee 114 116, Nuthetal, Germany
    Int J Obes (Lond) 36:735-43. 2012
    ..To examine in mice the acute effects of epigallocatechin gallate (EGCG), a green tea bioactive polyphenol on substrate metabolism with focus on the fate of dietary lipids...
  9. ncbi Metabolic and hemodynamic response of adipose tissue to angiotensin II
    M Boschmann
    Department of Biochemistry and Physiology of Nutrition, German Institute of Human Nutrition, Potsdam, Germany
    Obes Res 9:486-91. 2001
    ....
  10. ncbi Development of diabetes in obese, insulin-resistant mice: essential role of dietary carbohydrate in beta cell destruction
    H S Jürgens
    Department of Pharmacology, German Institute of Human Nutrition, Potsdam Rehbrucke, Arthur Scheunert Allee 114 116, 14558, Nuthetal, Germany
    Diabetologia 50:1481-9. 2007
    ..Here we analysed the effects of diets with and without carbohydrate on obesity, insulin resistance and development of beta cell failure in the obese, diabetes-prone New Zealand Obese (NZO) mouse...
  11. ncbi Effect of the beta(3)-adrenergic agonist Cl316,243 on functional differentiation of white and brown adipocytes in primary cell culture
    S Klaus
    The German Institute of Human Nutrition DIfE, Bergholz Rehbrücke, Germany
    Biochim Biophys Acta 1539:85-92. 2001
    ....
  12. doi Skeletal muscle uncoupling-induced longevity in mice is linked to increased substrate metabolism and induction of the endogenous antioxidant defense system
    S Keipert
    German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    Am J Physiol Endocrinol Metab 304:E495-506. 2013
    ..This stress induction in turn increases the endogenous antioxidant defense system and redox signaling. Altogether, our data argue for an adaptive role of reactive species as essential signaling molecules for health and longevity...
  13. ncbi Habitual fat intake and basal fat oxidation in obese and non-obese Caucasians
    I Kunz
    German Institute of Human Nutrition, Division of Biochemistry and Physiology of Nutrition, Potsdam Rehbrucke, Germany
    Int J Obes Relat Metab Disord 26:150-6. 2002
    ..To examine the relationship between habitual fat intake and basal fat oxidation in obese and non-obese Caucasian men and women...
  14. doi Metabolic effects of diets differing in glycaemic index depend on age and endogenous glucose-dependent insulinotrophic polypeptide in mice
    F Isken
    Department of Clinical Nutrition, German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    Diabetologia 52:2159-68. 2009
    ..Different effects of these diets could be age-dependent, as well as mediated, in part, by carbohydrate-induced stimulation of glucose-dependent insulinotrophic polypeptide (GIP) signalling...
  15. ncbi Differential gene expression in white and brown preadipocytes
    S Boeuf
    German Institute of Human Nutrition in Potsdam, , Germany
    Physiol Genomics 7:15-25. 2001
    ....
  16. ncbi Gender-specific response to interstitial angiotensin II in human white adipose tissue
    M Boschmann
    German Institute of Human Nutrition, Potsdam, Germany
    Horm Metab Res 34:726-30. 2002
    ..This is associated with an impaired glucose supply and metabolism. Additionally, Ang II inhibits lipolysis...
  17. ncbi Age-related changes of Renin-Angiotensin system genes in white adipose tissue of rats
    F Adams
    German Institute of Human Nutrition, Potsdam, Germany
    Horm Metab Res 34:716-20. 2002
    ..We conclude that age and depot-specific mechanisms are of more importance for the expression of AGT and AT 1 -receptor genes during the first 12 weeks of age than a short period of overfeeding...
  18. ncbi Leptin-induced nuclear translocation of STAT3 immunoreactivity in hypothalamic nuclei involved in body weight regulation
    T Hübschle
    German Institute of Human Nutrition, Departments of Biochemistry and Physiology of Nutrition and Molecular Genetics, D 14558 Potsdam Rehbrücke, Germany
    J Neurosci 21:2413-24. 2001
    ..They further support the importance of ventrally located caudal hypothalamic structures representing the main leptin targets involved in body weight regulation...
  19. ncbi Evidence for Nr4a1 as a cold-induced effector of brown fat thermogenesis
    Timo Kanzleiter
    Department of Animal Physiology, Biology Faculty, Philipps University Marburg, Marburg, Germany
    Physiol Genomics 24:37-44. 2005
    ..We conclude that NUR77 is a cold-induced negative regulator of Ucp1, but phenotypic consequences in knockout mice are compensated by functional redundancy of Nor1...
  20. ncbi Interleukin-6 g.-174G>C promoter polymorphism is associated with obesity in the EPIC-Potsdam Study
    Kerstin Klipstein-Grobusch
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal
    Obesity (Silver Spring) 14:14-8. 2006
    ..044) and was most pronounced in subjects with the CC genotype, suggesting that the IL-6 g.-174G>C promoter polymorphism is a susceptibility or modifying locus for common obesity and weight gain...
  21. ncbi Hyperphagia, lower body temperature, and reduced running wheel activity precede development of morbid obesity in New Zealand obese mice
    Hella S Jürgens
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany
    Physiol Genomics 25:234-41. 2006
    ..Because NZO mice differ strikingly from the ob/ob strain in their resistance to cold stress, we suggest that the molecular defects causing hyperphagia in NZO mice are located distal from leptin and its receptor...
  22. ncbi Hemodynamic and metabolic responses to interstitial angiotensin II in normal weight and obese men
    Michael Boschmann
    Franz Volhard Clinical Research Center, Charite, Universitary Medicine Berlin, Germany
    J Hypertens 24:1165-71. 2006
    ..Therefore, we hypothesized that peripheral tissues of obese subjects are hypersensitive to angiotensin (Ang) II...
  23. ncbi Short-term, increasing dietary protein and fat moderately affect energy expenditure, substrate oxidation and uncoupling protein gene expression in rats
    Klaus J Petzke
    Groups of Stable Isotopes and of Energy Metabolism, German Institute of Human Nutrition in Potsdam Rehbrücke DIfE, D 14558 Nuthetal, Germany
    J Nutr Biochem 18:400-7. 2007
    ..A function of UCPs in energy balance and dissipating food energy was suggested. Future experiments are focused on the regulation of UCP gene expression by dietary protein, which could be important for body-weight management...
  24. ncbi Prenatal high protein exposure decreases energy expenditure and increases adiposity in young rats
    Maren Daenzer
    Department Biochemistry and Physiology of Nutrition, German Institute of Human Nutrition, 14558 Bergholz Rehbrucke, Germany
    J Nutr 132:142-4. 2002
    ..05). Postnatal HP alone had no significant effect on body composition or metabolic rate. These results indicate that in utero exposure to a high protein level reprograms body weight and energy homeostasis...
  25. ncbi Dissociation of obesity and insulin resistance in transgenic mice with skeletal muscle expression of uncoupling protein 1
    Yvonne Katterle
    German Institute of Human Nutrition in Potsdam Rehbruecke, Group of Energy Metabolism, Nuthetal, Germany
    Physiol Genomics 32:352-9. 2008
    ..Rather it can lead to a "healthy" obese phenotype by preserving insulin sensitivity and a high metabolic flexibility, thus protecting from the development of obesity associated disturbances of glucose homeostasis...
  26. doi Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover, and insulin sensitivity in vivo
    Susanne Neschen
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Physiol Genomics 33:333-40. 2008
    ..UCP1-mediated uncoupling of oxidative phosphorylation in skeletal muscle was paralleled by AMPK activation and thereby stimulated insulin-mediated glucose uptake in skeletal muscle...
  27. ncbi Tissue-specific response to interstitial angiotensin II in humans
    Michael Boschmann
    German Institute of Human Nutrition, Department of Biochemistry and Physiology of Nutrition, Potsdam, Germany
    Hypertension 41:37-41. 2003
    ..However, interstitial angiotensin II modulates lipid and carbohydrate metabolism in a tissue specific fashion. Thus, the physiology of interstitial angiotensin II cannot be predicted from intravascular studies...
  28. ncbi Carbon and nitrogen stable isotopic composition of hair protein and amino acids can be used as biomarkers for animal-derived dietary protein intake in humans
    Klaus J Petzke
    German Institute of Human Nutrition Potsdam Rehbruecke DIfE, D 14558 Nuthetal, Germany
    J Nutr 135:1515-20. 2005
    ....
  29. ncbi Water-induced thermogenesis
    Michael Boschmann
    Franz Volhard Clinical Research Center and Helios Klinikum Berlin, Medical Faculty of the Charite, Humboldt University, D 13125 Berlin, Germany
    J Clin Endocrinol Metab 88:6015-9. 2003
    ..Therefore, the thermogenic effect of water should be considered when estimating energy expenditure, particularly during weight loss programs...
  30. ncbi Self-selected macronutrient diet affects energy and glucose metabolism in brown fat-ablated mice
    Sylvia Ortmann
    German Institute of Human Nutrition in Potsdam, Bergholz Rehbrücke, Germany
    Obes Res 11:1536-44. 2003
    ..We investigated macronutrient self-selection and its effect on development of obesity, diabetes, and energy homeostasis in UCP-DTA mice...
  31. ncbi Norepinephrine transporter function and autonomic control of metabolism
    Michael Boschmann
    German Institute of Human Nutrition, 14558 Potsdam, Germany
    J Clin Endocrinol Metab 87:5130-7. 2002
    ..This effect cannot be explained by increased systemic or adipose tissue norepinephrine concentrations. Instead, NET inhibition may sensitize adipose tissue to beta-adrenergic stimulation...
  32. ncbi cis-9,trans-11 and trans-10,cis-12 CLA affect lipid metabolism differently in primary white and brown adipocytes of Djungarian hamsters
    Cornelia C Metges
    German Institute of Human Nutrition, 14558 Bergholz Rehbrucke, Germany
    Lipids 38:1133-42. 2003
    ..The opposite effects of c9,t11-CLA and t10,c12-CLA are evident in both WAT and BAT cultures; however, brown adipocytes seem to be more susceptible to CLA treatment...
  33. ncbi Individual variation of adipose gene expression and identification of covariated genes by cDNA microarrays
    Stephane Boeuf
    German Institute of Human Nutrition in Potsdam, 14558 Bergholz Rehbrucke, Germany, RIKILT, 6700 AE Wageningen, The Netherlands
    Physiol Genomics 11:31-6. 2002
    ..Uncoupling protein 1 (UCP1) displayed a high variability of gene expression in brown fat, which was negatively correlated with the gene expression of complement factor B (FactB), implying a possible functional relationship...
  34. ncbi High level of uncoupling protein 1 expression in muscle of transgenic mice selectively affects muscles at rest and decreases their IIb fiber content
    Elodie Couplan
    Ceremod CNRS UPR9078, 9 rue Jules Hetzel, 92190 Meudon, France
    J Biol Chem 277:43079-88. 2002
    ..This very likely constitutes the origin of the signal leading to the transition in fiber types at rest...
  35. ncbi The novel antiobesic HMR1426 reduces food intake without affecting energy expenditure in rats
    Sylvia Ortmann
    Group of Energy Metabolism, German Institute of Human Nutrition in Potsdam, Nuthetal, Germany
    Obes Res 12:1290-7. 2004
    ..To determine the effect of acute and chronic administration of a new food intake-reducing compound (HMR1426) with novel mode of action (retardation of gastric emptying) on body weight development, food intake, and energy metabolism in rats...
  36. ncbi World Health Organization equations have shortcomings for predicting resting energy expenditure in persons from a modern, affluent population: generation of a new reference standard from a retrospective analysis of a German database of resting energy expe
    Manfred J Muller
    Christian Albrechts Universitat zu Kiel, Institut fur Humanernahrung und Lebensmittelkunde, Kiel, Germany
    Am J Clin Nutr 80:1379-90. 2004
    ..Reference standards for resting energy expenditure (REE) are widely used. Current standards are based on measurements made in the first part of the past century in various races and locations...
  37. ncbi Long-term dietary high protein intake up-regulates tissue specific gene expression of uncoupling proteins 1 and 2 in rats
    Klaus J Petzke
    German Institute of Human Nutrition, Potsdam Rehbrücke DIfE, 14558 Nuthetal, Germany
    Eur J Nutr 44:414-21. 2005
    ..We hypothesized that the dietary protein level can affect gene expression of uncoupling protein (UCP) homologues which is suggested to be involved in thermogenesis, substrate oxidation, and energy expenditure...
  38. ncbi Energy metabolism of young rats after early postnatal overnutrition
    Petra Wiedmer
    Department of Biochemistry and Physiology of Nutrition, German Institute of Human Nutrition DlfE, Postdam Rehbrücke, Germany
    Br J Nutr 88:301-6. 2002
    ..We conclude that although PNO rats display increased adiposity in early life, there seem to be no long-lasting effects on energy metabolism in later life, even if a tendency to increased adiposity can still be detected...
  39. ncbi In vivo response to alpha(1)-adrenoreceptor stimulation in human white adipose tissue
    Michael Boschmann
    German Institute of Human Nutrition, Potsdam, Germany
    Obes Res 10:555-8. 2002
    ..Recent studies in rats suggest an important effect of alpha(1)-adrenoreceptor stimulation on glucose uptake in white adipocytes. It is not known if alpha(1)-adrenoreceptor stimulation elicits similar metabolic effects in humans...
  40. ncbi Gender dimorphism of body mass perception and regulation in mice
    Petra Wiedmer
    German Institute of Human Nutrition DIfE Potsdam Rehbruecke, Nuthetal, Germany
    J Exp Biol 207:2859-66. 2004
    ..Our results suggest that lean body mass rather than body mass per se seems to be tightly regulated. Higher efficiency of energy utilization in females compared to males could explain the gender-specific changes in energy balance...