F Kiessling

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. ncbi request reprint Magnetic resonance imaging of nude mice with heterotransplanted high-grade squamous cell carcinomas: use of a low-loaded, covalently bound Gd-Hsa conjugate as contrast agent with high tumor affinity
    F Kiessling
    Department of Oncological Diagnostics and Therapy, University of Essen, Germany
    Invest Radiol 37:193-8. 2002
  2. pmc Dynamic contrast-enhanced magnetic resonance imaging rapidly indicates vessel regression in human squamous cell carcinomas grown in nude mice caused by VEGF receptor 2 blockade with DC101
    Fabian Kiessling
    Division of Medical Physics in Radiology, German Cancer Research Center, INF 280, Heidelberg 96121, Germany
    Neoplasia 6:213-23. 2004
  3. ncbi request reprint Simple models improve the discrimination of prostate cancers from the peripheral gland by T1-weighted dynamic MRI
    Fabian Kiessling
    Department of Medical Physics in Radiology, Deutsches Krebsforschungszentrum, INF 280, Heidelberg, Germany
    Eur Radiol 14:1793-801. 2004
  4. ncbi request reprint Volumetric computed tomography (VCT): a new technology for noninvasive, high-resolution monitoring of tumor angiogenesis
    Fabian Kiessling
    Department of Medical Physics in Radiology, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany
    Nat Med 10:1133-8. 2004
  5. ncbi request reprint Non-invasive assessment of vessel morphology and function in tumors by magnetic resonance imaging
    Fabian Kiessling
    Junior Group Molecular Imaging, German Cancer Research Center, INF 280, 96121, Heidelberg, Germany
    Eur Radiol 17:2136-48. 2007
  6. ncbi request reprint Improved correlation of histological data with DCE MRI parameter maps by 3D reconstruction, reslicing and parameterization of the histological images
    Fabian Kiessling
    Department of Medical Physics in Radiology, German Cancer Research Center, Heidelberg
    Eur Radiol 15:1079-86. 2005
  7. ncbi request reprint Contrast agents and applications to assess tumor angiogenesis in vivo by magnetic resonance imaging
    F Kiessling
    Molecular Imaging Group, Department of Medical Physics in Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Curr Med Chem 14:77-91. 2007
  8. ncbi request reprint [Status and perspectives of non invasive cell tracking]
    Fabian Kiessling
    Abteilung Medizinische Physik in der Radiologie, Deutsches Krebsforschungszentrum, Heidelberg
    Z Med Phys 15:169-75. 2005
  9. ncbi request reprint Synthesis and characterization of HE-24.8: a polymeric contrast agent for magnetic resonance angiography
    Fabian Kiessling
    Division of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany
    Bioconjug Chem 17:42-51. 2006
  10. ncbi request reprint Dynamic magnetic resonance tomography and proton magnetic resonance spectroscopy of prostate cancers in rats treated by radiotherapy
    Fabian Kiessling
    Department of Oncological Diagnostics and Therapy, German Cancer Research Center DKFZ, Heidelberg, Germany
    Invest Radiol 39:34-44. 2004

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Magnetic resonance imaging of nude mice with heterotransplanted high-grade squamous cell carcinomas: use of a low-loaded, covalently bound Gd-Hsa conjugate as contrast agent with high tumor affinity
    F Kiessling
    Department of Oncological Diagnostics and Therapy, University of Essen, Germany
    Invest Radiol 37:193-8. 2002
    ..Malignant tumors often show an increased uptake and metabolism of plasma proteins, especially albumin...
  2. pmc Dynamic contrast-enhanced magnetic resonance imaging rapidly indicates vessel regression in human squamous cell carcinomas grown in nude mice caused by VEGF receptor 2 blockade with DC101
    Fabian Kiessling
    Division of Medical Physics in Radiology, German Cancer Research Center, INF 280, Heidelberg 96121, Germany
    Neoplasia 6:213-23. 2004
    ....
  3. ncbi request reprint Simple models improve the discrimination of prostate cancers from the peripheral gland by T1-weighted dynamic MRI
    Fabian Kiessling
    Department of Medical Physics in Radiology, Deutsches Krebsforschungszentrum, INF 280, Heidelberg, Germany
    Eur Radiol 14:1793-801. 2004
    ....
  4. ncbi request reprint Volumetric computed tomography (VCT): a new technology for noninvasive, high-resolution monitoring of tumor angiogenesis
    Fabian Kiessling
    Department of Medical Physics in Radiology, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany
    Nat Med 10:1133-8. 2004
    ..Thus, VCT substantially improves imaging of vascularization in tumors and offers a promising tool for preclinical studies of tumor angiogenesis and antiangiogenic therapies...
  5. ncbi request reprint Non-invasive assessment of vessel morphology and function in tumors by magnetic resonance imaging
    Fabian Kiessling
    Junior Group Molecular Imaging, German Cancer Research Center, INF 280, 96121, Heidelberg, Germany
    Eur Radiol 17:2136-48. 2007
    ..This review summarizes strategies for non-invasive characterization of tumor vascularization by functional and molecular MRI, hereby introducing representative preclinical and clinical applications...
  6. ncbi request reprint Improved correlation of histological data with DCE MRI parameter maps by 3D reconstruction, reslicing and parameterization of the histological images
    Fabian Kiessling
    Department of Medical Physics in Radiology, German Cancer Research Center, Heidelberg
    Eur Radiol 15:1079-86. 2005
    ..This method can be used with any histological stain, thus enabling a multivariable correlation of non-invasive data and histology...
  7. ncbi request reprint Contrast agents and applications to assess tumor angiogenesis in vivo by magnetic resonance imaging
    F Kiessling
    Molecular Imaging Group, Department of Medical Physics in Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Curr Med Chem 14:77-91. 2007
    ..Besides a general introduction of the different measurement and postprocessing methods and its previous applications, design, structure and use of different types of CA are the main focus of this article...
  8. ncbi request reprint [Status and perspectives of non invasive cell tracking]
    Fabian Kiessling
    Abteilung Medizinische Physik in der Radiologie, Deutsches Krebsforschungszentrum, Heidelberg
    Z Med Phys 15:169-75. 2005
    ..Non-invasive cell tracking is already established in basic research; in the future, a clinical application of cell tracking is foreseeable in the framework of cell therapy...
  9. ncbi request reprint Synthesis and characterization of HE-24.8: a polymeric contrast agent for magnetic resonance angiography
    Fabian Kiessling
    Division of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany
    Bioconjug Chem 17:42-51. 2006
    ..8; however, contrast of vessels was higher in HE-24.8-enhanced scans. HE-24.8 is considered a macromolecular contrast agent highly suited for experimental MR studies...
  10. ncbi request reprint Dynamic magnetic resonance tomography and proton magnetic resonance spectroscopy of prostate cancers in rats treated by radiotherapy
    Fabian Kiessling
    Department of Oncological Diagnostics and Therapy, German Cancer Research Center DKFZ, Heidelberg, Germany
    Invest Radiol 39:34-44. 2004
    ..To establish an experimental setting for monitoring perfusion and metabolism in orthotopic prostate cancer at 1.5 T using dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) and 1H-MR spectroscopy (MRS)...
  11. ncbi request reprint Comparing dynamic parameters of tumor vascularization in nude mice revealed by magnetic resonance imaging and contrast-enhanced intermittent power Doppler sonography
    Fabian Kiessling
    Division of Oncological Diagnostics and Therapy, German Cancer Research Center, Heidelberg, Germany
    Invest Radiol 38:516-24. 2003
    ..In this study, dynamic parameters obtained using intermittent contrast-enhanced Doppler sonography and dynamic MRI were compared and correlated with microvessel density...
  12. ncbi request reprint [Pulmonary nodules in a patient with high temperature. Acute pulmonary histoplasmosis]
    F Kiessling
    Abteilung für Onkologische Diagnostik und Therapie, Deutsches Krebsforschungszentum DKFZ Heidelberg
    Radiologe 43:856-60. 2003
  13. ncbi request reprint Dynamic T1-weighted monitoring of vascularization in human carcinoma heterotransplants by magnetic resonance imaging
    Fabian Kiessling
    Division of Oncological Diagnostics and Therapy, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 104:113-20. 2003
    ..This technique provides functional data characterizing essential features of tumor biology and is thus appropriate for monitoring antiangiogenic therapies...
  14. ncbi request reprint [Hemodynamic and metabolic characterization of orthotopic rat prostate carcinomas using dynamic MRI and proton magnetic resonance spectroscopy]
    F Kiessling
    Abteilung Onkologische Diagnostik und Therapie, Deutsches Krebsforschungszentrum DKFZ Heidelberg
    Radiologe 43:489-94. 2003
    ..The aim of this study was the noninvasive characterization of prostate carcinoma orthotopically implanted in rats using Gd-DTPA-assisted dynamic MRI (dMRI) and proton magnetic resonance spectroscopy ((1)H-MRS)...
  15. ncbi request reprint [Apical pulmonary coin lesion. Sarcoidosis]
    F Kiessling
    Abteilung für Onkologische Diagnostik und Therapie, Deutsches Krebsforschungszentum DKFZ, Heidelberg
    Radiologe 42:655-7. 2002
  16. ncbi request reprint Initial Experience with a Novel Low-Dose Micro-CT System
    W Stiller
    Medical Physics in Radiology E020, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg
    Rofo 179:669-75. 2007
    ..Investigation of the hardware and image characteristics of a novel micro-CT system and evaluation of its potential to image animals and tissue samples...
  17. ncbi request reprint Volumetric high-frequency Doppler ultrasound enables the assessment of early antiangiogenic therapy effects on tumor xenografts in nude mice
    Manfred Jugold
    Junior Group Molecular Imaging, German Cancer Research Center, INF 280, 69120, Heidelberg, Germany
    Eur Radiol 18:753-8. 2008
    ..01). Additionally, the fraction of mature (SMA-positive) vessels increased under therapy. Thus, HF-VPDU can be considered as an easily applicable and fast method to screen high animal numbers for antiangiogenic therapy effects...
  18. doi request reprint Molecular profiling of angiogenesis with targeted ultrasound imaging: early assessment of antiangiogenic therapy effects
    Moritz Palmowski
    Department of Diagnostic Radiology, Ruprecht Karls University, Heidelberg, Germany
    Mol Cancer Ther 7:101-9. 2008
    ..In conclusion, targeted ultrasound appears feasible for the longitudinal molecular profiling of tumor angiogenesis and for the sensitive assessment of therapy effects in vivo...
  19. ncbi request reprint An optimized workflow for the integration of biological information into radiotherapy planning: experiences with T1w DCE-MRI
    T Neff
    Department of Medical Physics in Radiation Therapy, Deutsches Krebsforschungszentrum DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Phys Med Biol 50:4209-23. 2005
    ..The results were compared with the clinical plans for radiation therapy. Generated parameter maps give additional information about tumour spread, which can be incorporated in the definition of safety margins...
  20. pmc Image-guided and passively tumour-targeted polymeric nanomedicines for radiochemotherapy
    T Lammers
    Department of Innovative Cancer Diagnosis and Therapy, Clinical Cooperation Unit Radiotherapeutic Oncology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Br J Cancer 99:900-10. 2008
    ..Based on these findings, and on the fact that its principles are likely broadly applicable, we propose carrier-based radiochemotherapy as a novel concept for treating advanced solid malignancies...
  21. doi request reprint Fully automated intrinsic respiratory and cardiac gating for small animal CT
    J Kuntz
    Department of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany
    Phys Med Biol 55:2069-85. 2010
    ..This algorithm obviates the necessity of both gating hardware and user interaction. The simplicity of the proposed algorithm enables adoption in a wide range of small animal cone-beam CT scanners...
  22. pmc Platelet-derived growth factor-B normalizes micromorphology and vessel function in vascular endothelial growth factor-A-induced squamous cell carcinomas
    Wiltrud Lederle
    Tumor and Microenvironment A101, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany
    Am J Pathol 176:981-94. 2010
    ..These data clearly demonstrate the need for a concerted action of different growth factors in the establishment of solid tumors with functional vasculature and emphasize the need for a multifactorial therapy...
  23. doi request reprint Intrinsic respiratory gating in small-animal CT
    Soenke H Bartling
    Junior Group Molecular Imaging, German Cancer Research Center DKFZ, Heidelberg, Germany
    Eur Radiol 18:1375-84. 2008
    ..This method improves image quality and allows derivation of functional data. Therefore it bears the potential to find wide applications in small-animal CT imaging...
  24. ncbi request reprint Preoperative embolization of a tumor-bearing horseshoe kidney via both channels of a concomitant aortic dissection
    Moritz Palmowski
    Department of Diagnostic Radiology, Ruprecht Karls University, INF 110, 69120 Heidelberg, Germany
    Cardiovasc Intervent Radiol 30:501-3. 2007
    ..After devascularization of the tumor, organ-preserving surgery was performed without bleeding complications...
  25. ncbi request reprint Retrospective motion gating in small animal CT of mice and rats
    Soenke H Bartling
    Junior Group Molecular Imaging, Department of Medical Physics in Radiology, German Research Center DKFZ, Heidelberg, Germany
    Invest Radiol 42:704-14. 2007
    ..Implementation and evaluation of retrospective respiratory and cardiac gating of mice and rats using a flat-panel volume-CT prototype (fpVCT)...
  26. ncbi request reprint Interstitial magnetic resonance lymphography with gadobutrol in rats: evaluation of contrast kinetics
    Christian Fink
    Deutsches Krebsforschungszentrum, Forschungsschwerpunkt Radiologische Diagnostik und Therapie, Heidelberg, Germany
    Invest Radiol 37:655-62. 2002
    ..To evaluate the contrast kinetics of gadobutrol for interstitial MR lymphography...
  27. doi request reprint Imaging anti-angiogenic treatment response with DCE-VCT, DCE-MRI and DWI in an animal model of breast cancer bone metastasis
    Tobias Bauerle
    Department of Medical Physics in Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur J Radiol 73:280-7. 2010
    ..05 at days 40-60). In conclusion, anti-angiogenic treatment response in osteolytic breast cancer bone metastases can be assessed early with surrogate markers of vascularization, while DWI appears to be insensitive...
  28. ncbi request reprint Sensitive noninvasive monitoring of tumor perfusion during antiangiogenic therapy by intermittent bolus-contrast power Doppler sonography
    Martin Krix
    Departments of Radiological Diagnostics and Therapy, German Cancer Research Center, Heidelberg, Germany
    Cancer Res 63:8264-70. 2003
    ....
  29. ncbi request reprint Time-resolved contrast-enhanced three-dimensional pulmonary MR-angiography: 1.0 M gadobutrol vs. 0.5 M gadopentetate dimeglumine
    Christian Fink
    Department of Radiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Magn Reson Imaging 19:202-8. 2004
    ..To compare contrast characteristics and image quality of 1.0 M gadobutrol with 0.5 M Gd-DTPA for time-resolved three-dimensional pulmonary magnetic resonance angiography (MRA)...
  30. ncbi request reprint Low mechanical index contrast-enhanced ultrasound better reflects high arterial perfusion of liver metastases than arterial phase computed tomography
    Martin Krix
    Department of Radiology, German Cancer Research Center, Thoraxklinik, Heidelberg, Germany
    Invest Radiol 39:216-22. 2004
    ....
  31. ncbi request reprint A multivessel model describing replenishment kinetics of ultrasound contrast agent for quantification of tissue perfusion
    Martin Krix
    German Cancer Research Center, Department of Radiological Diagnostics and Therapy, Heidelberg, Germany
    Ultrasound Med Biol 29:1421-30. 2003
    ..In conclusion, a more valid, detailed and accurate calculation of perfusion parameters, especially of tumors, can be derived in vivo with the new multivessel model of intermittent sonography...
  32. ncbi request reprint Comparison of intermittent-bolus contrast imaging with conventional power Doppler sonography: quantification of tumour perfusion in small animals
    Martin Krix
    Radiological Diagnostics and Therapy, German Cancer Research Centre, Heidelberg, Germany
    Ultrasound Med Biol 29:1093-103. 2003
    ....
  33. doi request reprint Intrinsic gating for small-animal computed tomography: a robust ECG-less paradigm for deriving cardiac phase information and functional imaging
    Julien Dinkel
    Department of Radiology, German Cancer Research Center, Heidelberg, Germany
    Circ Cardiovasc Imaging 1:235-43. 2008
    ..A projection-based method of intrinsic cardiac gating in small-animal computed tomography imaging is presented...
  34. doi request reprint RGD-labeled USPIO inhibits adhesion and endocytotic activity of alpha v beta3-integrin-expressing glioma cells and only accumulates in the vascular tumor compartment
    Fabian Kiessling
    Department of Experimental Molecular Imaging, German Cancer Research Center, RWTH Aachen University, Pauwelsstrasse 20, 52074 Aachen, Germany
    Radiology 253:462-9. 2009
    ....
  35. ncbi request reprint Quantification of perfusion of liver tissue and metastases using a multivessel model for replenishment kinetics of ultrasound contrast agents
    Martin Krix
    Deutsches Krebsforschungszentrum, Department of Radiology, D 69120 Heidelberg, Germany
    Ultrasound Med Biol 30:1355-63. 2004
    ..This allows for the quantification of perfusion of liver tissue and hepatic metastases and provides promising parameters of tissue viability and tumor characterization...
  36. doi request reprint Assessment of vascular remodeling under antiangiogenic therapy using DCE-MRI and vessel size imaging
    Stefan Zwick
    Siemens AG, Healthcare Sector, Erlangen, Germany
    J Magn Reson Imaging 29:1125-33. 2009
    ....
  37. ncbi request reprint High-resolution three-dimensional MR angiography of rodent tumors: morphologic characterization of intratumoral vasculature
    Christian Fink
    Division Oncological Diagnostics and Therapy E010, Research Program Radiological Diagnostics and Therapy, Deutsches Krebsforschungszentrum DKFZ, Heidelberg, Germany
    J Magn Reson Imaging 18:59-65. 2003
    ..To evaluate high-resolution three-dimensional MR angiography (MRA) for the visualization and morphologic characterization of intratumoral vasculature...
  38. ncbi request reprint Computed tomography monitoring of radiation-induced lung fibrosis in mice
    Christian Plathow
    Department of Radiology, Deutsches Krebsforschungszentrum Heidelberg, Germany
    Invest Radiol 39:600-9. 2004
    ..To identify characteristics of lung fibrosis in a mouse model after radiotherapy (RT) using thin-section computed tomography (CT), histology and clinical parameters...
  39. pmc Bevacizumab inhibits breast cancer-induced osteolysis, surrounding soft tissue metastasis, and angiogenesis in rats as visualized by VCT and MRI
    Tobias Bauerle
    Department of Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Neoplasia 10:511-20. 2008
    ..In conclusion, bevacizumab significantly inhibited osteolysis, surrounding soft tissue tumor growth, and angiogenesis in an experimental model of breast cancer bone metastasis as visualized by VCT and MRI...
  40. doi request reprint Pharmacodynamics of streptavidin-coated cyanoacrylate microbubbles designed for molecular ultrasound imaging
    Moritz Palmowski
    Department of Diagnostic Radiology, Ruprecht Karls University, Heidelberg, Germany
    Invest Radiol 43:162-9. 2008
    ..To assess the pharmacodynamic behavior of cyanoacrylate, streptavidin-coated microbubbles (MBs) and to investigate their suitability for molecular ultrasound imaging...
  41. ncbi request reprint Physical and biological characterization of superparamagnetic iron oxide- and ultrasmall superparamagnetic iron oxide-labeled cells: a comparison
    Rui Sun
    Division of Medical Physics in Radiology, German Cancer Research Center, Heidelberg
    Invest Radiol 40:504-13. 2005
    ..The purpose of this study was to compare the labeling characteristics and efficiency as well as toxicity of superparamagnetic iron oxide (SPIO) and ultrasmall superparamagnetic iron oxide (USPIO) for 3 cell lines...
  42. ncbi request reprint Troponin I overexpression inhibits tumor growth, perfusion, and vascularization of morris hepatoma
    Kerstin Schmidt
    Department of Anatomy and Cell Biology III, University of Heidelberg, INF 307, Heidelberg, Germany
    J Nucl Med 47:1506-14. 2006
    ..Human troponin I (TnI) efficiently inhibits endothelial cell proliferation, migration, as well as angiogenesis and tumor growth in vivo. However, little is known about its effects on perfusion and tumor biology...
  43. ncbi request reprint Treatment of bone metastasis induced by MDA-MB-231 breast cancer cells with an antibody against bone sialoprotein
    Tobias Bauerle
    Unit of Toxicology and Chemotherapy, Deutsches Krebsforschungszentrum Heidelberg, 69120 Heidelberg, Germany
    Int J Oncol 28:573-83. 2006
    ..In conclusion, an anti-BSP antibody decreased proliferation, colony formation and migration of MDA-MB-231GFP cells in vitro and reduced osteolysis besides inducing bone formation in a nude rat model...
  44. ncbi request reprint [Multimodal diagnosis of multiple and heterogeneous liver lesions in a young patient]
    F Kiessling
    Abteilung für Onkologische Diagnostik und Therapie, Deutsches Krebsforschungszentrum DKFZ Heidelberg
    Radiologe 45:937-40. 2005
    ..This case clearly illustrates the difficulty to get a certain diagnosis of multiple liver lesions with heterogeneous appearance despite the multimodal diagnostic conduct...
  45. ncbi request reprint Perfusion CT in patients with advanced bronchial carcinomas: a novel chance for characterization and treatment monitoring?
    F Kiessling
    Department of Oncological Diagnostics and Therapy, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur Radiol 14:1226-33. 2004
    ..Tumor perfusion was dependent on tumor size and localization, but not on histology. Furthermore, perfusion CT disclosed blood supply from both pulmonary and/or bronchial vessels in some tumors...
  46. ncbi request reprint Specific targeting of tumor angiogenesis by RGD-conjugated ultrasmall superparamagnetic iron oxide particles using a clinical 1.5-T magnetic resonance scanner
    Chunfu Zhang
    Junior Group Molecular Imaging, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Cancer Res 67:1555-62. 2007
    ..Furthermore, these molecular MR imaging probes are capable of distinguishing tumors differing in the degree of alpha(v)beta(3) integrin expression and in their angiogenesis profile even when using a clinical 1.5-T MR scanner...
  47. ncbi request reprint Lumbar bone marrow microcirculation measurements from dynamic contrast-enhanced magnetic resonance imaging is a predictor of event-free survival in progressive multiple myeloma
    Jens Hillengass
    Department of Hematology, Oncology, and Rheumatology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Clin Cancer Res 13:475-81. 2007
    ..In this study, the prognostic value of the DCE-MRI variables for overall survival and event-free survival in patients with progressive multiple myeloma was investigated...
  48. doi request reprint TNF-alpha and the IFN-gamma-inducible protein 10 (IP-10/CXCL-10) delivered by parvoviral vectors act in synergy to induce antitumor effects in mouse glioblastoma
    M Enderlin
    Deutsches Krebsforschungszentrum, Infection and Cancer Program, Heidelberg, Germany
    Cancer Gene Ther 16:149-60. 2009
    ..In this tumor model, cytokine-mediated immunostimulation, rather than inhibition of vascularization, is likely responsible for the therapeutic efficacy...
  49. ncbi request reprint Characterization of a rat model with site-specific bone metastasis induced by MDA-MB-231 breast cancer cells and its application to the effects of an antibody against bone sialoprotein
    Tobias Bauerle
    Unit of Toxicology and Chemotherapy, Deutsches Krebsforschungszentrum Heidelberg, Heidelberg, Germany
    Int J Cancer 115:177-86. 2005
    ....
  50. pmc Impact of stroma on the growth, microcirculation, and metabolism of experimental prostate tumors
    Christian M Zechmann
    Department of Radiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Neoplasia 9:57-67. 2007
    ..Differences in growth between subcutaneous and orthotopic H tumors can be attributed to tumor-stroma interaction and perfusion. Here, SMC, may stabilize glandular structures and contribute to the maintenance of differentiated phenotype...
  51. ncbi request reprint Determination of pharmacokinetic parameters in DCE MRI: Consequence of nonlinearity between contrast agent concentration and signal intensity
    Melanie Heilmann
    Department of Medical Physics in Radiology, German Cancer Research Center Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Invest Radiol 41:536-43. 2006
    ..We sought to compare pharmacokinetic modeling of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data by assuming a linear and nonlinear relationship between signal intensity (SI) and contrast agent (CA) concentration...
  52. ncbi request reprint Silica- and alkoxysilane-coated ultrasmall superparamagnetic iron oxide particles: a promising tool to label cells for magnetic resonance imaging
    Chunfu Zhang
    Junior Group Molecular Imaging and Departments of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany
    Langmuir 23:1427-34. 2007
    ..This suggests silica-coated USPIO particles are most suited for cell labeling approaches in MRI...
  53. ncbi request reprint Dynamic contrast-enhanced MRI for assessing the disease activity of multiple myeloma: a comparative study with histology and clinical markers
    Sílvia Nosàs-Garcia
    Department of Radiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Magn Reson Imaging 22:154-62. 2005
    ..To examine whether parameters of dynamic, contrast-enhanced MRI (DCE MRI) reflect the degree of infiltration and vessel density in corresponding bone marrow biopsy specimens...
  54. pmc Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis
    Amir Abdollahi
    Department of Radiation Oncology, German Cancer Research Center, Heidelberg 69120, Germany
    J Exp Med 201:925-35. 2005
    ..This study points the way to a potential new approach for treating idiopathic or therapy-related forms of lung fibrosis...
  55. pmc Potential applications of flat-panel volumetric CT in morphologic and functional small animal imaging
    Susanne Greschus
    Department of Neuroradiology, University Giessen, Klinikstrasse 29, Giessen 35385, Germany
    Neoplasia 7:730-40. 2005
    ..Beyond scanning of small animal models as demonstrated here, fpVCT provides the ability to image animals up to the size of primates...
  56. ncbi request reprint Microcirculation and microvasculature in breast tumors: pharmacokinetic analysis of dynamic MR image series
    Gunnar Brix
    Division of Medical Radiation Hygiene and Dosimetry, Department of Radiation Protection and Health, Federal Office for Radiation Protection, Oberschleissheim, Germany
    Magn Reson Med 52:420-9. 2004
    ..The functional imaging technique presented appears promising to quantitatively characterize tumor pathophysiology. Its impact on diagnosis and therapy management of breast tumors, however, has to be evaluated in larger patient studies...
  57. ncbi request reprint [New contrast agents for medical MR imaging]
    Fabian Kiessling
    Z Med Phys 18:81. 2008
  58. doi request reprint Flt-1 signaling in macrophages promotes glioma growth in vivo
    Mark Kerber
    Tumor Angiogenesis Research Group, Department of Neurosurgery, University of Freiburg, Freiburg, Germany
    Cancer Res 68:7342-51. 2008
    ..Collectively, these results suggest that Flt-1 signaling in myeloid cells is essential to amplify the angiogenic response and to promote glioma growth...
  59. ncbi request reprint Local injection of stem cell factor (SCF) improves myocardial homing of systemically delivered c-kit + bone marrow-derived stem cells
    Matthias Lutz
    Department of Cardiology, Internal Medicine III, University of Heidelberg, INF 410, D 69120 Heidelberg, Germany
    Cardiovasc Res 77:143-50. 2008
    ..We therefore tested whether local administration of stem cell factor (SCF) improves myocardial homing of intravenously infused lin-/c-kit+ stem cells after myocardial infarction...
  60. doi request reprint Vessel fractions in tumor xenografts depicted by flow- or contrast-sensitive three-dimensional high-frequency Doppler ultrasound respond differently to antiangiogenic treatment
    Moritz Palmowski
    Medical Physics in Radiology, German Cancer Research Center
    Cancer Res 68:7042-9. 2008
    ....
  61. pmc Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival
    Peter Vajkoczy
    Department of Neurosurgery, Medical Faculty of the University of Heidelberg, D 68167 Mannheim, Germany
    Proc Natl Acad Sci U S A 103:5799-804. 2006
    ..Our findings implicate Axl in gliomagenesis and validate it as a promising target for the development of approaches toward a therapy of these highly aggressive but, as yet, therapy-refractory, tumors...
  62. doi request reprint Vascular normalization in Rgs5-deficient tumours promotes immune destruction
    Juliana Hamzah
    Western Australian Institute for Medical Research, UWA Centre for Medical Research, Perth, Western Australia 6000, Australia
    Nature 453:410-4. 2008
    ....