F Hoppe-Seyler

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. pmc Expression of inhibitor of apoptosis protein Livin in renal cell carcinoma and non-tumorous adult kidney
    N Wagener
    German Cancer Research Center, Molecular Therapy of Virus Associated Cancers F065, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
    Br J Cancer 97:1271-6. 2007
  2. pmc EZH2 depletion blocks the proliferation of colon cancer cells
    Bettina Fussbroich
    Molecular Therapy of Virus Associated Cancers, German Cancer Research Center, DKFZ, Heidelberg, Germany
    PLoS ONE 6:e21651. 2011
  3. pmc Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma
    Nina Wagener
    German Cancer Research Center, Molecular Therapy of Virus Associated Cancers F065, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
    BMC Cancer 10:524. 2010
  4. ncbi request reprint Peptide aptamers: specific inhibitors of protein function
    Felix Hoppe-Seyler
    Deutsches Krebsforschungszentrum, Programm Infektion und Krebs, Im Neuenheimer Feld 242, D 69120 Heidelberg, Germany
    Curr Mol Med 4:529-38. 2004
  5. ncbi request reprint Peptide aptamers: new tools to study protein interactions
    F Hoppe-Seyler
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, D 69120, Heidelberg, Germany
    J Steroid Biochem Mol Biol 78:105-11. 2001
  6. doi request reprint Emerging topics in human tumor virology
    Felix Hoppe-Seyler
    Research Program Infection and Cancer, Molecular Therapy of Virus Associated Cancers, D 69120 Heidelberg, Germany
    Int J Cancer 129:1289-99. 2011
  7. ncbi request reprint Peptide aptamers: powerful new tools for molecular medicine
    F Hoppe-Seyler
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Mol Med (Berl) 78:426-30. 2000
  8. ncbi request reprint Targeted inhibition of Livin resensitizes renal cancer cells towards apoptosis
    I Crnkovic-Mertens
    German Cancer Research Center, Molecular Therapy of Virus Associated Cancers F065, Im Neuenheimer Feld 242, D 69120 Heidelberg, Germany
    Cell Mol Life Sci 64:1137-44. 2007
  9. ncbi request reprint Peptide aptamers targeting the hepatitis B virus core protein: a new class of molecules with antiviral activity
    K Butz
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, D-69120 Heidelberg, Germany
    Oncogene 20:6579-86. 2001
  10. ncbi request reprint Expression pattern of AP-2 transcription factors in cervical cancer cells and analysis of their influence on human papillomavirus oncogene transcription
    M Beger
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Mol Med 79:314-20. 2001

Collaborators

  • A Haferkamp
  • Nina Wagener
  • Stephan Macher-Goeppinger
  • Johannes Husing
  • J Bedke
  • Karin Butz
  • A Schneider
  • M Vogt
  • Kilian Weigand
  • Irena Crnkovic-Mertens
  • Karin Hoppe-Seyler
  • Claudia Lohrey
  • Bettina Fussbroich
  • Kerstin Nagel-Wolfrum
  • Claudia Buerger
  • Holger Sultmann
  • Daniela Holland
  • Ayelet Armon-Omer
  • Ruprecht Kuner
  • I Crnkovic-Mertens
  • C Denk
  • Evangelia Tomai
  • Julia Semzow
  • Arnd Hengstermann
  • Ilka Wittig
  • Bernd Groner
  • B Klevenz
  • M Beger
  • Maria Fälth
  • Angela Holzer
  • Axel Benner
  • Peter Sauer
  • Amnon Hizi
  • Matthias Dürst
  • Abraham Loyter
  • Assaf Friedler
  • Aviad Levin
  • Zvi Hayouka
  • Julia Maroldt
  • Bettina Schuller
  • Shoshana Loya
  • Julia Bulkescher
  • Annemarie Poustka
  • Susanne Dymalla
  • J Semzow
  • Andreas Buness
  • E F Gröne
  • Mark Fellmann
  • M Hohenfellner
  • Bettina Hartenstein
  • Thomas Muley
  • Fritz Von Weizsacker
  • Hanswalter Zentgraf
  • Michael Meister
  • Martin Scheffner
  • Michael A D'silva
  • Petric Kuballa
  • Christian Kunz
  • H C Hurst
  • T Williams

Detail Information

Publications28

  1. pmc Expression of inhibitor of apoptosis protein Livin in renal cell carcinoma and non-tumorous adult kidney
    N Wagener
    German Cancer Research Center, Molecular Therapy of Virus Associated Cancers F065, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
    Br J Cancer 97:1271-6. 2007
    ....
  2. pmc EZH2 depletion blocks the proliferation of colon cancer cells
    Bettina Fussbroich
    Molecular Therapy of Virus Associated Cancers, German Cancer Research Center, DKFZ, Heidelberg, Germany
    PLoS ONE 6:e21651. 2011
    ..In conclusion, our results demonstrate that EZH2 depletion blocks the growth of colon cancer cells. These findings might provide benefits for the treatment of colon cancer...
  3. pmc Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma
    Nina Wagener
    German Cancer Research Center, Molecular Therapy of Virus Associated Cancers F065, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
    BMC Cancer 10:524. 2010
    ..Here, we studied a possible association between EZH2 expression and prognosis in patients with renal cell carcinoma (RCC)...
  4. ncbi request reprint Peptide aptamers: specific inhibitors of protein function
    Felix Hoppe-Seyler
    Deutsches Krebsforschungszentrum, Programm Infektion und Krebs, Im Neuenheimer Feld 242, D 69120 Heidelberg, Germany
    Curr Mol Med 4:529-38. 2004
    ..Moreover, the peptide aptamer molecules themselves should possess therapeutic potential, both as lead structures for drug design and as a basis for the development of protein drugs...
  5. ncbi request reprint Peptide aptamers: new tools to study protein interactions
    F Hoppe-Seyler
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, D 69120, Heidelberg, Germany
    J Steroid Biochem Mol Biol 78:105-11. 2001
    ..Peptide aptamers represent a new basis for drug design and protein therapy, with implications for basic and applied research, for a broad variety of different types of diseases...
  6. doi request reprint Emerging topics in human tumor virology
    Felix Hoppe-Seyler
    Research Program Infection and Cancer, Molecular Therapy of Virus Associated Cancers, D 69120 Heidelberg, Germany
    Int J Cancer 129:1289-99. 2011
    ..These topics are discussed by summarizing recent developments, pointing out unresolved issues and suggesting possible strategies for their solution...
  7. ncbi request reprint Peptide aptamers: powerful new tools for molecular medicine
    F Hoppe-Seyler
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Mol Med (Berl) 78:426-30. 2000
    ..In addition, peptide aptamers provide a basis for the development of novel diagnostic and therapeutic strategies, with implications for a broad variety of different disease entities, including metabolic disorders, infections, and cancer...
  8. ncbi request reprint Targeted inhibition of Livin resensitizes renal cancer cells towards apoptosis
    I Crnkovic-Mertens
    German Cancer Research Center, Molecular Therapy of Virus Associated Cancers F065, Im Neuenheimer Feld 242, D 69120 Heidelberg, Germany
    Cell Mol Life Sci 64:1137-44. 2007
    ..Targeted inhibition of livin could represent a novel therapeutic strategy to increase the sensitivity of renal cancers towards pro-apoptotic agents...
  9. ncbi request reprint Peptide aptamers targeting the hepatitis B virus core protein: a new class of molecules with antiviral activity
    K Butz
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, D-69120 Heidelberg, Germany
    Oncogene 20:6579-86. 2001
    ..Hence, C1-1 is a novel model compound for inhibiting HBV replication by blocking capsid formation and provides a new basis for the development of therapeutic molecules with specific antiviral potential against HBV infections...
  10. ncbi request reprint Expression pattern of AP-2 transcription factors in cervical cancer cells and analysis of their influence on human papillomavirus oncogene transcription
    M Beger
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Mol Med 79:314-20. 2001
    ..These results indicate that, although a rare event, loss of AP-2 expression occurs in cervical cancer cells. Moreover, AP-2alpha, AP-2beta, and AP-2gamma are neither sufficient nor required to activate the viral E6/E7 promoter...
  11. ncbi request reprint Inhibition of Bax activity is crucial for the antiapoptotic function of the human papillomavirus E6 oncoprotein
    M Vogt
    Deutsches Krebsforschungszentrum, Arbeitsgruppe Molekulare Therapie Virus assoziierter Tumore F065, Im Neuenheimer Feld 242, Heidelberg, Germany
    Oncogene 25:4009-15. 2006
    ..Thus, interference with the p53/PUMA/Bax cascade is crucial for the antiapoptotic function of the viral E6 oncogene in HPV-positive cancer cells...
  12. ncbi request reprint Peptide aptamers: exchange of the thioredoxin-A scaffold by alternative platform proteins and its influence on target protein binding
    B Klevenz
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
    Cell Mol Life Sci 59:1993-8. 2002
    ..Therefore, sequence analyses of TrxA-based peptide aptamers, isolated by two-hybrid screening from randomized expression libraries, should also be useful to find cellular binding partners for a given target protein, by homology...
  13. ncbi request reprint The anti-apoptotic livin gene is an important determinant for the apoptotic resistance of non-small cell lung cancer cells
    Irena Crnkovic-Mertens
    Deutsches Krebsforschungszentrum, Molekulare Therapie Virus assoziierter Tumore F065, Im Neuenheimer Feld 242, D 69120 Heidelberg, Germany
    Lung Cancer 54:135-42. 2006
    ..Our results indicate that Livin is an important contributor to the apoptosis resistance of NSCLC cells and may serve as a novel molecular target for therapeutic inhibition in NSCLC...
  14. ncbi request reprint Cellular growth inhibition by FK778 is linked to G1 arrest or S phase accumulation, dependent on the functional status of the retinoblastoma protein
    Karin Hoppe-Seyler
    Molecular Therapy of Virus Associated Cancers F065, German Cancer Research Center, D 69120 Heidelberg, Germany
    Int J Mol Med 23:415-20. 2009
    ..Although growth of HPV-positive cells was strongly inhibited by FK778, we did not observe significant effects on viral E7 expression, indicating that the antiproliferative effect is not linked to an antiviral activity of FK778...
  15. ncbi request reprint Isoform-specific silencing of the Livin gene by RNA interference defines Livin beta as key mediator of apoptosis inhibition in HeLa cells
    Irena Crnkovic-Mertens
    Deutsches Krebsforschungszentrum, Molekulare Therapie Virus assoziierter Tumore F065, Im Neuenheimer Feld 242, 69120, Heidelberg, Germany
    J Mol Med (Berl) 84:232-40. 2006
    ..Studies evaluating Livin as a novel diagnostic and prognostic tumor marker should benefit from isoform-specific expression analyses...
  16. ncbi request reprint p53 mutations are rare events in recurrent cervical cancer
    C Denk
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Mol Med 79:283-8. 2001
    ..These results indicate that p53 mutations are rare events in recurrent cervical carcinomas, and that somatic mutations of p53 do not provide cervical cancer cells with a selective growth advantage for recurrence...
  17. ncbi request reprint Activation of the enhancer of zeste homologue 2 gene by the human papillomavirus E7 oncoprotein
    Daniela Holland
    Molecular Therapy of Virus Associated Cancers F065, German Cancer Research Center, Heidelberg, Germany
    Cancer Res 68:9964-72. 2008
    ..Moreover, EZH2 may serve as a novel therapeutic target for the treatment of cervical cancer...
  18. ncbi request reprint Induction of apoptosis in tumor cells by siRNA-mediated silencing of the livin/ML-IAP/KIAP gene
    Irena Crnkovic-Mertens
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, Heidelberg D 69120, Germany
    Oncogene 22:8330-6. 2003
    ....
  19. ncbi request reprint Human tumor viruses
    F Hoppe-Seyler
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Anticancer Res 19:4747-58. 1999
    ..Malignant transformation typically requires additional genetic alterations of the host cell, to which tumor viruses can contribute by destabilizating the cellular genome...
  20. doi request reprint The enhancer of zeste homolog 2 gene contributes to cell proliferation and apoptosis resistance in renal cell carcinoma cells
    Nina Wagener
    German Cancer Research Center, Molecular Therapy of Virus Associated Cancers F065, Heidelberg, Germany
    Int J Cancer 123:1545-50. 2008
    ..Targeted inhibition of EZH2 could therefore represent a novel strategy to improve the therapeutic response of RCC...
  21. doi request reprint High nuclear Livin expression is a favourable prognostic indicator in renal cell carcinoma
    Axel Haferkamp
    Department of Urology, University of Heidelberg, Heidelberg, Germany
    BJU Int 102:1700-6. 2008
    ..To assess the protein expression of Livin, an apoptosis inhibitor, in renal cell carcinoma (RCC) and to determine its prognostic relevance...
  22. ncbi request reprint Peptide aptamer-mediated inhibition of target proteins by sequestration into aggresomes
    Evangelia Tomai
    Molecular Therapy of Virus Associated Cancers Group F065, German Cancer Research Center, Heidelberg
    J Biol Chem 281:21345-52. 2006
    ..The observation that PAs induce the specific sequestration of bound proteins into aggresomes defines a novel mechanism as to how this new class of intracellular inhibitors blocks the function of their target proteins...
  23. pmc Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53
    Arnd Hengstermann
    Center for Biochemistry, Faculty of Medicine, University of Cologne, Germany
    J Virol 79:9296-300. 2005
    ..These data indicate that the anti-growth-suppressive properties of E6-AP in HPV-positive cells depend on its ability to induce p53 degradation...
  24. doi request reprint Correlation between shiftide activity and HIV-1 integrase inhibition by a peptide selected from a combinatorial library
    Ayelet Armon-Omer
    Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Mol Biol 376:971-82. 2008
    ..Thus, the results show a distinct correlation between the ability of the selected peptides to inhibit IN activity and that to shift its oligomerization equilibrium...
  25. ncbi request reprint Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells
    Claudia Buerger
    Georg Speyer Haus, Institute for Biomedical Research, Paul Ehrlich Strasse 42, D 60596 Frankfurt am Main, Germany
    J Biol Chem 278:37610-21. 2003
    ..Transduction of a short synthetic peptide aptamer sequence not embedded into the scaffold protein resulted in the same impairment of EGF-induced Stat3 activation...
  26. ncbi request reprint Identification of cellular targets for the human papillomavirus E6 and E7 oncogenes by RNA interference and transcriptome analyses
    Ruprecht Kuner
    Molecular Genome Analysis, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    J Mol Med (Berl) 85:1253-62. 2007
    ..Comparison with published microarray data revealed a substantial concordance between the genes repressed by RNAi-mediated E6/E7 silencing in HeLa cells and genes reported to be upregulated in HPV-positive cervical cancer biopsies...
  27. ncbi request reprint siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells
    Karin Butz
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, Heidelberg D 69120, Germany
    Oncogene 22:5938-45. 2003
    ..Thus, by sequence-specific targeting of antiapoptotic genes, siRNAs may be developed into novel therapeutics that can efficiently correct the apoptosis deficiency of cancer cells...
  28. ncbi request reprint The interaction of specific peptide aptamers with the DNA binding domain and the dimerization domain of the transcription factor Stat3 inhibits transactivation and induces apoptosis in tumor cells
    Kerstin Nagel-Wolfrum
    Georg Speyer Haus, Institute for Biomedical Research, Frankfurt am Main, Germany
    Mol Cancer Res 2:170-82. 2004
    ..The inhibition of Stat3 functions through the interaction with peptide aptamers counteracts the transformed phenotype and could become useful in targeted tumor therapy...