Michael Hoffmeister

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. pmc Hormone replacement therapy, body mass, and the risk of colorectal cancer among postmenopausal women from Germany
    M Hoffmeister
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Br J Cancer 97:1486-92. 2007
  2. doi request reprint Male sex and smoking have a larger impact on the prevalence of colorectal neoplasia than family history of colorectal cancer
    Michael Hoffmeister
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Clin Gastroenterol Hepatol 8:870-6. 2010
  3. doi request reprint [Screening: prerequisites]
    M Hoffmeister
    Abteilung Klinische Epidemiologie und Alternsforschung, Deutsches Krebsforschungszentrum, Bergheimer Strasse 20, 69115, Heidelberg, Germany
    Internist (Berl) 49:655-6, 658-9. 2008
  4. doi request reprint No evidence for variation in colorectal cancer risk associated with different types of postmenopausal hormone therapy
    M Hoffmeister
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Clin Pharmacol Ther 86:416-24. 2009
  5. doi request reprint Copy number variations of GSTT1 and GSTM1, colorectal cancer risk and possible effect modification of cigarette smoking and menopausal hormone therapy
    Anja Rudolph
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 131:E841-8. 2012
  6. ncbi request reprint SULT1A1 genotype and susceptibility to colorectal cancer
    Carmen Lilla
    Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 120:201-6. 2007
  7. doi request reprint Low risk of colorectal cancer and advanced adenomas more than 10 years after negative colonoscopy
    Hermann Brenner
    Division of Clinical Epidemiology of Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Gastroenterology 138:870-6. 2010
  8. doi request reprint Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM
    Bernd Frank
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, 69115 Heidelberg, Germany
    Carcinogenesis 31:442-5. 2010
  9. doi request reprint Protection from right- and left-sided colorectal neoplasms after colonoscopy: population-based study
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    J Natl Cancer Inst 102:89-95. 2010
  10. doi request reprint The association of cyclin D1 G870A and E-cadherin C-160A polymorphisms with the risk of colorectal cancer in a case control study and meta-analysis
    Xiang Lin Tan
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 122:2573-80. 2008

Detail Information

Publications69

  1. pmc Hormone replacement therapy, body mass, and the risk of colorectal cancer among postmenopausal women from Germany
    M Hoffmeister
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Br J Cancer 97:1486-92. 2007
    ..The reasons for the inconsistency of results regarding the potential risk modifying effect of postmenopausal hormones in the association of BMI with CRC remain inconclusive and require further study...
  2. doi request reprint Male sex and smoking have a larger impact on the prevalence of colorectal neoplasia than family history of colorectal cancer
    Michael Hoffmeister
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Clin Gastroenterol Hepatol 8:870-6. 2010
    ..Screening recommendations for colorectal cancer (CRC) commonly take family history but no other risk factors into account. We compared and assessed risk factors of colorectal polyps in a large population undergoing screening colonoscopy...
  3. doi request reprint [Screening: prerequisites]
    M Hoffmeister
    Abteilung Klinische Epidemiologie und Alternsforschung, Deutsches Krebsforschungszentrum, Bergheimer Strasse 20, 69115, Heidelberg, Germany
    Internist (Berl) 49:655-6, 658-9. 2008
    ..e. the diagnosis of clinically irrelevant disease). Benefits from screening must be achieved at acceptable costs. Implementation of screening has to be based on scientific evidence and accompanied by scientific evaluation...
  4. doi request reprint No evidence for variation in colorectal cancer risk associated with different types of postmenopausal hormone therapy
    M Hoffmeister
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Clin Pharmacol Ther 86:416-24. 2009
    ..40, 0.17-0.90) or with oral tablets (0.59, 0.39-0.90). In combination with estrogen, progestagens of the norethisterone and levonorgestrel families were associated with strong reduction in CRC risk...
  5. doi request reprint Copy number variations of GSTT1 and GSTM1, colorectal cancer risk and possible effect modification of cigarette smoking and menopausal hormone therapy
    Anja Rudolph
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 131:E841-8. 2012
    ..18) for GSTM1. No significant interaction with smoking and MHT use was observed. Our study does not provide evidence for a strong association between CRC risk and CNVs of GSTT1 or GSTM1 or for an effect modification of smoking or MHT use...
  6. ncbi request reprint SULT1A1 genotype and susceptibility to colorectal cancer
    Carmen Lilla
    Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 120:201-6. 2007
    ....
  7. doi request reprint Low risk of colorectal cancer and advanced adenomas more than 10 years after negative colonoscopy
    Hermann Brenner
    Division of Clinical Epidemiology of Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Gastroenterology 138:870-6. 2010
    ..There is little empirical evidence available about the optimal interval for screening, making this a subject of debate. We associated the prevalence of advanced colorectal neoplasms with time since negative colonoscopies...
  8. doi request reprint Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM
    Bernd Frank
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, 69115 Heidelberg, Germany
    Carcinogenesis 31:442-5. 2010
    ..Although none of them showed a significant association with CRC, the association of BLM P868L with rectal cancer risk requires further investigation...
  9. doi request reprint Protection from right- and left-sided colorectal neoplasms after colonoscopy: population-based study
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    J Natl Cancer Inst 102:89-95. 2010
    ....
  10. doi request reprint The association of cyclin D1 G870A and E-cadherin C-160A polymorphisms with the risk of colorectal cancer in a case control study and meta-analysis
    Xiang Lin Tan
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 122:2573-80. 2008
    ..However, the CCND1 G870A polymorphism may modify the protective effect of postmenopausal hormone use on the development of CRC...
  11. ncbi request reprint Interval cancers after negative colonoscopy: population-based case-control study
    Hermann Brenner
    Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Heidelberg, Germany
    Gut 61:1576-82. 2012
    ..The risk of colorectal cancer after a previous negative colonoscopy is very low. Nevertheless, interval cancers occur. We aimed to assess the characteristics and predictors of interval cancers after negative colonoscopy...
  12. doi request reprint Effect of type 2 diabetes predisposing genetic variants on colorectal cancer risk
    Juan Sainz
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Clin Endocrinol Metab 97:E845-51. 2012
    ..The link between colorectal cancer (CRC) and type 2 diabetes mellitus (T2D) has been extensively studied. Although it is commonly accepted that T2D is a risk factor for CRC, the underlying mechanisms are still poorly understood...
  13. ncbi request reprint Expected reduction of colorectal cancer incidence within 8 years after introduction of the German screening colonoscopy programme: estimates based on 1,875,708 screening colonoscopies
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, D 69115 Heidelberg, Germany
    Eur J Cancer 45:2027-33. 2009
    ..Our results forecast a major rapid reduction of the CRC burden in Germany by screening colonoscopy...
  14. doi request reprint Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer
    Bernd Frank
    German Cancer Research Center, Heidelberg, Germany
    Carcinogenesis 31:1381-6. 2010
    ..However, our results provide evidence that CRC subsets may be affected. If confirmed, this knowledge may be used to assess individual susceptibility and to target potential measures of cancer prevention...
  15. doi request reprint Exposure to environmental tobacco smoke and the risk of colorectal cancer in a case-control study from Germany
    Emaculate Verla-Tebit
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Eur J Cancer Prev 18:9-12. 2009
    ..03-12.15) and for women exposed to >23 pack-years of spousal smoking (OR: 3.02; 95% CI: 0.99-9.28). Our findings do not indicate a major impact of ETS on CRC risk but suggest that risk may be increased following spousal exposure...
  16. ncbi request reprint Cigarette smoking and colorectal cancer risk in Germany: a population-based case-control study
    Emaculate Verla-Tebit
    Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 119:630-5. 2006
    ..This study supports the hypothesis that smoking for a long duration at a high cumulative dose increases the risk for colorectal cancer, particularly among women, and suggests that there is risk reduction after longterm smoking cessation...
  17. doi request reprint Role of colonoscopy and polyp characteristics in colorectal cancer after colonoscopic polyp detection: a population-based case-control study
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Ann Intern Med 157:225-32. 2012
    ..Studies have identified characteristics of adenomas detected on colonoscopy to be predictive of adenoma recurrence...
  18. doi request reprint Risk of colorectal cancer after detection and removal of adenomas at colonoscopy: population-based case-control study
    Hermann Brenner
    German Cancer Research Center, Heidelberg, Germany
    J Clin Oncol 30:2969-76. 2012
    ..We aimed to assess risk of colorectal cancer (CRC) according to time since polypectomy and factors that might be relevant for risk stratification...
  19. ncbi request reprint Sex, age, and birth cohort effects in colorectal neoplasms: a cohort analysis
    Hermann Brenner
    German Cancer Research Center, Heidelberg, Germany
    Ann Intern Med 152:697-703. 2010
    ..Cross-sectional analyses estimated that men reach an equivalent prevalence at a much younger age than women. However, cross-sectional estimates may be confounded by birth cohort effects...
  20. ncbi request reprint Death receptor 4 variants and colorectal cancer risk
    Bernd Frank
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 15:2002-5. 2006
    ..37; 95% CI, 0.98-5.76). The score statistic yielded an empirical P of 0.03 of the haplotype-specific test for 626C-683C based on 20,000 simulations, suggesting that DR4 626C-683C may affect colorectal cancer predisposition...
  21. ncbi request reprint Men with negative results of guaiac-based fecal occult blood test have higher prevalences of colorectal neoplasms than women with positive results
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Heidelberg, Germany German Cancer Consortium DKTK, Heidelberg, Germany
    Int J Cancer 134:2927-34. 2014
    ..Our findings underline need to move forward from and overcome shortcomings of gFOBT-based colorectal cancer screening. ..
  22. ncbi request reprint Reduced risk of colorectal cancer up to 10 years after screening, surveillance, or diagnostic colonoscopy
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany German Cancer Consortium, Heidelberg, Germany Electronic address
    Gastroenterology 146:709-17. 2014
    ..Observational studies have suggested that colonoscopies strongly reduce the risk of CRC, but there is little specific evidence on the effects of screening colonoscopies...
  23. doi request reprint Colorectal cancers occurring after colonoscopy with polyp detection: sites of polyps and sites of cancers
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, Heidelberg, Germany
    Int J Cancer 133:1672-9. 2013
    ..8%, 95% confidence interval 2.7%-19.3%). Our study suggests that less than one of nine CRCs occurring within 10 years after colonoscopy with polyp detection may be due to field effects or polyp recrudescence. ..
  24. ncbi request reprint Validity of self-reported endoscopies of the large bowel and implications for estimates of colorectal cancer risk
    Michael Hoffmeister
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Am J Epidemiol 166:130-6. 2007
    ..58), and reasonable for year of examination (kappa = 0.70). Self-reports of previous colorectal endoscopies agreed well with medical records, but validation appears to be essential with respect to details of the examination...
  25. pmc Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases
    Stefanie Huhn
    Department of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Med Genet 13:94. 2012
    ..A two-stage case-control study on CRC susceptibility was conducted to assess the influence of the ancestral alleles in the polymorphisms previously associated with nutrition-related complex diseases...
  26. doi request reprint Genetic polymorphisms in GST genes and survival of colorectal cancer patients treated with chemotherapy
    Silvia Funke
    German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Pharmacogenomics 11:33-41. 2010
    ..Genetic polymorphisms in GST genes (GSTP1 Ile105Val, copy-number variants of GSTM1 and GSTT1) that lead to diminished enzyme activity have been associated with increased chemotherapeutic treatment benefit in colorectal cancer patients...
  27. ncbi request reprint Case-control study supports extension of surveillance interval after colonoscopic polypectomy to at least 5 yr
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany, and Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Am J Gastroenterol 102:1739-44. 2007
    ..Whereas previous evidence is mainly based on observations of adenoma recurrence, we aimed to assess risk of CRC occurrence according to time since polypectomy...
  28. ncbi request reprint Polymorphisms in the insulin like growth factor 1 and IGF binding protein 3 genes and risk of colorectal cancer
    Sonali Pechlivanis
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer Detect Prev 31:408-16. 2007
    ..We wanted to study if these polymorphisms or any haplotypes of the IGF1 and the IGFBP3 genes are associated with CRC...
  29. pmc Risk of progression of advanced adenomas to colorectal cancer by age and sex: estimates based on 840,149 screening colonoscopies
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Gut 56:1585-9. 2007
    ..To derive age and sex specific estimates of transition rates from advanced adenomas to colorectal cancer by combining data of a nationwide screening colonoscopy registry and national data on colorectal cancer (CRC) incidence...
  30. doi request reprint Natural history of colorectal adenomas: birth cohort analysis among 3.6 million participants of screening colonoscopy
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 22:1043-51. 2013
    ..Most colorectal cancers (CRC) develop from adenomas. Knowledge of the natural history of colorectal adenomas, which is not directly observable for ethical reasons, is crucial for designing cost-effective CRC screening strategies...
  31. doi request reprint Colorectal cancer risk associated with hormone use varies by expression of estrogen receptor-β
    Anja Rudolph
    Divisions of Cancer Epidemiology, Clinical Epidemiology and Aging Research, and Molecular Tumor Pathology, German Cancer Research Center, Heidelberg, Germany
    Cancer Res 73:3306-15. 2013
    ..5 years ago; Pheterogeneity = 0.023) but not for associations with reproductive factors. In conclusion, our results suggest that hormone use decreases risk for ESR2-positive but not ESR2-negative colorectal cancer...
  32. doi request reprint Association of hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD) variants and colorectal cancer risk
    Bernd Frank
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Carcinogenesis 32:190-6. 2011
    ..82, 95% CI = 0.70, 0.95, P = 0.01) as well as among smokers (OR = 0.74, 95% CI = 0.61, 0.90, P = 0.003). Yet, our data do not support the previously reported associations of HPGD tagSNPs and risk of CRC...
  33. doi request reprint Modification of menopausal hormone therapy-associated colorectal cancer risk by polymorphisms in sex steroid signaling, metabolism and transport related genes
    Anja Rudolph
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Endocr Relat Cancer 18:371-84. 2011
    ..83-1.18). Results of this exploratory study provide first evidence that polymorphisms in genes related to estrogen transport and signaling may modify MHT-associated CRC risk but warrant replication in an independent population...
  34. doi request reprint Polymorphisms in inflammatory pathway genes and their association with colorectal cancer risk
    Bernd Frank
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 127:2822-30. 2010
    ..23; 95% CI, 1.04-1.45; p = 0.02 and OR, 1.32; 95% CI, 1.05-1.67; p = 0.02, respectively). Our results support a role of variants in inflammatory pathway genes in CRC susceptibility and progression...
  35. doi request reprint Protection from colorectal cancer after colonoscopy: a population-based, case-control study
    Hermann Brenner
    German Cancer Research Center, University Clinic Heidelberg, University of Heidelberg, Germany
    Ann Intern Med 154:22-30. 2011
    ..However, the degree of protection achievable in a population setting with high-quality colonoscopy resources remains to be quantified...
  36. pmc Eight years of colonoscopic bowel cancer screening in Germany: initial findings and projections
    Hermann Brenner
    Abteilung Klinische Epidemiologie und Alternsforschung, Deutsches Kresbforschungszentrum, Bergheimer Str 20, 69115 Heidelberg, Germany
    Dtsch Arztebl Int 107:753-9. 2010
    ..Screening colonoscopy has been offered in Germany since the end of 2002. Our aim was to estimate numbers of colorectal cancers prevented or detected early by screening colonoscopy in 2003-2010...
  37. ncbi request reprint Genetic polymorphisms in TP53, nonsteroidal anti-inflammatory drugs and the risk of colorectal cancer: evidence for gene-environment interaction?
    Xiang Lin Tan
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Pharmacogenet Genomics 17:639-45. 2007
    ..We assessed the association of TP53 Arg72Pro and p53PIN3 polymorphisms with colorectal cancer risk and their possible interaction with nonsteroidal anti-inflammatory drug use...
  38. doi request reprint Family history and age at initiation of colorectal cancer screening
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Am J Gastroenterol 103:2326-31. 2008
    ....
  39. ncbi request reprint Stage-specific associations between beta blocker use and prognosis after colorectal cancer
    Lina Jansen
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Heidelberg, Germany
    Cancer 120:1178-86. 2014
    ..Because evidence is limited for colorectal cancer (CRC), the association of beta blocker use and prognosis was investigated in a large population-based cohort of patients with CRC...
  40. ncbi request reprint GWAS-identified common variants for obesity are not associated with the risk of developing colorectal cancer
    Juan Sainz
    Authors Affiliations Division of Molecular Genetic Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany and Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmo, Sweden
    Cancer Epidemiol Biomarkers Prev 23:1125-8. 2014
    ..Because both traits are genetically determined and share some metabolic biomarkers, we hypothesized that obesity-related polymorphisms could also influence the risk of developing colorectal cancer...
  41. doi request reprint In the era of widespread endoscopy use, randomized trials may strongly underestimate the effects of colorectal cancer screening
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelber, Germany
    J Clin Epidemiol 66:1144-50. 2013
    ..We aimed to quantify their potential impact in RCTs evaluating endoscopic screening for colorectal cancer (CRC)...
  42. ncbi request reprint Individual and joint use of statins and low-dose aspirin and risk of colorectal cancer: a population-based case-control study
    Michael Hoffmeister
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 121:1325-30. 2007
    ....
  43. pmc A comprehensive investigation on common polymorphisms in the MDR1/ABCB1 transporter gene and susceptibility to colorectal cancer
    Daniele Campa
    Genomic Epidemiology Group, German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 7:e32784. 2012
    ..In conclusion, in this study of about 8,800 individuals we show that ABCB1 gene polymorphisms play at best a minor role in the susceptibility to CRC...
  44. doi request reprint Helicobacter pylori infection and colorectal cancer risk: evidence from a large population-based case-control study in Germany
    Yan Zhang
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Am J Epidemiol 175:441-50. 2012
    ..22 (95% CI: 1.02, 1.45), suggesting that H. pylori infection may be associated with a small yet relevant risk increase in the left colorectum...
  45. pmc Age-specific administration of chemotherapy and long-term quality of life in stage II and III colorectal cancer patients: a population-based prospective cohort
    Lina Jansen
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Heidelberg, Germany
    Oncologist 16:1741-51. 2011
    ..To investigate the age-specific pattern of administration of chemotherapy and its association with long-term survival and quality of life (QoL) in stage II and III colorectal cancer patients...
  46. ncbi request reprint Potential for colorectal cancer prevention of sigmoidoscopy versus colonoscopy: population-based case control study
    Hermann Brenner
    Department of Epidemiology, German Cancer Research Center, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 16:494-9. 2007
    ..Among men, this regimen may be almost as effective as colonoscopy, at least at previous performance levels of colonoscopy...
  47. doi request reprint Sojourn time of preclinical colorectal cancer by sex and age: estimates from the German national screening colonoscopy database
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer ResearchCenter, Im Neuenheimer Feld 581, Heidelberg, Germany
    Am J Epidemiol 174:1140-6. 2011
    ..This study provides, for the first time, precise estimates of sojourn time by age and sex, and it suggests that sojourn times are remarkably consistent across age groups and in both sexes...
  48. doi request reprint Long-term risk of colorectal cancer after negative colonoscopy
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany D 69120
    J Clin Oncol 29:3761-7. 2011
    ..We aimed to assess the risk of CRC according to time since negative colonoscopy, overall, and by sex, smoking, and family history of CRC, in a large population-based case-control study...
  49. ncbi request reprint ARLTS1 variants and risk of colorectal cancer
    Bernd Frank
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Cancer Lett 244:172-5. 2006
    ..However, we showed a non-significant increased risk of familial CRC for both variants (OR=1.40 and 1.45), indicating a possible role of ARLTS1 in familial CRC...
  50. doi request reprint Estimated long-term effects of the initial 6 years of the German screening colonoscopy program
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Gastrointest Endosc 72:784-9. 2010
    ..Colorectal cancer is the most common cancer in Germany. Screening colonoscopies have been offered as a primary screening tool in Germany since the end of 2002...
  51. pmc Genetic Polymorphisms in Genes Related to Oxidative Stress (GSTP1, GSTM1, GSTT1, CAT, MnSOD, MPO, eNOS) and Survival of Rectal Cancer Patients after Radiotherapy
    Silvia Funke
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Cancer Epidemiol 2009:302047. 2009
    ....
  52. doi request reprint Diagnostic performance of guaiac-based fecal occult blood test in routine screening: state-wide analysis from Bavaria, Germany
    Hermann Brenner
    1 Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Heidelberg, Germany 2 German Cancer Consortium DKTK, Heidelberg, Germany
    Am J Gastroenterol 109:427-35. 2014
    ..We aimed for a comprehensive evaluation of diagnostic performance of gFOBT by age and sex under routine screening conditions...
  53. doi request reprint Expression analysis of aldehyde dehydrogenase 1A1 (ALDH1A1) in colon and rectal cancer in association with prognosis and response to chemotherapy
    Christoph Kahlert
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
    Ann Surg Oncol 19:4193-201. 2012
    ..We have investigated the prognostic role of ALDH1A1 in primary colorectal cancer and its value in predicting response to chemotherapy in metastatic colorectal cancer...
  54. ncbi request reprint Helicobacter pylori infection, interleukin-1 gene polymorphisms and the risk of colorectal cancer: evidence from a case-control study in Germany
    Natalia Zumkeller
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Eur J Cancer 43:1283-9. 2007
    ..Additionally, a pro-inflammatory genotype did not increase the colorectal cancer risk associated with H. pylori infection. H. pylori positive subjects carrying the pro-inflammatory genotypes even had a lower risk...
  55. pmc Inter-physician variation in follow-up colonoscopies after screening colonoscopy
    Christian Stock
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 8:e69312. 2013
    ..Surveillance is an integral part of the colorectal cancer (CRC) screening process. We aimed to investigate inter-physician variation in follow-up procedures after screening colonoscopy in an opportunistic CRC screening program...
  56. ncbi request reprint Adverse events requiring hospitalization within 30 days after outpatient screening and nonscreening colonoscopies
    Christian Stock
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Heidelberg, Germany
    Gastrointest Endosc 77:419-29. 2013
    ..The incidence of adverse events (AEs) is a crucial factor when colonoscopy is considered for mass screening, but few studies have addressed delayed and non-GI AEs...
  57. doi request reprint Beta blocker use and colorectal cancer risk: population-based case-control study
    Lina Jansen
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Cancer 118:3911-9. 2012
    ..Thus, the authors investigated the association of beta blocker use and CRC risk in a large population-based case-control study (DACHS study)...
  58. ncbi request reprint The functional genetic variant Arg324Gly of frizzled-related protein is associated with colorectal cancer risk
    Kalai S Shanmugam
    Helmholtz University Group Molecular Epidemiology, Heidelberg, Germany
    Carcinogenesis 28:1914-7. 2007
    ..66, 95% CI = 1.14-11.76, P < 0.05). Since modified Wnt signaling and down-regulation of frizzled-related proteins have been observed in many human cancers, this variant may also affect the susceptibility to other cancers...
  59. doi request reprint Smoking, lower gastrointestinal endoscopy, and risk for colorectal cancer
    Michael Hoffmeister
    Authors Affiliations Division of Clinical Epidemiology and Aging Research Institute of Medical Biometry and Informatics, University of Heidelberg and Unit of Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 23:525-33. 2014
    ..Thus, we aimed to investigate whether utilization of lower gastrointestinal endoscopy modifies the effect of lifetime smoking exposure on colorectal cancer risk in a population-based case-control study...
  60. doi request reprint [Colorectal cancer screening]
    Hermann Brenner
    Abteilung Klinische Epidemiologie und Alternsforschung, Deutsches Krebsforschungszentrum, Heidelberg
    Ther Umsch 70:231-5; discussion 236. 2013
    ..Evidence from a range of countries shows that the highest participation rates are obtained when programs are designed to invite eligible individuals to come in for screening...
  61. ncbi request reprint Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumption
    Carmen Lilla
    Division of Clinical Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 15:99-107. 2006
    ....
  62. doi request reprint Clotting factor gene polymorphisms and colorectal cancer risk
    Carla Y Vossen
    German Cancer Research Center, Heidelberg, Germany
    J Clin Oncol 29:1722-7. 2011
    ..We examined the association between six well-known clotting factor gene polymorphisms and colorectal cancer risk in a large case-control study...
  63. ncbi request reprint Do older adults using NSAIDs have a reduced risk of colorectal cancer?
    Michael Hoffmeister
    Department of Epidemiology, German Centre for Research on Ageing DZFA, Heidelberg, Germany
    Drugs Aging 23:513-23. 2006
    ..We specifically reviewed current evidence regarding the effects of NSAIDs on CRC risk in individuals aged > or =65 years, a rapidly growing age group...
  64. doi request reprint Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility
    Jesus Lascorz
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg 69120, Germany
    Carcinogenesis 31:1612-9. 2010
    ..The risk of CRC increased significantly with an increasing number of risk alleles in seven genes involved in MAPK signalling events (P(trend) = 2.2 x 10(-16), OR(per allele) = 1.34, 95% CI 1.11-1.61)...
  65. pmc Adherence to physician recommendations for surveillance in opportunistic colorectal cancer screening: the necessity of organized surveillance
    Christian Stock
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Heidelberg, Germany Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 8:e82676. 2013
    ..Limited evidence exists on the utilization of surveillance colonoscopy in colorectal cancer (CRC) screening programs. We assessed adherence to physician recommendations for surveillance in opportunistic CRC screening in Germany...
  66. pmc Does a negative screening colonoscopy ever need to be repeated?
    H Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre, Heidelberg, Germany
    Gut 55:1145-50. 2006
    ..The aim of this study was to assess the long term risk of clinically manifest colorectal cancer among subjects with negative findings at colonoscopy...
  67. pmc Genetic predictors of circulating 25-hydroxyvitamin d and risk of colorectal cancer
    Linda T Hiraki
    Authors Affiliations Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Departments of Nutrition, and Biostatistics, Harvard School of Public Health Department of Medicine, and Channing Division of Network Medicine, Brigham and Women s Hospital Division of Gastroenterology, Massachusetts General Hospital Department of Medicine, Harvard Medical School Gastrointestinal Malignancy Program, and Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts Public Health Sciences Division, Fred Hutchinson Cancer Research Center Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina Divisions of Cancer Epidemiology and Genetics, and Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda University of Maryland, School of Medicine, Baltimore, Maryland Service de Génétique Médicale, CHU Nantes, Nantes, France Divisions of Clinical Epidemiology and Aging Research and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany Division of Research, Kaiser Permanente Medical Care Program, Oakland Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California Translational Genomics Research Institute, Phoenix, Arizona Department of Surgery, Turkey
    Cancer Epidemiol Biomarkers Prev 22:2037-46. 2013
    ..The identified single-nucleotide polymorphisms (SNPs) from four gene regions collectively explain approximately 5% of the variance in circulating 25(OH)D...
  68. pmc Gender differences in colorectal cancer: implications for age at initiation of screening
    H Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Br J Cancer 96:828-31. 2007
    ..The gender differences were remarkably constant across populations and over time. These patterns suggest that gender differentiation of age at initiation may be worthwhile to utilise CRC-screening resources more efficiently...
  69. pmc Should colorectal cancer screening start at the same age in European countries? Contributions from descriptive epidemiology
    H Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse 20, Heidelberg D 69115, Germany
    Br J Cancer 99:532-5. 2008
    ..The ages at which defined levels of incidence and mortality were reached varied between 9 and 17 years between countries. This variation requires consideration in the definition of screening guidelines...