K Hemminki

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. ncbi request reprint Constraints for genetic association studies imposed by attributable fraction and familial risk
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Carcinogenesis 28:648-56. 2007
  2. doi request reprint Familial risks for cancer as the basis for evidence-based clinical referral and counseling
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Oncologist 13:239-47. 2008
  3. ncbi request reprint Gene-environment interactions in cancer: do they exist?
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120, Heidelberg, Germany
    Ann N Y Acad Sci 1076:137-48. 2006
  4. pmc Familial risks for nerve, nerve root and plexus disorders in siblings based on hospitalisations in Sweden
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    J Epidemiol Community Health 61:80-4. 2007
  5. ncbi request reprint Familial associations of rheumatoid arthritis with autoimmune diseases and related conditions
    Kari Hemminki
    German Cancer Research Center, Heidelberg, Germany, and Karolinska Institute, Huddinge, Sweden
    Arthritis Rheum 60:661-8. 2009
  6. ncbi request reprint Risks for familial and contralateral breast cancer interact multiplicatively and cause a high risk
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Cancer Res 67:868-70. 2007
  7. ncbi request reprint Cancer in immigrants as a pointer to the causes of cancer
    Kari Hemminki
    1 Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, D 69120, Heidelberg, Germany2 Center for Primary Health Care Research, Lund University, 205 02 Malmo, Sweden
    Eur J Public Health 24:64-71. 2014
  8. pmc Prostate cancer as a first and second cancer: effect of family history
    H Zhang
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg 69120, Germany
    Br J Cancer 101:935-9. 2009
  9. pmc Do reproductive factors influence T, N, and M classes of ductal and lobular breast cancers? A nation-wide follow-up study
    Seyed Mohsen Mousavi
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 8:e58867. 2013
  10. pmc Effect of autoimmune diseases on incidence and survival in subsequent multiple myeloma
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, Heidelberg, D 69120, Germany
    J Hematol Oncol 5:59. 2012

Collaborators

Detail Information

Publications221 found, 100 shown here

  1. ncbi request reprint Constraints for genetic association studies imposed by attributable fraction and familial risk
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Carcinogenesis 28:648-56. 2007
    ..The results may challenge the common disease-common variant hypothesis, which posits common variants with low GRRs and large PAFs, however failing to accommodate the empirical FRRs...
  2. doi request reprint Familial risks for cancer as the basis for evidence-based clinical referral and counseling
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Oncologist 13:239-47. 2008
    ..We provide uniform data on familial risks in all common cancers...
  3. ncbi request reprint Gene-environment interactions in cancer: do they exist?
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120, Heidelberg, Germany
    Ann N Y Acad Sci 1076:137-48. 2006
    ..Enhancing the likelihood that the disease causation is genetic, for example, by selecting familial cases, may increase the power of the studies, and the rareness of those cases calls for collaborative networks...
  4. pmc Familial risks for nerve, nerve root and plexus disorders in siblings based on hospitalisations in Sweden
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    J Epidemiol Community Health 61:80-4. 2007
    ..Nerve, nerve root and plexus disorders are common diseases, but little is known about familial clustering in these diseases. This is, to our knowledge, the first systematic family study carried out on these diseases...
  5. ncbi request reprint Familial associations of rheumatoid arthritis with autoimmune diseases and related conditions
    Kari Hemminki
    German Cancer Research Center, Heidelberg, Germany, and Karolinska Institute, Huddinge, Sweden
    Arthritis Rheum 60:661-8. 2009
    ..This study was undertaken to estimate associations of rheumatoid arthritis (RA) with any of 33 autoimmune diseases and related conditions among parents and offspring, singleton siblings, twins, and spouses...
  6. ncbi request reprint Risks for familial and contralateral breast cancer interact multiplicatively and cause a high risk
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Cancer Res 67:868-70. 2007
    ..21, which was predicted by the multiplicative model. Although the data do not rule out polygenic mechanisms, they suggest that epigenetic imprinting events may be involved for the contralateral breast cancer...
  7. ncbi request reprint Cancer in immigrants as a pointer to the causes of cancer
    Kari Hemminki
    1 Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, D 69120, Heidelberg, Germany2 Center for Primary Health Care Research, Lund University, 205 02 Malmo, Sweden
    Eur J Public Health 24:64-71. 2014
    ..We discuss the experiences in cancer registration in Morocco and Egypt. We show the usefulness and limitations in predicting cancer incidence in the countries of origin. ..
  8. pmc Prostate cancer as a first and second cancer: effect of family history
    H Zhang
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg 69120, Germany
    Br J Cancer 101:935-9. 2009
    ..Diagnosis with prostate cancer has been reported to increase the risk of subsequent tumours. However, specific data on individuals with a parental history are not available so far...
  9. pmc Do reproductive factors influence T, N, and M classes of ductal and lobular breast cancers? A nation-wide follow-up study
    Seyed Mohsen Mousavi
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 8:e58867. 2013
    ..However, the possible association of TNM classes with reproductive factors has remained largely unexplored. Because every woman has a reproductive history, implications to outcome prediction are potentially significant...
  10. pmc Effect of autoimmune diseases on incidence and survival in subsequent multiple myeloma
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, Heidelberg, D 69120, Germany
    J Hematol Oncol 5:59. 2012
    ..We systematically analyzed myeloma risk and survival in patients diagnosed with 33 different AIDs...
  11. pmc Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases
    Stefanie Huhn
    Department of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Med Genet 13:94. 2012
    ..A two-stage case-control study on CRC susceptibility was conducted to assess the influence of the ancestral alleles in the polymorphisms previously associated with nutrition-related complex diseases...
  12. pmc Polymorphisms in the mitochondrial oxidative phosphorylation chain genes as prognostic markers for colorectal cancer
    Jesus Lascorz
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, Heidelberg, 69120, Germany
    BMC Med Genet 13:31. 2012
    ..Recently, we identified the mitochondrial oxidative phosphorylation chain as a consistently overrepresented category in the published gene expression profiling (GEP) studies on CRC prognosis...
  13. pmc Subsequent brain tumors in patients with autoimmune disease
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Neuro Oncol 15:1142-50. 2013
    ..No data are available on survival among patients with AId from brain tumors. We analyzed systematically risks and survival in histological types of brain tumors among patients who received a diagnosis of 33 different AIds...
  14. doi request reprint Subsequent leukaemia in autoimmune disease patients
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, Heidelberg, Germany
    Br J Haematol 161:677-87. 2013
    ..Leukaemia is a rare complication in AI disease but findings about this comorbidity at the time of leukaemia diagnosis may help to optimize the treatment and improve survival...
  15. doi request reprint Site-specific survival rates for cancer of unknown primary according to location of metastases
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, Heidelberg, Germany
    Int J Cancer 133:182-9. 2013
    ....
  16. pmc Comparison of survival of patients with metastases from known versus unknown primaries: survival in metastatic cancer
    Matias Riihimäki
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre, DKFZ, 69120 Heidelberg, Germany
    BMC Cancer 13:36. 2013
    ..Such data may give insight into the biology of CUP and the metastatic process in general...
  17. doi request reprint Effect of autoimmune diseases on risk and survival in histology-specific lung cancer
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany
    Eur Respir J 40:1489-95. 2012
    ..0 are known to present with lung manifestations, suggesting that the autoimmune process contributes to lung cancer susceptibility. The data on survival are reassuring that autoimmune diseases do not influence prognosis in lung cancer...
  18. doi request reprint Site-specific cancer deaths in cancer of unknown primary diagnosed with lymph node metastasis may reveal hidden primaries
    K Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre, DKFZ, Heidelberg, Germany
    Int J Cancer 132:944-50. 2013
    ..Importantly, half of all site-specific cancer deaths (266/530) were due to lung tumors. Thus, an intense search should be mounted to find lung cancer in CUP patients with lymph node metastases...
  19. pmc Incidence and survival in non-hereditary amyloidosis in Sweden
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, Heidelberg 69120, Germany
    BMC Public Health 12:974. 2012
    ..Amyloidosis is a heterogeneous disease caused by deposition of amyloid fibrils in organs and thereby interfering with physiological functions. Hardly any incidence data are available and most survival data are limited to specialist clinics...
  20. ncbi request reprint Effect of autoimmune diseases on risk and survival in female cancers
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Gynecol Oncol 127:180-5. 2012
    ..Patients with autoimmune (AI) diseases are diagnosed with increased frequencies of some cancers, which may depend on the underlying dysregulation of the immune system or treatment. Data on female cancers are limited...
  21. pmc Co-morbidity between early-onset leukemia and type 1 diabetes--suggestive of a shared viral etiology?
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    PLoS ONE 7:e39523. 2012
    ..Based on our previous results on co-morbidity between leukemia and T1D, we updated the Swedish dataset and focused on early onset leukemias in patients who had been hospitalized for T1D, comparing to those not hospitalized for T1D...
  22. doi request reprint Do discordant cancers share familial susceptibility?
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Im NeuenheimerFeld 580, Heidelberg, Germany
    Eur J Cancer 48:1200-7. 2012
    ..Yet, a population level search for shared susceptibility between discordant cancers has been hampered because of lacking population sizes...
  23. doi request reprint Risk of asthma and autoimmune diseases and related conditions in patients hospitalized for obesity
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Ann Med 44:289-95. 2012
    ..Although there are putative mechanistic links between obesity and autoimmune diseases, obesity is not considered a risk factor for most autoimmune diseases...
  24. doi request reprint Autoimmune disease and subsequent digestive tract cancer by histology
    K Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Ann Oncol 23:927-33. 2012
    ..We analyzed systematically the occurrence of histology-specific digestive tract cancers in patients diagnosed with 33 different autoimmune diseases in order to address the question of shared susceptibility...
  25. doi request reprint Power and limits of modern cancer diagnostics: cancer of unknown primary
    K Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany
    Ann Oncol 23:760-4. 2012
    ..We want to use the detection rate of second cancers as a measure of efficacy of the diagnostic modalities in finding tumors, assuming that the detection rates have increased with modern technologies...
  26. doi request reprint Familial risk and familial survival in prostate cancer
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    World J Urol 30:143-8. 2012
    ..In the present review, I focus on three lines of family studies with novel results...
  27. pmc Representation of genetic association via attributable familial relative risks in order to identify polymorphisms functionally relevant to rheumatoid arthritis
    Justo Lorenzo Bermejo
    Institute of Medical Biometry and Informatics, University Hospital Heidelberg, INF 305, 69120 Heidelberg, Germany
    BMC Proc 3:S10. 2009
    ....
  28. pmc A gene-wide investigation on polymorphisms in the taste receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer
    Daniele Campa
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Med Genet 11:88. 2010
    ..TAS2R14 is one of the better characterized members of the taste receptor family and has several polymorphic variants. Several substances that have been shown to activate TAS2R14 are powerful toxic and carcinogenic agents...
  29. pmc High-throughput genotyping of a common deletion polymorphism disrupting the TRY6 gene and its association with breast cancer risk
    Kerstin Wagner
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, Heidelberg, Germany
    BMC Genet 8:41. 2007
    ..Therefore, genotyping of such deletion polymorphisms in case-control studies could give important insights into risk associations...
  30. pmc Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study
    Daniele Campa
    Genomic Epidemiology Group, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    BMC Gastroenterol 10:112. 2010
    ..Accumulating evidence also indicates a role of ghrelin in cancer development...
  31. pmc BRIP1 (BACH1) variants and familial breast cancer risk: a case-control study
    Bernd Frank
    Helmholtz University Group Molecular Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany
    BMC Cancer 7:83. 2007
    ..Inactivating and truncating mutations of the nuclear BRCA1-interacting protein 1 (BRIP1) have been shown to be the major cause of Fanconi anaemia and, due to subsequent alterations of BRCA1 function, predispose to breast cancer (BC)...
  32. pmc Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk: a case-control study
    Barbara Burwinkel
    Helmholtz University Group Molecular Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany
    BMC Cancer 6:268. 2006
    ..Genetic alterations in TCF7L2 may therefore affect cancer risk. Recently, TCF7L2 variants, including the microsatellite marker DG10S478 and the nearly perfectly linked SNP rs12233372, were identified to associate with type 2 diabetes...
  33. ncbi request reprint Familial risks for cervical tumors in full and half siblings: etiologic apportioning
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg
    Cancer Epidemiol Biomarkers Prev 15:1413-4. 2006
    ..No evidence for gene-environment interactions was found. The intractable difficulty in separating cervical cancer causation will be an obstacle for a successful identification of susceptibility genes...
  34. ncbi request reprint Incidence and familial risks in pituitary adenoma and associated tumors
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Endocr Relat Cancer 14:103-9. 2007
    ..Whether these associations can be explained by the recently identified pituitary adenoma predisposing gene, AIP, remains to be established...
  35. ncbi request reprint High familial risks for cerebral palsy implicate partial heritable aetiology
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany
    Paediatr Perinat Epidemiol 21:235-41. 2007
    ..The lack of discordant pairs may suggest that heritable factors are disorder type-specific. Affected concordant sibling pairs should be subjected to molecular studies aiming at identifying the susceptibility gene...
  36. ncbi request reprint Familial risks in testicular cancer as aetiological clues
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany
    Int J Androl 29:205-10. 2006
    ..However, the theory cannot be excluded but should be taken up for study when further data are available on maternal smoking. The high familial risk may be the product of shared childhood environment and heritable causes...
  37. ncbi request reprint Risk of familial breast cancer is not increased after pregnancy
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Breast Cancer Res Treat 108:417-20. 2008
    ..77; there was no evidence of increased RRs immediately after last pregnancy. The present study is by far the largest one published on the theme. It shows that pregnancy is not an additional risk factor for women with a family history...
  38. ncbi request reprint Relationships between familial risks of cancer and the effects of heritable genes and their SNP variants
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Mutat Res 592:6-17. 2005
    ..Overall, we consider the likelihood of a successful application of SNPs in gene-environment studies small, unless established environmental risk factors are tested on proven candidate genes...
  39. ncbi request reprint Familial association of prostate cancer with other cancers in the Swedish Family-Cancer Database
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg
    Prostate 65:188-94. 2005
    ..Familial associations between cancer sites may implicate true familial clustering which is relevant for the identification of new cancer syndromes and for clinical counseling...
  40. ncbi request reprint Survival in breast cancer is familial
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Breast Cancer Res Treat 110:177-82. 2008
    ..The consistency of the results suggests that the prognosis in breast cancer is in part heritable which is likely to be explained by yet unknown genetic mechanisms...
  41. ncbi request reprint How common is familial cancer?
    K Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Ann Oncol 19:163-7. 2008
    ..It can be described by the proportion of the familial disease, i.e. same disease in two or more family members. A family history always needs to be specified as to the number of generations covered and their ages...
  42. ncbi request reprint Etiologic impact of known cancer susceptibility genes
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Mutat Res 658:42-54. 2008
    ..Although of low risk, these common variants appear to explain large proportions of breast and prostate cancers in the population...
  43. ncbi request reprint Familial risks for nonmedullary thyroid cancer
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    J Clin Endocrinol Metab 90:5747-53. 2005
    ..Reliable data on familial risks are important for clinical counseling and cancer genetics...
  44. ncbi request reprint Endometrial cancer: population attributable risks from reproductive, familial and socioeconomic factors
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Eur J Cancer 41:2155-9. 2005
    ..84%. Although the present analysis lacked data on some important risk factors for endometrial cancer, the results suggest that a large proportion of the etiology of endometrial cancer can be defined by known epidemiological risk factors...
  45. ncbi request reprint Familial risks for diseases of myoneural junction and muscle in siblings based on hospitalizations and deaths in sweden
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Twin Res Hum Genet 9:573-9. 2006
    ..The very high overall SIRs for the diseases of the myoneural junction and muscle imply that the sporadic forms of these diseases are relatively rare and these diseases are overwhelmingly heritable...
  46. ncbi request reprint Familial risks for main neurological diseases in siblings based on hospitalizations in Sweden
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany Center for Family Medicine, Karolinska Institute, Huddinge, Sweden
    Twin Res Hum Genet 9:580-6. 2006
    ..The high familial risks for neurological disease imply heritable etiology and opportunities for identification of further susceptibility genes...
  47. ncbi request reprint Familial risks for epilepsy among siblings based on hospitalizations in Sweden
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, Heidelberg, Germany
    Neuroepidemiology 27:67-73. 2006
    ..We aim at defining familial risks for siblings to be hospitalized because of epilepsy...
  48. ncbi request reprint Familial risks for eye melanoma and retinoblastoma: results from the Swedish Family-Cancer Database
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany
    Melanoma Res 16:191-5. 2006
    ....
  49. ncbi request reprint Lifestyle and cancer: effect of parental divorce
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Eur J Cancer Prev 15:524-30. 2006
    ..Divorce is becoming increasingly common in many countries and any deviant cancer patterns among offspring of divorced parents will have an impact on the population risk...
  50. ncbi request reprint Familial risks for migraine and other headaches among siblings based on hospitalizations in Sweden
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Neurogenetics 6:217-24. 2005
    ..All subtypes of hospitalized migraines and other headaches show an increased familial risk, at least in specific age groups. The different subtypes appear to share susceptibility, which may imply common disease mechanisms...
  51. ncbi request reprint Are twins at risk of cancer: results from the Swedish family-cancer database
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Twin Res Hum Genet 8:509-14. 2005
    ..The results should encourage others working on twin and singleton populations to examine the specific associations and emerging hypotheses...
  52. ncbi request reprint Parental lung cancer as predictor of cancer risks in offspring: clues about multiple routes of harmful influence?
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 118:744-8. 2006
    ..The data suggest that passive smoking during childhood is associated with an increase risk of nasal cancer. For bladder and kidney cancers, a contribution by tobacco carcinogens is implicated through breastfeeding and in utero exposure...
  53. ncbi request reprint The balance between heritable and environmental aetiology of human disease
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Nat Rev Genet 7:958-65. 2006
    ..Using cancer as an example of complex disease, we examine the scientific evidence for the hypothesis that human diseases result from interactions between genetic variants and the environment...
  54. ncbi request reprint Familial risks for asthma among twins and other siblings based on hospitalizations in Sweden
    K Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Clin Exp Allergy 37:1320-5. 2007
    ..Asthma is a common disabling condition, with known environmental and familial risk factors and with their assumed interactions. We wanted to carry out a family study on asthma to address gene-environment interactions at a population level...
  55. ncbi request reprint Modification of risk for subsequent cancer after female breast cancer by a family history of breast cancer
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Breast Cancer Res Treat 111:165-9. 2008
    ....
  56. ncbi request reprint Associated cancers in parents and offspring of polycythaemia vera and myelofibrosis patients
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Br J Haematol 147:526-30. 2009
    ....
  57. doi request reprint Low-risk variants FGFR2, TNRC9 and LSP1 in German familial breast cancer patients
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, Heidelberg, Germany
    Int J Cancer 126:2858-62. 2010
    ....
  58. pmc Familial risks for type 2 diabetes in Sweden
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Diabetes Care 33:293-7. 2010
    ..Our aim was to characterize familial risks for type 2 diabetes by the type and number of affected family members, including half-siblings, adoptees, and spouses, to quantify risks and estimate the contribution of environmental effect...
  59. doi request reprint Second cancers after testicular cancer diagnosed after 1980 in Sweden
    K Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany
    Ann Oncol 21:1546-51. 2010
    ..The late effects of these therapeutic practices have not been properly evaluated because of the relatively short time since their application...
  60. doi request reprint Subsequent autoimmune or related disease in asthma patients: clustering of diseases or medical care?
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, Heidelberg, Germany
    Ann Epidemiol 20:217-22. 2010
    ..Asthma includes immunological components that may share mechanisms with autoimmune diseases. We analyzed the subsequent occurrence of any of 22 autoimmune and related conditions in hospitalized asthma patients...
  61. pmc The updated Swedish family-cancer database used to assess familial risks of prostate cancer during rapidly increasing incidence
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Hered Cancer Clin Pract 4:186-92. 2006
    ..Increased surveillance and the availability of PSA screening are the likely reasons for the overestimated familial relative risk shortly after the first diagnosis. This lead time bias should be considered in clinical counselling...
  62. pmc The Swedish family-cancer database: update, application to colorectal cancer and clinical relevance
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Hered Cancer Clin Pract 3:7-18. 2005
    ..The implementation of a unified management plan for familial cancers at large will be a major challenge to the clinical genetic counselling community...
  63. doi request reprint Histology-specific risks in testicular cancer in immigrants to Sweden
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, Heidelberg, Germany
    Endocr Relat Cancer 17:329-34. 2010
    ..These factors appear to influence seminoma risk in a more enduring way than they influence non-seminoma...
  64. doi request reprint Preventable breast cancer is postmenopausal
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, 69120 Heidelberg, Germany
    Breast Cancer Res Treat 125:163-7. 2011
    ..These differences offer opportunities for the identification of factors underlying breast cancer etiology and tools for prevention...
  65. pmc Risk of cancer following hospitalization for type 2 diabetes
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Oncologist 15:548-55. 2010
    ..Cancer and type 2 diabetes (T2D) are two common diseases that may share risk factors. We aimed at determining subsequent cancer risks in patients hospitalized for T2D in Sweden...
  66. pmc Familial risks in nervous system tumours: joint Nordic study
    K Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Br J Cancer 102:1786-90. 2010
    ..Familial nervous system cancers are rare and limited data on familial aspects are available particularly on site-specific tumours...
  67. pmc Tumor location and patient characteristics of colon and rectal adenocarcinomas in relation to survival and TNM classes
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    BMC Cancer 10:688. 2010
    ..Recent data show that colonoscopy is efficient in preventing left-sided cancers only. We examine the association of Tumor Node Metastasis (TNM) classes with diagnostic age and patient characteristics...
  68. doi request reprint Incidence and mortality in epithelial ovarian cancer by family history of any cancer
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer 117:3972-80. 2011
    ..If fatal forms of cancer are a highly familial subtype, then familial risk for mortality may exceed that of incidence, which is relevant for clinical decision making and counseling...
  69. ncbi request reprint Familial association of inflammatory bowel diseases with other autoimmune and related diseases
    Kari Hemminki
    German Cancer Research Center, Heidelberg, Germany
    Am J Gastroenterol 105:139-47. 2010
    ..We wanted to estimate the associations of ulcerative colitis (UC) and Crohn's disease (CD) with 32 autoimmune and related diseases among parents and offspring, singleton siblings, twins, and spouses...
  70. doi request reprint Familial association between type 1 diabetes and other autoimmune and related diseases
    K Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120, Heidelberg, Germany
    Diabetologia 52:1820-8. 2009
    ..We wanted to estimate associations between type 1 diabetes mellitus and 33 autoimmune and related diseases in parents, offspring, singleton siblings and twins...
  71. doi request reprint Familial risks for common diseases: etiologic clues and guidance to gene identification
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Mutat Res 658:247-58. 2008
    ..To our knowledge this is a first attempt to summarize familial risks for a large number of diseases using data from a single population on which reasonable uniform diagnostic criteria have been applied...
  72. doi request reprint Risk of subsequent solid tumors after non-Hodgkin's lymphoma: effect of diagnostic age and time since diagnosis
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Im Neuenheimer Feld 580, Heidelberg, Germany
    J Clin Oncol 26:1850-7. 2008
    ..Quantitative data on solid tumors are limited. We focus on survivors of non-Hodgkin's lymphoma (NHL) because the disease is diagnosed at a wide range of ages and treated uniformly primarily with chemotherapy...
  73. doi request reprint Concordance of survival in family members with prostate cancer
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    J Clin Oncol 26:1705-9. 2008
    ..To prove this, we searched for familial clustering of survival (ie, concordance of survival among family members)...
  74. doi request reprint Cancer risk in hospitalized rheumatoid arthritis patients
    K Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Rheumatology (Oxford) 47:698-701. 2008
    ..Patients diagnosed with RA have been at an increased risk of many cancers and at a decreased risk of some cancers. We planned to revisit the theme by using a nation-wide population of RA patients...
  75. doi request reprint Familial risks for chronic obstructive pulmonary disease among siblings based on hospitalisations in Sweden
    K Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    J Epidemiol Community Health 62:398-401. 2008
    ..We carried out a family study on COPD in order to address the role of heritable and environmental risk factors at a population level...
  76. pmc The 'common disease-common variant' hypothesis and familial risks
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 3:e2504. 2008
    ..However, the population attributable fractions of the two alleles are equal. The penetrance mode of the causative locus may be very difficult to deduce from the apparent penetrance mode of the marker locus...
  77. doi request reprint Cancer risks in ulcerative colitis patients
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Int J Cancer 123:1417-21. 2008
    ..However, some of these, including small intestinal carcinoids, prostate cancers and nonthyroid endocrine tumors, may be in excess because of intensified medical surveillance of the patients...
  78. ncbi request reprint New cancer susceptibility loci: population and familial risks
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 123:1726-9. 2008
    ....
  79. ncbi request reprint Cancer risks in Crohn disease patients
    K Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Ann Oncol 20:574-80. 2009
    ..Patients diagnosed with Crohn disease (CD) are known to be at an increased risk of bowel cancers and lymphoma. CD is an autoimmune disease and we hypothesize that the patients are predisposed to a wider spectrum of cancers...
  80. ncbi request reprint Familial risks for hospitalization with endocrine diseases
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    J Clin Endocrinol Metab 93:4755-8. 2008
    ..Familial clustering of a disease is an indicator of a possible heritable cause. In the era of genome scans, the consideration of data on heritability should be important in the assessment of the likely success of the scans...
  81. doi request reprint Risk for multiple sclerosis in relatives and spouses of patients diagnosed with autoimmune and related conditions
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Neurogenetics 10:5-11. 2009
    ..The shared familial risks of MS with amyotrophic lateral sclerosis and asthma suggest shared genetic basis...
  82. doi request reprint Familial risks for amyotrophic lateral sclerosis and autoimmune diseases
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120, Heidelberg, Germany
    Neurogenetics 10:111-6. 2009
    ..These findings should guide future genomic studies. The high spouse correlation will be a challenge to environmental epidemiology of ALS...
  83. ncbi request reprint Familial risks in nervous-system tumours: a histology-specific analysis from Sweden and Norway
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Lancet Oncol 10:481-8. 2009
    ..There are limited data available on tumour subtype-specific familial risks for nervous-system tumours. We aimed to provide such data at the population level...
  84. ncbi request reprint Familial bladder cancer and the related genes
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre DKFZ, Heidelberg, Germany
    Curr Opin Urol 21:386-92. 2011
    ..Recent data have shown that family history influences survival of bladder cancer. Gene identification has been successful particularly on low-risk genes influencing susceptibility and prognosis...
  85. ncbi request reprint Familial risks for colorectal cancer show evidence on recessive inheritance
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 115:835-8. 2005
    ..75% of all CRCs. Its high prevalence and predilection to right-sided colon suggest that only a small proportion of this familial aggregation could be due to MYH mutations...
  86. ncbi request reprint Familial clustering of ovarian and endometrial cancers
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Eur J Cancer 40:90-5. 2004
    ..40 in the daughter when the mother presented with endometrial cancer. Our data show a strong familial coupling of ovarian and endometrial cancers, which appears to be specific to the endometrioid morphology...
  87. ncbi request reprint Prostate cancer screening, changing age-specific incidence trends and implications on familial risk
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Int J Cancer 113:312-5. 2005
    ..The data are probably explained by the healthy brother seeking medical advice upon diagnosis in another brother. This effect is likely to bias familial risk estimates...
  88. ncbi request reprint Familial breast cancer: scope for more susceptibility genes?
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Breast Cancer Res Treat 82:17-22. 2003
    ..Such data would be valuable for prevention and gene identification strategies...
  89. ncbi request reprint Familial risk of cancer: data for clinical counseling and cancer genetics
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 108:109-14. 2004
    ..If, for example, a familial SIR of 2.2 would be use as an action level, counseling would be needed for most cancers at some diagnostic age groups. The present data provide the basis for clinical counseling...
  90. ncbi request reprint Familial risk of urological cancers: data for clinical counseling
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    World J Urol 21:377-81. 2004
    ..Urological cancers also offer a challenge to molecular geneticists attempting to identify the susceptibility genes underlying the familial clustering...
  91. ncbi request reprint Familial risk for lung cancer by histology and age of onset: evidence for recessive inheritance
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Exp Lung Res 31:205-15. 2005
    ..The present data suggest that 1.7% of lung cancers up to age 68 years are heritable and probably due to a high-penetrant recessive gene or genes that predispose to tobacco carcinogens...
  92. pmc Clinical genetic counselling for familial cancers requires reliable data on familial cancer risks and general action plans
    K Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    J Med Genet 41:801-7. 2004
    ..The data will be helpful in implementing evidence based guidelines for helping the general medical system to ascertain and refer even familial cancer clusters to cancer genetics professionals...
  93. ncbi request reprint Effects of screening for breast cancer on its age-incidence relationships and familial risk
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Int J Cancer 117:145-9. 2005
    ..However, the effects on the estimation of familial risk are so far small...
  94. ncbi request reprint Genetic epidemiology of cancer: from families to heritable genes
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 111:944-50. 2004
    ..Clinical genetic counseling would benefit from reviewing established familial risks on all main types of cancer...
  95. ncbi request reprint Familial and second primary pancreatic cancers: a nationwide epidemiologic study from Sweden
    Kari Hemminki
    Department of Biosciences, CNT Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Int J Cancer 103:525-30. 2003
    ..The strong association of pancreatic and lung cancers is puzzling, and it remains unclear to what extent this represents familial sharing of smoking habits...
  96. ncbi request reprint Genetic Epidemiology--science and ethics on familial cancers
    K Hemminki
    Department of Biosciences, Karolinska Institute, Huddinge, Sweden
    Acta Oncol 40:439-44. 2001
    ..The results have implications for design of genetic studies and for clinical counselling...
  97. ncbi request reprint Clinical course of bladder neoplasms and single nucleotide polymorphisms in the CDKN2A gene
    Shigeru Sakano
    Department of Biosciences, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 104:98-103. 2003
    ..Further, the results indicate, a role for the 3' UTR polymorphisms in the CDKN2A gene in tumor invasiveness...
  98. ncbi request reprint Basal cell carcinoma and variants in genes coding for immune response, DNA repair, folate and iron metabolism
    Fabiola Festa
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Mutat Res 574:105-11. 2005
    ..Only the combined distributions of TT/AA genotypes in MTHFR exon 4 (C/T) and exon 7 (A/C) showed slight increase in BCC compared to controls (P < 0.07, OR: 1.94; 95% CI: 0.96-3.89)...
  99. ncbi request reprint Differences in global gene expression in melanoma cell lines with and without homozygous deletion of the CDKN2A locus genes
    Sandra Bloethner
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Melanoma Res 16:297-307. 2006
    ..Our results highlight effects of homozygous deletion of the CDKN2A locus on global gene expression...