M Heer

Summary

Affiliation: German Aerospace Center
Country: Germany

Publications

  1. ncbi request reprint Bone turnover during inpatient nutritional therapy and outpatient follow-up in patients with anorexia nervosa compared with that in healthy control subjects
    Martina Heer
    DLR Institute of Aerospace Medicine, Space Physiology, Linder Hoehe, 51170 Cologne, Germany
    Am J Clin Nutr 80:774-81. 2004
  2. ncbi request reprint Nutritional interventions related to bone turnover in European space missions and simulation models
    Martina Heer
    Institute of Aerospace Medicine, German Aerospace Center, DLR, Cologne, Germany
    Nutrition 18:853-6. 2002
  3. ncbi request reprint Immobilization induces a very rapid increase in osteoclast activity
    Martina Heer
    Institute of Aerospace Medicine, German Aerospace Center DLR, Cologne, Germany
    Acta Astronaut 57:31-6. 2005
  4. ncbi request reprint Changes in bone turnover in patients with anorexia nervosa during eleven weeks of inpatient dietary treatment
    Martina Heer
    DLR Institute of Aerospace Medicine, Space Physiology, 51170 Cologne, Germany
    Clin Chem 48:754-60. 2002
  5. ncbi request reprint Body mass changes, energy, and protein metabolism in space
    M Heer
    Institute of Aerospace Medicine, German Aerospace Center DLR, Cologne, Germany
    Am J Kidney Dis 38:691-5. 2001
  6. ncbi request reprint Energy and fluid metabolism in microgravity
    M Heer
    German Aerospace Center Deutschen Zentrum für Luft und Raumfahrt, Institute of Aerospace Medicine, Cologne, Germany
    Curr Opin Clin Nutr Metab Care 4:307-11. 2001
  7. ncbi request reprint Nutrient supply during recent European missions
    M Heer
    DLR Institute of Aerospace Medicine, Cologne, Germany
    Pflugers Arch 441:R8-14. 2000
  8. ncbi request reprint Space motion sickness: incidence, etiology, and countermeasures
    Martina Heer
    DLR Institute of Aerospace Medicine, 51170 Koln, Germany
    Auton Neurosci 129:77-9. 2006
  9. ncbi request reprint Bone resorption is induced on the second day of bed rest: results of a controlled crossover trial
    Natalie Baecker
    German Aerospace Center Institute of Aerospace Medicine, Linder Hoehe, 51170 Cologne, Germany
    J Appl Physiol 95:977-82. 2003
  10. ncbi request reprint Water and sodium balances and their relation to body mass changes in microgravity
    C Drummer
    Institut für Luft und Raumfahrtmedizin, DLR, Cologne, Germany
    Eur J Clin Invest 30:1066-75. 2000

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Bone turnover during inpatient nutritional therapy and outpatient follow-up in patients with anorexia nervosa compared with that in healthy control subjects
    Martina Heer
    DLR Institute of Aerospace Medicine, Space Physiology, Linder Hoehe, 51170 Cologne, Germany
    Am J Clin Nutr 80:774-81. 2004
    ..Osteopenia and osteoporosis are among the most frequent and severe complications in adolescents with anorexia nervosa...
  2. ncbi request reprint Nutritional interventions related to bone turnover in European space missions and simulation models
    Martina Heer
    Institute of Aerospace Medicine, German Aerospace Center, DLR, Cologne, Germany
    Nutrition 18:853-6. 2002
    ..During and after supplementation, bone formation markers increased significantly during this part of the mission. Therefore, vitamin K seems to play a significant role in bone turnover during space flight...
  3. ncbi request reprint Immobilization induces a very rapid increase in osteoclast activity
    Martina Heer
    Institute of Aerospace Medicine, German Aerospace Center DLR, Cologne, Germany
    Acta Astronaut 57:31-6. 2005
    ..Thus, it appears possible to use short-term bed rest studies as a first step for the development of countermeasures to immobilization...
  4. ncbi request reprint Changes in bone turnover in patients with anorexia nervosa during eleven weeks of inpatient dietary treatment
    Martina Heer
    DLR Institute of Aerospace Medicine, Space Physiology, 51170 Cologne, Germany
    Clin Chem 48:754-60. 2002
    ..Many adolescents with anorexia nervosa suffer from severe osteopenia and osteoporosis. We hypothesized that individualized nutrition therapy may improve bone turnover in anorectic patients...
  5. ncbi request reprint Body mass changes, energy, and protein metabolism in space
    M Heer
    Institute of Aerospace Medicine, German Aerospace Center DLR, Cologne, Germany
    Am J Kidney Dis 38:691-5. 2001
    ..In conclusion, the body mass loss in microgravity is likely a result of undernutrition instead of diuresis and natriuresis caused by the fluid shift...
  6. ncbi request reprint Energy and fluid metabolism in microgravity
    M Heer
    German Aerospace Center Deutschen Zentrum für Luft und Raumfahrt, Institute of Aerospace Medicine, Cologne, Germany
    Curr Opin Clin Nutr Metab Care 4:307-11. 2001
    ..Despite numerous countermeasures, bone mass is lost in microgravity situations. These are body composition changes that need to be challenged before humans can be sent to space for extra-long missions...
  7. ncbi request reprint Nutrient supply during recent European missions
    M Heer
    DLR Institute of Aerospace Medicine, Cologne, Germany
    Pflugers Arch 441:R8-14. 2000
    ..Therefore, more emphasis has to be placed on investigating the effects of a deficient nutrient intake on astronauts during exposure to microgravity, to manage their nutritional care appropriately during long-term missions...
  8. ncbi request reprint Space motion sickness: incidence, etiology, and countermeasures
    Martina Heer
    DLR Institute of Aerospace Medicine, 51170 Koln, Germany
    Auton Neurosci 129:77-9. 2006
    ..Space motion sickness is usually treated using pharmaceuticals, most of which have undesirable side effects. Further studies elucidating the underlying mechanism for space motion sickness may be required for developing new treatments...
  9. ncbi request reprint Bone resorption is induced on the second day of bed rest: results of a controlled crossover trial
    Natalie Baecker
    German Aerospace Center Institute of Aerospace Medicine, Linder Hoehe, 51170 Cologne, Germany
    J Appl Physiol 95:977-82. 2003
    ..8 +/- 8.3% (P < 0.001). Creatinine, urea, and 3-methylhistidine excretion did not change. We conclude that 24 h of bed rest are sufficient to induce a significant rise in osteoclast activity in healthy subjects...
  10. ncbi request reprint Water and sodium balances and their relation to body mass changes in microgravity
    C Drummer
    Institut für Luft und Raumfahrtmedizin, DLR, Cologne, Germany
    Eur J Clin Invest 30:1066-75. 2000
    ....
  11. ncbi request reprint Calcium metabolism in microgravity
    M Heer
    DLR Institute of Aerospace Medicine, D 51170 Cologne, Germany
    Eur J Med Res 4:357-60. 1999
    ....
  12. ncbi request reprint High dietary sodium chloride consumption may not induce body fluid retention in humans
    M Heer
    Deutsche Forschungsansalt für Luft und Raumfahrt Institute of Aerospace Medicine, 51170 Cologne, Germany
    Am J Physiol Renal Physiol 278:F585-95. 2000
    ....
  13. ncbi request reprint Increased renal natriuretic peptide (urodilatin) excretion in heart failure patients
    C Drummer
    DLR Institute of Aerospace Medicine, Cologne, D 51170, Germany
    Eur J Med Res 2:347-54. 1997
    ..4 micromol/min). Our data suggest that renal urodilatin synthesis, may not be involved in the etiology of sodium retention in CHF, but may rather be stimulated to counteract antinatriuresis during CHF...
  14. ncbi request reprint Body fluid regulation in micro-gravity differs from that on Earth: an overview
    C Drummer
    Institut für Luft und Raumfahrtmedizin, Deutsches Zentrum fur Luft und Raumfahrt, Cologne, Germany
    Pflugers Arch 441:R66-72. 2000
    ..A revision of the classical "micro-gravity fluid shift" scheme is required...
  15. ncbi request reprint Sclerostin and DKK1 levels during 14 and 21 days of bed rest in healthy young men
    P Frings-Meuthen
    German Aerospace Center DLR, Institute of Aerospace Medicine, Linder Hoehe, 51147 Cologne, Germany
    J Musculoskelet Neuronal Interact 13:45-52. 2013
    ..Wnt signaling pathway may be crucial in the pathogenesis of disuse-induced bone loss. Sclerostin and DKK1, antagonists of the Wnt signaling pathway, were assessed during immobilization by bed rest in young, healthy people...
  16. doi request reprint Short-term high dietary calcium intake during bedrest has no effect on markers of bone turnover in healthy men
    Natalie Baecker
    Deutsches Zentrum fuer Luft und Raumfahrt, Institute of Aerospace Medicine, Linder Hoehe, Cologne, Germany
    Nutrition 26:522-7. 2010
    ..Immobilization and space flight are causes of disuse osteoporosis. Increasing calcium intake may counteract this disuse-induced bone loss...
  17. ncbi request reprint Effects of L-arginine supplementation on bone metabolism
    Natalie Kamps
    DLR, German Aerospace Center, Institute of Aerospace Medicine, Linder Hohe, Cologne, Germany
    J Gravit Physiol 9:P179-80. 2002
    ..In conclusion, L-arginine-hydrochloride supplementation at that concentration seems to have no effect on bone cell activity in healthy postmenopausal women...
  18. doi request reprint 20-Hz whole body vibration training fails to counteract the decrease in leg muscle volume caused by 14 days of 6 degrees head down tilt bed rest
    Jochen Zange
    Institute of Aerospace Medicine, Deutsches Zentrum fur Luft und Raumfahrt, German Aerospace Center DLR e V, Linder Hohe, 51170 Cologne, Germany
    Eur J Appl Physiol 105:271-7. 2009
    ..HDT combined with control intervention caused a significant (P < 0.05) decrease in the volumes of muscles by -4 to -6.5%. VT failed to counteract the decrease in leg muscle volume induced by HDT...
  19. ncbi request reprint Increased urinary excretion rates of serotonin and metabolites during bedrest
    Petra Platen
    Institute of Cardiology and Sports Medicine, German Sports University, Cologne, Germany
    Acta Astronaut 56:801-8. 2005
    ..Therefore, changes in central SES might be involved in the mechanisms associated with space flight or microgravity, including possible maladaptations such as voluntary undernutrition...
  20. ncbi request reprint L-arginine, the natural precursor of NO, is not effective for preventing bone loss in postmenopausal women
    Natalie Baecker
    DLR Institute of Aerospace Medicine, Linder Hoehe, Cologne, Germany
    J Bone Miner Res 20:471-9. 2005
    ..L-Arginine, the natural precursor of NO, can enhance NO production. However, no effect of L-arginine hydrochloride supplementation was found on bone metabolism or on BMD, bone mass, or bone structure of healthy postmenopausal women...
  21. ncbi request reprint Regulation of body fluid and salt homeostasis--from observations in space to new concepts on Earth
    R Gerzer
    Institute of Aerospace Medicine, German Aerospace Centre DLR, 51147 Cologne, Germany
    Curr Pharm Biotechnol 6:299-304. 2005
    ..But, as data from space demonstrate, we do not...
  22. doi request reprint Vibration training intervention to maintain cartilage thickness and serum concentrations of cartilage oligometric matrix protein (COMP) during immobilization
    A M Liphardt
    Institute of Aerospace Medicine, Deutsches Zentrum fur Luft und Raumfahrt, DLR, Cologne, Germany
    Osteoarthritis Cartilage 17:1598-603. 2009
    ....
  23. doi request reprint The effect of L-arginine administration on muscle force and power in postmenopausal women
    Oliver Fricke
    Children s Hospital, University of Cologne, Cologne, Germany
    Clin Physiol Funct Imaging 28:307-11. 2008
    ..In conclusion, the administration of L-arginine increased maximal force in mechanographic analyses and may prevent a decline of muscle force in postmenopausal women...
  24. ncbi request reprint Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption
    Petra Frings-Meuthen
    German Aerospace Center DLR, Institute of Aerospace Medicine, Cologne, Germany
    J Bone Miner Res 23:517-24. 2008
    ..This was most likely the cause for increased bone resorption during high sodium chloride intake, as determined by analyzing bone resorption markers...
  25. ncbi request reprint Dietary treatment enhances bone formation in malnourished patients
    C Mika
    DLR, German Aerospace Center, Institute of Aerospace Medicine, Cologne, Germany
    J Gravit Physiol 9:P331-2. 2002
    ..After 15 weeks we found a significant increase of the bone formation marker PICP. Thus dietary treatment seems to be a promising tool to counteract bone loss in these patients...
  26. doi request reprint Increasing sodium intake from a previous low or high intake affects water, electrolyte and acid-base balance differently
    Martina Heer
    German Aerospace Center DLR, Institute of Aerospace Medicine, Cologne, Germany
    Br J Nutr 101:1286-94. 2009
    ..01) and bicarbonate (P<0.001) levels decreased. We conclude that a high NaCl intake may increase GAG synthesis; this might play a role in osmotically inactive Na retention in humans...
  27. doi request reprint WISE-2005: supine treadmill exercise within lower body negative pressure and flywheel resistive exercise as a countermeasure to bed rest-induced bone loss in women during 60-day simulated microgravity
    Scott M Smith
    Human Adaptation and Countermeasures Division, National Aeronautics and Space Administration Lyndon B Johnson Space Center, Houston, TX 77058, USA
    Bone 42:572-81. 2008
    ..The combination of resistive and aerobic exercise did not prevent bone resorption but did promote bone formation, and helped mitigate the net bone loss associated with simulated microgravity...
  28. ncbi request reprint Calorie restriction accelerates the catabolism of lean body mass during 2 wk of bed rest
    Gianni Biolo
    Department of Clinical, Technological and Morphological Sciences, Division of Internal Medicine, University of Trieste, Italy
    Am J Clin Nutr 86:366-72. 2007
    ..Muscle inactivity and low energy intake commonly occur in persons with acute or chronic disease, in astronauts during space flight, and during aging...
  29. pmc Short-term bed rest impairs amino acid-induced protein anabolism in humans
    Gianni Biolo
    Clinica Medica, Ospedale di Cattinara, Strada di Fiume 447, Trieste 34149, Italy
    J Physiol 558:381-8. 2004
    ..In conclusion, short-term bed rest leads to reduced stimulation of whole-body protein synthesis by amino acid administration. Results of this study were, in part, presented at the meeting, Experimental Biology, 2004, Washington DC...
  30. ncbi request reprint Modulation of endothelial and smooth muscle function by bed rest and hypoenergetic, low-fat nutrition
    Christiane Hesse
    Dept of Internal Medicine VI, Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Germany
    J Appl Physiol 99:2196-203. 2005
    ..A hypoenergetic, low-fat diet modulates serum lipids, improves endothelium-dependent and -independent relaxation, and may antagonize the unfavorable effects of simulated microgravity on endothelial function...
  31. ncbi request reprint Sympathetic nervous activity decreases during head-down bed rest but not during microgravity
    Niels J Christensen
    Department of Endocrinology, Herlev University Hospital, University of Copenhagen, Denmark
    J Appl Physiol (1985) 99:1552-7. 2005
    ..HDBR cannot be applied to simulate changes in sympathoadrenal activity during microgravity...
  32. ncbi request reprint Calcium and bone metabolism during space flight
    Scott M Smith
    Human Adaptation and Countermeasures Office, NASA Johnson Space Center, Houston, Texas 77058, USA
    Nutrition 18:849-52. 2002
    ..It also highlights areas where nutrition may play a specific role in this bone loss, and where countermeasures may be developed to mitigate that loss...
  33. ncbi request reprint Improvement of nutritional status as assessed by multifrequency BIA during 15 weeks of refeeding in adolescent girls with anorexia nervosa
    Claudia Mika
    Department of Child and Adolescent Psychiatry and Psychotherapy, Technical University of Aachen, Aachen, Germany
    J Nutr 134:3026-30. 2004
    ..An individually determined and controlled hyperenergetic diet as part of a multidimensional, interdisciplinary treatment program for eating disorders seems to quickly improve the nutritional status of AN patients...
  34. ncbi request reprint Elevated physical activity and low leptin levels co-occur in patients with anorexia nervosa
    Kristian Holtkamp
    Department of Child and Adolescent Psychiatry and Psychotherapy, Aachen University, D 52074 Aachen, Germany
    J Clin Endocrinol Metab 88:5169-74. 2003
    ..003). Our results suggest that, similar to semistarvation-induced hyperactivity in rats, hypoleptinemia in patients with AN may be one important factor underlying the excessive physical activity...
  35. doi request reprint Norepinephrine transporter inhibition alters the hemodynamic response to hypergravitation
    Sebastian Strempel
    Franz Volhard Clinical Research Center, Medical University Charité, Campus Buch, Wiltbergstrasse 50, Haus 129, Berlin, Germany
    J Appl Physiol (1985) 104:756-60. 2008
    ..Redistribution of sympathetic activity to the heart or changes in baroreflex responses could explain the excessive tachycardia that we observed...
  36. ncbi request reprint Microgravity as a model of ageing
    Gianni Biolo
    Department of Clinical, Morphological and Technological Sciences, Division of Internal Medicine, University of Trieste, Trieste, Italy
    Curr Opin Clin Nutr Metab Care 6:31-40. 2003
    ..This review will outline how the endocrine, metabolic, immune and musculoskeletal systems are affected by microgravity and ageing, drawing analogies between the observed changes in an attempt to highlight common mechanisms...
  37. ncbi request reprint Low urinary albumin excretion in astronauts during space missions
    Massimo Cirillo
    Nephrology, Second University of Naples, Naples, Italy
    Nephron Physiol 93:p102-5. 2003
    ..Physiological changes occur in man during space missions also at the renal level. Proteinuria was hypothesized for space missions but research data are missing...