Research Topics
| M HeerSummaryAffiliation: German Aerospace Center Country: Germany Publications
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Detail Information
Publications
Bone turnover during inpatient nutritional therapy and outpatient follow-up in patients with anorexia nervosa compared with that in healthy control subjectsMartina Heer
DLR Institute of Aerospace Medicine, Space Physiology, Linder Hoehe, 51170 Cologne, Germany
Am J Clin Nutr 80:774-81. 2004..Osteopenia and osteoporosis are among the most frequent and severe complications in adolescents with anorexia nervosa...- Nutritional interventions related to bone turnover in European space missions and simulation modelsMartina Heer
Institute of Aerospace Medicine, German Aerospace Center, DLR, Cologne, Germany
Nutrition 18:853-6. 2002..During and after supplementation, bone formation markers increased significantly during this part of the mission. Therefore, vitamin K seems to play a significant role in bone turnover during space flight... - Immobilization induces a very rapid increase in osteoclast activityMartina Heer
Institute of Aerospace Medicine, German Aerospace Center DLR, Cologne, Germany
Acta Astronaut 57:31-6. 2005..Thus, it appears possible to use short-term bed rest studies as a first step for the development of countermeasures to immobilization... - Changes in bone turnover in patients with anorexia nervosa during eleven weeks of inpatient dietary treatmentMartina Heer
DLR Institute of Aerospace Medicine, Space Physiology, 51170 Cologne, Germany
Clin Chem 48:754-60. 2002..Many adolescents with anorexia nervosa suffer from severe osteopenia and osteoporosis. We hypothesized that individualized nutrition therapy may improve bone turnover in anorectic patients... - Body mass changes, energy, and protein metabolism in spaceM Heer
Institute of Aerospace Medicine, German Aerospace Center DLR, Cologne, Germany
Am J Kidney Dis 38:691-5. 2001..In conclusion, the body mass loss in microgravity is likely a result of undernutrition instead of diuresis and natriuresis caused by the fluid shift... - Energy and fluid metabolism in microgravityM Heer
German Aerospace Center Deutschen Zentrum für Luft und Raumfahrt, Institute of Aerospace Medicine, Cologne, Germany
Curr Opin Clin Nutr Metab Care 4:307-11. 2001..Despite numerous countermeasures, bone mass is lost in microgravity situations. These are body composition changes that need to be challenged before humans can be sent to space for extra-long missions... - Nutrient supply during recent European missionsM Heer
DLR Institute of Aerospace Medicine, Cologne, Germany
Pflugers Arch 441:R8-14. 2000..Therefore, more emphasis has to be placed on investigating the effects of a deficient nutrient intake on astronauts during exposure to microgravity, to manage their nutritional care appropriately during long-term missions... - Space motion sickness: incidence, etiology, and countermeasuresMartina Heer
DLR Institute of Aerospace Medicine, 51170 Koln, Germany
Auton Neurosci 129:77-9. 2006..Space motion sickness is usually treated using pharmaceuticals, most of which have undesirable side effects. Further studies elucidating the underlying mechanism for space motion sickness may be required for developing new treatments... - Bone resorption is induced on the second day of bed rest: results of a controlled crossover trialNatalie Baecker
German Aerospace Center-Institute of Aerospace Medicine, Linder Hoehe, 51170 Cologne, Germany
J Appl Physiol 95:977-82. 2003..8 +/- 8.3% (P < 0.001). Creatinine, urea, and 3-methylhistidine excretion did not change. We conclude that 24 h of bed rest are sufficient to induce a significant rise in osteoclast activity in healthy subjects... - Water and sodium balances and their relation to body mass changes in microgravityC Drummer
Institut für Luft und Raumfahrtmedizin, DLR, Cologne, Germany
Eur J Clin Invest 30:1066-75. 2000.... - Calcium metabolism in microgravityM Heer
DLR Institute of Aerospace Medicine, D 51170 Cologne, Germany
Eur J Med Res 4:357-60. 1999.... - High dietary sodium chloride consumption may not induce body fluid retention in humansM Heer
Deutsche Forschungsansalt für Luft und Raumfahrt Institute of Aerospace Medicine, 51170 Cologne, Germany
Am J Physiol Renal Physiol 278:F585-95. 2000.... - Increased renal natriuretic peptide (urodilatin) excretion in heart failure patientsC Drummer
DLR Institute of Aerospace Medicine, Cologne, D 51170, Germany
Eur J Med Res 2:347-54. 1997..4 micromol/min). Our data suggest that renal urodilatin synthesis, may not be involved in the etiology of sodium retention in CHF, but may rather be stimulated to counteract antinatriuresis during CHF... - Body fluid regulation in micro-gravity differs from that on Earth: an overviewC Drummer
Institut für Luft und Raumfahrtmedizin, Deutsches Zentrum fur Luft und Raumfahrt, Cologne, Germany
Pflugers Arch 441:R66-72. 2000..A revision of the classical "micro-gravity fluid shift" scheme is required... - Increased urinary excretion rates of serotonin and metabolites during bedrestPetra Platen
Institute of Cardiology and Sports Medicine, German Sports University, Cologne, Germany
Acta Astronaut 56:801-8. 2005..Therefore, changes in central SES might be involved in the mechanisms associated with space flight or microgravity, including possible maladaptations such as voluntary undernutrition... - L-arginine, the natural precursor of NO, is not effective for preventing bone loss in postmenopausal womenNatalie Baecker
DLR Institute of Aerospace Medicine, Linder Hoehe, Cologne, Germany
J Bone Miner Res 20:471-9. 2005..L-Arginine, the natural precursor of NO, can enhance NO production. However, no effect of L-arginine hydrochloride supplementation was found on bone metabolism or on BMD, bone mass, or bone structure of healthy postmenopausal women... - 20-Hz whole body vibration training fails to counteract the decrease in leg muscle volume caused by 14 days of 6 degrees head down tilt bed restJochen Zange
Institute of Aerospace Medicine, Deutsches Zentrum fur Luft und Raumfahrt, German Aerospace Center DLR e V, Linder Hohe, 51170 Cologne, Germany
Eur J Appl Physiol 105:271-7. 2009..HDT combined with control intervention caused a significant (P < 0.05) decrease in the volumes of muscles by -4 to -6.5%. VT failed to counteract the decrease in leg muscle volume induced by HDT... - Short-term high dietary calcium intake during bedrest has no effect on markers of bone turnover in healthy menNatalie Baecker
Deutsches Zentrum fuer Luft und Raumfahrt, Institute of Aerospace Medicine, Linder Hoehe, Cologne, Germany
Nutrition 26:522-7. 2010..Immobilization and space flight are causes of disuse osteoporosis. Increasing calcium intake may counteract this disuse-induced bone loss... - Effects of L-Arginine supplementation on bone metabolismNatalie Kamps
DLR, German Aerospace Center, Institute of Aerospace Medicine, Linder Hohe, Cologne, Germany
J Gravit Physiol 9:P179-80. 2002..In conclusion, L-Arginine-hydrochloride supplementation at that concentration seems to have no effect on bone cell activity in healthy postmenopausal women... - Regulation of body fluid and salt homeostasis--from observations in space to new concepts on EarthR Gerzer
Institute of Aerospace Medicine, German Aerospace Centre DLR, 51147 Cologne, Germany
Curr Pharm Biotechnol 6:299-304. 2005..But, as data from space demonstrate, we do not... - Vibration training intervention to maintain cartilage thickness and serum concentrations of cartilage oligometric matrix protein (COMP) during immobilizationA M Liphardt
Institute of Aerospace Medicine, Deutsches Zentrum fur Luft und Raumfahrt, DLR, Cologne, Germany
Osteoarthritis Cartilage 17:1598-603. 2009.... - The effect of L-arginine administration on muscle force and power in postmenopausal womenOliver Fricke
Children s Hospital, University of Cologne, Cologne, Germany
Clin Physiol Funct Imaging 28:307-11. 2008..In conclusion, the administration of L-arginine increased maximal force in mechanographic analyses and may prevent a decline of muscle force in postmenopausal women... - Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorptionPetra Frings-Meuthen
German Aerospace Center DLR, Institute of Aerospace Medicine, Cologne, Germany
J Bone Miner Res 23:517-24. 2008..This was most likely the cause for increased bone resorption during high sodium chloride intake, as determined by analyzing bone resorption markers... - Dietary treatment enhances bone formation in malnourished patientsC Mika
DLR, German Aerospace Center, Institute of Aerospace Medicine, Cologne, Germany
J Gravit Physiol 9:P331-2. 2002..After 15 weeks we found a significant increase of the bone formation marker PICP. Thus dietary treatment seems to be a promising tool to counteract bone loss in these patients... - Increasing sodium intake from a previous low or high intake affects water, electrolyte and acid-base balance differentlyMartina Heer
German Aerospace Center DLR, Institute of Aerospace Medicine, Cologne, Germany
Br J Nutr 101:1286-94. 2009..01) and bicarbonate (P<0.001) levels decreased. We conclude that a high NaCl intake may increase GAG synthesis; this might play a role in osmotically inactive Na retention in humans... - Calorie restriction accelerates the catabolism of lean body mass during 2 wk of bed restGianni Biolo
Department of Clinical, Technological and Morphological Sciences, Division of Internal Medicine, University of Trieste, Italy
Am J Clin Nutr 86:366-72. 2007..Muscle inactivity and low energy intake commonly occur in persons with acute or chronic disease, in astronauts during space flight, and during aging... - WISE-2005: supine treadmill exercise within lower body negative pressure and flywheel resistive exercise as a countermeasure to bed rest-induced bone loss in women during 60-day simulated microgravityScott M Smith
Human Adaptation and Countermeasures Division, National Aeronautics and Space Administration Lyndon B Johnson Space Center, Houston, TX 77058, USA
Bone 42:572-81. 2008..The combination of resistive and aerobic exercise did not prevent bone resorption but did promote bone formation, and helped mitigate the net bone loss associated with simulated microgravity... - Modulation of endothelial and smooth muscle function by bed rest and hypoenergetic, low-fat nutritionChristiane Hesse
Dept. of Internal Medicine VI, Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Germany
J Appl Physiol 99:2196-203. 2005..A hypoenergetic, low-fat diet modulates serum lipids, improves endothelium-dependent and -independent relaxation, and may antagonize the unfavorable effects of simulated microgravity on endothelial function... - Sympathetic nervous activity decreases during head-down bed rest but not during microgravityNiels J Christensen
Department of Endocrinology, Herlev University Hospital, University of Copenhagen, Denmark
J Appl Physiol 99:1552-7. 2005..HDBR cannot be applied to simulate changes in sympathoadrenal activity during microgravity... - Calcium and bone metabolism during space flightScott M Smith
Human Adaptation and Countermeasures Office, NASA Johnson Space Center, Houston, Texas 77058, USA
Nutrition 18:849-52. 2002..It also highlights areas where nutrition may play a specific role in this bone loss, and where countermeasures may be developed to mitigate that loss... - Improvement of nutritional status as assessed by multifrequency BIA during 15 weeks of refeeding in adolescent girls with anorexia nervosaClaudia Mika
Department of Child and Adolescent Psychiatry and Psychotherapy, Technical University of Aachen, Aachen, Germany
J Nutr 134:3026-30. 2004..An individually determined and controlled hyperenergetic diet as part of a multidimensional, interdisciplinary treatment program for eating disorders seems to quickly improve the nutritional status of AN patients... - Short-term bed rest impairs amino acid-induced protein anabolism in humansGianni Biolo
Clinica Medica, Ospedale di Cattinara, Strada di Fiume 447, Trieste 34149, Italy
J Physiol 558:381-8. 2004..In conclusion, short-term bed rest leads to reduced stimulation of whole-body protein synthesis by amino acid administration. Results of this study were, in part, presented at the meeting, Experimental Biology, 2004, Washington DC... - Norepinephrine transporter inhibition alters the hemodynamic response to hypergravitationSebastian Strempel
Franz Volhard Clinical Research Center, Medical University Charité, Campus Buch, Wiltbergstrasse 50, Haus 129, Berlin, Germany
J Appl Physiol 104:756-60. 2008..Redistribution of sympathetic activity to the heart or changes in baroreflex responses could explain the excessive tachycardia that we observed... - Microgravity as a model of ageingGianni Biolo
Department of Clinical, Morphological and Technological Sciences, Division of Internal Medicine, University of Trieste, Trieste, Italy
Curr Opin Clin Nutr Metab Care 6:31-40. 2003..This review will outline how the endocrine, metabolic, immune and musculoskeletal systems are affected by microgravity and ageing, drawing analogies between the observed changes in an attempt to highlight common mechanisms... - Elevated physical activity and low leptin levels co-occur in patients with anorexia nervosaKristian Holtkamp
Department of Child and Adolescent Psychiatry and Psychotherapy, Aachen University, D-52074 Aachen, Germany
J Clin Endocrinol Metab 88:5169-74. 2003..003). Our results suggest that, similar to semistarvation-induced hyperactivity in rats, hypoleptinemia in patients with AN may be one important factor underlying the excessive physical activity... - Low urinary albumin excretion in astronauts during space missionsMassimo Cirillo
Nephrology, Second University of Naples, Naples, Italy
Nephron Physiol 93:p102-5. 2003..CONCLUSIONS: Urinary albumin excretion is low during space mission compared to data on the ground before or after mission. Low urinary albumin excretion could be another effect of exposure to weightlessness (microgravity)...