H Glatt

Summary

Affiliation: German Institute of Human Nutrition
Country: Germany

Publications

  1. ncbi request reprint Sulfotransferases: genetics and role in toxicology
    H Glatt
    Department of Toxicology, German Institute of Human Nutrition DIfE, Arthur Scheunert Allee 114 116, D 14558, Potsdam Rehbrucke, Germany
    Toxicol Lett 112:341-8. 2000
  2. ncbi request reprint Sulfotransferases in the bioactivation of xenobiotics
    H Glatt
    Department of Toxicology, Deutsches Institut für Ernährungsforschung DIfE, Arthur Scheunert Allee 114 116, D 14558, Potsdam Rehbrucke, Germany
    Chem Biol Interact 129:141-70. 2000
  3. ncbi request reprint Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects
    H Glatt
    Department of Toxicology, German Institute of Human Nutrition DIfE, Arthur Scheunert Allee 114 116, D 14558 Potsdam Rehbrücke, Germany
    Mutat Res 482:27-40. 2001
  4. ncbi request reprint Sulfotransferase-mediated activation of mutagens studied using heterologous expression systems
    H Glatt
    German Institute of Human Nutrition, Department of Toxicology, Potsdam Rehbrucke
    Chem Biol Interact 109:195-219. 1998
  5. ncbi request reprint Genotoxicity characteristics of reverse diol-epoxides of chrysene
    H Glatt
    Department of Toxicology, University of Mainz, Germany
    Carcinogenesis 14:11-9. 1993
  6. ncbi request reprint Structure and localization of the human SULT1B1 gene: neighborhood to SULT1E1 and a SULT1D pseudogene
    W Meinl
    Department of Toxicology, German Institute of Human Nutrition DIfE, Arthur Scheunert Allee 114 116, Bergholz Rehbrücke, 14558, Germany
    Biochem Biophys Res Commun 288:855-62. 2001
  7. ncbi request reprint Protection by beverages, fruits, vegetables, herbs, and flavonoids against genotoxicity of 2-acetylaminofluorene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in metabolically competent V79 cells
    R Edenharder
    Department of Hygiene and Environmental Medicine, University of Mainz, Obere Zahlbacher Str 67, D 55131 Mainz, Germany
    Mutat Res 521:57-72. 2002
  8. ncbi request reprint Human platelet phenolsulfotransferases: cDNA cloning, stable expression in V79 cells and identification of a novel allelic variant of the phenol-sulfating form
    A L Jones
    Department of Biochemical Medicine, University of Dundee, Ninewells Hospital and Medical School, Scotland, UK
    Biochem Biophys Res Commun 208:855-62. 1995
  9. ncbi request reprint Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2
    C E Engelke
    Department of Toxicology, German Institute of Human Nutrition Potsdam Rehbrucke
    Pharmacogenetics 10:163-9. 2000
  10. ncbi request reprint Human fetal adrenal hydroxysteroid sulphotransferase: cDNA cloning, stable expression in V79 cells and functional characterisation of the expressed enzyme
    K J Forbes
    Department of Biochemical Medicine, University of Dundee, Ninewells Hospital and Medical School, Scotland, UK
    Mol Cell Endocrinol 112:53-60. 1995

Collaborators

  • D H Phillips
  • M W Coughtrie
  • F Oesch
  • U Andrae
  • E Muckel
  • R Edenharder
  • W Meinl
  • B J Majer
  • J A Williams
  • K Glatt
  • C E Engelke
  • S Strehl
  • M Lalande
  • F Kassie
  • W Pfau
  • F Darroudi
  • Y Sasaki
  • S Knasmuller
  • G Fakis
  • J A Cordell
  • E M Stone
  • N Johnson
  • E Sim
  • A L Jones
  • H Boeing
  • K J Forbes
  • M Hagen
  • Q M Liu
  • R Hume
  • R C Roberts
  • C Wölfel
  • K L Platt
  • J Doehmer
  • S Dogra
  • F Wachter

Detail Information

Publications15

  1. ncbi request reprint Sulfotransferases: genetics and role in toxicology
    H Glatt
    Department of Toxicology, German Institute of Human Nutrition DIfE, Arthur Scheunert Allee 114 116, D 14558, Potsdam Rehbrucke, Germany
    Toxicol Lett 112:341-8. 2000
    ..However, some promutagens were activated by only one or several of the human SULTs. Pronounced differences in promutagen activation were also detected between orthologous rat and human SULTs, and between allelic variants of human SULTs...
  2. ncbi request reprint Sulfotransferases in the bioactivation of xenobiotics
    H Glatt
    Department of Toxicology, Deutsches Institut für Ernährungsforschung DIfE, Arthur Scheunert Allee 114 116, D 14558, Potsdam Rehbrucke, Germany
    Chem Biol Interact 129:141-70. 2000
    ..SULT-mediated reactivation may even occur if another initial reactive species, e.g. an epoxide, has reacted with water...
  3. ncbi request reprint Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects
    H Glatt
    Department of Toxicology, German Institute of Human Nutrition DIfE, Arthur Scheunert Allee 114 116, D 14558 Potsdam Rehbrücke, Germany
    Mutat Res 482:27-40. 2001
    ..Only initial results are available from the analysis of SULT allele frequencies in different population groups, e.g. subjects suffering from specific diseases and corresponding controls...
  4. ncbi request reprint Sulfotransferase-mediated activation of mutagens studied using heterologous expression systems
    H Glatt
    German Institute of Human Nutrition, Department of Toxicology, Potsdam Rehbrucke
    Chem Biol Interact 109:195-219. 1998
    ..This site-dependent expression together with the limitations in the distribution of reactive sulfuric acid conjugates may explain organotropic effects of compounds activated by this metabolic pathway...
  5. ncbi request reprint Genotoxicity characteristics of reverse diol-epoxides of chrysene
    H Glatt
    Department of Toxicology, University of Mainz, Germany
    Carcinogenesis 14:11-9. 1993
    ..Unlike other investigated diastereomeric pairs of diol-epoxides, it was also shorter-lived than its syn-diastereomer (t1/2 = 340 min)...
  6. ncbi request reprint Structure and localization of the human SULT1B1 gene: neighborhood to SULT1E1 and a SULT1D pseudogene
    W Meinl
    Department of Toxicology, German Institute of Human Nutrition DIfE, Arthur Scheunert Allee 114 116, Bergholz Rehbrücke, 14558, Germany
    Biochem Biophys Res Commun 288:855-62. 2001
    ..This SULT gene cluster is located on the minus strand of chromosome 4 with SULT1B1 being closest to the centromer...
  7. ncbi request reprint Protection by beverages, fruits, vegetables, herbs, and flavonoids against genotoxicity of 2-acetylaminofluorene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in metabolically competent V79 cells
    R Edenharder
    Department of Hygiene and Environmental Medicine, University of Mainz, Obere Zahlbacher Str 67, D 55131 Mainz, Germany
    Mutat Res 521:57-72. 2002
    ....
  8. ncbi request reprint Human platelet phenolsulfotransferases: cDNA cloning, stable expression in V79 cells and identification of a novel allelic variant of the phenol-sulfating form
    A L Jones
    Department of Biochemical Medicine, University of Dundee, Ninewells Hospital and Medical School, Scotland, UK
    Biochem Biophys Res Commun 208:855-62. 1995
    ....
  9. ncbi request reprint Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2
    C E Engelke
    Department of Toxicology, German Institute of Human Nutrition Potsdam Rehbrucke
    Pharmacogenetics 10:163-9. 2000
    ..The results demonstrate a strong association of the alleles producing the more active enzyme variants (SULT1A1*Arg and SULT1A2*Asn) and of those encoding the less active variants (SULT1A1*His and SULT1A2*Thr)...
  10. ncbi request reprint Human fetal adrenal hydroxysteroid sulphotransferase: cDNA cloning, stable expression in V79 cells and functional characterisation of the expressed enzyme
    K J Forbes
    Department of Biochemical Medicine, University of Dundee, Ninewells Hospital and Medical School, Scotland, UK
    Mol Cell Endocrinol 112:53-60. 1995
    ..We have therefore created a valuable resource for the study of this important enzyme...
  11. ncbi request reprint N-Acetyltransferases, sulfotransferases and heterocyclic amine activation in the breast
    J A Williams
    Institute of Cancer Research, Haddow Laboratories, Sutton, UK
    Pharmacogenetics 11:373-88. 2001
    ..Western blot analysis of mammary cytosolic protein showed detectable levels of SULT1A1 and SULT1A3...
  12. ncbi request reprint Stable expression of rat cytochrome P450IA2 cDNA and hydroxylation of 17 beta-estradiol and 2-aminofluorene in V79 Chinese hamster cells
    C Wölfel
    Institut fur Toxikologie, Johannes Gutenberg Universitat, Mainz, Germany
    Mol Carcinog 4:489-98. 1991
    ....
  13. ncbi request reprint Characterization of two novel protocadherins (PCDH8 and PCDH9) localized on human chromosome 13 and mouse chromosome 14
    S Strehl
    Genetics Division, Children s Hospital and Harvard Medical School, Boston, Massachusetts, 02215, USA
    Genomics 53:81-9. 1998
    ..The differences in the genomic structure of cadherin subfamilies will be discussed in the context of the evolution of the cadherin superfamily...
  14. ncbi request reprint Structure and organization of GABRB3 and GABRA5
    K Glatt
    Genetics Division, Children s Hospital, Boston, Massachusetts 02115, USA
    Genomics 41:63-9. 1997
    ....
  15. ncbi request reprint Investigation of the genotoxic effects of 2-amino-9H-pyrido[2,3-b]indole in different organs of rodents and in human derived cells
    B J Majer
    Institute of Cancer Research, University of Vienna, Borschkegasse 8a, A 1090 Vienna, Austria
    J Chromatogr B Analyt Technol Biomed Life Sci 802:167-73. 2004
    ..Therefore, our findings can be taken as an indication that the human health risk caused by exposure to AalphaC is higher than that of other HAs that are formed during the cooking of meat and fish...