Clarissa Gerhauser

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. ncbi request reprint Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop
    Clarissa Gerhauser
    Deutsches Krebstforschungszentrum, Abteilung Toxikologie und Krebsrisikofaktoren, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mol Cancer Ther 1:959-69. 2002
  2. ncbi request reprint Cancer chemoprevention by targeting the epigenome
    Joseph Huang
    Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Curr Drug Targets 12:1925-56. 2011
  3. doi request reprint Epigenetic impact of dietary isothiocyanates in cancer chemoprevention
    Clarissa Gerhauser
    Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Curr Opin Clin Nutr Metab Care 16:405-10. 2013
  4. doi request reprint Cancer chemoprevention and nutriepigenetics: state of the art and future challenges
    Clarissa Gerhauser
    Division Epigenomics and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Top Curr Chem 329:73-132. 2013
  5. doi request reprint Identification of 3-hydroxy-beta-damascone and related carotenoid-derived aroma compounds as novel potent inducers of Nrf2-mediated phase 2 response with concomitant anti-inflammatory activity
    Clarissa Gerhauser
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Mol Nutr Food Res 53:1237-44. 2009
  6. doi request reprint Cancer chemopreventive potential of apples, apple juice, and apple components
    Clarissa Gerhauser
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Planta Med 74:1608-24. 2008
  7. ncbi request reprint Development of novel cancer chemopreventive agents in Europe--neglected Cinderella or rising phoenix? A critical commentary. ESF Workshop on Cancer Chemoprevention, DKFZ, Heidelberg, September 18-20, 2005
    Clarissa Gerhauser
    German Cancer Research Center, Toxicology and Cancer Risk Factors, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur J Cancer 42:1338-43. 2006
  8. ncbi request reprint Broad spectrum anti-infective potential of xanthohumol from hop (Humulus lupulus L.) in comparison with activities of other hop constituents and xanthohumol metabolites
    Clarissa Gerhauser
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Mol Nutr Food Res 49:827-31. 2005
  9. ncbi request reprint Mechanism-based in vitro screening of potential cancer chemopreventive agents
    Clarissa Gerhauser
    Division of Toxicology and Cancer Risk Factors, C010 2 Chemoprevention, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mutat Res 523:163-72. 2003
  10. ncbi request reprint Beer constituents as potential cancer chemopreventive agents
    Clarissa Gerhauser
    Deutsches Krebsforschungszentrum DKFZ, Abteilung Toxikologie und Krebsrisikofaktoren, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur J Cancer 41:1941-54. 2005

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop
    Clarissa Gerhauser
    Deutsches Krebstforschungszentrum, Abteilung Toxikologie und Krebsrisikofaktoren, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mol Cancer Ther 1:959-69. 2002
    ..Together, our data provide evidence for the potential application of XN as a novel, readily available chemopreventive agent, and clinical investigations are warranted once efficacy and safety in animal models have been established...
  2. ncbi request reprint Cancer chemoprevention by targeting the epigenome
    Joseph Huang
    Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Curr Drug Targets 12:1925-56. 2011
    ..Future research will need to identify best strategies for chemopreventive intervention, taking into account the importance of epigenetic mechanisms for gene regulation...
  3. doi request reprint Epigenetic impact of dietary isothiocyanates in cancer chemoprevention
    Clarissa Gerhauser
    Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Curr Opin Clin Nutr Metab Care 16:405-10. 2013
    ..The present report will summarize novel findings of ITCs on histone deacetylase activity, DNA methylation, and short noncoding microRNAs, focusing on sulforaphane (SFN) from broccoli and phenethylisothiocyanate from watercress...
  4. doi request reprint Cancer chemoprevention and nutriepigenetics: state of the art and future challenges
    Clarissa Gerhauser
    Division Epigenomics and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Top Curr Chem 329:73-132. 2013
    ....
  5. doi request reprint Identification of 3-hydroxy-beta-damascone and related carotenoid-derived aroma compounds as novel potent inducers of Nrf2-mediated phase 2 response with concomitant anti-inflammatory activity
    Clarissa Gerhauser
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Mol Nutr Food Res 53:1237-44. 2009
    ....
  6. doi request reprint Cancer chemopreventive potential of apples, apple juice, and apple components
    Clarissa Gerhauser
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Planta Med 74:1608-24. 2008
    ..Apple products have been shown to prevent skin, mammary and colon carcinogenesis in animal models. Epidemiological observations indicate that regular consumption of one or more apples a day may reduce the risk for lung and colon cancer...
  7. ncbi request reprint Development of novel cancer chemopreventive agents in Europe--neglected Cinderella or rising phoenix? A critical commentary. ESF Workshop on Cancer Chemoprevention, DKFZ, Heidelberg, September 18-20, 2005
    Clarissa Gerhauser
    German Cancer Research Center, Toxicology and Cancer Risk Factors, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur J Cancer 42:1338-43. 2006
    ..Overall the workshop aimed at raising awareness among European clinical and laboratory researchers of the importance of the development of novel, efficacious and safe cancer preventive agents...
  8. ncbi request reprint Broad spectrum anti-infective potential of xanthohumol from hop (Humulus lupulus L.) in comparison with activities of other hop constituents and xanthohumol metabolites
    Clarissa Gerhauser
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Mol Nutr Food Res 49:827-31. 2005
    ..Overall, these activities further contribute to the broad spectrum of biological effects observed with XN...
  9. ncbi request reprint Mechanism-based in vitro screening of potential cancer chemopreventive agents
    Clarissa Gerhauser
    Division of Toxicology and Cancer Risk Factors, C010 2 Chemoprevention, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mutat Res 523:163-72. 2003
    ..Further, PEITC inhibited phorbol ester-induced superoxide anion radical production in granulocytes, and ODC induction in the 308 cell line. These mechanisms might contribute to the chemopreventive potential of PEITC...
  10. ncbi request reprint Beer constituents as potential cancer chemopreventive agents
    Clarissa Gerhauser
    Deutsches Krebsforschungszentrum DKFZ, Abteilung Toxikologie und Krebsrisikofaktoren, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur J Cancer 41:1941-54. 2005
    ....
  11. ncbi request reprint Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention
    Elisabeth Bertl
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, C010 2 Chemoprevention, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mol Cancer Ther 5:575-85. 2006
    ..These novel antiangiogenic activities of sulforaphane are likely to contribute to its cancer chemopreventive and therapeutic potential...
  12. ncbi request reprint Xanthohumol induces apoptosis in cultured 40-16 human colon cancer cells by activation of the death receptor- and mitochondrial pathway
    Lydia Pan
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Mol Nutr Food Res 49:837-43. 2005
    ..We conclude that induction of apoptosis by downregulation of Bcl-2 and activation of the caspase cascade may contribute to the chemopreventive or therapeutic potential of XN...
  13. ncbi request reprint Biphasic modulation of cell proliferation by sulforaphane at physiologically relevant exposure times in a human colon cancer cell line
    Gerlinde Pappa
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Mol Nutr Food Res 51:977-84. 2007
    ..Depletion of GSH does not seem to play a role in SFN-mediated apoptosis induction. Our data clearly contribute to a better understanding of the kinetics of antiproliferative activity of SFN...
  14. doi request reprint Xanthohumol-induced transient superoxide anion radical formation triggers cancer cells into apoptosis via a mitochondria-mediated mechanism
    Julia Strathmann
    German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    FASEB J 24:2938-50. 2010
    ..In summary, we have identified mitochondria as a novel cellular target of XN action, resulting in increased O(2)(-*) production, disruption of cellular redox balance and mitochondrial integrity, and subsequent apoptosis...
  15. ncbi request reprint Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae
    Gerlinde Pappa
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, DKFZ, 69120 Heidelberg, Germany
    Mutat Res 599:76-87. 2006
    ....
  16. ncbi request reprint A safety study of oral xanthohumol administration and its influence on fertility in Sprague Dawley rats
    Ragna Hussong
    Division of Toxicology and Cancer Risk Factors, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Mol Nutr Food Res 49:861-7. 2005
    ..027) increased the sex ratio of male to female offspring. Overall, lifelong treatment at a daily dose of 100 mg/kg b.w. in a two-generation study did not affect the development of SD rats...
  17. ncbi request reprint Time-dependent modulation of thioredoxin reductase activity might contribute to sulforaphane-mediated inhibition of NF-kappaB binding to DNA
    Elke Heiss
    Division C010, Toxicology and Cancer Risk Factors, Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany
    Antioxid Redox Signal 7:1601-11. 2005
    ..These findings further emphasize the importance of redox modulation or thiol reactivity for the regulation of NF-kappaB-dependent transcription by SFN. Antioxid. Redox Signal. 7, 1601-1611...
  18. ncbi request reprint Inhibition of endothelial cell functions by novel potential cancer chemopreventive agents
    Elisabeth Bertl
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Biochem Biophys Res Commun 325:287-95. 2004
    ..Overall, our data indicate that inhibition of endothelial cell function contributes to various extents to the chemopreventive or anti-angiogenic potential of these lead compounds...
  19. ncbi request reprint Quantitative combination effects between sulforaphane and 3,3'-diindolylmethane on proliferation of human colon cancer cells in vitro
    Gerlinde Pappa
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, C010 2 Chemoprevention, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Carcinogenesis 28:1471-7. 2007
    ..These data stress the need for elucidating mechanistic interactions for better predicting beneficial health effects of bioactive food components...
  20. doi request reprint Substituted purine and 7-deazapurine compounds as modulators of epigenetic enzymes: a patent evaluation (WO2012075381)
    Daniel B Lipka
    German Cancer Research Center DKFZ, Division Epigenomics and Cancer Risk Factors, Heidelberg, Germany
    Expert Opin Ther Pat 23:537-43. 2013
    ..Overall, the prospective of a targeted product (i.e., a drug targeting a commonly affected chromatin modifier) is very promising, and exponentially growing investments into this market are anticipated...