Clarissa Gerhauser

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. ncbi Cancer chemoprevention and nutri-epigenetics: state of the art and future challenges
    Clarissa Gerhauser
    Division Epigenomics and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Top Curr Chem 329:73-132. 2013
  2. ncbi Identification of 3-hydroxy-beta-damascone and related carotenoid-derived aroma compounds as novel potent inducers of Nrf2-mediated phase 2 response with concomitant anti-inflammatory activity
    Clarissa Gerhauser
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Mol Nutr Food Res 53:1237-44. 2009
  3. ncbi Cancer chemopreventive potential of apples, apple juice, and apple components
    Clarissa Gerhauser
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Planta Med 74:1608-24. 2008
  4. ncbi Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop
    Clarissa Gerhauser
    Deutsches Krebstforschungszentrum, Abteilung Toxikologie und Krebsrisikofaktoren, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mol Cancer Ther 1:959-69. 2002
  5. ncbi Development of novel cancer chemopreventive agents in Europe--neglected Cinderella or rising phoenix? A critical commentary. ESF Workshop on Cancer Chemoprevention, DKFZ, Heidelberg, September 18-20, 2005
    Clarissa Gerhauser
    German Cancer Research Center, Toxicology and Cancer Risk Factors, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur J Cancer 42:1338-43. 2006
  6. ncbi Broad spectrum anti-infective potential of xanthohumol from hop (Humulus lupulus L.) in comparison with activities of other hop constituents and xanthohumol metabolites
    Clarissa Gerhauser
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Mol Nutr Food Res 49:827-31. 2005
  7. ncbi Beer constituents as potential cancer chemopreventive agents
    Clarissa Gerhauser
    Deutsches Krebsforschungszentrum DKFZ, Abteilung Toxikologie und Krebsrisikofaktoren, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur J Cancer 41:1941-54. 2005
  8. ncbi Mechanism-based in vitro screening of potential cancer chemopreventive agents
    Clarissa Gerhauser
    Division of Toxicology and Cancer Risk Factors, C010 2 Chemoprevention, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mutat Res 523:163-72. 2003
  9. ncbi Xanthohumol-induced transient superoxide anion radical formation triggers cancer cells into apoptosis via a mitochondria-mediated mechanism
    Julia Strathmann
    German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    FASEB J 24:2938-50. 2010
  10. ncbi Biphasic modulation of cell proliferation by sulforaphane at physiologically relevant exposure times in a human colon cancer cell line
    Gerlinde Pappa
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Mol Nutr Food Res 51:977-84. 2007

Collaborators

Detail Information

Publications12

  1. ncbi Cancer chemoprevention and nutri-epigenetics: state of the art and future challenges
    Clarissa Gerhauser
    Division Epigenomics and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Top Curr Chem 329:73-132. 2013
    ....
  2. ncbi Identification of 3-hydroxy-beta-damascone and related carotenoid-derived aroma compounds as novel potent inducers of Nrf2-mediated phase 2 response with concomitant anti-inflammatory activity
    Clarissa Gerhauser
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Mol Nutr Food Res 53:1237-44. 2009
    ....
  3. ncbi Cancer chemopreventive potential of apples, apple juice, and apple components
    Clarissa Gerhauser
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Planta Med 74:1608-24. 2008
    ..Apple products have been shown to prevent skin, mammary and colon carcinogenesis in animal models. Epidemiological observations indicate that regular consumption of one or more apples a day may reduce the risk for lung and colon cancer...
  4. ncbi Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop
    Clarissa Gerhauser
    Deutsches Krebstforschungszentrum, Abteilung Toxikologie und Krebsrisikofaktoren, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mol Cancer Ther 1:959-69. 2002
    ..Together, our data provide evidence for the potential application of XN as a novel, readily available chemopreventive agent, and clinical investigations are warranted once efficacy and safety in animal models have been established...
  5. ncbi Development of novel cancer chemopreventive agents in Europe--neglected Cinderella or rising phoenix? A critical commentary. ESF Workshop on Cancer Chemoprevention, DKFZ, Heidelberg, September 18-20, 2005
    Clarissa Gerhauser
    German Cancer Research Center, Toxicology and Cancer Risk Factors, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur J Cancer 42:1338-43. 2006
    ..Overall the workshop aimed at raising awareness among European clinical and laboratory researchers of the importance of the development of novel, efficacious and safe cancer preventive agents...
  6. ncbi Broad spectrum anti-infective potential of xanthohumol from hop (Humulus lupulus L.) in comparison with activities of other hop constituents and xanthohumol metabolites
    Clarissa Gerhauser
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Mol Nutr Food Res 49:827-31. 2005
    ..Overall, these activities further contribute to the broad spectrum of biological effects observed with XN...
  7. ncbi Beer constituents as potential cancer chemopreventive agents
    Clarissa Gerhauser
    Deutsches Krebsforschungszentrum DKFZ, Abteilung Toxikologie und Krebsrisikofaktoren, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur J Cancer 41:1941-54. 2005
    ....
  8. ncbi Mechanism-based in vitro screening of potential cancer chemopreventive agents
    Clarissa Gerhauser
    Division of Toxicology and Cancer Risk Factors, C010 2 Chemoprevention, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mutat Res 523:163-72. 2003
    ..Further, PEITC inhibited phorbol ester-induced superoxide anion radical production in granulocytes, and ODC induction in the 308 cell line. These mechanisms might contribute to the chemopreventive potential of PEITC...
  9. ncbi Xanthohumol-induced transient superoxide anion radical formation triggers cancer cells into apoptosis via a mitochondria-mediated mechanism
    Julia Strathmann
    German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    FASEB J 24:2938-50. 2010
    ..In summary, we have identified mitochondria as a novel cellular target of XN action, resulting in increased O(2)(-*) production, disruption of cellular redox balance and mitochondrial integrity, and subsequent apoptosis...
  10. ncbi Biphasic modulation of cell proliferation by sulforaphane at physiologically relevant exposure times in a human colon cancer cell line
    Gerlinde Pappa
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Mol Nutr Food Res 51:977-84. 2007
    ..Depletion of GSH does not seem to play a role in SFN-mediated apoptosis induction. Our data clearly contribute to a better understanding of the kinetics of antiproliferative activity of SFN...
  11. ncbi Cancer chemoprevention by targeting the epigenome
    Joseph Huang
    Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Curr Drug Targets 12:1925-56. 2011
    ..Future research will need to identify best strategies for chemopreventive intervention, taking into account the importance of epigenetic mechanisms for gene regulation...
  12. ncbi Quantitative combination effects between sulforaphane and 3,3'-diindolylmethane on proliferation of human colon cancer cells in vitro
    Gerlinde Pappa
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, C010 2 Chemoprevention, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Carcinogenesis 28:1471-7. 2007
    ..These data stress the need for elucidating mechanistic interactions for better predicting beneficial health effects of bioactive food components...