Timo Gaber

Summary

Affiliation: German Rheumatism Research Centre
Country: Germany

Publications

  1. pmc Hypoxia promotes osteogenesis but suppresses adipogenesis of human mesenchymal stromal cells in a hypoxia-inducible factor-1 dependent manner
    Markus Wagegg
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    PLoS ONE 7:e46483. 2012
  2. doi request reprint Pathophysiological hypoxia affects the redox state and IL-2 signalling of human CD4+ T cells and concomitantly impairs survival and proliferation
    Timo Gaber
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Eur J Immunol 43:1588-97. 2013
  3. doi request reprint Adaptation of human CD4+ T cells to pathophysiological hypoxia: a transcriptome analysis
    Timo Gaber
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Chariteplatz 1, 10117 Berlin, Germany
    J Rheumatol 36:2655-69. 2009
  4. doi request reprint Macrophage migration inhibitory factor counterregulates dexamethasone-mediated suppression of hypoxia-inducible factor-1 alpha function and differentially influences human CD4+ T cell proliferation under hypoxia
    Timo Gaber
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, 10117 Berlin, Germany
    J Immunol 186:764-74. 2011
  5. doi request reprint Rimexolone inhibits proliferation, cytokine expression and signal transduction of human CD4+ T-cells
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Campus Mitte, Chariteplatz 1, Berlin, Germany
    Immunol Lett 131:24-32. 2010
  6. doi request reprint High-sensitivity immunofluorescence staining: a comparison of the liposome procedure and the FASER technique on mGR detection
    Cindy Strehl
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    J Fluoresc 23:509-18. 2013
  7. doi request reprint Human CD4(+) T cells maintain specific functions even under conditions of extremely restricted ATP production
    Robert Tripmacher
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin, Germany
    Eur J Immunol 38:1631-42. 2008
  8. pmc Osteoarthritis synovial fluid activates pro-inflammatory cytokines in primary human chondrocytes
    Paula Hoff
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Int Orthop 37:145-51. 2013
  9. pmc Human early fracture hematoma is characterized by inflammation and hypoxia
    Paula Kolar
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Chariteplatz 1, 10117 Berlin, Germany
    Clin Orthop Relat Res 469:3118-26. 2011
  10. doi request reprint Preoperative irradiation for the prevention of heterotopic ossification induces local inflammation in humans
    Paula Hoff
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Bone 55:93-101. 2013

Collaborators

Detail Information

Publications18

  1. pmc Hypoxia promotes osteogenesis but suppresses adipogenesis of human mesenchymal stromal cells in a hypoxia-inducible factor-1 dependent manner
    Markus Wagegg
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    PLoS ONE 7:e46483. 2012
    ..Therefore, we analyzed the impact of hypoxia and HIF-1 on the competitive differentiation potential of hMSCs towards adipogenic and osteogenic lineages...
  2. doi request reprint Pathophysiological hypoxia affects the redox state and IL-2 signalling of human CD4+ T cells and concomitantly impairs survival and proliferation
    Timo Gaber
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Eur J Immunol 43:1588-97. 2013
    ..The level of iROS may therefore act as a mediator of immune functions leading to down-regulation of long-term T-cell activity in inflamed tissues...
  3. doi request reprint Adaptation of human CD4+ T cells to pathophysiological hypoxia: a transcriptome analysis
    Timo Gaber
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Chariteplatz 1, 10117 Berlin, Germany
    J Rheumatol 36:2655-69. 2009
    ..Inflamed tissues are usually characterized by low oxygen levels. We investigated whether pathophysiological hypoxia (pO(2) < 1%) as found in the rheumatoid synovium modulates the transcriptome of human CD4+ T cells...
  4. doi request reprint Macrophage migration inhibitory factor counterregulates dexamethasone-mediated suppression of hypoxia-inducible factor-1 alpha function and differentially influences human CD4+ T cell proliferation under hypoxia
    Timo Gaber
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, 10117 Berlin, Germany
    J Immunol 186:764-74. 2011
    ..Therefore, we suggest that HIF and/or MIF could be useful targets to optimize GC therapy when treating inflammation...
  5. doi request reprint Rimexolone inhibits proliferation, cytokine expression and signal transduction of human CD4+ T-cells
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Campus Mitte, Chariteplatz 1, Berlin, Germany
    Immunol Lett 131:24-32. 2010
    ..It is implied that these effects contribute to the well-known beneficial anti-inflammatory and immunomodulatory effects of glucocorticoid therapy...
  6. doi request reprint High-sensitivity immunofluorescence staining: a comparison of the liposome procedure and the FASER technique on mGR detection
    Cindy Strehl
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    J Fluoresc 23:509-18. 2013
    ..Our data demonstrate the FASER technique to be more sensitive and also more specific for the detection of mGR as compared to the liposome technique. However, both methods have advantages and disadvantages which are discussed in detail...
  7. doi request reprint Human CD4(+) T cells maintain specific functions even under conditions of extremely restricted ATP production
    Robert Tripmacher
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin, Germany
    Eur J Immunol 38:1631-42. 2008
    ..Our data demonstrate an unexpectedly high, clinically relevant adaptive potential of human CD4(+) T cells to maintain specific functions even under severely impaired bioenergetic conditions...
  8. pmc Osteoarthritis synovial fluid activates pro-inflammatory cytokines in primary human chondrocytes
    Paula Hoff
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Int Orthop 37:145-51. 2013
    ..The aim of the present study was to investigate the effects of the synovial fluid environment of OA patients in comparison with synovial fluids of RA patients on human chondrocytes in vitro...
  9. pmc Human early fracture hematoma is characterized by inflammation and hypoxia
    Paula Kolar
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Chariteplatz 1, 10117 Berlin, Germany
    Clin Orthop Relat Res 469:3118-26. 2011
    ..An effective immune system, especially during the inflammatory phase, putatively influences the quality and likelihood of bone healing. If and how this is reflected within the initial fracture hematoma is unclear...
  10. doi request reprint Preoperative irradiation for the prevention of heterotopic ossification induces local inflammation in humans
    Paula Hoff
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Bone 55:93-101. 2013
    ..This increase of inflammatory activity together with the observed suppression in VEGF secretion may contribute to the prevention of HO...
  11. doi request reprint Human immune cells' behavior and survival under bioenergetically restricted conditions in an in vitro fracture hematoma model
    Paula Hoff
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Cell Mol Immunol 10:151-8. 2013
    ....
  12. doi request reprint Origin and functional activity of the membrane-bound glucocorticoid receptor
    Cindy Strehl
    Charité University Hospital and German Rheumatism Research Centre, Berlin, Germany
    Arthritis Rheum 63:3779-88. 2011
    ..Most likely, membrane-bound GRs (mGR) are involved in nongenomic GC signaling. The aim of this study was to investigate the origin and functional activity of mGR...
  13. doi request reprint Hypoxia: how does the monocyte-macrophage system respond to changes in oxygen availability?
    Cindy Strehl
    2 Charité Universitätsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    J Leukoc Biol 95:233-41. 2014
    ..Notably, oxygen availability is a crucial parameter in the cellular energy metabolism, itself an important factor in determining the function of immune cells. ..
  14. doi request reprint Inflammatory synovial fluid microenvironment drives primary human chondrocytes to actively take part in inflammatory joint diseases
    Eric Röhner
    Department of Traumatology and Orthopedics, Charite University Hospital, Berlin, Germany
    Immunol Res 52:169-75. 2012
    ..The inflammatory synovial fluid microenvironment mediates apoptosis and cell death of chondrocytes. Moreover, in terms of cytokine secretion, it also induces an active participation of chondrocytes in ongoing inflammation...
  15. doi request reprint Acute murine antigen-induced arthritis is not affected by disruption of osteoblastic glucocorticoid signalling
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    BMC Musculoskelet Disord 15:31. 2014
    ..To determine whether or not the modulation of the inflammatory response by osteoblasts involves T cells, we studied the effects of disrupted osteoblastic GC-signalling in the T cell-dependent model of antigen-induced arthritis (AIA)...
  16. pmc Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus
    Jens Y Humrich
    Department of Rheumatology and Clinical Immunology, University Hospital Charite, 10117 Berlin, Germany
    Proc Natl Acad Sci U S A 107:204-9. 2010
    ..The reversibility of this homeostatic Treg disorder provides promising approaches for the treatment of SLE...
  17. ncbi request reprint Membrane glucocorticoid receptors (mGCR) are expressed in normal human peripheral blood mononuclear cells and up-regulated after in vitro stimulation and in patients with rheumatoid arthritis
    Burkhard Bartholome
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    FASEB J 18:70-80. 2004
    ..These receptors may reflect a feedback mechanism of the organism upon immunostimulation and/or play a role in pathogenesis...
  18. doi request reprint The early fracture hematoma and its potential role in fracture healing
    Paula Kolar
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Tissue Eng Part B Rev 16:427-34. 2010
    ....