Timo Gaber

Summary

Affiliation: German Rheumatism Research Centre
Country: Germany

Publications

  1. ncbi Adaptation of human CD4+ T cells to pathophysiological hypoxia: a transcriptome analysis
    Timo Gaber
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Chariteplatz 1, 10117 Berlin, Germany
    J Rheumatol 36:2655-69. 2009
  2. ncbi Macrophage migration inhibitory factor counterregulates dexamethasone-mediated suppression of hypoxia-inducible factor-1 alpha function and differentially influences human CD4+ T cell proliferation under hypoxia
    Timo Gaber
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, 10117 Berlin, Germany
    J Immunol 186:764-74. 2011
  3. ncbi Rimexolone inhibits proliferation, cytokine expression and signal transduction of human CD4+ T-cells
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Campus Mitte, Chariteplatz 1, Berlin, Germany
    Immunol Lett 131:24-32. 2010
  4. ncbi Human early fracture hematoma is characterized by inflammation and hypoxia
    Paula Kolar
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Chariteplatz 1, 10117 Berlin, Germany
    Clin Orthop Relat Res 469:3118-26. 2011
  5. ncbi Human CD4(+) T cells maintain specific functions even under conditions of extremely restricted ATP production
    Robert Tripmacher
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin, Germany
    Eur J Immunol 38:1631-42. 2008
  6. ncbi Osteoarthritis synovial fluid activates pro-inflammatory cytokines in primary human chondrocytes
    Paula Hoff
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Int Orthop 37:145-51. 2013
  7. ncbi Inflammatory synovial fluid microenvironment drives primary human chondrocytes to actively take part in inflammatory joint diseases
    Eric Röhner
    Department of Traumatology and Orthopedics, Charite University Hospital, Berlin, Germany
    Immunol Res 52:169-75. 2012
  8. ncbi Hypoxia promotes osteogenesis but suppresses adipogenesis of human mesenchymal stromal cells in a hypoxia-inducible factor-1 dependent manner
    Markus Wagegg
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    PLoS ONE 7:e46483. 2012
  9. ncbi The early fracture hematoma and its potential role in fracture healing
    Paula Kolar
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Tissue Eng Part B Rev 16:427-34. 2010
  10. ncbi Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus
    Jens Y Humrich
    Department of Rheumatology and Clinical Immunology, University Hospital Charite, 10117 Berlin, Germany
    Proc Natl Acad Sci U S A 107:204-9. 2010

Collaborators

Detail Information

Publications11

  1. ncbi Adaptation of human CD4+ T cells to pathophysiological hypoxia: a transcriptome analysis
    Timo Gaber
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Chariteplatz 1, 10117 Berlin, Germany
    J Rheumatol 36:2655-69. 2009
    ..Inflamed tissues are usually characterized by low oxygen levels. We investigated whether pathophysiological hypoxia (pO(2) < 1%) as found in the rheumatoid synovium modulates the transcriptome of human CD4+ T cells...
  2. ncbi Macrophage migration inhibitory factor counterregulates dexamethasone-mediated suppression of hypoxia-inducible factor-1 alpha function and differentially influences human CD4+ T cell proliferation under hypoxia
    Timo Gaber
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, 10117 Berlin, Germany
    J Immunol 186:764-74. 2011
    ..Therefore, we suggest that HIF and/or MIF could be useful targets to optimize GC therapy when treating inflammation...
  3. ncbi Rimexolone inhibits proliferation, cytokine expression and signal transduction of human CD4+ T-cells
    Cornelia M Spies
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Campus Mitte, Chariteplatz 1, Berlin, Germany
    Immunol Lett 131:24-32. 2010
    ..It is implied that these effects contribute to the well-known beneficial anti-inflammatory and immunomodulatory effects of glucocorticoid therapy...
  4. ncbi Human early fracture hematoma is characterized by inflammation and hypoxia
    Paula Kolar
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Chariteplatz 1, 10117 Berlin, Germany
    Clin Orthop Relat Res 469:3118-26. 2011
    ..An effective immune system, especially during the inflammatory phase, putatively influences the quality and likelihood of bone healing. If and how this is reflected within the initial fracture hematoma is unclear...
  5. ncbi Human CD4(+) T cells maintain specific functions even under conditions of extremely restricted ATP production
    Robert Tripmacher
    Department of Rheumatology and Clinical Immunology, Charite University Medicine, Berlin, Germany
    Eur J Immunol 38:1631-42. 2008
    ..Our data demonstrate an unexpectedly high, clinically relevant adaptive potential of human CD4(+) T cells to maintain specific functions even under severely impaired bioenergetic conditions...
  6. ncbi Osteoarthritis synovial fluid activates pro-inflammatory cytokines in primary human chondrocytes
    Paula Hoff
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    Int Orthop 37:145-51. 2013
    ..The aim of the present study was to investigate the effects of the synovial fluid environment of OA patients in comparison with synovial fluids of RA patients on human chondrocytes in vitro...
  7. ncbi Inflammatory synovial fluid microenvironment drives primary human chondrocytes to actively take part in inflammatory joint diseases
    Eric Röhner
    Department of Traumatology and Orthopedics, Charite University Hospital, Berlin, Germany
    Immunol Res 52:169-75. 2012
    ..The inflammatory synovial fluid microenvironment mediates apoptosis and cell death of chondrocytes. Moreover, in terms of cytokine secretion, it also induces an active participation of chondrocytes in ongoing inflammation...
  8. ncbi Hypoxia promotes osteogenesis but suppresses adipogenesis of human mesenchymal stromal cells in a hypoxia-inducible factor-1 dependent manner
    Markus Wagegg
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    PLoS ONE 7:e46483. 2012
    ..Therefore, we analyzed the impact of hypoxia and HIF-1 on the competitive differentiation potential of hMSCs towards adipogenic and osteogenic lineages...
  9. ncbi The early fracture hematoma and its potential role in fracture healing
    Paula Kolar
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Tissue Eng Part B Rev 16:427-34. 2010
    ....
  10. ncbi Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus
    Jens Y Humrich
    Department of Rheumatology and Clinical Immunology, University Hospital Charite, 10117 Berlin, Germany
    Proc Natl Acad Sci U S A 107:204-9. 2010
    ..The reversibility of this homeostatic Treg disorder provides promising approaches for the treatment of SLE...
  11. ncbi Membrane glucocorticoid receptors (mGCR) are expressed in normal human peripheral blood mononuclear cells and up-regulated after in vitro stimulation and in patients with rheumatoid arthritis
    Burkhard Bartholome
    Department of Rheumatology and Clinical Immunology, , Berlin, Germany
    FASEB J 18:70-80. 2004
    ..These receptors may reflect a feedback mechanism of the organism upon immunostimulation and/or play a role in pathogenesis...