Bernd Frank

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. pmc Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk: a case-control study
    Barbara Burwinkel
    Helmholtz University Group Molecular Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany
    BMC Cancer 6:268. 2006
  2. pmc BRIP1 (BACH1) variants and familial breast cancer risk: a case-control study
    Bernd Frank
    Helmholtz University Group Molecular Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany
    BMC Cancer 7:83. 2007
  3. ncbi The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study
    Bernd Frank
    Helmholtz University Group Molecular Epidemiology, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany
    Breast Cancer Res Treat 111:139-44. 2008
  4. doi Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis
    Bernd Frank
    Helmholtz University Group Molecular Epidemiology, Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    J Natl Cancer Inst 100:437-42. 2008
  5. doi Association of hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD) variants and colorectal cancer risk
    Bernd Frank
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Carcinogenesis 32:190-6. 2011
  6. ncbi Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer
    Bernd Frank
    German Cancer Research Center, Heidelberg, Germany
    Carcinogenesis 31:1381-6. 2010
  7. ncbi Death receptor 4 variants and colorectal cancer risk
    Bernd Frank
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 15:2002-5. 2006
  8. ncbi ARLTS1 variants and melanoma risk
    Bernd Frank
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany
    Int J Cancer 119:1736-7. 2006
  9. doi Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM
    Bernd Frank
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, 69115 Heidelberg, Germany
    Carcinogenesis 31:442-5. 2010
  10. ncbi ARLTS1 variants and risk of colorectal cancer
    Bernd Frank
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Cancer Lett 244:172-5. 2006

Detail Information

Publications35

  1. pmc Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk: a case-control study
    Barbara Burwinkel
    Helmholtz University Group Molecular Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany
    BMC Cancer 6:268. 2006
    ..Genetic alterations in TCF7L2 may therefore affect cancer risk. Recently, TCF7L2 variants, including the microsatellite marker DG10S478 and the nearly perfectly linked SNP rs12233372, were identified to associate with type 2 diabetes...
  2. pmc BRIP1 (BACH1) variants and familial breast cancer risk: a case-control study
    Bernd Frank
    Helmholtz University Group Molecular Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany
    BMC Cancer 7:83. 2007
    ..Inactivating and truncating mutations of the nuclear BRCA1-interacting protein 1 (BRIP1) have been shown to be the major cause of Fanconi anaemia and, due to subsequent alterations of BRCA1 function, predispose to breast cancer (BC)...
  3. ncbi The CASP8 -652 6N del promoter polymorphism and breast cancer risk: a multicenter study
    Bernd Frank
    Helmholtz University Group Molecular Epidemiology, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany
    Breast Cancer Res Treat 111:139-44. 2008
    ..The combined per allele odds ratio (OR) was 0.97 (95% confidence interval (CI), 95% CI = 0.93-1.02). The present result indicates that the CASP8 -652 6N del variant has no significant effect on BC risk in Europeans...
  4. doi Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis
    Bernd Frank
    Helmholtz University Group Molecular Epidemiology, Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    J Natl Cancer Inst 100:437-42. 2008
    ..10 (95% CI = 1.04 to 1.17, P = .001). Among the combined subset of 2795 familial breast cancer patients, the respective ORs were 1.27 (95% CI = 1.12 to 1.45, P = .0003) and 1.16 (95% CI = 1.06 to 1.27, P = .001)...
  5. doi Association of hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD) variants and colorectal cancer risk
    Bernd Frank
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Carcinogenesis 32:190-6. 2011
    ..82, 95% CI = 0.70, 0.95, P = 0.01) as well as among smokers (OR = 0.74, 95% CI = 0.61, 0.90, P = 0.003). Yet, our data do not support the previously reported associations of HPGD tagSNPs and risk of CRC...
  6. ncbi Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer
    Bernd Frank
    German Cancer Research Center, Heidelberg, Germany
    Carcinogenesis 31:1381-6. 2010
    ..However, our results provide evidence that CRC subsets may be affected. If confirmed, this knowledge may be used to assess individual susceptibility and to target potential measures of cancer prevention...
  7. ncbi Death receptor 4 variants and colorectal cancer risk
    Bernd Frank
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 15:2002-5. 2006
    ..37; 95% CI, 0.98-5.76). The score statistic yielded an empirical P of 0.03 of the haplotype-specific test for 626C-683C based on 20,000 simulations, suggesting that DR4 626C-683C may affect colorectal cancer predisposition...
  8. ncbi ARLTS1 variants and melanoma risk
    Bernd Frank
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany
    Int J Cancer 119:1736-7. 2006
    ..43, 95% CI = 1.05-1.95, p = 0.02). An additional risk enhancement, though statistically non-significant, was observed in individuals with multiple melanomas (OR = 2.33, 95% CI = 0.87-6.26, p = 0.08)...
  9. doi Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM
    Bernd Frank
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, 69115 Heidelberg, Germany
    Carcinogenesis 31:442-5. 2010
    ..Although none of them showed a significant association with CRC, the association of BLM P868L with rectal cancer risk requires further investigation...
  10. ncbi ARLTS1 variants and risk of colorectal cancer
    Bernd Frank
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Cancer Lett 244:172-5. 2006
    ..However, we showed a non-significant increased risk of familial CRC for both variants (OR=1.40 and 1.45), indicating a possible role of ARLTS1 in familial CRC...
  11. ncbi Association of the ARLTS1 Cys148Arg variant with familial breast cancer risk
    Bernd Frank
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 118:2505-8. 2006
    ..48, 95% CI=1.10-1.99, p=0.009; ptrend=0.003). On the basis of the small number of 46 cases, we additionally showed an association between the Trp149Stop mutation and an increased risk of bilateral BC (OR=4.11, 95% CI=1.27-13.31, p=0.011)...
  12. ncbi Association of the CASP10 V410I variant with reduced familial breast cancer risk and interaction with the CASP8 D302H variant
    Bernd Frank
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Carcinogenesis 27:606-9. 2006
    ..35, P(trend) = 0.007), pointing to the interaction between the CASP10 and CASP8 polymorphisms in breast carcinogenesis...
  13. doi Polymorphisms in inflammatory pathway genes and their association with colorectal cancer risk
    Bernd Frank
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 127:2822-30. 2010
    ..23; 95% CI, 1.04-1.45; p = 0.02 and OR, 1.32; 95% CI, 1.05-1.67; p = 0.02, respectively). Our results support a role of variants in inflammatory pathway genes in CRC susceptibility and progression...
  14. doi Polymorphisms in MUC1, MUC2, MUC5B and MUC6 genes are not associated with the risk of chronic atrophic gastritis
    Bernd Frank
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Eur J Cancer 48:114-20. 2012
    ..None of the analysed SNPs was associated with CAG. However, large studies are needed to disclose or exclude potential weak associations of these SNPs with CAG risk...
  15. pmc TP53-binding protein variants and breast cancer risk: a case-control study
    Bernd Frank
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Breast Cancer Res 7:R502-5. 2005
    ..We have therefore examined the effects of 53BP1 single nucleotide polymorphisms (D353E, G412S, and K1136Q) and the novel 53BP1 6bp deletion (1347_1352delTATCCC) on breast cancer risk...
  16. ncbi Association of death receptor 4 haplotype 626C-683C with an increased breast cancer risk
    Bernd Frank
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Carcinogenesis 26:1975-7. 2005
    ..84, 95% confidence interval (CI) = 0.65-1.08, P = 0.18 and OR = 0.89, 95% CI = 0.72-1.12, P = 0.30]. However, haplotype analysis revealed a 3.5-fold risk for carriers of the 626C-683C haplotype (OR = 3.52, 95% CI = 1.45-8.52, P = 0.003)...
  17. pmc DNA repair gene polymorphisms and risk of chronic atrophic gastritis: a case-control study
    Bernd Frank
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    BMC Cancer 11:440. 2011
    ..Recent studies have reported associations of DNA repair pathway gene variants and risk of various cancers and precancerous lesions, such as chronic atrophic gastritis (CAG)...
  18. ncbi The rare ERBB2 variant Ile654Val is associated with an increased familial breast cancer risk
    Bernd Frank
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Carcinogenesis 26:643-7. 2005
    ..We hypothesize that ERBB2 Val654 represents an oncogenic variant which might, in addition, influence clinical outcome and predict a worse prognosis...
  19. ncbi Copy number variant in the candidate tumor suppressor gene MTUS1 and familial breast cancer risk
    Bernd Frank
    Division of Molecular Genetic Epidemiology, Helmholtz University Group Molecular Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany
    Carcinogenesis 28:1442-5. 2007
    ..37-0.90, P = 0.01 and OR = 0.41, 95% CI = 0.23-0.74, P = 0.003), supporting its role in human cancer. To our knowledge, the present study is the first to determine the impact of a CNV in a tumor suppressor gene on cancer risk...
  20. ncbi SNPs in ultraconserved elements and familial breast cancer risk
    Rongxi Yang
    Helmholtz University Group Molecular Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Carcinogenesis 29:351-5. 2008
    ..27, 95% CI 1.11-1.45, P = 0.0005; [GG] versus [AA]: OR = 1.60, 95% CI 1.22-2.10, P = 0.0007) pointing to an age- or hormone-related effect. This is the first study indicating that SNPs in UCEs might be associated with cancer risk...
  21. ncbi Interaction of Werner and Bloom syndrome genes with p53 in familial breast cancer
    Michael Wirtenberger
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120, Heidelberg, Germany
    Carcinogenesis 27:1655-60. 2006
    ..39, 95% CI 1.19-9.71). In conclusion, our study indicates the importance of inherited variants in the WRN and p53 genes for familial breast cancer susceptibility...
  22. ncbi Association of NCOA3 polymorphisms with breast cancer risk
    Barbara Burwinkel
    Division of Molecular Genetic Epidemiology C050, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Clin Cancer Res 11:2169-74. 2005
    ..79; 95% confidence interval, 0.67-0.93; P = 0.004). Because of the impact of NCOA3 in antiestrogen therapy resistance, these polymorphisms might also influence therapy outcome in breast cancer...
  23. doi Effect of type 2 diabetes predisposing genetic variants on colorectal cancer risk
    Juan Sainz
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Clin Endocrinol Metab 97:E845-51. 2012
    ..The link between colorectal cancer (CRC) and type 2 diabetes mellitus (T2D) has been extensively studied. Although it is commonly accepted that T2D is a risk factor for CRC, the underlying mechanisms are still poorly understood...
  24. ncbi Investigation of the human serotonin receptor gene HTR3B in bipolar affective and schizophrenic patients
    Bernd Frank
    Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
    Am J Med Genet B Neuropsychiatr Genet 131:1-5. 2004
    ..49, 95% CI: 0.3-0.82; genotype-wise: 15,5% vs. 29,0%, P = 0.005, OR = 0.45, 95% CI: 0.26-0.77). We suggest that this deletion may influence translational efficiency, thereby possibly affecting the development of bipolar affective disease...
  25. ncbi Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families
    Bernd Frank
    Helmholtz University Group Molecular Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany
    Cancer Lett 271:153-7. 2008
    ..No associations of any of the 10 nsSNPs with colorectal cancer could be replicated. The combined analyses indicated that further research based on additional independent samples is required...
  26. ncbi GWAS-identified common variants for obesity are not associated with the risk of developing colorectal cancer
    Juan Sainz
    Authors Affiliations Division of Molecular Genetic Epidemiology, Division of Clinical Epidemiology and Aging Research, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany and Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmo, Sweden
    Cancer Epidemiol Biomarkers Prev 23:1125-8. 2014
    ..Because both traits are genetically determined and share some metabolic biomarkers, we hypothesized that obesity-related polymorphisms could also influence the risk of developing colorectal cancer...
  27. pmc A comprehensive investigation on common polymorphisms in the MDR1/ABCB1 transporter gene and susceptibility to colorectal cancer
    Daniele Campa
    Genomic Epidemiology Group, German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 7:e32784. 2012
    ..In conclusion, in this study of about 8,800 individuals we show that ABCB1 gene polymorphisms play at best a minor role in the susceptibility to CRC...
  28. doi Modification of menopausal hormone therapy-associated colorectal cancer risk by polymorphisms in sex steroid signaling, metabolism and transport related genes
    Anja Rudolph
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Endocr Relat Cancer 18:371-84. 2011
    ..83-1.18). Results of this exploratory study provide first evidence that polymorphisms in genes related to estrogen transport and signaling may modify MHT-associated CRC risk but warrant replication in an independent population...
  29. ncbi Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients
    Bernd Frank
    Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
    Clin Rheumatol 23:338-44. 2004
    ..Sequence variants of the serotonin receptor subunit genes HTR3A and HTR3B indicate no obvious significance in the aetiology of fibromyalgia, yet they represent the basis for future studies on their pharmacogenetic relevance...
  30. ncbi Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E
    Beate Niesler
    Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 328, 69120, Heidelberg, Germany
    Gene 310:101-11. 2003
    ....
  31. ncbi A bias in genotyping the ERBB2 (HER2) Ile655Val variant
    Bernd Frank
    Carcinogenesis 26:1649. 2005
  32. ncbi Re: Association of a common variant of the CASP8 gene with reduced risk of breast cancer
    Bernd Frank
    J Natl Cancer Inst 97:1012; author reply 1012-3. 2005
  33. ncbi Variable number of tandem repeats polymorphism in the SMYD3 promoter region and the risk of familial breast cancer
    Bernd Frank
    Int J Cancer 118:2917-8. 2006
  34. ncbi Molecular genetic analysis of NBS1 in German melanoma patients
    Peter Meyer
    Institute of Human Genetics, Molecular Oncogenetics Unit, University Hospital, Tuebingen, Germany
    Melanoma Res 17:109-16. 2007
    ..These results suggest that NBS1 does not play a major role in predisposition to melanoma in the Southern German population but that alterations of this gene might contribute to the risk of this cancer...
  35. ncbi Familial cancer and ARLTS1
    Bernd Frank
    N Engl J Med 353:313-4; author reply 313-4. 2005