Genomes and Genes
Affiliation: German Cancer Research Center
- Frank B, Hemminki K, Brenner H, Hoffmeister M, Chang Claude J, Burwinkel B. ARLTS1 variants and risk of colorectal cancer. Cancer Lett. 2006;244:172-5 pubmed..However, we showed a non-significant increased risk of familial CRC for both variants (OR=1.40 and 1.45), indicating a possible role of ARLTS1 in familial CRC. ..
- Frank B, Meyer P, Boettger M, Hemminki K, Stapelmann H, Gast A, et al. ARLTS1 variants and melanoma risk. Int J Cancer. 2006;119:1736-7 pubmed..43, 95% CI = 1.05-1.95, p = 0.02). An additional risk enhancement, though statistically non-significant, was observed in individuals with multiple melanomas (OR = 2.33, 95% CI = 0.87-6.26, p = 0.08). ..
- Frank B, Shanmugam K, Beckmann L, Hemminki K, Brenner H, Hoffmeister M, et al. Death receptor 4 variants and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 2006;15:2002-5 pubmed..37; 95% CI, 0.98-5.76). The score statistic yielded an empirical P of 0.03 of the haplotype-specific test for 626C-683C based on 20,000 simulations, suggesting that DR4 626C-683C may affect colorectal cancer predisposition. ..
- Frank B, Bermejo J, Hemminki K, Sutter C, Wappenschmidt B, Meindl A, et al. Copy number variant in the candidate tumor suppressor gene MTUS1 and familial breast cancer risk. Carcinogenesis. 2007;28:1442-5 pubmed..37-0.90, P = 0.01 and OR = 0.41, 95% CI = 0.23-0.74, P = 0.003), supporting its role in human cancer. To our knowledge, the present study is the first to determine the impact of a CNV in a tumor suppressor gene on cancer risk. ..
- Frank B, Hoffmeister M, Klopp N, Illig T, Chang Claude J, Brenner H. Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM. Carcinogenesis. 2010;31:442-5 pubmed publisher..Although none of them showed a significant association with CRC, the association of BLM P868L with rectal cancer risk requires further investigation. ..
- Frank B, Hoeft B, Hoffmeister M, Linseisen J, Breitling L, Chang Claude J, et al. Association of hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD) variants and colorectal cancer risk. Carcinogenesis. 2011;32:190-6 pubmed publisher..82, 95% CI = 0.70, 0.95, P = 0.01) as well as among smokers (OR = 0.74, 95% CI = 0.61, 0.90, P = 0.003). Yet, our data do not support the previously reported associations of HPGD tagSNPs and risk of CRC. ..
- Frank B, Weck M, Muller H, Klopp N, Illig T, Raum E, et al. Polymorphisms in MUC1, MUC2, MUC5B and MUC6 genes are not associated with the risk of chronic atrophic gastritis. Eur J Cancer. 2012;48:114-20 pubmed publisher..None of the analysed SNPs was associated with CAG. However, large studies are needed to disclose or exclude potential weak associations of these SNPs with CAG risk. ..