Laure Dossus

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. ncbi request reprint Reproductive risk factors and endometrial cancer: the European Prospective Investigation into Cancer and Nutrition
    Laure Dossus
    German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 127:442-51. 2010
  2. pmc PTGS2 and IL6 genetic variation and risk of breast and prostate cancer: results from the Breast and Prostate Cancer Cohort Consortium (BPC3)
    Laure Dossus
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Carcinogenesis 31:455-61. 2010
  3. doi request reprint Hormonal, metabolic, and inflammatory profiles and endometrial cancer risk within the EPIC cohort--a factor analysis
    Laure Dossus
    Division of Cancer Epidemiology, German Cancer Research Center Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Am J Epidemiol 177:787-99. 2013
  4. pmc Obesity, inflammatory markers, and endometrial cancer risk: a prospective case-control study
    Laure Dossus
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg, Germany
    Endocr Relat Cancer 17:1007-19. 2010
  5. ncbi request reprint Premenopausal serum sex hormone levels in relation to breast cancer risk, overall and by hormone receptor status - results from the EPIC cohort
    Rudolf Kaaks
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 134:1947-57. 2014
  6. pmc Reproductive factors and risk of hormone receptor positive and negative breast cancer: a cohort study
    Rebecca Ritte
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Cancer 13:584. 2013
  7. pmc Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status: a large prospective cohort study
    Rebecca Ritte
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld TP4, Heidelberg, 69120, Germany
    Breast Cancer Res 14:R76. 2012
  8. ncbi request reprint Insulin-like growth factor I and risk of breast cancer by age and hormone receptor status-A prospective study within the EPIC cohort
    Rudolf Kaaks
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ Heidelberg, Germany
    Int J Cancer 134:2683-90. 2014
  9. ncbi request reprint Tumor necrosis factor (TNF)-α, soluble TNF receptors and endometrial cancer risk: the EPIC study
    Laure Dossus
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 129:2032-7. 2011
  10. doi request reprint Plasma 25-hydroxyvitamin D and the risk of breast cancer in the European prospective investigation into cancer and nutrition: a nested case-control study
    Tilman Kühn
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 581, Heidelberg, Germany
    Int J Cancer 133:1689-700. 2013

Detail Information

Publications27

  1. ncbi request reprint Reproductive risk factors and endometrial cancer: the European Prospective Investigation into Cancer and Nutrition
    Laure Dossus
    German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 127:442-51. 2010
    ....
  2. pmc PTGS2 and IL6 genetic variation and risk of breast and prostate cancer: results from the Breast and Prostate Cancer Cohort Consortium (BPC3)
    Laure Dossus
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Carcinogenesis 31:455-61. 2010
    ..38, 99% CI: 1.04-1.83). No association was observed between PTGS2 polymorphisms and prostate cancer risk. In conclusion, common genetic variation in these two genes might play at best a limited role in breast and prostate cancers...
  3. doi request reprint Hormonal, metabolic, and inflammatory profiles and endometrial cancer risk within the EPIC cohort--a factor analysis
    Laure Dossus
    Division of Cancer Epidemiology, German Cancer Research Center Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Am J Epidemiol 177:787-99. 2013
    ..In conclusion, besides the well-known associations of risk with sex hormones and insulin-regulated physiological axes, our data further support the hypothesis that inflammation factors play a role in endometrial carcinogenesis...
  4. pmc Obesity, inflammatory markers, and endometrial cancer risk: a prospective case-control study
    Laure Dossus
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg, Germany
    Endocr Relat Cancer 17:1007-19. 2010
    ..We provided epidemiological evidence that chronic inflammation might mediate the association between obesity and endometrial cancer and that endometrial carcinogenesis could be promoted by an inflammatory milieu...
  5. ncbi request reprint Premenopausal serum sex hormone levels in relation to breast cancer risk, overall and by hormone receptor status - results from the EPIC cohort
    Rudolf Kaaks
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 134:1947-57. 2014
    ....
  6. pmc Reproductive factors and risk of hormone receptor positive and negative breast cancer: a cohort study
    Rebecca Ritte
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Cancer 13:584. 2013
    ..The association of reproductive factors with hormone receptor (HR)-negative breast tumors remains uncertain...
  7. pmc Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status: a large prospective cohort study
    Rebecca Ritte
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld TP4, Heidelberg, 69120, Germany
    Breast Cancer Res 14:R76. 2012
    ....
  8. ncbi request reprint Insulin-like growth factor I and risk of breast cancer by age and hormone receptor status-A prospective study within the EPIC cohort
    Rudolf Kaaks
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ Heidelberg, Germany
    Int J Cancer 134:2683-90. 2014
    ..ER-/PR- disease). Our data add to a global body of evidence indicating that higher circulating IGF-I levels may increase risk specifically of receptor-positive, but not receptor-negative, breast cancer diagnosed at 50 years or older...
  9. ncbi request reprint Tumor necrosis factor (TNF)-α, soluble TNF receptors and endometrial cancer risk: the EPIC study
    Laure Dossus
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 129:2032-7. 2011
    ..This is the first study of its kind and therefore deserves replication in further prospective studies...
  10. doi request reprint Plasma 25-hydroxyvitamin D and the risk of breast cancer in the European prospective investigation into cancer and nutrition: a nested case-control study
    Tilman Kühn
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 581, Heidelberg, Germany
    Int J Cancer 133:1689-700. 2013
    ..This result is in line with findings in the majority of prospective studies and does not support a role of vitamin D in the development of breast cancer. ..
  11. doi request reprint Postmenopausal serum sex steroids and risk of hormone receptor-positive and -negative breast cancer: a nested case-control study
    Rebecca E James
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer Prev Res (Phila) 4:1626-35. 2011
    ....
  12. doi request reprint Concentrations of IGF-I and IGFBP-3 and brain tumor risk in the European Prospective Investigation into Cancer and Nutrition
    Sabine Rohrmann
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 20:2174-82. 2011
    ..Insulin-like growth factor-1 (IGF-I) is important in normal brain development but in the adult brain, IGF-I overexpression may be a risk factor for tumor development...
  13. doi request reprint Physical activity and risk of breast cancer overall and by hormone receptor status: the European prospective investigation into cancer and nutrition
    Karen Steindorf
    Unit of Physical Activity and Cancer, Divisions of Environmental Epidemiology and Preventive Oncology, German Cancer Research Center, DKFZ, Heidelberg, Germany
    Int J Cancer 132:1667-78. 2013
    ..Heterogeneities by receptor status indicate hormone-related mechanisms...
  14. doi request reprint Height, age at menarche and risk of hormone receptor-positive and -negative breast cancer: a cohort study
    Rebecca Ritte
    Division of Cancer Epidemiology, German Cancer Research Centre DKFZ, Heidelberg, Germany
    Int J Cancer 132:2619-29. 2013
    ..The stronger associations of the components of height with ER+PR+ tumors among older women suggest possible hormonal links that could be specific for postmenopausal women...
  15. doi request reprint Prospective study on physical activity and risk of in situ breast cancer
    Karen Steindorf
    Unit of Physical Activity and Cancer, Divisions of Environmental Epidemiology and Preventive Oncology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 21:2209-19. 2012
    ..Physical activity has been identified as protective factor for invasive breast cancer risk, whereas comparable studies on in situ carcinoma are rare...
  16. doi request reprint The association of circulating adiponectin levels with pancreatic cancer risk: a study within the prospective EPIC cohort
    Verena A Grote
    German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 130:2428-37. 2012
    ..Therefore, further studies are needed to clarify the role of adiponectin in pancreatic cancer development...
  17. pmc Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    Federico Canzian
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Cancer 9:257. 2009
    ..We studied the association between breast cancer risk and polymorphisms in genes that code for GNRH1 and its receptor (GNRHR) in the large National Cancer Institute Breast and Prostate Cancer Cohort Consortium (NCI-BPC3)...
  18. pmc Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium
    Federico Canzian
    German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Hum Mol Genet 19:3873-84. 2010
    ..Although previous studies have shown that variations in these genes can influence endogenous hormone levels, the magnitude of the effect of single SNPs does not appear to be sufficient to alter breast cancer risk...
  19. doi request reprint Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (
    Laure Dossus
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Carcinogenesis 29:1360-6. 2008
    ..These associations, however, might also be due to chance findings and further large studies are needed to confirm our results...
  20. doi request reprint Nutrition, metabolic factors and cancer risk
    Laure Dossus
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, Heidelberg, Germany
    Best Pract Res Clin Endocrinol Metab 22:551-71. 2008
    ....
  21. ncbi request reprint Validity of multiplex-based assays for cytokine measurements in serum and plasma from "non-diseased" subjects: comparison with ELISA
    Laure Dossus
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, Heidelberg 69120, Germany
    J Immunol Methods 350:125-32. 2009
    ..60). In conclusion, multiplex-based assays can give an accurate estimate of the relative risk in large-scale epidemiological studies but only for cytokines that are present in relatively large concentrations (ng/mL)...
  22. doi request reprint Insulin-like growth factor-II methylation status in lymphocyte DNA and colon cancer risk in the Northern Sweden Health and Disease cohort
    Rudolf Kaaks
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer Res 69:5400-5. 2009
    ..The results from this study population do not support the hypothesis that colon cancer can be predicted from the different degrees of methylation of DMR in the IGFII gene from lymphocyte DNA...
  23. pmc Human chorionic gonadotropin and alpha-fetoprotein concentrations in pregnancy and maternal risk of breast cancer: a nested case-control study
    Annekatrin Lukanova
    Division of Cancer Epidemiology, German Cancer Research Center, In Neuenheimer Feld 280, Heidelberg 69120, Germany
    Am J Epidemiol 168:1284-91. 2008
    ..27, 1.03; P = 0.06). These findings, though very preliminary, are consistent with a possible long-term protective association of breast cancer risk with elevated levels of circulating hCG in the early stages of pregnancy...
  24. doi request reprint Prediagnostic plasma testosterone, sex hormone-binding globulin, IGF-I and hepatocellular carcinoma: etiological factors or risk markers?
    Annekatrin Lukanova
    Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany Department of Medical Biosciences, Pathology, University of Umea, Umea, Sweden
    Int J Cancer 134:164-73. 2014
    ..SHBG has a potential to be tested as prediagnostic risk marker for HCC...
  25. doi request reprint Obesity related hyperinsulinaemia and hyperglycaemia and cancer development
    Susen Becker
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Arch Physiol Biochem 115:86-96. 2009
    ....
  26. doi request reprint A genome-wide "pleiotropy scan" does not identify new susceptibility loci for estrogen receptor negative breast cancer
    Daniele Campa
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 9:e85955. 2014
    ..049 to 2.3 × 10(-4). None of the variants reached statistical significance in the replication phase. In conclusion, this study did not identify any novel susceptibility loci for ER-breast cancer using a "pleiotropic approach"...
  27. doi request reprint Pregnancy loss and risk of cardiovascular disease: a prospective population-based cohort study (EPIC-Heidelberg)
    Elham Kharazmi
    German Cancer Research Center, Division of Cancer Epidemiology, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany
    Heart 97:49-54. 2011
    ..To examine whether pregnancy loss (miscarriage, abortion or stillbirth) is associated with a higher risk of myocardial infarction (MI) and stroke...