Hedwig E Deubzer

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. ncbi request reprint Histone deacetylase inhibitor Helminthosporium carbonum (HC)-toxin suppresses the malignant phenotype of neuroblastoma cells
    Hedwig E Deubzer
    Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 122:1891-900. 2008
  2. doi request reprint HDAC11 is a novel drug target in carcinomas
    Hedwig E Deubzer
    Clinical Cooperation Unit Pediatric Oncology G340, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 132:2200-8. 2013
  3. doi request reprint Anti-neuroblastoma activity of Helminthosporium carbonum (HC)-toxin is superior to that of other differentiating compounds in vitro
    Hedwig E Deubzer
    Clinical Cooperation Unit Pediatric Oncology G340, German Cancer Research Center, Heidelberg, Germany
    Cancer Lett 264:21-8. 2008
  4. doi request reprint HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth
    Till Milde
    Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Heidelberg, Germany
    Clin Cancer Res 16:3240-52. 2010
  5. doi request reprint Nestin expression identifies ependymoma patients with poor outcome
    Till Milde
    Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Heidelberg, Germany
    Brain Pathol 22:848-60. 2012
  6. doi request reprint Targeting of HDAC8 and investigational inhibitors in neuroblastoma
    Ina Oehme
    German Cancer Research Center, CCU Pediatric Oncology, INF 280, D 69120 Heidelberg, Germany
    Expert Opin Investig Drugs 18:1605-17. 2009
  7. doi request reprint Histone deacetylase 8 in neuroblastoma tumorigenesis
    Ina Oehme
    Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Heidelberg, Germany
    Clin Cancer Res 15:91-9. 2009
  8. doi request reprint HKI 46F08, a novel potent histone deacetylase inhibitor, exhibits antitumoral activity against embryonic childhood cancer cells
    Dennis Wegener
    CCU Pediatric Oncology G340, German Cancer Research Center, Heidelberg, Germany
    Anticancer Drugs 19:849-57. 2008
  9. doi request reprint HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment
    Till Milde
    Clinical Cooperation Unit Pediatric Oncology G340, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    J Neurooncol 110:335-48. 2012
  10. doi request reprint HDAC family: What are the cancer relevant targets?
    Olaf Witt
    CCU Pediatric Oncology G340, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany
    Cancer Lett 277:8-21. 2009

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Histone deacetylase inhibitor Helminthosporium carbonum (HC)-toxin suppresses the malignant phenotype of neuroblastoma cells
    Hedwig E Deubzer
    Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 122:1891-900. 2008
    ..In conclusion, nanomolar doses of the HDACI HC-toxin cause a shift to a differentiated and benign phenotype of NB cells that is associated with an activation of the RB tumor suppressor network...
  2. doi request reprint HDAC11 is a novel drug target in carcinomas
    Hedwig E Deubzer
    Clinical Cooperation Unit Pediatric Oncology G340, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 132:2200-8. 2013
    ..Altogether, our data show that HDAC11 plays a critical role in cancer cell survival and may represent a novel drug target in oncology...
  3. doi request reprint Anti-neuroblastoma activity of Helminthosporium carbonum (HC)-toxin is superior to that of other differentiating compounds in vitro
    Hedwig E Deubzer
    Clinical Cooperation Unit Pediatric Oncology G340, German Cancer Research Center, Heidelberg, Germany
    Cancer Lett 264:21-8. 2008
    ..Without this functional group, those cellular effects are not observed. In conclusion, the anti-NB activity of HC-toxin is superior to that of RAs and that of all other HDACIs tested...
  4. doi request reprint HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth
    Till Milde
    Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Heidelberg, Germany
    Clin Cancer Res 16:3240-52. 2010
    ..This study investigated the expression levels of individual human HDAC family members in primary medulloblastoma samples, their potential as risk stratification markers, and their roles in tumor cell growth...
  5. doi request reprint Nestin expression identifies ependymoma patients with poor outcome
    Till Milde
    Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Heidelberg, Germany
    Brain Pathol 22:848-60. 2012
    ..In summary, our data implicate nestin as a useful novel marker for intracranial ependymoma risk stratification easily implementable in routine diagnostics...
  6. doi request reprint Targeting of HDAC8 and investigational inhibitors in neuroblastoma
    Ina Oehme
    German Cancer Research Center, CCU Pediatric Oncology, INF 280, D 69120 Heidelberg, Germany
    Expert Opin Investig Drugs 18:1605-17. 2009
    ..Because HDAC8-selective inhibitors are available, HDAC8 may be a potential drug target for neuroblastoma differentiation therapy using selective inhibitors, avoiding unspecific side effects...
  7. doi request reprint Histone deacetylase 8 in neuroblastoma tumorigenesis
    Ina Oehme
    Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Heidelberg, Germany
    Clin Cancer Res 15:91-9. 2009
    ..The purpose of this study was to evaluate the role of individual HDACs in neuroblastoma tumorigenesis...
  8. doi request reprint HKI 46F08, a novel potent histone deacetylase inhibitor, exhibits antitumoral activity against embryonic childhood cancer cells
    Dennis Wegener
    CCU Pediatric Oncology G340, German Cancer Research Center, Heidelberg, Germany
    Anticancer Drugs 19:849-57. 2008
    ..In summary, we identified HKI 48F08 as a structural novel, potent HDAC inhibitor with strong antitumoral activity against embryonic childhood cancer cells in the low micromolar range...
  9. doi request reprint HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment
    Till Milde
    Clinical Cooperation Unit Pediatric Oncology G340, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    J Neurooncol 110:335-48. 2012
    ..In summary, our data indicate that HD-MB03 is a suitable preclinical model for Group 3 medulloblastoma, and HDACis could represent a therapeutic option for this subgroup...
  10. doi request reprint HDAC family: What are the cancer relevant targets?
    Olaf Witt
    CCU Pediatric Oncology G340, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany
    Cancer Lett 277:8-21. 2009
    ..The aim of this review is to discuss individual HDAC family members as drug targets in cancer taking into consideration their function under physiological conditions and their oncogenic potential in malignant disease...
  11. doi request reprint A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat
    Till Milde
    Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Heidelberg, Germany
    Acta Neuropathol 122:637-50. 2011
    ....
  12. doi request reprint Enhancement of radiation response in osteosarcoma and rhabdomyosarcoma cell lines by histone deacetylase inhibition
    Claudia Blattmann
    Department of Pediatric Oncology, University of Heidelberg, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 78:237-45. 2010
    ..We investigated the effect of pan-HDACIs such as suberoylanilide hydroxamic acid (SAHA) on radiation response in two osteosarcoma (OS) and two rhabdomyosarcoma (RMS) cell lines...
  13. pmc MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma
    Marco Lodrini
    Clinical Cooperation Unit Pediatric Oncology G340, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Nucleic Acids Res 41:6018-33. 2013
    ..These data reveal miR-183 tumor suppressive properties in neuroblastoma that are jointly repressed by MYCN and HDAC2, and suggest a novel way to bypass MYCN function. ..
  14. doi request reprint Parvovirus H1 selectively induces cytotoxic effects on human neuroblastoma cells
    Jeannine Lacroix
    Program Infection and Cancer, Department F010 and INSERM U701, German Cancer Research Center, Im Neuenheimer Feld 242, D 69120 Heidelberg, Germany
    Int J Cancer 127:1230-9. 2010
    ....
  15. pmc Histone deacetylase 10 promotes autophagy-mediated cell survival
    Ina Oehme
    Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center DKFZ, D 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 110:E2592-601. 2013
    ..Moreover, these results propose a promising way to considerably improve treatment response in the neuroblastoma patient subgroup with the poorest outcome. ..
  16. doi request reprint Stepwise accumulation of distinct genomic aberrations in a patient with progressively metastasizing ependymoma
    Till Milde
    Clinical Cooperation Unit Pediatric Oncology G340, German Cancer Research Center, Heidelberg, Germany
    Genes Chromosomes Cancer 48:229-38. 2009
    ..This analysis provides molecular insights into the chronology of genetic events in this case from initial localized tumor to widespread metastasized disease...
  17. doi request reprint Identification of novel small-molecule histone deacetylase inhibitors by medium-throughput screening using a fluorigenic assay
    Dennis Wegener
    Department of Molecular Genetics and Preparative Molecular Biology, Institute for Microbiology and Genetics, Grisebachstrasse 8, 37077 Gottingen, Germany
    Biochem J 413:143-50. 2008
    ..In conclusion, screening of a compound library using FB188 HDAH as model enzyme identified several promising new lead structures for further development...