Research Topics
Genomes and Genes | Hedwig E DeubzerSummaryAffiliation: German Cancer Research Center Country: Germany Publications
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Detail Information
Publications
Histone deacetylase inhibitor Helminthosporium carbonum (HC)-toxin suppresses the malignant phenotype of neuroblastoma cellsHedwig E Deubzer
Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center DKFZ, Heidelberg, Germany
Int J Cancer 122:1891-900. 2008..In conclusion, nanomolar doses of the HDACI HC-toxin cause a shift to a differentiated and benign phenotype of NB cells that is associated with an activation of the RB tumor suppressor network...
HDAC11 is a novel drug target in carcinomasHedwig E Deubzer
Clinical Cooperation Unit Pediatric Oncology G340, German Cancer Research Center DKFZ, Heidelberg, Germany
Int J Cancer 132:2200-8. 2013..Altogether, our data show that HDAC11 plays a critical role in cancer cell survival and may represent a novel drug target in oncology...- Anti-neuroblastoma activity of Helminthosporium carbonum (HC)-toxin is superior to that of other differentiating compounds in vitroHedwig E Deubzer
Clinical Cooperation Unit Pediatric Oncology G340, German Cancer Research Center, Heidelberg, Germany
Cancer Lett 264:21-8. 2008..Without this functional group, those cellular effects are not observed. In conclusion, the anti-NB activity of HC-toxin is superior to that of RAs and that of all other HDACIs tested... - HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growthTill Milde
Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Heidelberg, Germany
Clin Cancer Res 16:3240-52. 2010..This study investigated the expression levels of individual human HDAC family members in primary medulloblastoma samples, their potential as risk stratification markers, and their roles in tumor cell growth... - Nestin expression identifies ependymoma patients with poor outcomeTill Milde
Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Heidelberg, Germany
Brain Pathol 22:848-60. 2012..In summary, our data implicate nestin as a useful novel marker for intracranial ependymoma risk stratification easily implementable in routine diagnostics... - Targeting of HDAC8 and investigational inhibitors in neuroblastomaIna Oehme
German Cancer Research Center, CCU Pediatric Oncology, INF 280, D 69120 Heidelberg, Germany
Expert Opin Investig Drugs 18:1605-17. 2009..Because HDAC8-selective inhibitors are available, HDAC8 may be a potential drug target for neuroblastoma differentiation therapy using selective inhibitors, avoiding unspecific side effects... - Histone deacetylase 8 in neuroblastoma tumorigenesisIna Oehme
Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Heidelberg, Germany
Clin Cancer Res 15:91-9. 2009..The purpose of this study was to evaluate the role of individual HDACs in neuroblastoma tumorigenesis... - HKI 46F08, a novel potent histone deacetylase inhibitor, exhibits antitumoral activity against embryonic childhood cancer cellsDennis Wegener
CCU Pediatric Oncology G340, German Cancer Research Center, Heidelberg, Germany
Anticancer Drugs 19:849-57. 2008..In summary, we identified HKI 48F08 as a structural novel, potent HDAC inhibitor with strong antitumoral activity against embryonic childhood cancer cells in the low micromolar range... - HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatmentTill Milde
Clinical Cooperation Unit Pediatric Oncology G340, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
J Neurooncol 110:335-48. 2012..In summary, our data indicate that HD-MB03 is a suitable preclinical model for Group 3 medulloblastoma, and HDACis could represent a therapeutic option for this subgroup... - HDAC family: What are the cancer relevant targets?Olaf Witt
CCU Pediatric Oncology G340, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany
Cancer Lett 277:8-21. 2009..The aim of this review is to discuss individual HDAC family members as drug targets in cancer taking into consideration their function under physiological conditions and their oncogenic potential in malignant disease... - A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor VorinostatTill Milde
Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Heidelberg, Germany
Acta Neuropathol 122:637-50. 2011.... - Enhancement of radiation response in osteosarcoma and rhabdomyosarcoma cell lines by histone deacetylase inhibitionClaudia Blattmann
Department of Pediatric Oncology, University of Heidelberg, Heidelberg, Germany
Int J Radiat Oncol Biol Phys 78:237-45. 2010..We investigated the effect of pan-HDACIs such as suberoylanilide hydroxamic acid (SAHA) on radiation response in two osteosarcoma (OS) and two rhabdomyosarcoma (RMS) cell lines... - Parvovirus H1 selectively induces cytotoxic effects on human neuroblastoma cellsJeannine Lacroix
Program Infection and Cancer, Department F010 and INSERM U701, German Cancer Research Center, Im Neuenheimer Feld 242, D 69120 Heidelberg, Germany
Int J Cancer 127:1230-9. 2010.... - Stepwise accumulation of distinct genomic aberrations in a patient with progressively metastasizing ependymomaTill Milde
Clinical Cooperation Unit Pediatric Oncology G340, German Cancer Research Center, Heidelberg, Germany
Genes Chromosomes Cancer 48:229-38. 2009..This analysis provides molecular insights into the chronology of genetic events in this case from initial localized tumor to widespread metastasized disease... - Identification of novel small-molecule histone deacetylase inhibitors by medium-throughput screening using a fluorigenic assayDennis Wegener
Department of Molecular Genetics and Preparative Molecular Biology, Institute for Microbiology and Genetics, Grisebachstrasse 8, 37077 Gottingen, Germany
Biochem J 413:143-50. 2008..In conclusion, screening of a compound library using FB188 HDAH as model enzyme identified several promising new lead structures for further development...