Research Topics
Genomes and Genes | Gary DavidsonSummaryAffiliation: German Cancer Research Center Country: Germany Publications
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Detail Information
Publications
Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transductionGary Davidson
Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Nature 438:867-72. 2005..Our results reveal an evolutionarily conserved mechanism that couples Wnt receptor activation to the cytoplasmic signal transduction apparatus...
Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterningGary Davidson
Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Development 129:5587-96. 2002..The results indicate that Krm proteins function in a Wnt inhibition pathway regulating early AP patterning of the CNS...
Cell cycle control of wnt receptor activationGary Davidson
Division of Molecular Embryology, Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Hermann von Helmholtz Platz 1, 76344 Eggenstein Leopoldshafen, Germany
Dev Cell 17:788-99. 2009..G2/M priming of LRP6 by a Cyclin/CDK complex introduces an unexpected new layer of regulation of Wnt signaling...
Dkk1 and noggin cooperate in mammalian head inductionIvan del Barco Barrantes
Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Genes Dev 17:2239-44. 2003..The results provide genetic evidence for the dual inhibition model and indicate that dkk1 and noggin functionally cooperate in the head organizer...
Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylationJosipa Bilic
Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Science 316:1619-22. 2007..We propose that Wnts induce coclustering of receptors and Dvl in LRP6-signalosomes, which in turn triggers LRP6 phosphorylation to promote Axin recruitment and beta-catenin stabilization...
Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signallingBingyu Mao
Molecular Embryology Division, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Nature 417:664-7. 2002..The results indicate that Kremen1 and Kremen2 are components of a membrane complex modulating canonical Wnt signalling through LRP6 in vertebrates...
