Boldizsar Czeh

Summary

Affiliation: German Primate Center
Country: Germany

Publications

  1. doi request reprint Antidepressants act directly on astrocytes: evidences and functional consequences
    Boldizsar Czeh
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Eur Neuropsychopharmacol 23:171-85. 2013
  2. ncbi request reprint Chronic social stress inhibits cell proliferation in the adult medial prefrontal cortex: hemispheric asymmetry and reversal by fluoxetine treatment
    Boldizsar Czeh
    Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Germany
    Neuropsychopharmacology 32:1490-503. 2007
  3. ncbi request reprint What causes the hippocampal volume decrease in depression? Are neurogenesis, glial changes and apoptosis implicated?
    Boldizsar Czeh
    Clinical Neurobiology Laboratory, German Primate Center, Kellnerweg 4, 37077 Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 257:250-60. 2007
  4. doi request reprint Chronic stress-induced cellular changes in the medial prefrontal cortex and their potential clinical implications: does hemisphere location matter?
    Boldizsar Czeh
    Clinical Neurobiology Laboratory, German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, Gottingen, Germany
    Behav Brain Res 190:1-13. 2008
  5. doi request reprint Quantitative changes in hippocampal microvasculature of chronically stressed rats: no effect of fluoxetine treatment
    Boldizsar Czeh
    Clinical Neurobiology Laboratory, German Primate Center, Leibniz Institute for Primate Research, Gottingen, Germany
    Hippocampus 20:174-85. 2010
  6. ncbi request reprint Selective enhancement of spatial learning under chronic psychosocial stress
    Alessandro Bartolomucci
    Division of Neurobiology, German Primate Center, Göttingen 37077, Germany
    Eur J Neurosci 15:1863-6. 2002
  7. ncbi request reprint Diurnal rhythm and stress regulate dendritic architecture and spine density of pyramidal neurons in the rat infralimbic cortex
    Claudia Perez-Cruz
    Clinical Neurobiology Laboratory, German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Gottingen, Germany
    Behav Brain Res 205:406-13. 2009
  8. ncbi request reprint Astroglial plasticity in the hippocampus is affected by chronic psychosocial stress and concomitant fluoxetine treatment
    Boldizsar Czeh
    Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Germany
    Neuropsychopharmacology 31:1616-26. 2006
  9. ncbi request reprint Examining SLV-323, a novel NK1 receptor antagonist, in a chronic psychosocial stress model for depression
    Boldizsar Czeh
    Clinical Neurobiology Laboratory, German Primate Center, Kellnerweg 4, 37077 Gottingen, Germany
    Psychopharmacology (Berl) 180:548-57. 2005
  10. ncbi request reprint Age-dependent susceptibility of adult hippocampal cell proliferation to chronic psychosocial stress
    Maria Simon
    Clinical Neurobiology Laboratory, German Primate Center, University of Gottingen, Kellnerweg 4, 37077 Gottingen, Germany
    Brain Res 1049:244-8. 2005

Collaborators

Detail Information

Publications27

  1. doi request reprint Antidepressants act directly on astrocytes: evidences and functional consequences
    Boldizsar Czeh
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Eur Neuropsychopharmacol 23:171-85. 2013
    ....
  2. ncbi request reprint Chronic social stress inhibits cell proliferation in the adult medial prefrontal cortex: hemispheric asymmetry and reversal by fluoxetine treatment
    Boldizsar Czeh
    Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Germany
    Neuropsychopharmacology 32:1490-503. 2007
    ..These pronounced changes in gliogenesis after chronic stress exposure may relate to the abnormalities of glial cell numbers reported in the frontolimbic areas of depressed patients...
  3. ncbi request reprint What causes the hippocampal volume decrease in depression? Are neurogenesis, glial changes and apoptosis implicated?
    Boldizsar Czeh
    Clinical Neurobiology Laboratory, German Primate Center, Kellnerweg 4, 37077 Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 257:250-60. 2007
    ....
  4. doi request reprint Chronic stress-induced cellular changes in the medial prefrontal cortex and their potential clinical implications: does hemisphere location matter?
    Boldizsar Czeh
    Clinical Neurobiology Laboratory, German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, Gottingen, Germany
    Behav Brain Res 190:1-13. 2008
    ..We argue that it is important to define the kinds of structural changes that result from long-term stress exposure because this knowledge will improve the identification of cellular endophenotypes in various psychiatric disorders...
  5. doi request reprint Quantitative changes in hippocampal microvasculature of chronically stressed rats: no effect of fluoxetine treatment
    Boldizsar Czeh
    Clinical Neurobiology Laboratory, German Primate Center, Leibniz Institute for Primate Research, Gottingen, Germany
    Hippocampus 20:174-85. 2010
    ..Reduced microvasculature may also contribute to hippocampal volume decrease in stress-related disorders...
  6. ncbi request reprint Selective enhancement of spatial learning under chronic psychosocial stress
    Alessandro Bartolomucci
    Division of Neurobiology, German Primate Center, Göttingen 37077, Germany
    Eur J Neurosci 15:1863-6. 2002
    ..These results indicate that specific memory processes not only may remain intact, but indeed are facilitated by chronic stress, despite elevated cortisol levels and suppressed hippocampal cell proliferation...
  7. ncbi request reprint Diurnal rhythm and stress regulate dendritic architecture and spine density of pyramidal neurons in the rat infralimbic cortex
    Claudia Perez-Cruz
    Clinical Neurobiology Laboratory, German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Gottingen, Germany
    Behav Brain Res 205:406-13. 2009
    ..Our findings indicate that the diurnal rhythm has a unique impact on the structural plasticity of pyramidal cells in the ILC and that stress interferes with this form of neuroplasticity...
  8. ncbi request reprint Astroglial plasticity in the hippocampus is affected by chronic psychosocial stress and concomitant fluoxetine treatment
    Boldizsar Czeh
    Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Germany
    Neuropsychopharmacology 31:1616-26. 2006
    ....
  9. ncbi request reprint Examining SLV-323, a novel NK1 receptor antagonist, in a chronic psychosocial stress model for depression
    Boldizsar Czeh
    Clinical Neurobiology Laboratory, German Primate Center, Kellnerweg 4, 37077 Gottingen, Germany
    Psychopharmacology (Berl) 180:548-57. 2005
    ..Substance P antagonists have been proposed as candidates for a new class of antidepressant compounds...
  10. ncbi request reprint Age-dependent susceptibility of adult hippocampal cell proliferation to chronic psychosocial stress
    Maria Simon
    Clinical Neurobiology Laboratory, German Primate Center, University of Gottingen, Kellnerweg 4, 37077 Gottingen, Germany
    Brain Res 1049:244-8. 2005
    ..We found that older animals were significantly more vulnerable to the adverse effect of stress on dentate cell proliferation...
  11. pmc Hemispheric differences in basilar dendrites and spines of pyramidal neurons in the rat prelimbic cortex: activity- and stress-induced changes
    Claudia Perez-Cruz
    Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Germany
    Eur J Neurosci 29:738-47. 2009
    ..These morphological alterations reflect the capacity of the neurons to react to external stimuli and mirror presumptive changes in neuronal communication...
  12. ncbi request reprint Alterations of neuroplasticity in depression: the hippocampus and beyond
    Eberhard Fuchs
    Clinical Neurobiology Laboratory, German Primate Center, Kellnerweg 4, 37077 Gottingen, Germany
    Eur Neuropsychopharmacol 14:S481-90. 2004
    ..These findings support current theories proposing that major depressive disorders may be associated with impairment of structural plasticity and neural cellular resilience, and that antidepressants may act by correcting this dysfunction...
  13. ncbi request reprint [Neuroplasticity and depression]
    Boldizsar Czeh
    Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Németország
    Psychiatr Hung 20:4-17. 2005
    ..It is possible that antidepressant treatment could oppose these adverse cellular effects, which may be regarded as a loss of neural plasticity, by blocking or reversing the atrophy of neurons and by increasing cell survival and function...
  14. ncbi request reprint Chronic stress decreases the number of parvalbumin-immunoreactive interneurons in the hippocampus: prevention by treatment with a substance P receptor (NK1) antagonist
    Boldizsar Czeh
    Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Germany
    Neuropsychopharmacology 30:67-79. 2005
    ..Furthermore, the NK1R antagonist SLV-323 showed neurobiological efficacy similar to that of fluoxetine...
  15. pmc Stress impairs GABAergic network function in the hippocampus by activating nongenomic glucocorticoid receptors and affecting the integrity of the parvalbumin-expressing neuronal network
    Wen Hu
    Clinical Neurobiology Laboratory, German Primate Center, Leibniz Institute for Primate Research, Gottingen, Germany
    Neuropsychopharmacology 35:1693-707. 2010
    ..This stress-induced dysfunctional inhibitory network may in turn impair rhythmic oscillations and thus lead to cognitive deficits that are common in stress-related psychiatric disorders...
  16. ncbi request reprint Chronic psychosocial stress in tree shrews: effect of the substance P (NK1 receptor) antagonist L-760735 and clomipramine on endocrine and behavioral parameters
    Marieke G C van der Hart
    Clinical Neurobiology Laboratory, German Primate Center, Gottingen
    Psychopharmacology (Berl) 181:207-16. 2005
    ....
  17. ncbi request reprint Remodeling of neuronal networks by stress
    Eberhard Fuchs
    Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Germany
    Front Biosci 11:2746-58. 2006
    ..However, it is also possible that at least part of these changes reflect adaptive responses, as the network system rearranges its connections in order to cope with the changing requirements from the internal or external environment...
  18. ncbi request reprint Chronic psychosocial stress and concomitant repetitive transcranial magnetic stimulation: effects on stress hormone levels and adult hippocampal neurogenesis
    Boldizsar Czeh
    The German Primate Center, Division of Neurobiology, Gottingen, Germany
    Biol Psychiatry 52:1057-65. 2002
    ..The present study investigated the effect of chronic psychosocial stress and concomitant repetitive transcranial magnetic stimulation treatment on stress hormone regulation and hippocampal neurogenesis...
  19. doi request reprint Chronic restraint stress impairs endocannabinoid mediated suppression of GABAergic signaling in the hippocampus of adult male rats
    Wen Hu
    Clinical Neurobiology Laboratory, German Primate Center, Leibniz Institute for Primate Research, Gottingen, Germany
    Brain Res Bull 85:374-9. 2011
    ....
  20. ncbi request reprint Talking to the synapse: how antidepressants can target glial cells to reshape brain circuits
    Barbara Di Benedetto
    Max Planck Institute of Psychiatry, Molecular Psychopharmacology, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Curr Drug Targets 14:1329-35. 2013
    ..Such knowledge may help to improve current treatment regimens or identify novel targets for the development of more efficacious antidepressant drugs. ..
  21. ncbi request reprint The prototypic mineralocorticoid receptor agonist aldosterone influences neurogenesis in the dentate gyrus of the adrenalectomized rat
    Anja K Fischer
    Division of Neurobiology, German Primate Center, Kellnerweg 4, 37077 Gottingen, Germany
    Brain Res 947:290-3. 2002
    ..Our results indicate that aldosterone, most probably acting through mineralocorticoid receptors, may positively influence the proliferation and survival of newly-generated granule cells...
  22. ncbi request reprint Homeostatic maintenance in excitability of tree shrew hippocampal CA3 pyramidal neurons after chronic stress
    Maarten H P Kole
    Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Germany
    Hippocampus 14:742-51. 2004
    ....
  23. ncbi request reprint Safety aspects of chronic low-frequency transcranial magnetic stimulation based on localized proton magnetic resonance spectroscopy and histology of the rat brain
    David Liebetanz
    Georg August Universitat Gottingen, Abteilung Klinische Neurophysiologie, 37075, Gottingen, Germany
    J Psychiatr Res 37:277-86. 2003
    ..In conclusion, these data provide support for the safety of chronic rTMS. However, they do not exclude acute changes on neurotransmitters systems or other physiologic responses during or directly after the rTMS treatment...
  24. ncbi request reprint Differential expression of major histocompatibility complex class I molecules in the brain of a New World monkey, the common marmoset (Callithrix jacchus)
    Ulrike Rölleke
    Department of Primate Genetics, German Primate Center, Gottingen, Germany
    J Neuroimmunol 176:39-50. 2006
    ..Our data show that selected neurons in the brain of a non-human primate express MHC class I molecules and that this expression can be modulated by immunosuppression...
  25. ncbi request reprint NK1 receptor antagonists under investigation for the treatment of affective disorders
    Boldizsar Czeh
    German Primate Center, Clinical Neurobiology Laboratory, Kellnerweg 4, 37077 Gottingen, Germany
    Expert Opin Investig Drugs 15:479-86. 2006
    ..Furthermore, NK1 receptor antagonists that are ineffective in the treatment of mood disorders may still prove to be effective in the treatment of anxiety problems...
  26. ncbi request reprint Differential macrophage/microglia activation in neocortical EAE lesions in the marmoset monkey
    Doron Merkler
    Department of Neuropathology, Georg August University Gottingen, Gottingen, Germany
    Brain Pathol 16:117-23. 2006
    ..Our findings indicate that the inflammatory response, especially macrophage and microglia activation, may be regulated differently in gray matter areas in primate brain...
  27. doi request reprint Visualizing dopamine transporter integrity with iodine-123-FP-CIT SPECT in combination with high resolution MRI in the brain of the common marmoset monkey
    Enrique Garea-Rodríguez
    Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Kellnerweg 4, D 37077 Gottingen, Germany
    J Neurosci Methods 210:195-201. 2012
    ..The presented study demonstrates that ¹²³I-FP-CIT SPECT is a suitable tool to investigate DAT integrity in preclinical studies on common marmosets...