Research Topics
| Boldizsar CzehSummaryAffiliation: German Primate Center Country: Germany Publications
| Collaborators
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Detail Information
Publications
Antidepressants act directly on astrocytes: evidences and functional consequencesBoldizsar Czeh
Max Planck Institute of Psychiatry, 80804 Munich, Germany
Eur Neuropsychopharmacol 23:171-85. 2013....
Chronic social stress inhibits cell proliferation in the adult medial prefrontal cortex: hemispheric asymmetry and reversal by fluoxetine treatmentBoldizsar Czeh
Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Germany
Neuropsychopharmacology 32:1490-503. 2007..These pronounced changes in gliogenesis after chronic stress exposure may relate to the abnormalities of glial cell numbers reported in the frontolimbic areas of depressed patients...- What causes the hippocampal volume decrease in depression? Are neurogenesis, glial changes and apoptosis implicated?Boldizsar Czeh
Clinical Neurobiology Laboratory, German Primate Center, Kellnerweg 4, 37077 Gottingen, Germany
Eur Arch Psychiatry Clin Neurosci 257:250-60. 2007.... - Quantitative changes in hippocampal microvasculature of chronically stressed rats: no effect of fluoxetine treatmentBoldizsar Czeh
Clinical Neurobiology Laboratory, German Primate Center, Leibniz Institute for Primate Research, Gottingen, Germany
Hippocampus 20:174-85. 2010..Reduced microvasculature may also contribute to hippocampal volume decrease in stress-related disorders... - Chronic stress-induced cellular changes in the medial prefrontal cortex and their potential clinical implications: does hemisphere location matter?Boldizsar Czeh
Clinical Neurobiology Laboratory, German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, Gottingen, Germany
Behav Brain Res 190:1-13. 2008..We argue that it is important to define the kinds of structural changes that result from long-term stress exposure because this knowledge will improve the identification of cellular endophenotypes in various psychiatric disorders... - Diurnal rhythm and stress regulate dendritic architecture and spine density of pyramidal neurons in the rat infralimbic cortexClaudia Perez-Cruz
Clinical Neurobiology Laboratory, German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Gottingen, Germany
Behav Brain Res 205:406-13. 2009..Our findings indicate that the diurnal rhythm has a unique impact on the structural plasticity of pyramidal cells in the ILC and that stress interferes with this form of neuroplasticity... - Examining SLV-323, a novel NK1 receptor antagonist, in a chronic psychosocial stress model for depressionBoldizsar Czeh
Clinical Neurobiology Laboratory, German Primate Center, Kellnerweg 4, 37077 Gottingen, Germany
Psychopharmacology (Berl) 180:548-57. 2005..Substance P antagonists have been proposed as candidates for a new class of antidepressant compounds... - Astroglial plasticity in the hippocampus is affected by chronic psychosocial stress and concomitant fluoxetine treatmentBoldizsar Czeh
Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Germany
Neuropsychopharmacology 31:1616-26. 2006.... - Age-dependent susceptibility of adult hippocampal cell proliferation to chronic psychosocial stressMaria Simon
Clinical Neurobiology Laboratory, German Primate Center, University of Gottingen, Kellnerweg 4, 37077 Gottingen, Germany
Brain Res 1049:244-8. 2005..We found that older animals were significantly more vulnerable to the adverse effect of stress on dentate cell proliferation... 
Hemispheric differences in basilar dendrites and spines of pyramidal neurons in the rat prelimbic cortex: activity- and stress-induced changesClaudia Perez-Cruz
Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Germany
Eur J Neurosci 29:738-47. 2009..These morphological alterations reflect the capacity of the neurons to react to external stimuli and mirror presumptive changes in neuronal communication...- [Neuroplasticity and depression]Boldizsar Czeh
Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Németország
Psychiatr Hung 20:4-17. 2005..It is possible that antidepressant treatment could oppose these adverse cellular effects, which may be regarded as a loss of neural plasticity, by blocking or reversing the atrophy of neurons and by increasing cell survival and function... - Chronic psychosocial stress in tree shrews: effect of the substance P (NK1 receptor) antagonist L-760735 and clomipramine on endocrine and behavioral parametersMarieke G C van der Hart
Clinical Neurobiology Laboratory, German Primate Center, Gottingen
Psychopharmacology (Berl) 181:207-16. 2005.... - Chronic stress decreases the number of parvalbumin-immunoreactive interneurons in the hippocampus: prevention by treatment with a substance P receptor (NK1) antagonistBoldizsar Czeh
Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Germany
Neuropsychopharmacology 30:67-79. 2005..Furthermore, the NK1R antagonist SLV-323 showed neurobiological efficacy similar to that of fluoxetine... - Stress impairs GABAergic network function in the hippocampus by activating nongenomic glucocorticoid receptors and affecting the integrity of the parvalbumin-expressing neuronal networkWen Hu
Clinical Neurobiology Laboratory, German Primate Center, Leibniz Institute for Primate Research, Gottingen, Germany
Neuropsychopharmacology 35:1693-707. 2010..This stress-induced dysfunctional inhibitory network may in turn impair rhythmic oscillations and thus lead to cognitive deficits that are common in stress-related psychiatric disorders... - Chronic psychosocial stress and concomitant repetitive transcranial magnetic stimulation: effects on stress hormone levels and adult hippocampal neurogenesisBoldizsar Czeh
The German Primate Center, Division of Neurobiology, Gottingen, Germany
Biol Psychiatry 52:1057-65. 2002..The present study investigated the effect of chronic psychosocial stress and concomitant repetitive transcranial magnetic stimulation treatment on stress hormone regulation and hippocampal neurogenesis... - Remodeling of neuronal networks by stressEberhard Fuchs
Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Germany
Front Biosci 11:2746-58. 2006..However, it is also possible that at least part of these changes reflect adaptive responses, as the network system rearranges its connections in order to cope with the changing requirements from the internal or external environment... - Alterations of neuroplasticity in depression: the hippocampus and beyondEberhard Fuchs
Clinical Neurobiology Laboratory, German Primate Center, Kellnerweg 4, 37077 Gottingen, Germany
Eur Neuropsychopharmacol 14:S481-90. 2004..These findings support current theories proposing that major depressive disorders may be associated with impairment of structural plasticity and neural cellular resilience, and that antidepressants may act by correcting this dysfunction... - Chronic restraint stress impairs endocannabinoid mediated suppression of GABAergic signaling in the hippocampus of adult male ratsWen Hu
Clinical Neurobiology Laboratory, German Primate Center, Leibniz Institute for Primate Research, Gottingen, Germany
Brain Res Bull 85:374-9. 2011.... - Differential macrophage/microglia activation in neocortical EAE lesions in the marmoset monkeyDoron Merkler
Department of Neuropathology, Georg August University Gottingen, Gottingen, Germany
Brain Pathol 16:117-23. 2006..Our findings indicate that the inflammatory response, especially macrophage and microglia activation, may be regulated differently in gray matter areas in primate brain... - NK1 receptor antagonists under investigation for the treatment of affective disordersBoldizsar Czeh
German Primate Center, Clinical Neurobiology Laboratory, Kellnerweg 4, 37077 Gottingen, Germany
Expert Opin Investig Drugs 15:479-86. 2006..Furthermore, NK1 receptor antagonists that are ineffective in the treatment of mood disorders may still prove to be effective in the treatment of anxiety problems... - Homeostatic maintenance in excitability of tree shrew hippocampal CA3 pyramidal neurons after chronic stressMaarten H P Kole
Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Germany
Hippocampus 14:742-51. 2004.... - Safety aspects of chronic low-frequency transcranial magnetic stimulation based on localized proton magnetic resonance spectroscopy and histology of the rat brainDavid Liebetanz
Georg August Universitat Gottingen, Abteilung Klinische Neurophysiologie, 37075, Gottingen, Germany
J Psychiatr Res 37:277-86. 2003..In conclusion, these data provide support for the safety of chronic rTMS. However, they do not exclude acute changes on neurotransmitters systems or other physiologic responses during or directly after the rTMS treatment... - Visualizing dopamine transporter integrity with iodine-123-FP-CIT SPECT in combination with high resolution MRI in the brain of the common marmoset monkeyEnrique Garea-Rodríguez
Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Kellnerweg 4, D 37077 Gottingen, Germany
J Neurosci Methods 210:195-201. 2012..The presented study demonstrates that ¹²³I-FP-CIT SPECT is a suitable tool to investigate DAT integrity in preclinical studies on common marmosets... - Differential expression of major histocompatibility complex class I molecules in the brain of a New World monkey, the common marmoset (Callithrix jacchus)Ulrike Rölleke
Department of Primate Genetics, German Primate Center, Gottingen, Germany
J Neuroimmunol 176:39-50. 2006..Our data show that selected neurons in the brain of a non-human primate express MHC class I molecules and that this expression can be modulated by immunosuppression...