Jenny Chang-Claude

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. pmc Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium
    Linda E Kelemen
    Department of Population Health Research, Alberta Health Services Cancer Care, AB, Canada
    BMC Cancer 13:28. 2013
  2. pmc Coffee consumption modifies risk of estrogen-receptor negative breast cancer
    Jingmei Li
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Breast Cancer Res 13:R49. 2011
  3. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
  4. pmc Genetic predictors of acute toxicities related to radiation therapy following lumpectomy for breast cancer: a case-series study
    Christine B Ambrosone
    Department of Epidemiology, Division of Cancer Prevention and Population Science, Roswell Park Cancer Institute, Buffalo, New York, USA
    Breast Cancer Res 8:R40. 2006
  5. pmc Comparison of the power of haplotype-based versus single- and multilocus association methods for gene x environment (gene x sex) interactions and application to gene x smoking and gene x sex interactions in rheumatoid arthritis
    Astrid Dempfle
    Institute of Medical Biometry and Epidemiology, Philipps University Marburg, 35037 Marburg, Germany
    BMC Proc 1:S73. 2007
  6. pmc Comparison of measures for haplotype similarity
    Vivien Marquard
    Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    BMC Proc 1:S128. 2007
  7. pmc Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene
    Kirstin Mittelstrass
    Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Epidemiology, Munich Neuherberg, Germany
    BMC Cancer 8:113. 2008
  8. ncbi request reprint Age at menarche and menopause and breast cancer risk in the International BRCA1/2 Carrier Cohort Study
    Jenny Chang-Claude
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 16:740-6. 2007
  9. pmc Carcinogen metabolism, cigarette smoking, and breast cancer risk: a Bayes model averaging approach
    Nadine Stephenson
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Epidemiol Perspect Innov 7:10. 2010
  10. ncbi request reprint Association between polymorphisms in the DNA repair genes, XRCC1, APE1, and XPD and acute side effects of radiotherapy in breast cancer patients
    Jenny Chang-Claude
    Division of Clinical Epidemiology and Toxicology, German Cancer Research Center, Heidelberg, Germany
    Clin Cancer Res 11:4802-9. 2005

Detail Information

Publications141 found, 100 shown here

  1. pmc Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium
    Linda E Kelemen
    Department of Population Health Research, Alberta Health Services Cancer Care, AB, Canada
    BMC Cancer 13:28. 2013
    ..Because OC and ovarian borderline tumor histologic types differ genetically, molecularly and clinically, large numbers are needed to estimate risk associations...
  2. pmc Coffee consumption modifies risk of estrogen-receptor negative breast cancer
    Jingmei Li
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Breast Cancer Res 13:R49. 2011
    ..We assessed the association between coffee consumption and postmenopausal breast cancer risk in a large population-based study (2,818 cases and 3,111 controls), overall, and stratified by ER tumour subtypes...
  3. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
    ....
  4. pmc Genetic predictors of acute toxicities related to radiation therapy following lumpectomy for breast cancer: a case-series study
    Christine B Ambrosone
    Department of Epidemiology, Division of Cancer Prevention and Population Science, Roswell Park Cancer Institute, Buffalo, New York, USA
    Breast Cancer Res 8:R40. 2006
    ..We hypothesized that polymorphisms encoding reduced or absent activity in the GSTs might result in greater risk for radiation-associated toxicity...
  5. pmc Comparison of the power of haplotype-based versus single- and multilocus association methods for gene x environment (gene x sex) interactions and application to gene x smoking and gene x sex interactions in rheumatoid arthritis
    Astrid Dempfle
    Institute of Medical Biometry and Epidemiology, Philipps University Marburg, 35037 Marburg, Germany
    BMC Proc 1:S73. 2007
    ..The previously reported R620W single-nucleotide polymorphism was identified using logistic regression, but the haplotype-based methods did not provide any precise location information...
  6. pmc Comparison of measures for haplotype similarity
    Vivien Marquard
    Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    BMC Proc 1:S128. 2007
    ..While it yielded a much lower power, Yu's measure had 80% power around the disease locus...
  7. pmc Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene
    Kirstin Mittelstrass
    Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Epidemiology, Munich Neuherberg, Germany
    BMC Cancer 8:113. 2008
    ..Our results indicate that the MDM2 SNP309 is not significantly associated with lung carcinogenesis but point towards gender-specific differences...
  8. ncbi request reprint Age at menarche and menopause and breast cancer risk in the International BRCA1/2 Carrier Cohort Study
    Jenny Chang-Claude
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 16:740-6. 2007
    ..Early menarche and late menopause are important risk factors for breast cancer, but their effects on breast cancer risk in BRCA1 and BRCA2 carriers are unknown...
  9. pmc Carcinogen metabolism, cigarette smoking, and breast cancer risk: a Bayes model averaging approach
    Nadine Stephenson
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Epidemiol Perspect Innov 7:10. 2010
    ..We explore the use of a Bayes Model Averaging approach as an alternative to analyze the influence of genetic variants, environmental effects and their interactions on disease...
  10. ncbi request reprint Association between polymorphisms in the DNA repair genes, XRCC1, APE1, and XPD and acute side effects of radiotherapy in breast cancer patients
    Jenny Chang-Claude
    Division of Clinical Epidemiology and Toxicology, German Cancer Research Center, Heidelberg, Germany
    Clin Cancer Res 11:4802-9. 2005
    ..We evaluated the association of six polymorphisms in the DNA repair genes: XRCC1 (Arg194Trp, Arg280His, and Arg399Gln), APE1 (Asp148Glu), and XPD (Lys751Gln and Asp312Asn), with the risk of acute skin reactions following radiotherapy...
  11. ncbi request reprint Lifestyle determinants and mortality in German vegetarians and health-conscious persons: results of a 21-year follow-up
    Jenny Chang-Claude
    Division of Clinical Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 14:963-8. 2005
    ..The long-term observation of vegetarians in affluent countries can provide insight into the relative effects of a vegetarian diet and lifestyle factors on mortality...
  12. ncbi request reprint Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumption
    Carmen Lilla
    Division of Clinical Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 15:99-107. 2006
    ....
  13. ncbi request reprint Association between TP53 and p21 genetic polymorphisms and acute side effects of radiotherapy in breast cancer patients
    Xiang Lin Tan
    Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Breast Cancer Res Treat 97:255-62. 2006
    ..In conclusion, the TP53 72Pro variant may be associated with the development of acute skin toxicity after radiotherapy in patients with normal weight. Large clinical studies are needed to clearly confirm this association...
  14. ncbi request reprint Radiation-induced DNA damage and repair in lymphocytes from breast cancer patients and their correlation with acute skin reactions to radiotherapy
    Odilia Popanda
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 55:1216-25. 2003
    ..The study objective was to evaluate whether DNA repair data determined in vitro are correlated with the occurrence of acute side effects during radiotherapy...
  15. doi request reprint Hormonal, metabolic, and inflammatory profiles and endometrial cancer risk within the EPIC cohort--a factor analysis
    Laure Dossus
    Division of Cancer Epidemiology, German Cancer Research Center Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Am J Epidemiol 177:787-99. 2013
    ..In conclusion, besides the well-known associations of risk with sex hormones and insulin-regulated physiological axes, our data further support the hypothesis that inflammation factors play a role in endometrial carcinogenesis...
  16. ncbi request reprint Death receptor 4 variants and colorectal cancer risk
    Bernd Frank
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 15:2002-5. 2006
    ..37; 95% CI, 0.98-5.76). The score statistic yielded an empirical P of 0.03 of the haplotype-specific test for 626C-683C based on 20,000 simulations, suggesting that DR4 626C-683C may affect colorectal cancer predisposition...
  17. ncbi request reprint Predictive factors for late normal tissue complications following radiotherapy for breast cancer
    Carmen Lilla
    Division of Cancer Epidemiology, C020, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Breast Cancer Res Treat 106:143-50. 2007
    ..To identify prognostic factors for the development of late toxicity after radiotherapy, we conducted a prospective study of breast cancer patients...
  18. pmc SULT1A1 genotype, active and passive smoking, and breast cancer risk by age 50 years in a German case-control study
    Carmen Lilla
    Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Breast Cancer Res 7:R229-37. 2005
    ..Additional investigation of a common SULT1A1 genetic polymorphism associated with reduced enzyme activity and stability might therefore provide deeper insight into the modification of breast cancer susceptibility...
  19. pmc Vitamin D receptor gene polymorphisms and haplotypes and postmenopausal breast cancer risk
    Sascha Abbas
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld, 69120 Heidelberg, Germany
    Breast Cancer Res 10:R31. 2008
    ..Effect modification by serum 25-hydroxyvitamin D (25 [OH]D), the biomarker for vitamin D status in humans, has rarely been examined...
  20. ncbi request reprint Differential effect of NAT2 on the association between active and passive smoke exposure and breast cancer risk
    Jenny Chang-Claude
    Division of Clinical Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 11:698-704. 2002
    ....
  21. doi request reprint Copy number variations of GSTT1 and GSTM1, colorectal cancer risk and possible effect modification of cigarette smoking and menopausal hormone therapy
    Anja Rudolph
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 131:E841-8. 2012
    ..18) for GSTM1. No significant interaction with smoking and MHT use was observed. Our study does not provide evidence for a strong association between CRC risk and CNVs of GSTT1 or GSTM1 or for an effect modification of smoking or MHT use...
  22. doi request reprint Genetic polymorphisms in GST genes and survival of colorectal cancer patients treated with chemotherapy
    Silvia Funke
    German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Pharmacogenomics 11:33-41. 2010
    ..Genetic polymorphisms in GST genes (GSTP1 Ile105Val, copy-number variants of GSTM1 and GSTT1) that lead to diminished enzyme activity have been associated with increased chemotherapeutic treatment benefit in colorectal cancer patients...
  23. ncbi request reprint Genetic polymorphisms in the DNA double-strand break repair genes XRCC3, XRCC2, and NBS1 are not associated with acute side effects of radiotherapy in breast cancer patients
    Odilia Popanda
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 15:1048-50. 2006
  24. doi request reprint Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM
    Bernd Frank
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, 69115 Heidelberg, Germany
    Carcinogenesis 31:442-5. 2010
    ..Although none of them showed a significant association with CRC, the association of BLM P868L with rectal cancer risk requires further investigation...
  25. doi request reprint A distinct ERCC1 haplotype is associated with mRNA expression levels in prostate cancer patients
    Andreas Woelfelschneider
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Carcinogenesis 29:1758-64. 2008
    ..Our study further revealed a modulating effect by nutritional factors...
  26. ncbi request reprint SULT1A1 genotype and susceptibility to colorectal cancer
    Carmen Lilla
    Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 120:201-6. 2007
    ....
  27. doi request reprint Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer
    Maria Timofeeva
    Department of Epigenomics and Cancer Risk Factors, German Cancer Research Centre DKFZ, Heidelberg, Germany
    Int J Cancer 127:1547-61. 2010
    ..To confirm these observations and to eliminate possible bias in our analyses, larger studies are warranted...
  28. doi request reprint Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer
    Bernd Frank
    German Cancer Research Center, Heidelberg, Germany
    Carcinogenesis 31:1381-6. 2010
    ..However, our results provide evidence that CRC subsets may be affected. If confirmed, this knowledge may be used to assess individual susceptibility and to target potential measures of cancer prevention...
  29. doi request reprint The association of cyclin D1 G870A and E-cadherin C-160A polymorphisms with the risk of colorectal cancer in a case control study and meta-analysis
    Xiang Lin Tan
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 122:2573-80. 2008
    ..However, the CCND1 G870A polymorphism may modify the protective effect of postmenopausal hormone use on the development of CRC...
  30. doi request reprint The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status
    Sascha Abbas
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 17:1339-43. 2008
    ..Our results provide evidence for a serum 25(OH)D-independent effect of Gc2 allele carrier status in postmenopausal breast cancer...
  31. doi request reprint The association between dietary lignans, phytoestrogen-rich foods, and fiber intake and postmenopausal breast cancer risk: a German case-control study
    Aida Karina Zaineddin
    Unit of Genetic Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Nutr Cancer 64:652-65. 2012
    ..Our results provide evidence for a reduced postmenopausal breast cancer risk associated with increased consumption of sunflower and pumpkin seeds and soybeans...
  32. doi request reprint Serum enterolactone and postmenopausal breast cancer risk by estrogen, progesterone and herceptin 2 receptor status
    Aida Karina Zaineddin
    Unit of Genetic Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 130:1401-10. 2012
    ..The overall evidence together with other studies supports an inverse association between higher serum enterolactone levels and postmenopausal breast cancer risk...
  33. doi request reprint Postmenopausal sex hormones in relation to body fat distribution
    Stefanie Liedtke
    Unit of Environmental Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Obesity (Silver Spring) 20:1088-95. 2012
    ..On the whole, our results indicate that waist circumference and WHR, but not hip circumference, are associated with SHBG and SHBG-related sex hormones (free estradiol and free testosterone) independently of BMI...
  34. doi request reprint Entropy-supported marker selection and Mantel statistics for haplotype sharing analysis
    Anke Schulz
    Division of Cancer Epidemiology, Unit of Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, Heidelberg, Germany
    Genet Epidemiol 34:354-63. 2010
    ....
  35. pmc A genome-wide association study to identify genetic susceptibility loci that modify ductal and lobular postmenopausal breast cancer risk associated with menopausal hormone therapy use: a two-stage design with replication
    Rebecca Hein
    Unit of Genetic Epidemiology, Division of Cancer Epidemiology C020, German Cancer Research Center DKFZ, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany
    Breast Cancer Res Treat 138:529-42. 2013
    ..Our study, however, suggests that there are unlikely to be SNPs that interact strongly enough with MHT use to be clinically significant in European women...
  36. ncbi request reprint Genetic polymorphisms in TP53, nonsteroidal anti-inflammatory drugs and the risk of colorectal cancer: evidence for gene-environment interaction?
    Xiang Lin Tan
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Pharmacogenet Genomics 17:639-45. 2007
    ..We assessed the association of TP53 Arg72Pro and p53PIN3 polymorphisms with colorectal cancer risk and their possible interaction with nonsteroidal anti-inflammatory drug use...
  37. doi request reprint Effect of type 2 diabetes predisposing genetic variants on colorectal cancer risk
    Juan Sainz
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Clin Endocrinol Metab 97:E845-51. 2012
    ..The link between colorectal cancer (CRC) and type 2 diabetes mellitus (T2D) has been extensively studied. Although it is commonly accepted that T2D is a risk factor for CRC, the underlying mechanisms are still poorly understood...
  38. doi request reprint Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis
    Bernd Frank
    Helmholtz University Group Molecular Epidemiology, Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    J Natl Cancer Inst 100:437-42. 2008
    ..10 (95% CI = 1.04 to 1.17, P = .001). Among the combined subset of 2795 familial breast cancer patients, the respective ORs were 1.27 (95% CI = 1.12 to 1.45, P = .0003) and 1.16 (95% CI = 1.06 to 1.27, P = .001)...
  39. doi request reprint Plasma 25-hydroxyvitamin D and the risk of breast cancer in the European prospective investigation into cancer and nutrition: a nested case-control study
    Tilman Kühn
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 581, Heidelberg, Germany
    Int J Cancer 133:1689-700. 2013
    ..This result is in line with findings in the majority of prospective studies and does not support a role of vitamin D in the development of breast cancer. ..
  40. ncbi request reprint Dietary vitamin D and calcium intake and premenopausal breast cancer risk in a German case-control study
    Sascha Abbas
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Nutr Cancer 59:54-61. 2007
    ..29). No statistically significant interaction between the 2 nutrients was observed. Our data support a protective effect of dietary vitamin D on premenopausal breast cancer risk independent of dietary calcium intake...
  41. doi request reprint Association of pre-diagnosis physical activity with recurrence and mortality among women with breast cancer
    Martina E Schmidt
    Unit of Physical Activity and Cancer, Division of Environmental Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 133:1431-40. 2013
    ..0045. Thus, breast cancer patients with a physically inactive lifestyle pre-diagnosis may decease prematurely irrespective of their cancer prognosis. Higher levels of exercise may reduce the risk of recurrence of ER-/PR- breast tumors...
  42. doi request reprint Germline variants of base excision repair genes and breast cancer: A polymorphism in DNA polymerase gamma modifies gene expression and breast cancer risk
    Odilia Popanda
    Division of Epigenomics and Cancer Risk Factors, C010, German Cancer Research Center, DKFZ, Heidelberg, Germany
    Int J Cancer 132:55-62. 2013
    ..This could contribute to the reported increase in mitochondrial mutation frequency resulting in dysfunction and altered breast cancer risk. Risk effects and the functional impact of the POLG promoter variant require further confirmation...
  43. ncbi request reprint Potential for colorectal cancer prevention of sigmoidoscopy versus colonoscopy: population-based case control study
    Hermann Brenner
    Department of Epidemiology, German Cancer Research Center, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 16:494-9. 2007
    ..Among men, this regimen may be almost as effective as colonoscopy, at least at previous performance levels of colonoscopy...
  44. doi request reprint Serum enterolactone and prognosis of postmenopausal breast cancer
    Katharina Buck
    Unit of Genetic Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    J Clin Oncol 29:3730-8. 2011
    ..Dietary lignans are metabolized to enterolignans, which are subsequently absorbed and become bioavailable...
  45. doi request reprint Meta-analyses of lignans and enterolignans in relation to breast cancer risk
    Katharina Buck
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Am J Clin Nutr 92:141-53. 2010
    ..Epidemiologic studies that examined whether lignans, the most important class of phytoestrogens in the Western diet, protect against breast cancer have yielded inconsistent results...
  46. doi request reprint Pre-diagnostic alcohol consumption and postmenopausal breast cancer survival: a prospective patient cohort study
    Alina Vrieling
    Division of Cancer Epidemiology, Unit of Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Breast Cancer Res Treat 136:195-207. 2012
    ..58). In conclusion, our findings show that consumption of alcohol before diagnosis is non-linearly associated with increased breast cancer-specific mortality but may be associated with decreased risk of mortality due to other causes...
  47. ncbi request reprint Interval cancers after negative colonoscopy: population-based case-control study
    Hermann Brenner
    Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Heidelberg, Germany
    Gut 61:1576-82. 2012
    ..The risk of colorectal cancer after a previous negative colonoscopy is very low. Nevertheless, interval cancers occur. We aimed to assess the characteristics and predictors of interval cancers after negative colonoscopy...
  48. doi request reprint Role of colonoscopy and polyp characteristics in colorectal cancer after colonoscopic polyp detection: a population-based case-control study
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Ann Intern Med 157:225-32. 2012
    ..Studies have identified characteristics of adenomas detected on colonoscopy to be predictive of adenoma recurrence...
  49. doi request reprint Risk of colorectal cancer after detection and removal of adenomas at colonoscopy: population-based case-control study
    Hermann Brenner
    German Cancer Research Center, Heidelberg, Germany
    J Clin Oncol 30:2969-76. 2012
    ..We aimed to assess risk of colorectal cancer (CRC) according to time since polypectomy and factors that might be relevant for risk stratification...
  50. pmc CYP17 5'-UTR MspA1 polymorphism and the risk of premenopausal breast cancer in a German population-based case-control study
    Emaculate Verla-Tebit
    Division of Clinical Epidemiology, German Cancer Research Center, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Breast Cancer Res 7:R455-64. 2005
    ..Higher levels of estrogen have been reported among young nulliparous women with the A2 allele. Therefore we assessed the impact of CYP17 genotypes on the risk of premenopausal breast cancer, with emphasis on parity...
  51. ncbi request reprint In vitro radiation-induced expression of XPC mRNA as a possible biomarker for developing adverse reactions during radiotherapy
    Katrin Wiebalk
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 121:2340-5. 2007
    ..The predictive value of DNA damage-induced XPC levels as a possible biomarker for radiosensitivity has to be further investigated...
  52. doi request reprint Modification of menopausal hormone therapy-associated colorectal cancer risk by polymorphisms in sex steroid signaling, metabolism and transport related genes
    Anja Rudolph
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Endocr Relat Cancer 18:371-84. 2011
    ..83-1.18). Results of this exploratory study provide first evidence that polymorphisms in genes related to estrogen transport and signaling may modify MHT-associated CRC risk but warrant replication in an independent population...
  53. doi request reprint Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC)
    Daniele Campa
    German Cancer Research Center, DKFZ, Heidelberg, Germany
    Eur J Cancer 47:420-7. 2011
    ..None of the SNPs reached statistical significance after adjusting for multiple comparisons. Common SNPs in the fatty acid synthase pathway are not major contributors to prostate cancer risk...
  54. ncbi request reprint Serum 25-hydroxyvitamin D and risk of post-menopausal breast cancer--results of a large case-control study
    Sascha Abbas
    Division of Cancer Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany
    Carcinogenesis 29:93-9. 2008
    ....
  55. ncbi request reprint Polymorphisms in the insulin like growth factor 1 and IGF binding protein 3 genes and risk of colorectal cancer
    Sonali Pechlivanis
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer Detect Prev 31:408-16. 2007
    ..We wanted to study if these polymorphisms or any haplotypes of the IGF1 and the IGFBP3 genes are associated with CRC...
  56. doi request reprint Comparison of different haplotype-based association methods for gene-environment (GxE) interactions in case-control studies when haplotype-phase is ambiguous
    Rebecca Hein
    Department of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Hum Hered 68:252-67. 2009
    ..Furthermore, the methods are based on distinct assumptions (such as Hardy Weinberg equilibrium). The haplotype-based methods were also compared to single-marker logistic regression (LR)...
  57. doi request reprint Dietary intake of vitamin D and calcium and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition
    Sascha Abbas
    German Cancer Research Center, Division of Cancer Epidemiology, Heidelberg, Germany
    Nutr Cancer 65:178-87. 2013
    ..57 and 0.22 in pre- and postmenopausal women, respectively). In this large prospective cohort, we found no evidence for an association between dietary vitamin D or calcium intake and breast cancer risk...
  58. doi request reprint Colorectal cancer risk associated with hormone use varies by expression of estrogen receptor-β
    Anja Rudolph
    Divisions of Cancer Epidemiology, Clinical Epidemiology and Aging Research, and Molecular Tumor Pathology, German Cancer Research Center, Heidelberg, Germany
    Cancer Res 73:3306-15. 2013
    ..5 years ago; Pheterogeneity = 0.023) but not for associations with reproductive factors. In conclusion, our results suggest that hormone use decreases risk for ESR2-positive but not ESR2-negative colorectal cancer...
  59. doi request reprint Colorectal cancers occurring after colonoscopy with polyp detection: sites of polyps and sites of cancers
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, Heidelberg, Germany
    Int J Cancer 133:1672-9. 2013
    ..8%, 95% confidence interval 2.7%-19.3%). Our study suggests that less than one of nine CRCs occurring within 10 years after colonoscopy with polyp detection may be due to field effects or polyp recrudescence. ..
  60. ncbi request reprint Personal characteristics, therapy modalities and individual DNA repair capacity as predictive factors of acute skin toxicity in an unselected cohort of breast cancer patients receiving radiotherapy
    Dorothee Twardella
    German Cancer Research Center, Division of Clinical Epidemiology, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Radiother Oncol 69:145-53. 2003
    ..The influence of therapy modalities, personal characteristics and individual DNA repair capacity on the risk of acute skin toxicity was thus evaluated...
  61. pmc Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors
    Stefan Nickels
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS Genet 9:e1003284. 2013
    ..14 (1.11-1.17) in parous women and 0.98 (0.92-1.05) in nulliparous women. These data provide first strong evidence that the risk of breast cancer associated with some common genetic variants may vary with environmental risk factors...
  62. doi request reprint Prospective study on physical activity and risk of in situ breast cancer
    Karen Steindorf
    Unit of Physical Activity and Cancer, Divisions of Environmental Epidemiology and Preventive Oncology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 21:2209-19. 2012
    ..Physical activity has been identified as protective factor for invasive breast cancer risk, whereas comparable studies on in situ carcinoma are rare...
  63. pmc Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases
    Stefanie Huhn
    Department of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Med Genet 13:94. 2012
    ..A two-stage case-control study on CRC susceptibility was conducted to assess the influence of the ancestral alleles in the polymorphisms previously associated with nutrition-related complex diseases...
  64. doi request reprint Tumor necrosis factor (TNF)-α, soluble TNF receptors and endometrial cancer risk: the EPIC study
    Laure Dossus
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 129:2032-7. 2011
    ..This is the first study of its kind and therefore deserves replication in further prospective studies...
  65. pmc A comprehensive investigation on common polymorphisms in the MDR1/ABCB1 transporter gene and susceptibility to colorectal cancer
    Daniele Campa
    Genomic Epidemiology Group, German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 7:e32784. 2012
    ..In conclusion, in this study of about 8,800 individuals we show that ABCB1 gene polymorphisms play at best a minor role in the susceptibility to CRC...
  66. doi request reprint Fatigue and quality of life in breast cancer survivors: temporal courses and long-term pattern
    Martina E Schmidt
    Unit of Environmental Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany
    J Cancer Surviv 6:11-9. 2012
    ..We investigated different courses of fatigue from pre-diagnosis, through therapy, to long-term survivorship and evaluated potential implications on long-term quality of life (QoL)...
  67. pmc Serum 25-hydroxyvitamin D and postmenopausal breast cancer survival: a prospective patient cohort study
    Alina Vrieling
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Breast Cancer Res 13:R74. 2011
    ..Therefore, the aim of our study was to assess the effect of post-diagnostic serum 25-hydroxyvitamin D [25(OH)D] concentrations on overall survival and distant disease-free survival...
  68. doi request reprint Exposure to environmental tobacco smoke and the risk of colorectal cancer in a case-control study from Germany
    Emaculate Verla-Tebit
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Eur J Cancer Prev 18:9-12. 2009
    ..03-12.15) and for women exposed to >23 pack-years of spousal smoking (OR: 3.02; 95% CI: 0.99-9.28). Our findings do not indicate a major impact of ETS on CRC risk but suggest that risk may be increased following spousal exposure...
  69. ncbi request reprint Case-control study of physical activity and breast cancer risk among premenopausal women in Germany
    Karen Steindorf
    Unit of Environmental Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Am J Epidemiol 157:121-30. 2003
    ..The study prevalence of cycling and walking for transportation demonstrated that national habits need consideration in the exposure assessment...
  70. doi request reprint Association of hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD) variants and colorectal cancer risk
    Bernd Frank
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Carcinogenesis 32:190-6. 2011
    ..82, 95% CI = 0.70, 0.95, P = 0.01) as well as among smokers (OR = 0.74, 95% CI = 0.61, 0.90, P = 0.003). Yet, our data do not support the previously reported associations of HPGD tagSNPs and risk of CRC...
  71. ncbi request reprint The patched polymorphism Pro1315Leu (C3944T) may modulate the association between use of oral contraceptives and breast cancer risk
    Jenny Chang-Claude
    Unit of Genetic Epidemiology, Division of Clinical Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 103:779-83. 2003
    ....
  72. ncbi request reprint Test-retest reliability of self-reported reproductive and lifestyle data in the context of a German case-control study on breast cancer and postmenopausal hormone therapy
    Tracy Slanger
    German Cancer Research Center, Department of Clinical Epidemiology, Heidelberg, Germany
    Ann Epidemiol 17:993-8. 2007
    ....
  73. doi request reprint Variation in genes coding for AMP-activated protein kinase (AMPK) and breast cancer risk in the European Prospective Investigation on Cancer (EPIC)
    Daniele Campa
    Department of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Breast Cancer Res Treat 127:761-7. 2011
    ..We observed no statistically significant association between the SNPs in the PRKAs genes and BC risk and BMI after correction for multiple testing...
  74. doi request reprint CD24 polymorphisms in breast cancer: impact on prognosis and risk
    Katharina Buck
    Division of Preventive Oncology, National Center for Tumor Diseases NCT and German Cancer Research Center DKFZ, Im Neuenheimer Feld 460, Heidelberg, Germany
    Breast Cancer Res Treat 137:927-37. 2013
    ..Together with previous data of CD24 overexpression as a poor prognostic marker, the findings underline the biological importance of CD24 for breast cancer...
  75. doi request reprint Expression analysis of aldehyde dehydrogenase 1A1 (ALDH1A1) in colon and rectal cancer in association with prognosis and response to chemotherapy
    Christoph Kahlert
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
    Ann Surg Oncol 19:4193-201. 2012
    ..We have investigated the prognostic role of ALDH1A1 in primary colorectal cancer and its value in predicting response to chemotherapy in metastatic colorectal cancer...
  76. doi request reprint Physical activity in a German breast cancer patient cohort: one-year trends and characteristics associated with change in activity level
    Christina Huy
    Unit of Environmental Epidemiology, German Cancer Research Centre, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Eur J Cancer 48:297-304. 2012
    ..The objectives of this study were to describe PA behaviour in the course of breast cancer and to identify factors associated with change in PA...
  77. pmc Impact of genotyping errors on the type I error rate and the power of haplotype-based association methods
    Vivien Marquard
    Department of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    BMC Genet 10:3. 2009
    ..Differential and non-differential genotyping errors were introduced following a misclassification model with varying mean error rates per locus in the range of 0.2% to 15.6%...
  78. doi request reprint Postmenopausal serum sex steroids and risk of hormone receptor-positive and -negative breast cancer: a nested case-control study
    Rebecca E James
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer Prev Res (Phila) 4:1626-35. 2011
    ....
  79. ncbi request reprint The A(-336C) insulin-like growth factor binding protein-3 promoter polymorphism is not a modulator of breast cancer risk in Caucasian women
    Maren Rohrbacher
    Genetische Epidemiologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 14:289-90. 2005
  80. ncbi request reprint Reproductive factors and familial predisposition for breast cancer by age 50 years. A case-control-family study for assessing main effects and possible gene-environment interaction
    Heiko Becher
    University of Heidelberg, Department of Tropical Hygiene and Public Health, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    Int J Epidemiol 32:38-48. 2003
    ..The effect of environmental/lifestyle factors on breast cancer risk may be modified by genetic predisposition...
  81. doi request reprint Determinants of sports, cycling, walking and overall leisure-time physical activity among postmenopausal women in Germany
    Karen Steindorf
    Unit of Environmental Epidemiology, German Cancer Research Centre, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Public Health Nutr 13:1905-14. 2010
    ..Nevertheless, many women in Germany are insufficiently physically active. Activity promotion programmes should target women in particular need. Thus, we examined subject-related determinants of PA for postmenopausal women in Germany...
  82. doi request reprint Cancer risk factors associated with insulin-like growth factor (IGF)-I and IGF-binding protein-3 levels in healthy women: effect modification by menopausal status
    Benjamin B E Barnes
    Unit of Environmental Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Cancer Causes Control 20:1985-96. 2009
    ..Other observed associations suggest that neither IGF-I nor IGFBP-3 alone acts as mediator. Consideration of menopausal status may help disentangle carcinogenic pathways involving IGF proteins...
  83. doi request reprint Dietary patterns and the risk of postmenopausal breast cancer in a German case-control study
    Katharina Buck
    German Cancer Research Center, Heidelberg, Germany
    Cancer Causes Control 22:273-82. 2011
    ..Dietary patterns have been inconsistently associated with breast cancer risk. We assessed dietary patterns in association with postmenopausal breast cancer risk using an exploratory approach...
  84. doi request reprint Polymorphisms in inflammatory pathway genes and their association with colorectal cancer risk
    Bernd Frank
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 127:2822-30. 2010
    ..23; 95% CI, 1.04-1.45; p = 0.02 and OR, 1.32; 95% CI, 1.05-1.67; p = 0.02, respectively). Our results support a role of variants in inflammatory pathway genes in CRC susceptibility and progression...
  85. doi request reprint Protection from colorectal cancer after colonoscopy: a population-based, case-control study
    Hermann Brenner
    German Cancer Research Center, University Clinic Heidelberg, University of Heidelberg, Germany
    Ann Intern Med 154:22-30. 2011
    ..However, the degree of protection achievable in a population setting with high-quality colonoscopy resources remains to be quantified...
  86. doi request reprint Plasma 25-hydroxyvitamin D and premenopausal breast cancer risk in a German case-control study
    Sascha Abbas
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 124:250-5. 2009
    ..05, case-only model). Our findings support a protective effect of vitamin D for premenopausal breast cancer...
  87. doi request reprint Polymorphisms in oxidative stress-related genes and postmenopausal breast cancer risk
    Petra Seibold
    Cancer Epidemiology C020, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 129:1467-76. 2011
    ..Summary evidence including independent datasets indicated moderate effects in CYBA and TXN that warrant confirmation in large independent studies...
  88. ncbi request reprint Validity of self-reported endoscopies of the large bowel and implications for estimates of colorectal cancer risk
    Michael Hoffmeister
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Am J Epidemiol 166:130-6. 2007
    ..58), and reasonable for year of examination (kappa = 0.70). Self-reports of previous colorectal endoscopies agreed well with medical records, but validation appears to be essential with respect to details of the examination...
  89. ncbi request reprint Individual and joint use of statins and low-dose aspirin and risk of colorectal cancer: a population-based case-control study
    Michael Hoffmeister
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 121:1325-30. 2007
    ....
  90. doi request reprint Adult weight gain in relation to breast cancer risk by estrogen and progesterone receptor status: a meta-analysis
    Alina Vrieling
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Breast Cancer Res Treat 123:641-9. 2010
    ..In conclusion, the association between adult weight gain and postmenopausal breast cancer risk is heterogeneous according to ER/PR status and stronger for ER(+)PR(+) than for ER(-)PR(-) tumors...
  91. ncbi request reprint ARLTS1 variants and risk of colorectal cancer
    Bernd Frank
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Cancer Lett 244:172-5. 2006
    ..However, we showed a non-significant increased risk of familial CRC for both variants (OR=1.40 and 1.45), indicating a possible role of ARLTS1 in familial CRC...
  92. pmc Genetic Polymorphisms in Genes Related to Oxidative Stress (GSTP1, GSTM1, GSTT1, CAT, MnSOD, MPO, eNOS) and Survival of Rectal Cancer Patients after Radiotherapy
    Silvia Funke
    Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Cancer Epidemiol 2009:302047. 2009
    ....
  93. doi request reprint Long-term risk of colorectal cancer after negative colonoscopy
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany D 69120
    J Clin Oncol 29:3761-7. 2011
    ..We aimed to assess the risk of CRC according to time since negative colonoscopy, overall, and by sex, smoking, and family history of CRC, in a large population-based case-control study...
  94. ncbi request reprint Cigarette smoking and colorectal cancer risk in Germany: a population-based case-control study
    Emaculate Verla-Tebit
    Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 119:630-5. 2006
    ..This study supports the hypothesis that smoking for a long duration at a high cumulative dose increases the risk for colorectal cancer, particularly among women, and suggests that there is risk reduction after longterm smoking cessation...
  95. doi request reprint Genetic variation in normal tissue toxicity induced by ionizing radiation
    Odilia Popanda
    Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mutat Res 667:58-69. 2009
    ..Genetic variation contributing to radiosensitivity should be screened on a broader basis using newly developed, more comprehensive approaches such as genome-wide association studies...
  96. doi request reprint Sample size requirements for indirect association studies of gene-environment interactions (G x E)
    Rebecca Hein
    Department of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Genet Epidemiol 32:235-45. 2008
    ..Thus, the analysis of G x E appears to be an attractive option for the detection of weak genetic main effects of rare variants that may not be detectable in the analysis of genetic marginal effects only...
  97. ncbi request reprint Nutrition and breast cancer risk by age 50: a population-based case-control study in Germany
    Silke Hermann
    Department of Clinical Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Nutr Cancer 44:23-34. 2002
    ....
  98. ncbi request reprint Constitutive mRNA expression of DNA repair-related genes as a biomarker for clinical radio-resistance: A pilot study in prostate cancer patients receiving radiotherapy
    Jörg Hümmerich
    Division of Toxicology and Cancer Risk Factors, Heidelberg, Germany
    Int J Radiat Biol 82:593-604. 2006
    ..Constitutive mRNA expression of repair genes was investigated in such patients to analyze whether expression patterns are predictive for therapy-related acute side effects...
  99. ncbi request reprint Manganese superoxide dismutase Ala-9Val polymorphism, environmental modifiers, and risk of breast cancer in a German population
    Tracy E Slanger
    Division of Clinical Epidemiology, German Cancer Research Center Deutsches Krebsforschungszentrum, Postfach 101949, 69120, Heidelberg, Germany
    Cancer Causes Control 17:1025-31. 2006
    ..However, study findings have been inconsistent and sample sizes often small...
  100. ncbi request reprint The functional genetic variant Arg324Gly of frizzled-related protein is associated with colorectal cancer risk
    Kalai S Shanmugam
    Helmholtz University Group Molecular Epidemiology, Heidelberg, Germany
    Carcinogenesis 28:1914-7. 2007
    ..66, 95% CI = 1.14-11.76, P < 0.05). Since modified Wnt signaling and down-regulation of frizzled-related proteins have been observed in many human cancers, this variant may also affect the susceptibility to other cancers...