Adelheid Cerwenka

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. pmc Sustained effector function of IL-12/15/18-preactivated NK cells against established tumors
    Jing Ni
    Junior Research Group Innate Immunity, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    J Exp Med 209:2351-65. 2012
  2. doi request reprint Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells
    Nathalie Fiegler
    Innate Immunity Group, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany
    Blood 122:684-93. 2013
  3. pmc New twist on the regulation of NKG2D ligand expression
    Adelheid Cerwenka
    Group of Innate Immunity, German Cancer Research Center, 69120 Heidelberg, Germany
    J Exp Med 206:265-8. 2009
  4. doi request reprint Regulatory T cells control macrophage accumulation and activation in lymphoma
    Ioanna E Galani
    Boveri junior research group of Innate Immunity, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 127:1131-40. 2010
  5. pmc Mononuclear myeloid-derived "suppressor" cells express RAE-1 and activate natural killer cells
    Norman Nausch
    Division of Innate Immunity, German Cancer Research Center, Heidelberg, Germany
    Blood 112:4080-9. 2008
  6. pmc Regulation of triggering receptor expressed on myeloid cells 1 expression on mouse inflammatory monocytes
    Kai Zanzinger
    German Cancer Research Centre DKFZ, Innate Immunity, 69120 Heidelberg, Germany
    Immunology 128:185-95. 2009
  7. doi request reprint Interferon-gamma down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells
    Nicole Schwinn
    Division of Clinical Cooperation Unit Dermato Oncology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 124:1594-604. 2009
  8. ncbi request reprint CTLA-4 is expressed by activated mouse NK cells and inhibits NK Cell IFN-γ production in response to mature dendritic cells
    Ana Stojanovic
    Innate Immunity Group, German Cancer Research Center, 69120 Heidelberg, Germany
    J Immunol 192:4184-91. 2014
  9. doi request reprint Antitumor vaccination by Newcastle Disease Virus Hemagglutinin-Neuraminidase plasmid DNA application: changes in tumor microenvironment and activation of innate anti-tumor immunity
    Jing Ni
    Division of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany
    Vaccine 29:1185-93. 2011
  10. doi request reprint Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth
    Eva Schlecker
    Innate Immunity, Research Program Tumor Immunology, German Cancer Research Center, Heidelberg D 69120, Germany
    J Immunol 189:5602-11. 2012

Collaborators

Detail Information

Publications27

  1. pmc Sustained effector function of IL-12/15/18-preactivated NK cells against established tumors
    Jing Ni
    Junior Research Group Innate Immunity, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    J Exp Med 209:2351-65. 2012
    ..Moreover, our results reveal an essential role of CD4+ T cell help for sustained antitumor activity by NK cells linking adaptive and innate immunity...
  2. doi request reprint Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells
    Nathalie Fiegler
    Innate Immunity Group, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany
    Blood 122:684-93. 2013
    ..Thus, we identified a novel mechanism that governs B7-H6 expression in tumor cells that has implications for potential cancer treatments combining immunotherapy with HDACi. ..
  3. pmc New twist on the regulation of NKG2D ligand expression
    Adelheid Cerwenka
    Group of Innate Immunity, German Cancer Research Center, 69120 Heidelberg, Germany
    J Exp Med 206:265-8. 2009
    ..Thus, targeting the ubiquitination machinery in cancer cells might increase the susceptibility of tumors to NK cell-mediated killing...
  4. doi request reprint Regulatory T cells control macrophage accumulation and activation in lymphoma
    Ioanna E Galani
    Boveri junior research group of Innate Immunity, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 127:1131-40. 2010
    ..In our study, high numbers of macrophages infiltrating RMA-S tumors in the absence of Treg correlated with tumor rejection suggesting that macrophages are additional targets for Treg-mediated immune suppression in cancer...
  5. pmc Mononuclear myeloid-derived "suppressor" cells express RAE-1 and activate natural killer cells
    Norman Nausch
    Division of Innate Immunity, German Cancer Research Center, Heidelberg, Germany
    Blood 112:4080-9. 2008
    ..Thus, our results have great impact on the design of immune therapies against cancer aiming at the manipulation of MDSCs...
  6. pmc Regulation of triggering receptor expressed on myeloid cells 1 expression on mouse inflammatory monocytes
    Kai Zanzinger
    German Cancer Research Centre DKFZ, Innate Immunity, 69120 Heidelberg, Germany
    Immunology 128:185-95. 2009
    ..Our study reveals differential regulation of TREM-1 expression on mouse monocyte subpopulations and improves our understanding of the biological role of TREM-1 during disease...
  7. doi request reprint Interferon-gamma down-regulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells
    Nicole Schwinn
    Division of Clinical Cooperation Unit Dermato Oncology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 124:1594-604. 2009
    ..Our study suggests that IFN-gamma, by down-regulating ligand expression, might facilitate escape of MHC class I-negative melanoma cells from NKG2D-mediated killing by NK cells...
  8. ncbi request reprint CTLA-4 is expressed by activated mouse NK cells and inhibits NK Cell IFN-γ production in response to mature dendritic cells
    Ana Stojanovic
    Innate Immunity Group, German Cancer Research Center, 69120 Heidelberg, Germany
    J Immunol 192:4184-91. 2014
    ..Accordingly, our study might have implications for immunotherapy of cancer based on blocking anti-CTLA-4 mAbs. ..
  9. doi request reprint Antitumor vaccination by Newcastle Disease Virus Hemagglutinin-Neuraminidase plasmid DNA application: changes in tumor microenvironment and activation of innate anti-tumor immunity
    Jing Ni
    Division of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany
    Vaccine 29:1185-93. 2011
    ..This highlights thus the potential adjuvant activity of the HN gene in tumor therapy...
  10. doi request reprint Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth
    Eva Schlecker
    Innate Immunity, Research Program Tumor Immunology, German Cancer Research Center, Heidelberg D 69120, Germany
    J Immunol 189:5602-11. 2012
    ....
  11. doi request reprint Activating NK cell receptor ligands are differentially expressed during progression to cervical cancer
    Sonja Textor
    Division of Innate Immunity, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 123:2343-53. 2008
    ....
  12. doi request reprint Human NK cells are alerted to induction of p53 in cancer cells by upregulation of the NKG2D ligands ULBP1 and ULBP2
    Sonja Textor
    Innate Immunity Group, German Cancer Research Center, DKFZ ZMBH Alliance, Heidelberg, Germany
    Cancer Res 71:5998-6009. 2011
    ..One implication of our work is that activating p53 after adoptive transfer of NK cells might constitute an effective combinatorial strategy of NK cell-based immunochemotherapy in cancers in which wild-type p53 function is preserved...
  13. doi request reprint Btk is a positive regulator in the TREM-1/DAP12 signaling pathway
    Tereza Ormsby
    German Cancer Research Center DKFZ, Innate Immunity, Heidelberg, Germany
    Blood 118:936-45. 2011
    ..In conclusion, our data identify Btk as a positive regulator in the ITAM-mediated TREM-1/DAP12 pathway and suggest its implication in inflammatory processes...
  14. ncbi request reprint Identification of CLEC12B, an inhibitory receptor on myeloid cells
    Sabrina C Hoffmann
    Institute for Immunology, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany
    J Biol Chem 282:22370-5. 2007
    ....
  15. doi request reprint The TREM-1/DAP12 pathway
    Anja S Tessarz
    German Cancer Research Center DKFZ, Division of Innate Immunity, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Immunol Lett 116:111-6. 2008
    ..Therefore, it is of great importance to get further insight into the signaling cascade downstream of TREM-1. This review summarizes the current understanding of the TREM-1/DAP12 pathway in monocytes and neutrophils...
  16. doi request reprint NF-κ B-dependent upregulation of ICAM-1 by HPV16-E6/E7 facilitates NK cell/target cell interaction
    Sonja Textor
    German Cancer Research Center, Research Group Innate Immunity, Heidelberg, Germany
    Int J Cancer 128:1104-13. 2011
    ..Moreover, levels of the adhesion molecule ICAM-1 are enhanced by HPV16-E6/E7. Therefore, strategies that aim at harnessing NK cells might be beneficial for the treatment of cervical carcinoma...
  17. pmc Activation of natural killer cells by newcastle disease virus hemagglutinin-neuraminidase
    Mostafa Jarahian
    German Cancer Research Center, Heidelberg, Germany
    J Virol 83:8108-21. 2009
    ..These results suggest that direct activation of NK cells contributes to the antitumor effects of NDV...
  18. pmc Modulation of NKp30- and NKp46-mediated natural killer cell responses by poxviral hemagglutinin
    Mostafa Jarahian
    Translational Immunology Research Unit, German Cancer Research Center, Heidelberg, Germany
    PLoS Pathog 7:e1002195. 2011
    ..We conclude that poxviral HA represents a conserved ligand of NCR, exerting a novel immune escape mechanism through its blocking effect on NKp30-mediated activation at a late stage of infection...
  19. ncbi request reprint The coincidence of chromosome 15 aberrations and beta2-microglobulin gene mutations is causative for the total loss of human leukocyte antigen class I expression in melanoma
    Annette Paschen
    Skin Cancer Unit of the German Cancer Research Center Heidelberg, University Clinics of Mannheim, Mannheim, Germany
    Clin Cancer Res 12:3297-305. 2006
    ..We asked whether abnormalities of chromosome 15, harboring the beta2m gene on 15q21, in addition to beta2m gene mutations, are causative for the HLA class I-negative phenotype of melanoma cells...
  20. ncbi request reprint Non-T cell activation linker (NTAL) negatively regulates TREM-1/DAP12-induced inflammatory cytokine production in myeloid cells
    Anja S Tessarz
    German Cancer Research Center DKFZ, Division of Innate Immunity, Heidelberg, Germany, Europe
    J Immunol 178:1991-9. 2007
    ..Our results show that activation signals delivered via DAP12 can be counterbalanced by the adaptor NTAL, identifying NTAL as gatekeeper of TREM-1/DAP12-induced signaling in myeloid cells...
  21. doi request reprint Natural killer cell accumulation in tumors is dependent on IFN-gamma and CXCR3 ligands
    Marco Wendel
    Divisions of Innate Immunity and Immunogenetics, German Cancer Research Center, Heidelberg, Germany
    Cancer Res 68:8437-45. 2008
    ..Exploiting strategies to augment NK cell accumulation in the tumor might lead to the development of effective antitumor therapies...
  22. doi request reprint Natural killer cells and solid tumors
    Ana Stojanovic
    Innate Immunity, German Cancer Research Center, Heidelberg, Germany
    J Innate Immun 3:355-64. 2011
    ..This review summarizes our current knowledge of NK cells in solid tumors. We will discuss the impact of novel insights into NK cell responses against tumors on the design of NK cell-based therapies...
  23. ncbi request reprint NK cells--from basic research to cancer therapy
    Adelheid Cerwenka
    Institute for Immunology, INF 305, 69120 Heidelberg, Germany
    Eur J Immunol 37:1161-4. 2007
    ..50 scientists recently met for the Hengstberger Symposium on NK cells in Heidelberg, Germany to discuss the regulation and function of these important immune cells...
  24. doi request reprint Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke
    Arthur Liesz
    Department of Neurology, University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Brain 134:704-20. 2011
    ..Thus, targeting T lymphocyte-migration represents a promising therapeutic approach for ischaemic stroke...
  25. ncbi request reprint Cutting edge: the AP-1 subunit JunB determines NK cell-mediated target cell killing by regulation of the NKG2D-ligand RAE-1epsilon
    Norman Nausch
    Division of Innate Immunity, German Cancer Research Center, Heidelberg, Germany
    J Immunol 176:7-11. 2006
    ..Thus, up-regulated RAE-1epsilon expression due to low levels of JunB could alert immune cells to tumors and stressed cells...