Federico Canzian

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. pmc Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortium
    Daniele Campa
    Genomic Epidemiology Group, German Cancer Research Center Deutsches Krebsforschungszentrum DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Natl Cancer Inst 103:1252-63. 2011
  2. pmc A comprehensive investigation on common polymorphisms in the MDR1/ABCB1 transporter gene and susceptibility to colorectal cancer
    Daniele Campa
    Genomic Epidemiology Group, German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 7:e32784. 2012
  3. pmc Pancreatic cancer susceptibility loci and their role in survival
    Cosmeri Rizzato
    German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 6:e27921. 2011
  4. pmc Polymorphisms within inflammatory genes and colorectal cancer
    Stefano Landi
    Genetics Department of Biology, University of Pisa, Via S, Giuseppe 22, 56126, Pisa, Italy
    J Negat Results Biomed 5:15. 2006
  5. pmc A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Breast Cancer Res 8:R54. 2006
  6. pmc Unique spectrum of SPAST variants in Estonian HSP patients: presence of benign missense changes but lack of exonic rearrangements
    Mark Braschinsky
    Department of Neurology, University of Tartu, Estonia
    BMC Neurol 10:17. 2010
  7. pmc T.I.M.S: TaqMan Information Management System, tools to organize data flow in a genotyping laboratory
    Stephanie Monnier
    International Agency for Research on Cancer, F 69372, Lyon, France
    BMC Bioinformatics 6:246. 2005
  8. doi Genetic polymorphisms in mediators of inflammation and gastric precancerous lesions
    Federico Canzian
    German Cancer Research Center DKFZ, Heidelberg, Germany
    Eur J Cancer Prev 17:178-83. 2008
  9. pmc Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    Federico Canzian
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Cancer 9:257. 2009
  10. pmc PTGS2 and IL6 genetic variation and risk of breast and prostate cancer: results from the Breast and Prostate Cancer Cohort Consortium (BPC3)
    Laure Dossus
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Carcinogenesis 31:455-61. 2010

Detail Information

Publications91

  1. pmc Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortium
    Daniele Campa
    Genomic Epidemiology Group, German Cancer Research Center Deutsches Krebsforschungszentrum DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Natl Cancer Inst 103:1252-63. 2011
    ..Relatively little is known about the possible interactions between these loci and the established risk factors for breast cancer...
  2. pmc A comprehensive investigation on common polymorphisms in the MDR1/ABCB1 transporter gene and susceptibility to colorectal cancer
    Daniele Campa
    Genomic Epidemiology Group, German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 7:e32784. 2012
    ..In conclusion, in this study of about 8,800 individuals we show that ABCB1 gene polymorphisms play at best a minor role in the susceptibility to CRC...
  3. pmc Pancreatic cancer susceptibility loci and their role in survival
    Cosmeri Rizzato
    German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 6:e27921. 2011
    ..In conclusion, we found that rs8028529 could be, if these results are replicated, a promising marker for both risk and prognosis for this lethal disease...
  4. pmc Polymorphisms within inflammatory genes and colorectal cancer
    Stefano Landi
    Genetics Department of Biology, University of Pisa, Via S, Giuseppe 22, 56126, Pisa, Italy
    J Negat Results Biomed 5:15. 2006
    ....
  5. pmc A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Breast Cancer Res 8:R54. 2006
    ..Here, we report on the results of a large and comprehensive study of the association between genetic variation in the AR gene and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)...
  6. pmc Unique spectrum of SPAST variants in Estonian HSP patients: presence of benign missense changes but lack of exonic rearrangements
    Mark Braschinsky
    Department of Neurology, University of Tartu, Estonia
    BMC Neurol 10:17. 2010
    ..The most common autosomal-dominant form of the disease derives from mutations in the SPAST gene...
  7. pmc T.I.M.S: TaqMan Information Management System, tools to organize data flow in a genotyping laboratory
    Stephanie Monnier
    International Agency for Research on Cancer, F 69372, Lyon, France
    BMC Bioinformatics 6:246. 2005
    ..It produces large amounts of data that are difficult to process by hand. Laboratories not equipped with a Laboratory Information Management System (LIMS) need tools to organize the data flow...
  8. doi Genetic polymorphisms in mediators of inflammation and gastric precancerous lesions
    Federico Canzian
    German Cancer Research Center DKFZ, Heidelberg, Germany
    Eur J Cancer Prev 17:178-83. 2008
    ..60, 95% CI=1.01-2.54, and OR=0.66, 95% CI=0.43-0.99). We conclude that genetic variability in the genes we studied does not play a major role in the early stages of gastric carcinogenesis...
  9. pmc Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    Federico Canzian
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Cancer 9:257. 2009
    ..We studied the association between breast cancer risk and polymorphisms in genes that code for GNRH1 and its receptor (GNRHR) in the large National Cancer Institute Breast and Prostate Cancer Cohort Consortium (NCI-BPC3)...
  10. pmc PTGS2 and IL6 genetic variation and risk of breast and prostate cancer: results from the Breast and Prostate Cancer Cohort Consortium (BPC3)
    Laure Dossus
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Carcinogenesis 31:455-61. 2010
    ..38, 99% CI: 1.04-1.83). No association was observed between PTGS2 polymorphisms and prostate cancer risk. In conclusion, common genetic variation in these two genes might play at best a limited role in breast and prostate cancers...
  11. pmc A gene-wide investigation on polymorphisms in the taste receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer
    Daniele Campa
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Med Genet 11:88. 2010
    ..TAS2R14 is one of the better characterized members of the taste receptor family and has several polymorphic variants. Several substances that have been shown to activate TAS2R14 are powerful toxic and carcinogenic agents...
  12. pmc Risk of advanced gastric precancerous lesions in Helicobacter pylori infected subjects is influenced by ABO blood group and cagA status
    Cosmeri Rizzato
    Genomic Epidemiology Group, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 133:315-22. 2013
    ..We showed that SNPs in the ABO gene, predictive of ABO blood groups, are associated with risk of advanced precancerous gastric lesions in individuals infected with Hp, but the assessment of the risk is strictly dependent on cagA status...
  13. doi A gene-wide investigation on polymorphisms in the ABCG2/BRCP transporter and susceptibility to colorectal cancer
    Daniele Campa
    German Cancer Research Center DKFZ, Heidelberg, Germany
    Mutat Res 645:56-60. 2008
    ..56-0.94; P(value)=0.017), and 0.72 (95% CI 0.53-0.97; P(value)=0.03). Thus, we found no strong and clearcut association between ABCG2 polymorphisms and CRC risk. To our knowledge this is the first report on ABCG2 and CRC risk...
  14. doi Polymorphisms in fatty-acid-metabolism-related genes are associated with colorectal cancer risk
    Birgit Hoeft
    German Cancer Research Center, Heidelberg, Germany
    Carcinogenesis 31:466-72. 2010
    ..Our results support the key role of prostanoid signaling in colon carcinogenesis and suggest a relevance of genetic variation in fatty acid metabolism-related genes and CRC risk...
  15. pmc The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk
    Daniele Campa
    German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Cancer 10:563. 2010
    ..BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC)...
  16. doi Genetic variability of the forkhead box O3 and prostate cancer risk in the European Prospective Investigation on Cancer
    Daniele Campa
    German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Oncol Rep 26:979-86. 2011
    ..We conclude that polymorphisms in the FOXO3 gene that are associated with longevity are not major risk factors for PC risk, in this population of Caucasian men...
  17. ncbi ABO blood groups and pancreatic cancer risk and survival: results from the PANcreatic Disease ReseArch (PANDoRA) consortium
    Cosmeri Rizzato
    Genomic Epidemiology Group, German Cancer Research Center DKFZ, Heidelberg, Germany
    Oncol Rep 29:1637-44. 2013
    ..In addition, we investigated the possible influence that genetic variability at the ABO locus may have in pancreatic cancer survival, but we observed no effect in our population...
  18. pmc Genetic variation in PSCA and risk of gastric advanced preneoplastic lesions and cancer in relation to Helicobacter pylori infection
    Cosmeri Rizzato
    German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 8:e73100. 2013
    ....
  19. doi Polymorphisms in regulators of xenobiotic transport and metabolism genes PXR and CAR do not affect multiple myeloma risk: a case-control study in the context of the IMMEnSE consortium
    Alessandro Martino
    Genomic Epidemiology Group, German Cancer Research Center DKFZ, Heidelberg, Germany
    J Hum Genet 58:155-9. 2013
    ..We can therefore exclude that common genetic variants in the xenobiotic transport and metabolism regulator genes PXR and CAR affect MM risk...
  20. doi Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC)
    Daniele Campa
    German Cancer Research Center, DKFZ, Heidelberg, Germany
    Eur J Cancer 47:420-7. 2011
    ..None of the SNPs reached statistical significance after adjusting for multiple comparisons. Common SNPs in the fatty acid synthase pathway are not major contributors to prostate cancer risk...
  21. doi Interaction between functional polymorphic variants in cytokine genes, established risk factors and susceptibility to basal cell carcinoma of skin
    Cosmeri Rizzato
    German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Carcinogenesis 32:1849-54. 2011
    ..53, 95% CI 0.34-0.82, P = 0.0019). In conclusion, we found that two polymorphisms in inflammatory genes interacting with environmental risk factors could modulate BCC risk...
  22. ncbi Comprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMMEnSE consortium
    Daniele Campa
    Genomic Epidemiology Group, German Cancer Research Center DKFZ, Heidelberg, Germany
    Br J Haematol 157:331-8. 2012
    ..These data provide further evidence that the genetic variability in the 8q24 region is associated with cancer risk, particularly haematological malignancies...
  23. doi Lack of replication of seven pancreatic cancer susceptibility loci identified in two Asian populations
    Daniele Campa
    German Cancer Research Center DKFZ, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 22:320-3. 2013
    ..Two recent genome-wide association studies (GWAS) of pancreatic ductal adenocarcinoma (PDAC), conducted, respectively, in a Japanese and in a Chinese population, identified eight novel loci affecting PDAC risk...
  24. doi Variation in genes coding for AMP-activated protein kinase (AMPK) and breast cancer risk in the European Prospective Investigation on Cancer (EPIC)
    Daniele Campa
    Department of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Breast Cancer Res Treat 127:761-7. 2011
    ..We observed no statistically significant association between the SNPs in the PRKAs genes and BC risk and BMI after correction for multiple testing...
  25. doi Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk
    Daniele Campa
    Department of Cancer Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Breast Cancer Res Treat 118:565-74. 2009
    ..On the other hand, we found that two SNPs in FASN were associated with BMI...
  26. pmc Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study
    Daniele Campa
    Genomic Epidemiology Group, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    BMC Gastroenterol 10:112. 2010
    ..Accumulating evidence also indicates a role of ghrelin in cancer development...
  27. pmc Genetic variability of the mTOR pathway and prostate cancer risk in the European Prospective Investigation on Cancer (EPIC)
    Daniele Campa
    German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 6:e16914. 2011
    ..In conclusion, we found an association with prostate cancer risk for two SNPs belonging to PRKCI, a gene which is frequently overexpressed in various neoplasms, including prostate cancer...
  28. pmc Somatic mutations in exocrine pancreatic tumors: association with patient survival
    P Sivaramakrishna Rachakonda
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    PLoS ONE 8:e60870. 2013
    ..02) and a corresponding HR of 3.07 (95%CI 1.33-7.10). Our results are indicative of an association between mutational status and survival in PDAC patients, which if confirmed in subsequent studies can have potential clinical application...
  29. pmc Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium
    Federico Canzian
    German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Hum Mol Genet 19:3873-84. 2010
    ..Although previous studies have shown that variations in these genes can influence endogenous hormone levels, the magnitude of the effect of single SNPs does not appear to be sufficient to alter breast cancer risk...
  30. doi Interleukin promoter polymorphisms and prognosis in colorectal cancer
    Stefan Wilkening
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Carcinogenesis 29:1202-6. 2008
    ..The predicted biological effect of these SNPs in relation to promotion of cancer progression is consistent with the observed increased survival time...
  31. doi POMC and TP53 genetic variability and risk of basal cell carcinoma of skin: Interaction between host and genetic factors
    Cosmeri Rizzato
    German Cancer Research Center DKFZ, Heidelberg, Germany
    J Dermatol Sci 63:47-54. 2011
    ..Malfunction of the p53 pathway is an almost universal hallmark of human tumors. Polymorphisms in the gene encoding p53 (TP53) alter its transcriptional activity, which in turn may influence the UV radiation-induced tanning response...
  32. pmc Prediction of breast cancer risk by genetic risk factors, overall and by hormone receptor status
    Anika Husing
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    J Med Genet 49:601-8. 2012
    ..In this study we investigated the predictive capacity of 32 GWAS-detected common variants for breast cancer risk, alone and in combination with classical risk factors, and for tumours with different hormone receptor status...
  33. pmc Bitter taste receptor polymorphisms and human aging
    Daniele Campa
    Genomic Epidemiology Group, German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 7:e45232. 2012
    ..These data provide suggestive evidence on the possible correlation between human longevity and taste genetics...
  34. doi A comprehensive study of polymorphisms in ABCB1, ABCC2 and ABCG2 and lung cancer chemotherapy response and prognosis
    Daniele Campa
    Genomic Epidemiology Group, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 131:2920-8. 2012
    ....
  35. pmc Variations in Helicobacter pylori cytotoxin-associated genes and their influence in progression to gastric cancer: implications for prevention
    Cosmeri Rizzato
    German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 7:e29605. 2012
    ..The results of this study may provide preliminary information to target antibiotic treatment to high-risk individuals, if effects of these variants are confirmed in further investigations...
  36. doi Genetic susceptibility to pancreatic cancer and its functional characterisation: the PANcreatic Disease ReseArch (PANDoRA) consortium
    Daniele Campa
    German Cancer Research Center DKFZ, Heidelberg, Germany
    Dig Liver Dis 45:95-9. 2013
    ..The recruitment of additional collaborators and partner institutions is continuously on-going...
  37. doi Is there still a need for candidate gene approaches in the era of genome-wide association studies?
    Stefan Wilkening
    German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Genomics 93:415-9. 2009
    ..However, depending on the gene or the population, there may still be a need for candidate gene approaches, especially when looking at polymorphisms with low allele frequencies...
  38. pmc A comprehensive study of polymorphisms in the ABCB1, ABCC2, ABCG2, NR1I2 genes and lymphoma risk
    Daniele Campa
    Genomic Epidemiology Group, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 131:803-12. 2012
    ..0004), which could be replicated in an independent population. These results suggest a role for this gene in B-NHL susceptibility, especially for CLL...
  39. doi Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (
    Laure Dossus
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Carcinogenesis 29:1360-6. 2008
    ..These associations, however, might also be due to chance findings and further large studies are needed to confirm our results...
  40. pmc Allelotyping of pooled DNA with 250 K SNP microarrays
    Stefan Wilkening
    Department of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    BMC Genomics 8:77. 2007
    ..In the present study, we tested the accuracy of the 250 K Nsp array, which is part of the 500 K array set representing 500,568 SNPs. Furthermore, we compared different algorithms to estimate allele frequencies of pooled DNA...
  41. pmc A genome-wide "pleiotropy scan" does not identify new susceptibility loci for estrogen receptor negative breast cancer
    Daniele Campa
    Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 9:e85955. 2014
    ..049 to 2.3 × 10(-4). None of the variants reached statistical significance in the replication phase. In conclusion, this study did not identify any novel susceptibility loci for ER-breast cancer using a "pleiotropic approach"...
  42. ncbi Genetic variants and multiple myeloma risk: IMMEnSE validation of the best reported associations--an extensive replication of the associations from the candidate gene era
    Alessandro Martino
    Authors Affiliations Genomic Epidemiology Group, Division of Cancer Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany Department of Hematology, Cracow University Hospital, Cracow Medical University of Łodz Laboratory of Clinical and Transplant Immunology and Genetics, Copernicus Memorial Hospital, Łodz Rzeszow Regional Hospital, Rzeszow Holycross Cancer Center, Kielce, Poland Department of Hematology, Hospital Universitario Doce de Octubre, Madrid Morales Meseguer General University Hospital, Murcia University Hospital of Salamanca, Salamanca Genomic Oncology Area, GENYO, Centre for Genomics and Oncological Research Pfizer University of Granada Andalusian Regional Government Hematology Department, Virgen de las Nieves University Hospital, Granada IDIBELL Catalan Institute of Oncology, University of Barcelona, Barcelona, Spain Semmelweis University, Budapest, Hungary Institut National de la Santé et de la Recherche Medicale INSERM UMR 1052 CNRS 5286, Universite Claude Bernard Lyon I, Lyon Genetic Epidemiology of Cancer team, INSERM, U900, Institut Curie, Mines ParisTech, Paris, France Department of Biology, University of Pisa, Pisa, Italy Clinic of Immunology, Laboratory Center, Division of Clinical Sciences (North
    Cancer Epidemiol Biomarkers Prev 23:670-4. 2014
    ..Several single-nucleotide polymorphisms (SNP) associated with genetic susceptibility to multiple myeloma were identified in the last years, but only a few of them were validated in independent studies...
  43. doi Could polymorphisms in ATP-binding cassette C3/multidrug resistance associated protein 3 (ABCC3/MRP3) modify colorectal cancer risk?
    Daniele Campa
    German Cancer Research Center, 69120 Heidelberg, Germany
    Eur J Cancer 44:854-7. 2008
    ..We did not find any significant association between the two ABCC3 polymorphisms and colorectal cancer risk...
  44. doi Genetics and molecular epidemiology of multiple myeloma: the rationale for the IMMEnSE consortium (review)
    Alessandro Martino
    German Cancer Research Center, Genomic Epidemiology Group, Heidelberg, Germany
    Int J Oncol 40:625-38. 2012
    ....
  45. ncbi The interleukin-8-251*T/*A polymorphism is not associated with risk for gastric carcinoma development in a Portuguese population
    Paulo Canedo
    IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Eur J Cancer Prev 17:28-32. 2008
    ..In conclusion our results indicate that although the IL8-251 polymorphism might be a relevant host susceptibility factor for gastric carcinoma development, this association is likely to be ethnic-specific...
  46. ncbi Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease
    David G Cox
    Genome Analysis Team GAN, International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372 Lyon Cedex 08, France
    World J Gastroenterol 11:6003-8. 2005
    ..We aimed at examining genetic variants of PTGS2 that may be risk factors for IBD...
  47. ncbi A database of single-nucleotide polymorphisms and a genotyping microarray for genetic epidemiology of lung cancer
    Stefano Landi
    Dipartimento di Scienze dell Uomo e dell Ambiente, Genome Research Group, University of Pisa, Pisa, Italy
    Exp Lung Res 31:223-58. 2005
    ..They developed a microarray for genotyping these polymorphisms, based on arrayed primer extension (APEX)...
  48. ncbi Polymorphisms of glutathione-S-transferase M1 and manganese superoxide dismutase are associated with the risk of malignant pleural mesothelioma
    Stefano Landi
    Department of Biology, University of Pisa, Pisa, Italy
    Int J Cancer 120:2739-43. 2007
    ..These findings, if replicated, contribute substantial evidence to the hypothesis that oxidative stress and cellular antireactive oxygen species systems are involved in the pathogenesis and in the natural history of MPM...
  49. ncbi A catalogue of polymorphisms related to xenobiotic metabolism and cancer susceptibility
    Federica Gemignani
    Genome Analysis Group, International Agency for Research on Cancer, Lyon, France
    Pharmacogenetics 12:459-63. 2002
    ....
  50. ncbi Polymorphisms in genes related to bacterial lipopolysaccharide/peptidoglycan signaling and gastric precancerous lesions in a population at high risk for gastric cancer
    Ikuko Kato
    Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, Michigan 48201, USA
    Dig Dis Sci 52:254-61. 2007
    ..These results suggest that genetic polymorphisms in HP LPS signaling may be implicated in the development of intermediate stages of gastric premalignant lesions...
  51. ncbi Comprehensive evaluation of genetic variation in the IGF1 gene and risk of prostate cancer
    Mattias Johansson
    Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea University Hospital, Umea, Sweden
    Int J Cancer 120:539-42. 2007
    ..Further studies on genetic variations in the IGF1 gene in relation to prostate cancer risk as well as to circulating levels of IGF1 are needed to confirm this novel finding...
  52. ncbi Genetic polymorphisms in anti-inflammatory cytokine signaling and the prevalence of gastric precancerous lesions in Venezuela
    Ikuko Kato
    Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, MI, 48201, USA
    Cancer Causes Control 17:1183-91. 2006
    ..The aim of the study was to assess the effects of genetic polymorphisms in anti-inflammatory mediators, i.e., IL10, IL4 and IL4R on the prevalence of gastric precancerous lesions and their interactions with other environmental factors...
  53. ncbi Inflammation-related gene polymorphisms and colorectal adenoma
    Marc J Gunter
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 15:1126-31. 2006
    ..7; 95% CI, 0.3-1.5; P(interaction) = 0.01). These exploratory data provide evidence that polymorphic variation in genes that regulate inflammation could alter risk for colorectal adenoma...
  54. ncbi Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer
    Victor Moreno
    Institut d Investigacio Biomedica de Bellvitge, Institut Catala d Oncologia, Hospitalet, Barcelona, Spain
    Clin Cancer Res 12:2101-8. 2006
    ..We have undertaken a comprehensive study of common polymorphisms in genes of DNA repair, exploring both the risk of developing colorectal cancer and the prognosis of patients...
  55. ncbi Use of whole genome amplification to rescue DNA from plasma samples
    Yanhui Lu
    International Agency for Research on Cancer, Lyon, France
    Biotechniques 39:511-5. 2005
    ..There were only 3 disagreements out of 364 paired genotyping results for pre- and post-WGA DNAs, indicating an error rate of 0.82%. These results are encouraging for expanding the use of poor DNA resources in genotyping studies...
  56. ncbi Haplotype-based analysis of common variation in the acetyl-coA carboxylase alpha gene and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition
    Olga M Sinilnikova
    IARC, Lyon, France
    Cancer Epidemiol Biomarkers Prev 16:409-15. 2007
    ..However, they suggest a possible role of the ACC-alpha common sequence variants in susceptibility to breast cancer and encourage studies of other genes involved in fatty acid synthesis...
  57. pmc Haplotypes of the estrogen receptor beta gene and breast cancer risk
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, Boston, MA, USA
    Int J Cancer 122:387-92. 2008
    ..These data suggest that inherited variants in ESR2 (while possibly conferring a small increased risk of breast cancer) are not associated with appreciable (OR > 1.2) changes in breast cancer risk among Caucasian women...
  58. ncbi Association of common polymorphisms in inflammatory genes interleukin (IL)6, IL8, tumor necrosis factor alpha, NFKB1, and peroxisome proliferator-activated receptor gamma with colorectal cancer
    Stefano Landi
    International Agency for Research on Cancer, 69372 Lyon, France S L, L G P, F C
    Cancer Res 63:3560-6. 2003
    ..This is the first report that IL6, IL8, and PPARG genes are important in relation to inflammation-related risk of sporadic CRC...
  59. ncbi Host-bacterial interaction in the development of gastric precancerous lesions in a high risk population for gastric cancer in Venezuela
    Ikuko Kato
    Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Int J Cancer 119:1666-71. 2006
    ..The present study provides important evidence suggesting host-bacterial interactions in the development of gastric precancerous lesions...
  60. ncbi Helicobacter pylori cytotoxin-associated genotype and gastric precancerous lesions
    Martyn Plummer
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    J Natl Cancer Inst 99:1328-34. 2007
    ..pylori genes to the severity and progression of precancerous lesions is not well defined...
  61. ncbi Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer
    Daniele Campa
    Genome Analysis Group, International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372 Lyon Cedex 08, France
    Carcinogenesis 25:229-35. 2004
    ..This is the first study implicating polymorphisms in inflammatory genes in the risk of lung cancer...
  62. ncbi Polymorphisms of DNA repair genes and risk of non-small cell lung cancer
    Shanbeh Zienolddiny
    Department of Toxicology, National Institute of Occupational Health, Oslo, Norway
    Carcinogenesis 27:560-7. 2006
    ....
  63. ncbi Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nu
    Federico Canzian
    Hormones and Cancer Team, International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372 Lyon, France
    Cancer Epidemiol Biomarkers Prev 14:2316-25. 2005
    ....
  64. ncbi Lack of association between -251 T>A polymorphism of IL8 and lung cancer risk
    Daniele Campa
    IARC, Lyon, France
    Cancer Epidemiol Biomarkers Prev 14:2457-8. 2005
  65. ncbi Reliable detection of beta-thalassemia and G6PD mutations by a DNA microarray
    Federica Gemignani
    IARC, International Agency for Research on Cancer, 150, cours Albert Thomas, Lyon 69372, France
    Clin Chem 48:2051-4. 2002
  66. ncbi Evaluation of a microarray for genotyping polymorphisms related to xenobiotic metabolism and DNA repair
    Stefano Landi
    International Agency for Research on Cancer, Lyon, France
    Biotechniques 35:816-20, 822, 824-7. 2003
    ..Among 88 SNPs that yielded signals, 6 showed less than 99% of concordance, whereas 82 performed accurately, showing that APEX is a reliable and sensitive genotyping method...
  67. ncbi Polymorphisms of the dopamine receptor gene DRD2 and colorectal cancer risk
    Federica Gemignani
    International Agency for Research on Cancer, Lyon, France
    Cancer Epidemiol Biomarkers Prev 14:1633-8. 2005
    ..Future studies on dopamine receptor-mediated signal transduction may provide new insight into the mechanisms of colorectal cancer and suggest new therapeutic strategies...
  68. ncbi Lack of association between polymorphisms in inflammatory genes and lung cancer risk
    Daniele Campa
    IARC, 150 cours Albert Thomas, F 69372 Lyon 08, France
    Cancer Epidemiol Biomarkers Prev 14:538-9. 2005
  69. ncbi A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer
    Stefano Landi
    Genetica, Dip Scienze Uomo e Ambiente, University of Pisa, Italy
    Pharmacogenet Genomics 15:535-46. 2005
    ....
  70. ncbi A TP53 polymorphism is associated with increased risk of colorectal cancer and with reduced levels of TP53 mRNA
    Federica Gemignani
    International Agency for Research on Cancer, Lyon 69372, France
    Oncogene 23:1954-6. 2004
    ..However, we found reduced levels of TP53 mRNA associated with the A2 allele. In conclusion, the epidemiological study suggests a role for p53PIN3 in tumorigenesis, supported by the in vitro characterization of this variant...
  71. ncbi Polymorphisms of the interleukin-1 beta gene are associated with increased risk of non-small cell lung cancer
    Shanbeh Zienolddiny
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 109:353-6. 2004
    ..05). This is the first study to provide evidence for an association of 1L1B gene polymorphisms with lung cancer risk...
  72. ncbi Generation of a DNA microarray for determination of E6 natural variants of human papillomavirus type 16
    Federica Gemignani
    International Agency for Research on Cancer, World Health Organization, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    J Virol Methods 119:95-102. 2004
    ....
  73. ncbi Large-scale investigation of base excision repair genetic polymorphisms and lung cancer risk in a multicenter study
    Rayjean J Hung
    International Agency for Research on Cancer, Lyon, France
    J Natl Cancer Inst 97:567-76. 2005
    ..We examined associations among four well-characterized polymorphisms of BER genes (OGG1 Ser326Cys, XRCC1 Arg194Trp, XRCC1 Arg280His, and XRCC1 Arg399Gln) and lung cancer risk...
  74. ncbi Effect of cruciferous vegetables on lung cancer in patients stratified by genetic status: a mendelian randomisation approach
    Paul Brennan
    International Agency for Research on Cancer, Lyon, France
    Lancet 366:1558-60. 2005
    ..These data provide strong evidence for a substantial protective effect of cruciferous vegetable consumption on lung cancer...
  75. pmc Genetic variation in the HSD17B1 gene and risk of prostate cancer
    Peter Kraft
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 1:e68. 2005
    ..These results suggest that the germline variants in HSD17B1 characterized by these htSNPs do not substantially influence the risk of prostate cancer in U.S. and European whites...
  76. doi Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer
    Debora Landi
    Dipartimento di Biologia, University of Pisa, Via Derna, 1, 56126 Pisa, Italy
    Carcinogenesis 29:579-84. 2008
    ..24-6.04, for the variant homozygotes] and INSR genes (OR = 1.94; 95% CI = 1.03-3.66, for the variant homozygotes). These results are the first reporting positive association between miRNA-binding SNPs sequences and cancer risk...
  77. doi Sequence variants of NAT1 and NAT2 and other xenometabolic genes and risk of lung and aerodigestive tract cancers in Central Europe
    James D McKay
    Association for International Cancer Research, 150 cours Albert Thomas, Lyon Cedex 08, France
    Cancer Epidemiol Biomarkers Prev 17:141-7. 2008
    ..We therefore conclude that, of the genetic variation studied, NAT1 gene was the most likely candidate to influence the risk of developing a tobacco-related cancer...
  78. doi A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers
    Shanbeh Zienolddiny
    Section of Toxicology, Department of Biological and Chemical Work Environment, National Institute of Occupational Health N 0033, Oslo, Norway
    Carcinogenesis 29:1164-9. 2008
    ..However, only four of the previously reported associations with polymorphisms in the GSTP1 (Ala14Val), SOD2 (Val16Ala), EPHX1 (His139Arg) genes and the NAT1 fast acetylator phenotype remained significantly associated with lung cancer...
  79. pmc Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21
    Albert Tenesa
    Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Edinburgh EH4 2XU, UK
    Nat Genet 40:631-7. 2008
    ..008) and rs4939827 (P < 0.009). Carrying all six possible risk alleles yielded OR = 2.6 (95% CI = 1.75-3.89) for CRC. These findings extend our understanding of the role of common genetic variation in CRC etiology...
  80. pmc Development of a sensitive and specific multiplex PCR method combined with DNA microarray primer extension to detect Betapapillomavirus types
    Tarik Gheit
    International Agency for Research on Cancer, Lyon, France
    J Clin Microbiol 45:2537-44. 2007
    ..This favorable feature and the high-throughput potential make this assay ideal for large-scale clinical and epidemiological studies aimed at determining the spectrum of cutaneous types in skin cancer...
  81. pmc IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3)
    Alpa V Patel
    Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia, United States of America
    PLoS ONE 3:e2578. 2008
    ..In summary, the impact of genetic variation in IGF1 and IGFBP3 on circulating IGF levels does not appear to substantially influence breast cancer risk substantially among primarily Caucasian postmenopausal women...
  82. ncbi Folate-related genes and the risk of tobacco-related cancers in Central Europe
    Rayjean J Hung
    International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372, 69008, Lyon Cedex 08, France
    Carcinogenesis 28:1334-40. 2007
    ..These results support an important role of folate in protecting against tobacco-related cancers...
  83. ncbi Development of lung cancer before the age of 50: the role of xenobiotic metabolizing genes
    Federica Gemignani
    Genetics, Department of Biology, University of Pisa, Pisa, Italy
    Carcinogenesis 28:1287-93. 2007
    ..Finally, extensive EPHX1 metabolizers showed an increased risk as compared with the poor metabolizers...
  84. ncbi Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract
    Daniele Campa
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, France
    Cancer Causes Control 18:449-55. 2007
    ..The purpose of this study was to investigate the role of polymorphisms of genes involved in inflammation in the risk of cancers of the upper aerodigestive tract (UADT)...
  85. ncbi Haplotype-based analysis of common variation in the growth hormone receptor gene and prostate cancer risk
    James D McKay
    International Agency for Research on Cancer, Lyons, France
    Cancer Epidemiol Biomarkers Prev 16:169-73. 2007
    ..These results suggest that whereas genetic variation in the GHR gene does not seem to play a major role in prostate cancer etiology, one haplotype in the 3' region may be potentially relevant to cases with later onset of prostate cancer...
  86. ncbi Polymorphisms of dopamine receptor/transporter genes and risk of non-small cell lung cancer
    Daniele Campa
    International Agency for Research on Cancer, Lyon, France
    Lung Cancer 56:17-23. 2007
    ..The bioavailability of dopamine is regulated by dopamine receptors D2 (DRD2), D4 (DRD4) and dopamine transporter 1 (DAT1/SLC6A3) genes...
  87. ncbi No association between progesterone receptor gene +331G/A polymorphism and endometrial cancer
    Laure Dossus
    IARC, Lyon, France
    Cancer Epidemiol Biomarkers Prev 15:1415-6. 2006
  88. pmc Development of a sensitive and specific assay combining multiplex PCR and DNA microarray primer extension to detect high-risk mucosal human papillomavirus types
    Tarik Gheit
    Infections and Cancer Biology Group, International Agency for Research on Cancer, 150, cours Albert Thomas, 69372 Lyon, France
    J Clin Microbiol 44:2025-31. 2006
    ..These favorable features and the high-throughput potential make our present novel assay ideal for large-scale clinical and epidemiological studies aimed at determining the spectrum of mucosal HR HPV types in cervical specimens...
  89. ncbi Sequence variants of estrogen receptor beta and risk of prostate cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
    Yen Ching Chen
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 16:1973-81. 2007
    ..Estrogen receptor beta (ESR2) may play a role in modulating prostate carcinogenesis through the regulation of genes related to cell proliferation and apoptosis...
  90. ncbi Evidence for an important role of alcohol- and aldehyde-metabolizing genes in cancers of the upper aerodigestive tract
    Mia Hashibe
    IARC, Lyons, France
    Cancer Epidemiol Biomarkers Prev 15:696-703. 2006
    ..Genetic susceptibility to upper aerodigestive tract cancer in relation to such exposures is an important aspect that should be investigated among populations in this region...
  91. ncbi Inherited predisposition of lung cancer: a hierarchical modeling approach to DNA repair and cell cycle control pathways
    Rayjean J Hung
    IARC, 150 cours Albert Thomas, F 69372 Lyon Cedex 08, France
    Cancer Epidemiol Biomarkers Prev 16:2736-44. 2007
    ..In particular, further investigation of OGG1, MGMT, and CHEK2 focusing on the genetic regions where the present markers are located or the haplotype blocks tightly linked with these markers might be warranted...