Regina Brigelius-Flohe

Summary

Affiliation: German Institute of Human Nutrition
Country: Germany

Publications

  1. pmc The yin and yang of nrf2-regulated selenoproteins in carcinogenesis
    Regina Brigelius-Flohe
    Department Biochemistry of Micronutrients, German Institute of Human Nutrition, Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Int J Cell Biol 2012:486147. 2012
  2. doi request reprint Selenium in the redox regulation of the Nrf2 and the Wnt pathway
    Regina Brigelius-Flohe
    Department Biochemistry of Micronutrients, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Methods Enzymol 527:65-86. 2013
  3. doi request reprint Glutathione peroxidases
    Regina Brigelius-Flohe
    Department of Biochemistry of Micronutrients, German Institute of Human Nutrition, Nuthetal, Germany
    Biochim Biophys Acta 1830:3289-303. 2013
  4. doi request reprint Vitamin E: the shrew waiting to be tamed
    Regina Brigelius-Flohe
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Biochemistry of Micronutrients, Nuthetal, Germany
    Free Radic Biol Med 46:543-54. 2009
  5. pmc Basic principles and emerging concepts in the redox control of transcription factors
    Regina Brigelius-Flohe
    Department Biochemistry of Micronutrients, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, Nuthetal, Germany
    Antioxid Redox Signal 15:2335-81. 2011
  6. ncbi request reprint Glutathione peroxidases in different stages of carcinogenesis
    Regina Brigelius-Flohe
    Department Biochemistry of Micronutrients, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Biochim Biophys Acta 1790:1555-68. 2009
  7. pmc Commentary: oxidative stress reconsidered
    Regina Brigelius-Flohe
    German Institute of Human Nutrition Potsdam Rehbruecke, 14558, Nuthetal, Germany
    Genes Nutr 4:161-3. 2009
  8. doi request reprint Selenium compounds and selenoproteins in cancer
    Regina Brigelius-Flohe
    Department Biochemistry of Micronutrients, German Institute of Human Nutrition, Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal
    Chem Biodivers 5:389-95. 2008
  9. pmc Adverse effects of vitamin E by induction of drug metabolism
    Regina Brigelius-Flohe
    Department Biochemistry of Micronutrients, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558, Nuthetal, Germany
    Genes Nutr 2:249-56. 2007
  10. pmc Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply
    Susanne Krehl
    Department of Biochemistry of Micronutrients, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Carcinogenesis 33:620-8. 2012

Collaborators

Detail Information

Publications54

  1. pmc The yin and yang of nrf2-regulated selenoproteins in carcinogenesis
    Regina Brigelius-Flohe
    Department Biochemistry of Micronutrients, German Institute of Human Nutrition, Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Int J Cell Biol 2012:486147. 2012
    ..This paper considers beneficial and adverse consequences of the activation of Nrf2 and the selenoproteins which appear to depend on the cancer stage...
  2. doi request reprint Selenium in the redox regulation of the Nrf2 and the Wnt pathway
    Regina Brigelius-Flohe
    Department Biochemistry of Micronutrients, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Methods Enzymol 527:65-86. 2013
    ..However, not only healthy cells but also malignant ones benefit from intact Keap1/Nrf2 signaling, making a dysregulated hydroperoxide signaling a plausible explanation for the increased cancer risk in selenium deficiency. ..
  3. doi request reprint Glutathione peroxidases
    Regina Brigelius-Flohe
    Department of Biochemistry of Micronutrients, German Institute of Human Nutrition, Nuthetal, Germany
    Biochim Biophys Acta 1830:3289-303. 2013
    ..In mammals, the peroxidases inter alia comprise the 8 glutathione peroxidases (GPx1-GPx8) so far identified...
  4. doi request reprint Vitamin E: the shrew waiting to be tamed
    Regina Brigelius-Flohe
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Biochemistry of Micronutrients, Nuthetal, Germany
    Free Radic Biol Med 46:543-54. 2009
    ..Emerging knowledge on vitamin E is compiled here with the perspective to unravel the molecular mechanisms that could more likely explain the essentiality of the vitamin than its ability to scavenge free radicals...
  5. pmc Basic principles and emerging concepts in the redox control of transcription factors
    Regina Brigelius-Flohe
    Department Biochemistry of Micronutrients, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, Nuthetal, Germany
    Antioxid Redox Signal 15:2335-81. 2011
    ..S-transferases and Prxs are considered for system complementation. The impact of NF-κB and Nrf2 on hormesis, management of inflammatory diseases, and cancer prevention is critically discussed...
  6. ncbi request reprint Glutathione peroxidases in different stages of carcinogenesis
    Regina Brigelius-Flohe
    Department Biochemistry of Micronutrients, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Biochim Biophys Acta 1790:1555-68. 2009
    ..Metastasis, but also apoptosis, is inhibited by all GPxs. GPx-mediated regulation of COX/LOX activities may be relevant to early stages of inflammation-mediated carcinogenesis...
  7. pmc Commentary: oxidative stress reconsidered
    Regina Brigelius-Flohe
    German Institute of Human Nutrition Potsdam Rehbruecke, 14558, Nuthetal, Germany
    Genes Nutr 4:161-3. 2009
    ....
  8. doi request reprint Selenium compounds and selenoproteins in cancer
    Regina Brigelius-Flohe
    Department Biochemistry of Micronutrients, German Institute of Human Nutrition, Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal
    Chem Biodivers 5:389-95. 2008
    ..They may, however, also provide a selective advantage for pre-existing tumor cells in guaranteeing survival and continuous proliferation...
  9. pmc Adverse effects of vitamin E by induction of drug metabolism
    Regina Brigelius-Flohe
    Department Biochemistry of Micronutrients, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558, Nuthetal, Germany
    Genes Nutr 2:249-56. 2007
    ..It is recommended to work out at which threshold the drug-metabolizing system can be induced in humans before new trials with high dosages of vitamin E are started...
  10. pmc Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply
    Susanne Krehl
    Department of Biochemistry of Micronutrients, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Carcinogenesis 33:620-8. 2012
    ..Similarly, SFN requires selenium but not GPx2 for being protective...
  11. pmc Deletion of glutathione peroxidase-2 inhibits azoxymethane-induced colon cancer development
    Mike F Müller
    Department Biochemistry of Micronutrients, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    PLoS ONE 8:e72055. 2013
    ..In conclusion, the role of GPx2 and presumably also of selenium depends on the cancer stage and obviously on the involvement of inflammation. ..
  12. pmc The GI-GPx gene is a target for Nrf2
    Antje Banning
    German Institute of Human Nutrition, Potsdam Rehbruecke, Dept of Biochemistry and Micronutrients, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Mol Cell Biol 25:4914-23. 2005
    ..Thus, the presumed natural antioxidants sulforaphane and curcumin may exert their anti-inflammatory and anticarcinogenic effects not only by induction of phase 2 enzymes but also by the up-regulation of the selenoprotein GI-GPx...
  13. ncbi request reprint NF-kappaB, Nrf2, and HO-1 interplay in redox-regulated VCAM-1 expression
    Antje Banning
    German Institute of Human Nutrition, Potsdam Rehbruecke, Nuthetal, Germany
    Antioxid Redox Signal 7:889-99. 2005
    ..The moderate oxidative stress initiated by enhanced PHGPx or 15-LOX activity appears to induce a defense system that diminishes the response to further proinflammatory stimuli...
  14. ncbi request reprint Vitamin E activates gene expression via the pregnane X receptor
    Nico Landes
    Department of Vitamins and Atherosclerosis, German Institute of Human Nutrition, D 14558 Bergholz Rehbrücke, Germany
    Biochem Pharmacol 65:269-73. 2003
    ..This points to a potential interference of individual forms of Vitamin E with the metabolism and efficacy of drugs...
  15. doi request reprint Four selenoproteins, protein biosynthesis, and Wnt signalling are particularly sensitive to limited selenium intake in mouse colon
    Anna Kipp
    German Institute of Human Nutrition Potsdam Rehbruecke, Germany
    Mol Nutr Food Res 53:1561-72. 2009
    ..Modulation of cancer-related pathways may contribute to the higher susceptibility to colon carcinogenesis in low selenium status...
  16. ncbi request reprint Inhibition of basal and interleukin-1-induced VCAM-1 expression by phospholipid hydroperoxide glutathione peroxidase and 15-lipoxygenase in rabbit aortic smooth muscle cells
    Antje Banning
    Department of Vitamins and Atherosclerosis, German Institute of Human Nutrition, Potsdam Rehbrucke, Germany
    Free Radic Biol Med 36:135-44. 2004
    ..But hydroperoxides, when constitutively overproduced as in SMCLOX, inhibit CAM expression and render cells refractory to IL-1 stimulation likely due to oxidation of protein thiols of the signaling system...
  17. doi request reprint Marginal selenium deficiency down-regulates inflammation-related genes in splenic leukocytes of the mouse
    Anna P Kipp
    Department Biochemistry of Micronutrients, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    J Nutr Biochem 23:1170-7. 2012
    ..The selenoproteins found here to be sensitive to selenium intake in murine leukocytes might also be useful as biomarkers for a moderate selenium deficiency in humans...
  18. ncbi request reprint Is there a future for antioxidants in atherogenesis?
    Regina Brigelius-Flohe
    Department of Biochemistry of Micronutrients, German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    Mol Nutr Food Res 49:1083-9. 2005
    ..Thus, there is only a future for antioxidants in the prevention of any disease if their real mechanism of action is considered and suitable read-outs and biomarkers are established...
  19. ncbi request reprint Vitamin E: underestimated as an antioxidant
    Paul Pfluger
    Department of Vitamins and Atherosclerosis, German Institute of Human Nutrition, Potsdam Rehbrucke, Germany
    Redox Rep 9:249-54. 2004
    ..This article focuses on the metabolism and novel functions of vitamin E with special emphasis on differential biological activities of individual vitamin E forms...
  20. doi request reprint Breakdown products of neoglucobrassicin inhibit activation of Nrf2 target genes mediated by myrosinase-derived glucoraphanin hydrolysis products
    Michael Haack
    German Institute of Human Nutrition Potsdam Rehbrucke, Department Biochemistry of Micronutrients, Nuthetal, Germany
    Biol Chem 391:1281-93. 2010
    ..Thus, the AhR/XRE pathway can negatively interfere with the Nrf2/ARE pathway which has consequences for dietary recommendations and, therefore, needs further investigation...
  21. ncbi request reprint Cellular trafficking of the IL-1RI-associated kinase-1 requires intact kinase activity
    Gaby Fleur Böl
    German Institute of Human Nutrition Potsdam Rehbruecke, Biochemistry of Micronutrients, 14558 Nuthetal, Germany
    Biochem Biophys Res Commun 332:279-87. 2005
    ..It is therefore concluded that intracellular localization of IRAK-1 depends on its kinase activity and that IRAK-1 may also function as a kinase in the nucleus as shown by a new putative endogenous substrate...
  22. ncbi request reprint Modulation of Cyp3a11 mRNA expression by alpha-tocopherol but not gamma-tocotrienol in mice
    Dirk Kluth
    Department of Biochemistry of Micronutrients, German Institute of Human Nutrition, Potsdam Rehbrucke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Free Radic Biol Med 38:507-14. 2005
    ..If fed in supranutritional dosages, especially for longer times, alpha-tocopherol induces Cyp3a11 to levels which might interfere with drug metabolism...
  23. ncbi request reprint Selenium-dependent enzymes in endothelial cell function
    Regina Brigelius-Flohe
    Department of Vitamins and Atherosclerosis, German Institute of Human Nutrition, Arthur Scheunert Allee 114 116, D 14558 Bergholz Rehbrücke, Germany
    Antioxid Redox Signal 5:205-15. 2003
    ..A better understanding of the complex interplay of selenoproteins in regulating endothelial cell functions will help to develop a rationale for an improvement of health by an optimum selenium supply...
  24. ncbi request reprint Recruitment of the interleukin-1 receptor (IL-1RI)-associated kinase IRAK to the IL-1RI is redox regulated
    Gaby Fleur Böl
    Department of Vitamins and Atherosclerosis, German Institute of Human Nutrition, D 14558 Potsdam Rehbrücke, Germany
    Biol Chem 384:609-17. 2003
    ..We conclude that recruitment of IRAK to the IL-1RI is redox regulated by the glutathione system, a reduced status being a prerequisite for an appropiate IL-1 response...
  25. ncbi request reprint Identities and differences in the metabolism of tocotrienols and tocopherols in HepG2 cells
    Marc Birringer
    Department of Vitamins and Atherosclerosis, German Institute of Human Nutrition, University of Potsdam, D 14558 Bergholz Rehbruecke, Germany
    J Nutr 132:3113-8. 2002
    ..The pronounced quantitative differences in the metabolism between individual tocopherols as well as between tocotrienols and tocopherols in vitro suggest a corresponding lack of equivalence in vivo...
  26. ncbi request reprint Homologous metabolic and gene activating routes for vitamins E and K
    Nico Landes
    Department of Vitamins and Atherosclerosis, German Institute of Human Nutrition, University of Potsdam, Arthur Scheunert Allee 114 116, Bergholz Rehbruecke D 14558, Germany
    Mol Aspects Med 24:337-44. 2003
    ....
  27. doi request reprint Loss of GPx2 increases apoptosis, mitosis, and GPx1 expression in the intestine of mice
    Simone Florian
    German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Free Radic Biol Med 49:1694-702. 2010
    ..These data explain why spontaneous ileocolitis becomes manifested only if both Gpx2 and Gpx1 are deleted...
  28. doi request reprint A derivatization method for the simultaneous detection of glucosinolates and isothiocyanates in biological samples
    Julia Budnowski
    Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam Rehbruecke, 14558 Nuthetal, Germany
    Anal Biochem 441:199-207. 2013
    ..The novel method provides an essential tool for the analysis of bioactive glucosinolates and their hydrolysis products and, thus, will contribute to the elucidation of their bioavailability...
  29. ncbi request reprint Part of the series: from dietary antioxidants to regulators in cellular signaling and gene regulation. Sulforaphane and selenium, partners in adaptive response and prevention of cancer
    Regina Brigelius-Flohe
    German Institute of Human Nutrition, Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, D 14558, Nuthetal, Germany
    Free Radic Res 40:775-87. 2006
    ..The anticarcinogenic role of GI-GPx is evident from enhanced gastrointestinal tumor formation in gpx2/gpx1 double KO mice...
  30. doi request reprint The selenoproteins GPx2, TrxR2 and TrxR3 are regulated by Wnt signalling in the intestinal epithelium
    Anna P Kipp
    Department Biochemistry of Micronutrients, German Institute of Human Nutrition, Potsdam Rehbruecke, D 14558 Nuthetal, Germany
    Biochim Biophys Acta 1820:1588-96. 2012
    ..Together with additional selenoproteins, thioredoxin reductases TrxR2 and TrxR3, which are putative Wnt targets based on microarray analysis, Wnt-dependent GPx2 expression was analysed...
  31. doi request reprint Selenoprotein W as biomarker for the efficacy of selenium compounds to act as source for selenoprotein biosynthesis
    Anna Patricia Kipp
    Department Biochemistry of Micronutrients, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Methods Enzymol 527:87-112. 2013
    ..At the protein level, SepW1 responded as well as GPx1 and at the mRNA level, even better. Thus, the outcome of selenium treatment strongly depends on the chemical form, the cell type, and the biomarker used for testing efficacy. ..
  32. ncbi request reprint Estimation of individual types of glutathione peroxidases
    Regina Brigelius-Flohe
    Department of Vitamins and Atherosclerosis, German Institute of Human Nutrition, D 14558 Potsdam Rehbrücke, Germany
    Methods Enzymol 347:101-12. 2002
  33. ncbi request reprint Is there a role of glutathione peroxidases in signaling and differentiation?
    Regina Brigelius-Flohe
    German Institute of Human Nutrition, Arthur Scheunert Allee 114 116, D 14558 Bergholz Rehbrücke, Germany
    Biofactors 17:93-102. 2003
  34. ncbi request reprint Activation of the glutathione peroxidase 2 (GPx2) promoter by beta-catenin
    Anna Kipp
    Department Biochemistry of Micronutrients, German Institute of Human Nutrition Potsdam Rehbrucke, D 14558 Nuthetal, Germany
    Biol Chem 388:1027-33. 2007
    ..Whether up-regulation of GPx2 during carcinogenesis supports tumor growth or can rather be considered as a counteracting effect remains to be investigated...
  35. doi request reprint alpha-Tocopherol enhances degranulation in RBL-2H3 mast cells
    Jana Hemmerling
    German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Mol Nutr Food Res 54:652-60. 2010
    ....
  36. ncbi request reprint 3'UTRs of glutathione peroxidases differentially affect selenium-dependent mRNA stability and selenocysteine incorporation efficiency
    Cordula Müller
    German Institute of Human Nutrition, Department of Vitamins and Atherosclerosis, D 14558 Potsdam Rehbrücke, Germany
    Biol Chem 384:11-8. 2003
    ..We conclude that different mRNA sequences and/or RNA-binding proteins might regulate mRNA stability and translation of selenoprotein mRNA...
  37. doi request reprint GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells
    Antje Banning
    German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Antioxid Redox Signal 10:1491-500. 2008
    ..Thus, GPx2 may prevent undue responses to inflammatory stimuli and, in consequence, inflammation-driven initiation of carcinogenesis...
  38. doi request reprint Physiological functions of GPx2 and its role in inflammation-triggered carcinogenesis
    Regina Brigelius-Flohe
    Biochemistry of Micronutrients Department, German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    Ann N Y Acad Sci 1259:19-25. 2012
    ..The model further revealed a GPx2-independent decrease in tumor development by selenium (Se) and detrimental effects of the Nrf2-activator sulforaphane in moderate Se deficiency...
  39. ncbi request reprint Glucosinolates from pak choi and broccoli induce enzymes and inhibit inflammation and colon cancer differently
    Doris Lippmann
    German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Food Funct 5:1073-81. 2014
    ..GSLs can act anti-inflammatory and anti-carcinogenic but both effects depend on the specific amount and pattern of GSLs within a vegetable. Thus, a high Brassica consumption cannot be generally considered to be cancer-preventive. ..
  40. ncbi request reprint The European perspective on vitamin E: current knowledge and future research
    Regina Brigelius-Flohe
    German Institute of Human Nutrition, Potsdam Rehbrucke, Germany
    Am J Clin Nutr 76:703-16. 2002
    ..Future research on this essential vitamin should focus on what makes it essential for humans, why the body apparently utilizes alpha-tocopherol preferentially, and what functions other forms of vitamin E have...
  41. ncbi request reprint Redox events in interleukin-1 signaling
    Regina Brigelius-Flohe
    Department of Vitamins and Atheroscerosis, German Institute of Human Nutrition, Potsdam Rehbruecke, Bergholz Rehbruecke, Germany
    Arch Biochem Biophys 423:66-73. 2004
    ....
  42. ncbi request reprint Modulation of pregnane X receptor- and electrophile responsive element-mediated gene expression by dietary polyphenolic compounds
    Dirk Kluth
    German Institute of Human Nutrition, Potsdam Rehbrucke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Free Radic Biol Med 42:315-25. 2007
    ..It is concluded that individual polyphenols as well as polyphenol-rich plant extracts may affect phase 1 and 2 enzyme expression by distinct mechanisms that must be elucidated, before potential health effects can reliably be predicted...
  43. ncbi request reprint Is vitamin E an antioxidant, a regulator of signal transduction and gene expression, or a 'junk' food? Comments on the two accompanying papers: "Molecular mechanism of alpha-tocopherol action" by A. Azzi and "Vitamin E, antioxidant and noth
    Regina Brigelius-Flohe
    Department of Biochemistry of Micronutrients, German Institute of Human Nutrition, Potsdam Rehbruecke, D 14558 Germany
    Free Radic Biol Med 43:2-3. 2007
  44. ncbi request reprint Vitamin E and drug metabolism
    Regina Brigelius-Flohe
    Department of Vitamins and Atherosclerosis, German Institute of Human Nutrition, University of Potsdam, Potsdam Rehbruecke, Germany
    Biochem Biophys Res Commun 305:737-40. 2003
    ..The potential interference of vitamin E with drug metabolism is discussed in the light of related complications evoked by herbal remedies...
  45. ncbi request reprint Curcumin blocks interleukin-1 (IL-1) signaling by inhibiting the recruitment of the IL-1 receptor-associated kinase IRAK in murine thymoma EL-4 cells
    Nadine Jurrmann
    German Institute of Human Nutrition, Potsdam Rehbruecke, Biochemistry of Micronutrients, Nuthetal
    J Nutr 135:1859-64. 2005
    ..Hence, thiol modification might be a crucial step in the anti-inflammatory functions of curcumin...
  46. ncbi request reprint Glutathione Peroxidase 2 Inhibits Cyclooxygenase-2-Mediated Migration and Invasion of HT-29 Adenocarcinoma Cells but Supports Their Growth as Tumors in Nude Mice
    Antje Banning
    Department Biochemistry of Micronutrients, German Institute of Human Nutrition Potsdam Rehbruecke
    Cancer Res 68:9746-53. 2008
    ..The data also shed new light on the use of selenium as a chemopreventive trace element: a beneficial effect may depend on the stage of tumor development...
  47. ncbi request reprint PCR-verified microarray analysis and functional in vitro studies indicate a role of alpha-tocopherol in vesicular transport
    Sandra Nell
    German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany
    Free Radic Res 41:930-42. 2007
    ..A role of alpha-tocopherol in the vesicular transport might not only affect its own absorption and transport but also explain the neural dysfunctions observed in severe alpha-tocopherol deficiency...
  48. ncbi request reprint Induction of drug metabolizing enzymes by vitamin E
    Regina Brigelius-Flohe
    Department of Biochemistry of Micronutrients, German Institute of Human Nutrition, Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    J Plant Physiol 162:797-802. 2005
    ..These findings reveal that, in principle, vitamin E is able to directly influence gene activity. They also raise the question of whether vitamin E may interfere with drug metabolism in humans. Related research is urgently deeded...
  49. ncbi request reprint The effect of age on vitamin E status, metabolism, and function: metabolism as assessed by labeled tocopherols
    Regina Brigelius-Flohe
    German Institute of Human Nutrition, Potsdam Rehbrucke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Ann N Y Acad Sci 1031:40-3. 2004
    ..There was no effect of age. Thus, there might be no need for a higher vitamin E intake for healthy elderly nonsmoking men...
  50. doi request reprint The gastrointestinal microbiota affects the selenium status and selenoprotein expression in mice
    Juliane Hrdina
    Department of Biochemistry of Micronutrients, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    J Nutr Biochem 20:638-48. 2009
    ..A variable association with different microorganisms might influence the daily requirement of mice for selenium. Whether the microbiota also affects the human selenoprotein status appears worthy of investigation...
  51. ncbi request reprint Glutathione peroxidases and redox-regulated transcription factors
    Regina Brigelius-Flohe
    German Institute of Human Nutrition, Potsdam Rehbrucke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Biol Chem 387:1329-35. 2006
    ..Redox sensing and redox regulation of metabolic events have become attractive paradigms to unravel the specific and in part still enigmatic roles of GPxs...
  52. ncbi request reprint Introductory remarks to the new series of reviews: from dietary antioxidants to regulators in cellular signalling and gene expression
    Regina Brigelius-Flohe
    Dept Biochemistry of Micronutrients, German Institute of Human Nutrition Potsdam Rehbrucke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Free Radic Res 39:351. 2005
  53. pmc The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium
    Alexander Jaschke
    Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam Rehbruecke, D 14558 Nuthetal, Germany
    Hum Mol Genet 21:3128-42. 2012
    ..Thus, the GTPase ARFRP1 and its downstream proteins are required for the lipidation of chylo-microns and the assembly of ApoA-I to these particles in the Golgi of intestinal epithelial cells...
  54. doi request reprint Impact of gut microbiota on intestinal and hepatic levels of phase 2 xenobiotic-metabolizing enzymes in the rat
    Walter Meinl
    Departments of Nutritional Toxicology, German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany
    Drug Metab Dispos 37:1179-86. 2009
    ..6-fold in females. In conclusion, intestinal microbiota can affect levels of xenobiotic-metabolizing enzymes in large intestine and liver, but the effects observed were moderate compared with tissue-dependent expression differences...