Research Topics
Genomes and Genes
Species | Hermann BrennerSummaryAffiliation: German Cancer Research Center Country: Germany Publications
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Detail Information
Publications
Hospitalizations during the last months of life of nursing home residents: a retrospective cohort study from GermanyHeribert Ramroth
German Centre for Research on Ageing, Heidelberg, Germany
BMC Health Serv Res 6:70. 2006..To describe hospitalisations of nursing home (NH) residents in Germany during their last months of life...- Chlamydia pneumoniae, heat shock proteins 60 and risk of secondary cardiovascular events in patients with coronary heart disease under special consideration of diabetes: a prospective studyMercy Guech-Ongey
Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
BMC Cardiovasc Disord 6:17. 2006.... - Ovarian cancer survival population differences: a "high resolution study" comparing Philippine residents, and Filipino-Americans and Caucasians living in the USMaria Theresa M Redaniel
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
BMC Cancer 9:340. 2009..We aimed to compare ovarian cancer survival in Philippine residents, Filipino-Americans and Caucasians living in the US, using a high resolution approach, taking potential differences in prognostic factors into account... 
Maximizing the benefits of model-based period analysis of cancer patient survivalHermann Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
Cancer Epidemiol Biomarkers Prev 16:1675-81. 2007..Our analyses indicate opportunities to further maximize benefits of model-based period analysis of cancer survival...- Epidemiologic findings on serologically defined chronic atrophic gastritis strongly depend on the choice of the cutoff-valueHermann Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Int J Cancer 121:2782-6. 2007..The association of age and H. pylori infection with CAG may be strongly underestimated in studies in which CAG is defined by pepsinogen I only... - Recent major improvement in long-term survival of younger patients with multiple myelomaHermann Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse 20, Heidelberg, Germany
Blood 111:2521-6. 2008..Our period analysis discloses a major increase in long-term survival of younger patients with MM in recent years, which most likely reflects the effect of recent advances in therapy and their dissemination in clinical practice... - Period versus cohort modeling of up-to-date cancer survivalHermann Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse 20, Heidelberg, Germany
Int J Cancer 122:898-904. 2008.... - Ongoing improvement in long-term survival of patients with Hodgkin disease at all ages and recent catch-up of older patientsHermann Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Blood 111:2977-83. 2008..Our period analysis discloses ongoing, major improvement in long-term survival of patients with HD in recent years, particularly among older patients... - Should colorectal cancer screening start at the same age in European countries? Contributions from descriptive epidemiologyH Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse 20, Heidelberg D 69115, Germany
Br J Cancer 99:532-5. 2008..The ages at which defined levels of incidence and mortality were reached varied between 9 and 17 years between countries. This variation requires consideration in the definition of screening guidelines... 
Recent trends in long-term survival of patients with chronic myelocytic leukemia: disclosing the impact of advances in therapy on the population levelHermann Brenner
Division of Clinical Epidemiology and Aging Reseach, German Cancer Research Center, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
Haematologica 93:1544-9. 2008..Our analysis discloses a dramatic recent increase in long-term survival of younger patients with chronic myelocytic leukemia which most likely reflects rapid dissemination of advances in therapy on the population level...- Recent major progress in long-term cancer patient survival disclosed by modeled period analysisHermann Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
J Clin Oncol 25:3274-80. 2007..To disclose most recent trends in long-term cancer patient survival... - Up-to-date monitoring of childhood cancer long-term survival in Europe: leukaemias and lymphomasH Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Ann Oncol 18:1569-77. 2007..In recent decades, following the introduction of effective chemotherapy, the prognosis of children with leukaemia and lymphoma has dramatically improved, but data reflecting further possible improvement achieved in the 1990s are scarce... - Does a negative screening colonoscopy ever need to be repeated?H Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre, Heidelberg, Germany
Gut 55:1145-50. 2006..The aim of this study was to assess the long term risk of clinically manifest colorectal cancer among subjects with negative findings at colonoscopy... - Risk of progression of advanced adenomas to colorectal cancer by age and sex: estimates based on 840,149 screening colonoscopiesHermann Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
Gut 56:1585-9. 2007..To derive age and sex specific estimates of transition rates from advanced adenomas to colorectal cancer by combining data of a nationwide screening colonoscopy registry and national data on colorectal cancer (CRC) incidence... - Potential for colorectal cancer prevention of sigmoidoscopy versus colonoscopy: population-based case control studyHermann Brenner
Department of Epidemiology, German Cancer Research Center, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
Cancer Epidemiol Biomarkers Prev 16:494-9. 2007..Among men, this regimen may be almost as effective as colonoscopy, at least at previous performance levels of colonoscopy... - Model based hybrid analysis of cancer patient survivalHermann Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
Eur J Cancer 43:921-7. 2007..We conclude that modelling is useful for both hybrid and period analyses of cancer survival, but the different data structure needs to be taken into account in the set-up of models... - Up-to-date estimates of cancer patient survival even with common latency in cancer registrationHermann Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
Cancer Epidemiol Biomarkers Prev 15:1727-32. 2006..We conclude that the model-based approach may enable deriving up-to-date cancer survival rates even with the common latency in availability of cancer registry data... - Up-to-date and precise estimates of cancer patient survival: model-based period analysisHermann Brenner
Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
Am J Epidemiol 164:689-96. 2006..The modeling approach may further enhance the use of period analysis for deriving up-to-date cancer survival rates... - Trends in long-term survival of patients with chronic lymphocytic leukemia from the 1980s to the early 21st centuryHermann Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Blood 111:4916-21. 2008..Long-term survival expectations of patients with CLL have substantially improved over the past 2 decades except for patients 80 years of age or older at the time of diagnosis. Future studies are needed to confirm and expand our findings... - Period estimates of cancer patient survival are more up-to-date than complete estimates even at comparable levels of precisionHermann Brenner
Department of Epidemiology, German Center for Research on Aging, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
J Clin Epidemiol 59:570-5. 2006..Our objective was to compare the performance of period and complete analysis in terms of up-to-dateness and precision of survival estimates... - Patients with previous cancer should not be excluded in international comparative cancer survival studiesHermann Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
Int J Cancer 121:2274-8. 2007..9% points for crude and up to 1.7% points for age adjusted 5-year relative survival. These results caution against exclusion of patients with previous cancer diagnosis in comparative analyses of cancer survival... - Up-to-date monitoring of childhood cancer long-term survival in Europe: methodology and application to all forms of cancer combinedHermann Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Ann Oncol 18:1561-8. 2007..The 'period' method has been shown particularly useful for that purpose... - Improvement in survival of older adults with multiple myeloma: results of an updated period analysis of SEER dataDianne Pulte
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Oncologist 16:1600-3. 2011..Here, we update survival estimates for patients with myeloma in the early 21st century to determine whether continued improvement can be seen on a population level and whether or not it now extends to older patients... - Protection from colorectal cancer after colonoscopy: a population-based, case-control studyHermann Brenner
German Cancer Research Center, University Clinic Heidelberg, University of Heidelberg, Germany
Ann Intern Med 154:22-30. 2011..However, the degree of protection achievable in a population setting with high-quality colonoscopy resources remains to be quantified... - Gender differences in colorectal cancer: implications for age at initiation of screeningH Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
Br J Cancer 96:828-31. 2007..The gender differences were remarkably constant across populations and over time. These patterns suggest that gender differentiation of age at initiation may be worthwhile to utilise CRC-screening resources more efficiently... - Protection from right- and left-sided colorectal neoplasms after colonoscopy: population-based studyHermann Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
J Natl Cancer Inst 102:89-95. 2010.... - Eight years of colonoscopic bowel cancer screening in Germany: initial findings and projectionsHermann Brenner
Abteilung Klinische Epidemiologie und Alternsforschung, Deutsches Kresbforschungszentrum, Bergheimer Str 20, 69115 Heidelberg, Germany
Dtsch Arztebl Int 107:753-9. 2010..Screening colonoscopy has been offered in Germany since the end of 2002. Our aim was to estimate numbers of colorectal cancers prevented or detected early by screening colonoscopy in 2003-2010... - Low risk of colorectal cancer and advanced adenomas more than 10 years after negative colonoscopyHermann Brenner
Division of Clinical Epidemiology of Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
Gastroenterology 138:870-6. 2010..There is little empirical evidence available about the optimal interval for screening, making this a subject of debate. We associated the prevalence of advanced colorectal neoplasms with time since negative colonoscopies... - Survival expectations of patients diagnosed with Hodgkin's lymphoma in 2006-2010Hermann Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
Oncologist 14:806-13. 2009..The 10-year survival expectations are now close to or exceed 90% in all age groups up to age 45, and exceed 80% and 70% in the 45-54 and 55-64 age groups, respectively... - Implications of incomplete registration of deaths on long-term survival estimates from population-based cancer registriesHermann Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Int J Cancer 125:432-7. 2009..When such completeness cannot be achieved, long-term relative survival estimates and their comparison across populations must be interpreted with much caution... - Up-to-date cancer survival: period analysis and beyondHermann Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Int J Cancer 124:1384-90. 2009..While our analysis confirms advantages of period analysis over traditional methods in terms of up-to-dateness of cancer survival data, further improvements are possible by flexible use of model-based approaches... - Expected long-term survival of patients diagnosed with multiple myeloma in 2006-2010Hermann Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Haematologica 94:270-5. 2009..Patients diagnosed with multiple myeloma in 2006-2010, especially those diagnosed at younger ages, are expected to have much higher long-term survival perspectives than suggested by previously available survival statistics... - Expected reduction of colorectal cancer incidence within 8 years after introduction of the German screening colonoscopy programme: estimates based on 1,875,708 screening colonoscopiesHermann Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, D 69115 Heidelberg, Germany
Eur J Cancer 45:2027-33. 2009..Our results forecast a major rapid reduction of the CRC burden in Germany by screening colonoscopy... - Long-term survival in chronic myelocytic leukemia after a first primary malignancyHermann Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
Leuk Res 33:1604-8. 2009..0001) and from 7.6% to 23.8% (p<0.0001), respectively. Improvements were particularly strong in younger age groups. Prognosis of CML patients with previous malignancy no longer lags behind prognosis of patients with primary CML... - Dopamine-related genes and spontaneous smoking cessation in ever-heavy smokersLutz P Breitling
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, TP4 INF581, 69120 Heidelberg, Germany
Pharmacogenomics 12:1099-106. 2011..Several studies have provided evidence for associations of polymorphisms located in and near dopamine-related genes and nicotine dependence and other smoking-related phenotypes, including pharmacogenetic interactions... - Inverse association between a pro-inflammatory genetic profile and Helicobacter pylori seropositivity among patients with chronic atrophic gastritis: enhanced elimination of the infection during disease progression?Lei Gao
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, Heidelberg D 69115, Germany
Eur J Cancer 45:2860-6. 2009..There is increasing evidence of frequent clearance of the infection during progression of CAG. We aimed to assess the association between host inflammatory polymorphisms and H. pylori seropositivity among CAG patients from Germany... - The association of cyclin D1 G870A and E-cadherin C-160A polymorphisms with the risk of colorectal cancer in a case control study and meta-analysisXiang Lin Tan
Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
Int J Cancer 122:2573-80. 2008..However, the CCND1 G870A polymorphism may modify the protective effect of postmenopausal hormone use on the development of CRC... - Gender disparities in diabetes and coronary heart disease medication among patients with type 2 diabetes: results from the DIANA studyHeike U Krämer
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, D 69120, Heidelberg, Germany
Cardiovasc Diabetol 11:88. 2012..Coronary heart disease (CHD) is one of the most common long-term complications in people with type 2 diabetes. We analyzed whether or not gender differences exist in diabetes and CHD medication among people with type 2 diabetes... - Kidney graft survival in europe and the United States: strikingly different long-term outcomesAdam Gondos
1 Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany 2 Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany 3 Address correspondence to Adam Gondos, Ph D, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, PO Box 101909, 69009 Heidelberg, Germany
Transplantation 95:267-74. 2013..Kidney graft survival has never been systematically compared between Europe and the United States... - Evaluation of serum and urinary myeloid related protein-14 as a marker for early detection of prostate cancerHeiko Muller
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
J Urol 180:1309-12; discussion 1312-3. 2008..In diagnostic studies promising results were shown for myeloid related protein-14 in serum and urine. However, confirmation in longitudinal population based studies is needed... - Cancer survival in Germany and the United States at the beginning of the 21st century: an up-to-date comparison by period analysisAdam Gondos
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Int J Cancer 121:395-400. 2007..Among these, differences between patients with breast and prostate cancer are probably due to more intensive screening activities... - Prevalence and determinants of exocrine pancreatic insufficiency among older adults: results of a population-based studyDietrich Rothenbacher
Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
Scand J Gastroenterol 40:697-704. 2005..The prevalence and main determinants of exocrine pancreatic insufficiency were investigated in a large population-based sample of older adults by measuring pancreatic elastase-1 in stool... - Household contacts were key factor for children's colonization with resistant Escherichia coli in community settingSusanne Lietzau
Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
J Clin Epidemiol 60:1149-55. 2007..coli) can lead to life-threatening situations. Epidemiological data on the prevalence and major determinants of carriage of antibiotic resistant E. coli among children in the community setting are sparse... - Cigarette smoking and colorectal cancer risk in Germany: a population-based case-control studyEmaculate Verla-Tebit
Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
Int J Cancer 119:630-5. 2006..This study supports the hypothesis that smoking for a long duration at a high cumulative dose increases the risk for colorectal cancer, particularly among women, and suggests that there is risk reduction after longterm smoking cessation... - SULT1A1 genotype and susceptibility to colorectal cancerCarmen Lilla
Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
Int J Cancer 120:201-6. 2007.... - Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLMBernd Frank
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, 69115 Heidelberg, Germany
Carcinogenesis 31:442-5. 2010..Although none of them showed a significant association with CRC, the association of BLM P868L with rectal cancer risk requires further investigation... - Strong associations of 25-hydroxyvitamin D concentrations with all-cause, cardiovascular, cancer, and respiratory disease mortality in a large cohort studyBen Schöttker
Divisions of Clinical Epidemiology and Aging Research and Preventive Oncology, German Cancer Research Center, Heidelberg, Germany
Am J Clin Nutr 97:782-93. 2013..Serum 25-hydroxyvitamin D [25(OH)D] concentration has been linked to mortality in several studies, but appropriate cutoffs to define risk categories are under debate... - Copy number variations of GSTT1 and GSTM1, colorectal cancer risk and possible effect modification of cigarette smoking and menopausal hormone therapyAnja Rudolph
Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
Int J Cancer 131:E841-8. 2012..18) for GSTM1. No significant interaction with smoking and MHT use was observed. Our study does not provide evidence for a strong association between CRC risk and CNVs of GSTT1 or GSTM1 or for an effect modification of smoking or MHT use... - Mutant-enriched PCR and allele-specific hybridization reaction to detect K-ras mutations in stool DNA: high prevalence in a large sample of older adultsUlrike Haug
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Clin Chem 53:787-90. 2007..We investigated the prevalence and potential determinants of mutant K-ras in stool in a large sample of unselected older adults and assessed the association with colonoscopic findings... - Synergism between smoking and alcohol consumption with respect to serum gamma-glutamyltransferaseLutz Philipp Breitling
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Hepatology 49:802-8. 2009..12, P(males) = 0.0017). CONCLUSION: Our results support the notion of a detrimental interaction between cigarette smoking and alcohol consumption as determinants of elevated serum gamma-GT, especially in men... - Atopic diseases, immunoglobulin E and risk of cancer of the prostate, breast, lung and colorectumHao Wang
Department of Clinical Social Medicine, University of Heidelberg, and Unit of Health Monitoring, Saarland Cancer Registry, , Germany
Int J Cancer 119:695-701. 2006..The effect on cancer risk by atopy, defined by IgE reactivity, may differ from the effect by atopy-related clinically defined diseases such as asthma, hay fever and atopic dermatitis... - Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancerBernd Frank
German Cancer Research Center, Heidelberg, Germany
Carcinogenesis 31:1381-6. 2010..However, our results provide evidence that CRC subsets may be affected. If confirmed, this knowledge may be used to assess individual susceptibility and to target potential measures of cancer prevention... - Death receptor 4 variants and colorectal cancer riskBernd Frank
Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
Cancer Epidemiol Biomarkers Prev 15:2002-5. 2006..37; 95% CI, 0.98-5.76). The score statistic yielded an empirical P of 0.03 of the haplotype-specific test for 626C-683C based on 20,000 simulations, suggesting that DR4 626C-683C may affect colorectal cancer predisposition... - Interval cancers after negative colonoscopy: population-based case-control studyHermann Brenner
Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Heidelberg, Germany
Gut 61:1576-82. 2012..The risk of colorectal cancer after a previous negative colonoscopy is very low. Nevertheless, interval cancers occur. We aimed to assess the characteristics and predictors of interval cancers after negative colonoscopy... - Gender specific temporal and cross-sectional associations between BMI-class and symptoms of depression in the elderlyBeate Wild
Department of General Internal Medicine and Psychosomatics, Medical University Hospital, Heidelberg, Germany
J Psychosom Res 72:376-82. 2012..The aim of the study was the gender specific analysis of cross-sectional and longitudinal associations between body mass index class (BMI-class) and symptoms of depression in a representative sample of elderly German people... - Helicobacter pylori infection, chronic atrophic gastritis and major cardiovascular events: a population-based cohort studyBen Schöttker
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Atherosclerosis 220:569-74. 2012..There is debate whether infection with Helicobacter (H.) pylori, the main inducer of chronic atrophic gastritis (CAG), is a risk factor for cardiovascular disease and premature mortality... - Inter-country and ethnic variation in colorectal cancer survival: comparisons between a Philippine population, Filipino-Americans and CaucasiansMaria Theresa Redaniel
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
BMC Cancer 10:100. 2010.... - Alcohol consumption and chronic atrophic gastritis: population-based study among 9,444 older adults from GermanyLei Gao
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Int J Cancer 125:2918-22. 2009..pylori. However, the observed patterns suggest that other mechanisms are likely to contribute to the association as well... - Exposure to environmental tobacco smoke and the risk of colorectal cancer in a case-control study from GermanyEmaculate Verla-Tebit
Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
Eur J Cancer Prev 18:9-12. 2009..03-12.15) and for women exposed to >23 pack-years of spousal smoking (OR: 3.02; 95% CI: 0.99-9.28). Our findings do not indicate a major impact of ETS on CRC risk but suggest that risk may be increased following spousal exposure... - Alcohol consumption, serum gamma-glutamyltransferase, and helicobacter pylori infection in a population-based study among 9733 older adultsLei Gao
German Cancer Research Center, Heidelberg, Germany
Ann Epidemiol 20:122-8. 2010..pylori infection in a large population-based study... - Genetic polymorphisms in GST genes and survival of colorectal cancer patients treated with chemotherapySilvia Funke
German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Pharmacogenomics 11:33-41. 2010..Genetic polymorphisms in GST genes (GSTP1 Ile105Val, copy-number variants of GSTM1 and GSTT1) that lead to diminished enzyme activity have been associated with increased chemotherapeutic treatment benefit in colorectal cancer patients... - Changes of cardiovascular risk factors and their implications in subsequent birth cohorts of older adults in Germany: a life course approachElke Raum
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Eur J Cardiovasc Prev Rehabil 14:809-14. 2007.... - Sibship size, Helicobacter pylori infection and chronic atrophic gastritis: a population-based study among 9444 older adults from GermanyLei Gao
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Int J Epidemiol 39:129-34. 2010..We aimed to assess the association of sibship size with H. pylori infection and chronic atrophic gastritis (CAG) in a population-based study from Germany... - Epidemiology of chronic kidney disease: results from a population of older adults in GermanyQiu Li Zhang
German Cancer Research Center, Heidelberg, Germany
Prev Med 48:122-7. 2009..To determine prevalences and stages of chronic kidney disease (CKD), and evaluate association of CKD with related covariables in a large population of older adults... - Serum parathyroid hormone and risk of adverse outcomes in patients with stable coronary heart diseaseNorma Christine Grandi
Division of Clinical Epidemiology and Ageing Research C070, German Cancer Research Center, Heidelberg, Germany
Heart 97:1215-21. 2011..This study presents analyses of the prognostic value of baseline PTH for subsequent cardiovascular events and all-cause mortality in a high-risk population with stable coronary heart disease... - Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumptionCarmen Lilla
Division of Clinical Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany
Cancer Epidemiol Biomarkers Prev 15:99-107. 2006.... - Longitudinal predictors of health-related quality of life in middle-aged and older adults with hypertension: results of a population-based studyImad Maatouk
Department of General Internal Medicine and Psychosomatics, Medical University Hospital Heidelberg, Heidelberg, Germany
J Hypertens 30:1364-72. 2012..g. awareness of hypertension, number of types of antihypertensive drugs, comorbidity), and health-related quality of life (HRQOL) in a large cohort of patients with hypertension, over a follow-up period of 5 years... - Calcium, phosphate and the risk of cardiovascular events and all-cause mortality in a population with stable coronary heart diseaseNorma Christine Grandi
Division of Clinical Epidemiology and Aging Research C070, German Cancer Research Centre, POB 10 19 49, D 69009 Heidelberg, Germany
Heart 98:926-33. 2012..The association between baseline calcium and phosphate and prognosis was examined in a cohort study of patients with stable coronary heart disease... - Effect of type 2 diabetes predisposing genetic variants on colorectal cancer riskJuan Sainz
Division of Molecular Genetic Epidemiology, German Cancer Research Center, D 69120 Heidelberg, Germany
J Clin Endocrinol Metab 97:E845-51. 2012..The link between colorectal cancer (CRC) and type 2 diabetes mellitus (T2D) has been extensively studied. Although it is commonly accepted that T2D is a risk factor for CRC, the underlying mechanisms are still poorly understood... - Temporal predictors of health-related quality of life in elderly people with diabetes: results of a German cohort studyImad Maatouk
Department of General Internal Medicine and Psychosomatics, Medical University Hospital Heidelberg, Heidelberg, Germany
PLoS ONE 7:e31088. 2012..The aim of the study was to determine predictors that influence health-related quality of life (HRQOL) in a large cohort of elderly diabetes patients from primary care over a follow-up period of five years... - Model-based projections for deriving up-to-date cancer survival estimates: an international evaluationAdam Gondos
Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Heidelberg, Germany
Int J Cancer 125:2666-72. 2009..Projections from model-based analysis may contribute to improved timeliness of monitoring of concurrent trends in population-based cancer survival in cancer registries operating in different populations and socioeconomic environments... - Helicobacter pylori infection, interleukin-1 gene polymorphisms and the risk of colorectal cancer: evidence from a case-control study in GermanyNatalia Zumkeller
Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre, Bergheimer Str 20, D 69115 Heidelberg, Germany
Eur J Cancer 43:1283-9. 2007..Additionally, a pro-inflammatory genotype did not increase the colorectal cancer risk associated with H. pylori infection. H. pylori positive subjects carrying the pro-inflammatory genotypes even had a lower risk... - Genotype combinations of plasminogen activator inhibitor-1 and angiotensin-converting enzyme genes and risk for early onset of coronary heart diseaseMichael Loew
Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
Eur J Cardiovasc Prev Rehabil 13:449-56. 2006.... - Population-based prevalence estimates of history of colonoscopy or sigmoidoscopy: review and analysis of recent trendsChristian Stock
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Gastrointest Endosc 71:366-381.e2. 2010..We aimed to review prevalence estimates of history of colonoscopy or sigmoidoscopy in the general population and to analyze recent trends... - Age-specific administration of chemotherapy and long-term quality of life in stage II and III colorectal cancer patients: a population-based prospective cohortLina Jansen
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Heidelberg, Germany
Oncologist 16:1741-51. 2011..To investigate the age-specific pattern of administration of chemotherapy and its association with long-term survival and quality of life (QoL) in stage II and III colorectal cancer patients... - Helicobacter pylori infection and gastric cancer risk: evaluation of 15 H. pylori proteins determined by novel multiplex serologyLei Gao
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Cancer Res 69:6164-70. 2009..001). In conclusion, GroEL was identified as a new independent risk marker that may contribute to enhanced quantification of H. pylori-related GC risk... - Association between a pro-inflammatory genetic profile and the risk of chronic atrophic gastritis among older adults from GermanyLei Gao
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
Eur J Cancer 45:428-34. 2009..We aimed to assess their impact on the risk of chronic atrophic gastritis (CAG) in a population-based study... - Validity of self-reported endoscopies of the large bowel and implications for estimates of colorectal cancer riskMichael Hoffmeister
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Am J Epidemiol 166:130-6. 2007..58), and reasonable for year of examination (kappa = 0.70). Self-reports of previous colorectal endoscopies agreed well with medical records, but validation appears to be essential with respect to details of the examination... - The mother as source of Helicobacter pylori infectionMaria Weyermann
Department of Epidemiology, The German Centre for Research on Ageing, Heidelberg, Germany
Epidemiology 17:332-4. 2006..The number of older siblings was not a risk factor for H. pylori infection of the child. CONCLUSIONS: This longitudinal study suggests that infected mothers are the main source of H. pylori infection of their children... - Grb2-associated binder 1 (Gab1) genetic polymorphism, Helicobacter pylori infection, and chronic atrophic gastritis among older adults from GermanyLei Gao
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Mol Carcinog 49:869-73. 2010..pylori infection and CAG in this study population from Germany. Further studies with larger sample size are needed to clarify a potential modest effect of Gab1 genetic polymorphisms... - Quality of life in patients with colorectal cancer 1 year after diagnosis compared with the general population: a population-based studyVolker Arndt
Department of Epidemiology, German Centre for Research on Aging, Heidelberg, Germany
J Clin Oncol 22:4829-36. 2004.... - Helicobacter pylori and hepatitis A virus infections and the cardiovascular risk profile in patients with diabetes mellitus: results of a population-based studyMercy Ongey
Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
Eur J Cardiovasc Prev Rehabil 11:471-6. 2004..Therefore it seems unlikely that HP and HAV sero-prevalence strongly influence CVD progression in patients with diabetes... - Sex, age, and birth cohort effects in colorectal neoplasms: a cohort analysisHermann Brenner
German Cancer Research Center, Heidelberg, Germany
Ann Intern Med 152:697-703. 2010..Cross-sectional analyses estimated that men reach an equivalent prevalence at a much younger age than women. However, cross-sectional estimates may be confounded by birth cohort effects... - Role of infected parents in transmission of helicobacter pylori to their childrenDietrich Rothenbacher
Department of Epidemiology, The German Centre for Research on Ageing, Heidelberg
Pediatr Infect Dis J 21:674-9. 2002..8 to 5.3) when the father was saliva-positive. CONCLUSION: This study strengthens previous evidence that in the population studied infected parents, in particular mothers may play a key role in transmission of H. pylori to the child... - History of breastfeeding and Helicobacter pylori infection in pre-school children: results of a population-based study from GermanyDietrich Rothenbacher
Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
Int J Epidemiol 31:632-7. 2002..However, there are few current data from developed countries to elucidate this association. We investigated the relation between history of breastfeeding and H. pylori infection in a large population-based sample... - Short-term benefit of smoking cessation in patients with coronary heart disease: estimates based on self-reported smoking data and serum cotinine measurementsDorothee Twardella
Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Str 20, D 69115 Heidelberg, Germany
Eur Heart J 25:2101-8. 2004..To assess the short-term impact of smoking and smoking cessation measured by self-report and by serum cotinine on the risk of secondary cardiovascular disease events (CVD events)... - Quantitative immunochemical fecal occult blood testing for colorectal adenoma detection: evaluation in the target population of screening and comparison with qualitative testsUlrike Haug
German Cancer Research Center, Heidelberg, Germany
Am J Gastroenterol 105:682-90. 2010.... - Long-term survival expectations of cancer patients in Europe in 2000-2002Hermann Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Eur J Cancer 45:1028-41. 2009..Furthermore, relative survival was also better in female than in male patients and decreased with age for most cancer sites... - Helicobacter pylori infection and chronic atrophic gastritis: associations according to severity of diseaseMelanie N Weck
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Epidemiology 20:569-74. 2009..We assessed the association of H. pylori infection with chronic atrophic gastritis according to severity of disease... - Advanced detection of time trends in long-term cancer patient survival: experience from 50 years of cancer registration in FinlandHermann Brenner
Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
Am J Epidemiol 156:566-77. 2002..The authors conclude that period analysis should be routinely used to advance detection of progress in long-term cancer patient survival... - Association between chronic atrophic gastritis and serum antibodies to 15 Helicobacter pylori proteins measured by multiplex serologyLei Gao
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Cancer Res 69:2973-80. 2009..In conclusion, HcpC and GroEL were identified as new independent virulence factors, and in combination with the established virulence factors, CagA and VacA, were strongly associated with CAG... - Improvements in survival of adults diagnosed with acute myeloblastic leukemia in the early 21st centuryDianne Pulte
Div of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
Haematologica 93:594-600. 2008.... - Ethnicity and health care in cervical cancer survival: comparisons between a Filipino resident population, Filipino-Americans, and CaucasiansMaria Theresa Redaniel
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Cancer Epidemiol Biomarkers Prev 18:2228-34. 2009..01-1.47). The differences in cervical cancer survival between patients in the Philippines and in the United States highlight the importance of enhanced health care and access to diagnostic and treatment facilities in the Philippines... - Trends in 5- and 10-year survival after diagnosis with childhood hematologic malignancies in the United States, 1990-2004Dianne Pulte
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
J Natl Cancer Inst 100:1301-9. 2008.... - Are patients diagnosed with breast cancer before age 50 years ever cured?Hermann Brenner
Department of Epidemiology, German Centre for Research on Aging, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
J Clin Oncol 22:432-8. 2004..The aim of this study was to assess long-term survival in a large population-based sample of patients diagnosed with breast cancer before age 50 years... - Comparison of N-terminal pro-B-natriuretic peptide, C-reactive protein, and creatinine clearance for prognosis in patients with known coronary heart diseaseDietrich Rothenbacher
Department of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Arch Intern Med 166:2455-60. 2006..CONCLUSION: N-terminal proBNP may be a clinically useful marker weeks after an acute coronary event and may provide complementary prognostic information to established risk determinants... - Hybrid analysis for up-to-date long-term survival rates in cancer registries with delayed recording of incident casesHermann Brenner
Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
Eur J Cancer 40:2494-501. 2004.... - Reduction in selective under-ascertainment bias in population-based estimates of cancer patient survival by age adjustmentHermann Brenner
Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
Eur J Cancer 41:1788-93. 2005..Age adjusted estimates were less biased in most scenarios, which may be an additional argument for application of age adjustment in the analysis and reporting of population-based cancer survival rates... - Long-term survival rates of patients with prostate cancer in the prostate-specific antigen screening era: population-based estimates for the year 2000 by period analysisHermann Brenner
Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
J Clin Oncol 23:441-7. 2005..In this study, we applied a new method for up-to-date analysis of long-term survival to evaluate if and to what extent these patients still have any excess mortality compared to the general population... - Substantial overestimation of standard errors of relative survival rates of cancer patientsHermann Brenner
German Centre for Research on Ageing, Heidelberg, Germany
Am J Epidemiol 161:781-6. 2005..The authors conclude that conventional derivation may substantially overestimate standard errors for relative survival... - Recent increase in cancer survival according to age: higher survival in all age groups, but widening age gradientHermann Brenner
Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Strasse 20, Heidelberg, D 69115, Germany
Cancer Causes Control 15:903-10. 2004..We conclude that long-term survival expectations of cancer patients have increased in all age groups in the 1990s. However, for most common forms of cancer, the age gradient in survival has either persisted or widened...