Hermann Brenner


Affiliation: German Cancer Research Center
Country: Germany


  1. Chen C, Stock C, Jansen L, Chang Claude J, Hoffmeister M, Brenner H. Trends in colonoscopy and fecal occult blood test use after the introduction of dual screening offers in Germany: Results from a large population-based study, 2003-2016. Prev Med. 2019;123:333-340 pubmed publisher
    ..Although the overall adherence to CRC screening recommendations remained stable, the substantial shift of share from FOBT to colonoscopy is expected to yield more protection against CRC incidence and mortality. ..
  2. Yu H, Guan Z, Cuk K, Zhang Y, Brenner H. Circulating MicroRNA Biomarkers for Lung Cancer Detection in East Asian Populations. Cancers (Basel). 2019;11: pubmed publisher
    ..However, large studies with samples collected prospectively in true screening settings are required to validate the promising markers or marker panels. ..
  3. Jiang R, Poschet G, Owen R, Celik M, Jansen L, Hell R, et al. Serum Concentration of Genistein, Luteolin and Colorectal Cancer Prognosis. Nutrients. 2019;11: pubmed publisher
    ..Our study provides little evidence that serum genistein and luteolin are associated with colorectal cancer prognosis. Future studies are warranted to evaluate the potential interaction with adjuvant chemotherapy. ..
  4. Gao X, Gao X, Zhang Y, Holleczek B, Schöttker B, Brenner H. Oxidative stress and epigenetic mortality risk score: associations with all-cause mortality among elderly people. Eur J Epidemiol. 2019;34:451-462 pubmed publisher
    ..This study demonstrates that OS is highly associated with the epigenetic MS, and the latter at the same time has a higher predictive value for all-cause mortality. ..
  5. Chen C, Stock C, Hoffmeister M, Brenner H. The optimal age for screening colonoscopy: a modeling study. Gastrointest Endosc. 2019;: pubmed publisher
    ..When 2 or more screening colonoscopies are offered with 10-year intervals, screening should start at age 50 at the latest or possibly even younger for both genders. ..
  6. Qian J, Tikk K, Weigl K, Balavarca Y, Brenner H. Fibroblast growth factor 21 as a circulating biomarker at various stages of colorectal carcinogenesis. Br J Cancer. 2018;119:1374-1382 pubmed publisher
  7. Qian J, Tikk K, Werner S, Balavarca Y, Saadati M, Hechtner M, et al. Biomarker discovery study of inflammatory proteins for colorectal cancer early detection demonstrated importance of screening setting validation. J Clin Epidemiol. 2018;104:24-34 pubmed publisher
    ..Our results underline the importance of validation in screening settings subsequently to novel signature discovery for cancer early detection. ..
  8. Huang L, Jansen L, Balavarca Y, Babaei M, van der Geest L, Lemmens V, et al. Stratified survival of resected and overall pancreatic cancer patients in Europe and the USA in the early twenty-first century: a large, international population-based study. BMC Med. 2018;16:125 pubmed publisher
    ..Patients with advanced-stage disease and/or older age should undergo careful risk assessment before treatment. Limited but inspiring improvement in survival is observed. ..
  9. Maalmi H, Walter V, Jansen L, Boakye D, Schöttker B, Hoffmeister M, et al. Association between Blood 25-Hydroxyvitamin D Levels and Survival in Colorectal Cancer Patients: An Updated Systematic Review and Meta-Analysis. Nutrients. 2018;10: pubmed publisher
    ..The potential for enhancing prognosis of CRC patients by vitamin D supplementation should be explored by randomized trials. ..

More Information


  1. Brenner H, Altenhofen L, Hoffmeister M. Eight years of colonoscopic bowel cancer screening in Germany: initial findings and projections. Dtsch Arztebl Int. 2010;107:753-9 pubmed publisher
    ..Despite limited participation, the German screening colonoscopy program makes a major contribution to prevention and early detection of colorectal cancer. ..
  2. Erben V, Bhardwaj M, Schrotz King P, Brenner H. Metabolomics Biomarkers for Detection of Colorectal Neoplasms: A Systematic Review. Cancers (Basel). 2018;10: pubmed publisher
    ..However, to make metabolomic biomarkers clinically applicable, future research in larger studies and external validation of the results is required. ..
  3. Braig S, Genuneit J, Walter V, Brandt S, Wabitsch M, Goldbeck L, et al. Screen Time, Physical Activity and Self-Esteem in Children: The Ulm Birth Cohort Study. Int J Environ Res Public Health. 2018;15: pubmed publisher
    ..For parental reports similar associations were observed. These findings indicate that time sequence and potential mediators need further investigation in cohort studies with multiple assessments of screen time and self-esteem. ..
  4. Brenner H, Hakulinen T. Up-to-date cancer survival: period analysis and beyond. Int J Cancer. 2009;124:1384-90 pubmed publisher
    ..While our analysis confirms advantages of period analysis over traditional methods in terms of up-to-dateness of cancer survival data, further improvements are possible by flexible use of model-based approaches. ..
  5. Maalmi H, Walter V, Jansen L, Owen R, Ulrich A, Schöttker B, et al. Dose-Response Relationship between Serum Retinol Levels and Survival in Patients with Colorectal Cancer: Results from the DACHS Study. Nutrients. 2018;10: pubmed publisher
    ..The clinical implications of these findings require further investigation. ..
  6. Brenner H, Gondos A, Pulte D. Long-term survival in chronic myelocytic leukemia after a first primary malignancy. Leuk Res. 2009;33:1604-8 pubmed publisher
    ..0001) and from 7.6% to 23.8% (p<0.0001), respectively. Improvements were particularly strong in younger age groups. Prognosis of CML patients with previous malignancy no longer lags behind prognosis of patients with primary CML. ..
  7. request reprint
    Brenner H, Rothenbacher D, Weck M. Epidemiologic findings on serologically defined chronic atrophic gastritis strongly depend on the choice of the cutoff-value. Int J Cancer. 2007;121:2782-6 pubmed
    ..The association of age and H. pylori infection with CAG may be strongly underestimated in studies in which CAG is defined by pepsinogen I only. ..
  8. Chen H, Zucknick M, Werner S, Knebel P, Brenner H. Head-to-Head Comparison and Evaluation of 92 Plasma Protein Biomarkers for Early Detection of Colorectal Cancer in a True Screening Setting. Clin Cancer Res. 2015;21:3318-26 pubmed publisher
    ..The identified profile of protein biomarkers could contribute to the development of a powerful multimarker blood-based test for early detection of colorectal cancer. ..
  9. Weigl K, Thomsen H, Balavarca Y, Hellwege J, Shrubsole M, Brenner H. Genetic Risk Score Is Associated With Prevalence of Advanced Neoplasms in a Colorectal Cancer Screening Population. Gastroenterology. 2018;155:88-98.e10 pubmed publisher
    ..These findings might be used in defining risk-adapted screening ages. ..
  10. Zhang Y, Florath I, Saum K, Brenner H. Self-reported smoking, serum cotinine, and blood DNA methylation. Environ Res. 2016;146:395-403 pubmed publisher
    ..Our study corroborates and expands the list of smoking-associated DNA methylation markers. Methylation levels were linearly related to cotinine concentration and provided accurate measures for both current and past smoking exposure. ..
  11. Bozorgmehr K, San Sebastian M, Brenner H, Razum O, Maier W, Saum K, et al. Analysing horizontal equity in enrolment in Disease Management Programmes for coronary heart disease in Germany 2008-2010. Int J Equity Health. 2015;14:28 pubmed publisher
    ..Further research is needed to gain a better understanding of the mechanisms that contribute to deprivation-related horizontal inequities in DMP enrolment among women. ..
  12. Chen H, Knebel P, Brenner H. Empirical evaluation demonstrated importance of validating biomarkers for early detection of cancer in screening settings to limit the number of false-positive findings. J Clin Epidemiol. 2016;75:108-14 pubmed publisher
    ..9%, 18.6%, and 25.7% for algorithms identified in the clinical setting. Validation of early detection markers of cancer in a true screening setting is important to limit the number of false-positive findings. ..
  13. Lechner S, Herzog W, Boehlen F, Maatouk I, Saum K, Brenner H, et al. Control preferences in treatment decisions among older adults - Results of a large population-based study. J Psychosom Res. 2016;86:28-33 pubmed publisher
    ..Results indicate that physical and mental health in the elderly are associated with the preference role. It should, however, be investigated whether multimorbidity or mental diseases influence the treatment preference of older adults. ..
  14. Gao X, Mons U, Zhang Y, Breitling L, Brenner H. DNA methylation changes in response to active smoking exposure are associated with leukocyte telomere length among older adults. Eur J Epidemiol. 2016;31:1231-1241 pubmed publisher
    ..Further research is required to examine whether the identified epigenetic signatures of smoking can be of value in clinical practice to assess individual aging across the lifespan. ..
  15. Chen H, Werner S, Brenner H. Fresh vs Frozen Samples and Ambient Temperature Have Little Effect on Detection of Colorectal Cancer or Adenomas by a Fecal Immunochemical Test in a Colorectal Cancer Screening Cohort in Germany. Clin Gastroenterol Hepatol. 2017;15:1547-1556.e5 pubmed publisher
    ..Season of sample collection (based on outdoor temperature) did not affect detection of CRC using either sample type in this study from Middle Europe. ..
  16. Bock J, Konig H, Brenner H, Haefeli W, Quinzler R, Matschinger H, et al. Associations of frailty with health care costs--results of the ESTHER cohort study. BMC Health Serv Res. 2016;16:128 pubmed publisher
    ..Costs were rather attributable to frailty (and comorbidity) than to age. This stresses that the overlapping concepts of multimorbidity and frailty are both necessary to explain health care use and corresponding costs among older adults. ..
  17. Heider D, Matschinger H, Muller H, Saum K, Quinzler R, Haefeli W, et al. Health care costs in the elderly in Germany: an analysis applying Andersen's behavioral model of health care utilization. BMC Health Serv Res. 2014;14:71 pubmed publisher
    ..Overall, the variables used in the Andersen model explained only little of the total variance in health care costs. ..
  18. Weigl K, Jansen L, Chang Claude J, Knebel P, Hoffmeister M, Brenner H. Family history and the risk of colorectal cancer: The importance of patients' history of colonoscopy. Int J Cancer. 2016;139:2213-20 pubmed publisher
    ..Colonoscopy reduces the risk of CRC among those with FH far below levels of people with no FH and no colonoscopy. ..
  19. Chen C, Läcke E, Stock C, Hoffmeister M, Brenner H. Colonoscopy and sigmoidoscopy use among older adults in different countries: A systematic review. Prev Med. 2017;103:33-42 pubmed publisher
  20. Gao X, Gào X, Zhang Y, Breitling L, Schöttker B, Brenner H. Associations of self-reported smoking, cotinine levels and epigenetic smoking indicators with oxidative stress among older adults: a population-based study. Eur J Epidemiol. 2017;32:443-456 pubmed publisher
    ..The identified CpG sites could potentially be prognostic epigenetic markers of OS and OS-related health outcomes. Our findings and the underlying mechanisms should be followed up in further, preferably longitudinal studies. ..
  21. Chen H, Werner S, Tao S, Zörnig I, Brenner H. Blood autoantibodies against tumor-associated antigens as biomarkers in early detection of colorectal cancer. Cancer Lett. 2014;346:178-87 pubmed publisher
    ..In conclusion, autoantibody signatures may become a promising approach to noninvasive CRC screening. Optimized marker panels are yet to be developed, and promising results require validation in large screening populations. ..
  22. Brenner H, Chang Claude J, Seiler C, Rickert A, Hoffmeister M. Protection from colorectal cancer after colonoscopy: a population-based, case-control study. Ann Intern Med. 2011;154:22-30 pubmed publisher
    ..However, the degree of protection achievable in a population setting with high-quality colonoscopy resources remains to be quantified...
  23. Brenner H, Hakulinen T. Implications of incomplete registration of deaths on long-term survival estimates from population-based cancer registries. Int J Cancer. 2009;125:432-7 pubmed publisher
    ..When such completeness cannot be achieved, long-term relative survival estimates and their comparison across populations must be interpreted with much caution. ..