Hermann Brenner

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. pmc Geographic and ethnic differences in childhood leukaemia and lymphoma survival: comparisons of Philippine residents, Asian Americans and Caucasians in the United States
    M T Redaniel
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, Heidelberg D 69115, Germany
    Br J Cancer 103:149-54. 2010
  2. pmc Trends of population-based breast cancer survival in Germany and the US: decreasing discrepancies, but persistent survival gap of elderly patients in Germany
    Bernd Holleczek
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    BMC Cancer 12:317. 2012
  3. pmc A novel multiplex-protein array for serum diagnostics of colon cancer: a case-control study
    Stefanie Bünger
    Laboratory for Surgical Research, Department of Surgery, University of Lubeck, Ratzeburger Allee 160, D 23538, Lubeck, Germany
    BMC Cancer 12:393. 2012
  4. pmc Hospitalizations during the last months of life of nursing home residents: a retrospective cohort study from Germany
    Heribert Ramroth
    German Centre for Research on Ageing, Heidelberg, Germany
    BMC Health Serv Res 6:70. 2006
  5. pmc Chlamydia pneumoniae, heat shock proteins 60 and risk of secondary cardiovascular events in patients with coronary heart disease under special consideration of diabetes: a prospective study
    Mercy Guech-Ongey
    Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
    BMC Cardiovasc Disord 6:17. 2006
  6. pmc Ovarian cancer survival population differences: a "high resolution study" comparing Philippine residents, and Filipino-Americans and Caucasians living in the US
    Maria Theresa M Redaniel
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    BMC Cancer 9:340. 2009
  7. doi request reprint Trends in long-term survival of patients with chronic lymphocytic leukemia from the 1980s to the early 21st century
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Blood 111:4916-21. 2008
  8. pmc Should colorectal cancer screening start at the same age in European countries? Contributions from descriptive epidemiology
    H Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse 20, Heidelberg D 69115, Germany
    Br J Cancer 99:532-5. 2008
  9. ncbi request reprint Ongoing improvement in long-term survival of patients with Hodgkin disease at all ages and recent catch-up of older patients
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Blood 111:2977-83. 2008
  10. doi request reprint Recent trends in long-term survival of patients with chronic myelocytic leukemia: disclosing the impact of advances in therapy on the population level
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Reseach, German Cancer Research Center, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Haematologica 93:1544-9. 2008

Collaborators

Detail Information

Publications183 found, 100 shown here

  1. pmc Geographic and ethnic differences in childhood leukaemia and lymphoma survival: comparisons of Philippine residents, Asian Americans and Caucasians in the United States
    M T Redaniel
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, Heidelberg D 69115, Germany
    Br J Cancer 103:149-54. 2010
    ..Childhood cancer survival estimates from developing nations are rare...
  2. pmc Trends of population-based breast cancer survival in Germany and the US: decreasing discrepancies, but persistent survival gap of elderly patients in Germany
    Bernd Holleczek
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    BMC Cancer 12:317. 2012
    ..This population-based study aims at comparing most recent 5-year relative survival of breast cancer patients and preceding trends in both countries...
  3. pmc A novel multiplex-protein array for serum diagnostics of colon cancer: a case-control study
    Stefanie Bünger
    Laboratory for Surgical Research, Department of Surgery, University of Lubeck, Ratzeburger Allee 160, D 23538, Lubeck, Germany
    BMC Cancer 12:393. 2012
    ..Despite actual screening programs, about 50% of the patients are diagnosed at advanced tumor stages presenting poor prognosis. Innovative screening tools could aid the detection at early stages and allow curative treatment interventions...
  4. pmc Hospitalizations during the last months of life of nursing home residents: a retrospective cohort study from Germany
    Heribert Ramroth
    German Centre for Research on Ageing, Heidelberg, Germany
    BMC Health Serv Res 6:70. 2006
    ..To describe hospitalisations of nursing home (NH) residents in Germany during their last months of life...
  5. pmc Chlamydia pneumoniae, heat shock proteins 60 and risk of secondary cardiovascular events in patients with coronary heart disease under special consideration of diabetes: a prospective study
    Mercy Guech-Ongey
    Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
    BMC Cardiovasc Disord 6:17. 2006
    ....
  6. pmc Ovarian cancer survival population differences: a "high resolution study" comparing Philippine residents, and Filipino-Americans and Caucasians living in the US
    Maria Theresa M Redaniel
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    BMC Cancer 9:340. 2009
    ..We aimed to compare ovarian cancer survival in Philippine residents, Filipino-Americans and Caucasians living in the US, using a high resolution approach, taking potential differences in prognostic factors into account...
  7. doi request reprint Trends in long-term survival of patients with chronic lymphocytic leukemia from the 1980s to the early 21st century
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Blood 111:4916-21. 2008
    ..Long-term survival expectations of patients with CLL have substantially improved over the past 2 decades except for patients 80 years of age or older at the time of diagnosis. Future studies are needed to confirm and expand our findings...
  8. pmc Should colorectal cancer screening start at the same age in European countries? Contributions from descriptive epidemiology
    H Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse 20, Heidelberg D 69115, Germany
    Br J Cancer 99:532-5. 2008
    ..The ages at which defined levels of incidence and mortality were reached varied between 9 and 17 years between countries. This variation requires consideration in the definition of screening guidelines...
  9. ncbi request reprint Ongoing improvement in long-term survival of patients with Hodgkin disease at all ages and recent catch-up of older patients
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Blood 111:2977-83. 2008
    ..Our period analysis discloses ongoing, major improvement in long-term survival of patients with HD in recent years, particularly among older patients...
  10. doi request reprint Recent trends in long-term survival of patients with chronic myelocytic leukemia: disclosing the impact of advances in therapy on the population level
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Reseach, German Cancer Research Center, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Haematologica 93:1544-9. 2008
    ..Our analysis discloses a dramatic recent increase in long-term survival of younger patients with chronic myelocytic leukemia which most likely reflects rapid dissemination of advances in therapy on the population level...
  11. doi request reprint Up-to-date cancer survival: period analysis and beyond
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 124:1384-90. 2009
    ..While our analysis confirms advantages of period analysis over traditional methods in terms of up-to-dateness of cancer survival data, further improvements are possible by flexible use of model-based approaches...
  12. pmc Expected long-term survival of patients diagnosed with multiple myeloma in 2006-2010
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Haematologica 94:270-5. 2009
    ..Patients diagnosed with multiple myeloma in 2006-2010, especially those diagnosed at younger ages, are expected to have much higher long-term survival perspectives than suggested by previously available survival statistics...
  13. ncbi request reprint Up-to-date estimates of cancer patient survival even with common latency in cancer registration
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 15:1727-32. 2006
    ..We conclude that the model-based approach may enable deriving up-to-date cancer survival rates even with the common latency in availability of cancer registry data...
  14. doi request reprint Long-term survival in chronic myelocytic leukemia after a first primary malignancy
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Leuk Res 33:1604-8. 2009
    ..0001) and from 7.6% to 23.8% (p<0.0001), respectively. Improvements were particularly strong in younger age groups. Prognosis of CML patients with previous malignancy no longer lags behind prognosis of patients with primary CML...
  15. ncbi request reprint Expected reduction of colorectal cancer incidence within 8 years after introduction of the German screening colonoscopy programme: estimates based on 1,875,708 screening colonoscopies
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, D 69115 Heidelberg, Germany
    Eur J Cancer 45:2027-33. 2009
    ..Our results forecast a major rapid reduction of the CRC burden in Germany by screening colonoscopy...
  16. doi request reprint Implications of incomplete registration of deaths on long-term survival estimates from population-based cancer registries
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 125:432-7. 2009
    ..When such completeness cannot be achieved, long-term relative survival estimates and their comparison across populations must be interpreted with much caution...
  17. ncbi request reprint Period versus cohort modeling of up-to-date cancer survival
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse 20, Heidelberg, Germany
    Int J Cancer 122:898-904. 2008
    ....
  18. ncbi request reprint Recent major improvement in long-term survival of younger patients with multiple myeloma
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse 20, Heidelberg, Germany
    Blood 111:2521-6. 2008
    ..Our period analysis discloses a major increase in long-term survival of younger patients with MM in recent years, which most likely reflects the effect of recent advances in therapy and their dissemination in clinical practice...
  19. ncbi request reprint Epidemiologic findings on serologically defined chronic atrophic gastritis strongly depend on the choice of the cutoff-value
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 121:2782-6. 2007
    ..The association of age and H. pylori infection with CAG may be strongly underestimated in studies in which CAG is defined by pepsinogen I only...
  20. ncbi request reprint Model based hybrid analysis of cancer patient survival
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Eur J Cancer 43:921-7. 2007
    ..We conclude that modelling is useful for both hybrid and period analyses of cancer survival, but the different data structure needs to be taken into account in the set-up of models...
  21. ncbi request reprint Up-to-date and precise estimates of cancer patient survival: model-based period analysis
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
    Am J Epidemiol 164:689-96. 2006
    ..The modeling approach may further enhance the use of period analysis for deriving up-to-date cancer survival rates...
  22. ncbi request reprint Potential for colorectal cancer prevention of sigmoidoscopy versus colonoscopy: population-based case control study
    Hermann Brenner
    Department of Epidemiology, German Cancer Research Center, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 16:494-9. 2007
    ..Among men, this regimen may be almost as effective as colonoscopy, at least at previous performance levels of colonoscopy...
  23. ncbi request reprint Period estimates of cancer patient survival are more up-to-date than complete estimates even at comparable levels of precision
    Hermann Brenner
    Department of Epidemiology, German Center for Research on Aging, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    J Clin Epidemiol 59:570-5. 2006
    ..Our objective was to compare the performance of period and complete analysis in terms of up-to-dateness and precision of survival estimates...
  24. pmc Does a negative screening colonoscopy ever need to be repeated?
    H Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre, Heidelberg, Germany
    Gut 55:1145-50. 2006
    ..The aim of this study was to assess the long term risk of clinically manifest colorectal cancer among subjects with negative findings at colonoscopy...
  25. pmc Risk of progression of advanced adenomas to colorectal cancer by age and sex: estimates based on 840,149 screening colonoscopies
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Gut 56:1585-9. 2007
    ..To derive age and sex specific estimates of transition rates from advanced adenomas to colorectal cancer by combining data of a nationwide screening colonoscopy registry and national data on colorectal cancer (CRC) incidence...
  26. ncbi request reprint Patients with previous cancer should not be excluded in international comparative cancer survival studies
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Int J Cancer 121:2274-8. 2007
    ..9% points for crude and up to 1.7% points for age adjusted 5-year relative survival. These results caution against exclusion of patients with previous cancer diagnosis in comparative analyses of cancer survival...
  27. ncbi request reprint Up-to-date monitoring of childhood cancer long-term survival in Europe: leukaemias and lymphomas
    H Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Ann Oncol 18:1569-77. 2007
    ..In recent decades, following the introduction of effective chemotherapy, the prognosis of children with leukaemia and lymphoma has dramatically improved, but data reflecting further possible improvement achieved in the 1990s are scarce...
  28. pmc Gender differences in colorectal cancer: implications for age at initiation of screening
    H Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Br J Cancer 96:828-31. 2007
    ..The gender differences were remarkably constant across populations and over time. These patterns suggest that gender differentiation of age at initiation may be worthwhile to utilise CRC-screening resources more efficiently...
  29. ncbi request reprint Maximizing the benefits of model-based period analysis of cancer patient survival
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 16:1675-81. 2007
    ..Our analyses indicate opportunities to further maximize benefits of model-based period analysis of cancer survival...
  30. ncbi request reprint Up-to-date monitoring of childhood cancer long-term survival in Europe: methodology and application to all forms of cancer combined
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Ann Oncol 18:1561-8. 2007
    ..The 'period' method has been shown particularly useful for that purpose...
  31. doi request reprint Protection from right- and left-sided colorectal neoplasms after colonoscopy: population-based study
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    J Natl Cancer Inst 102:89-95. 2010
    ....
  32. ncbi request reprint Recent major progress in long-term cancer patient survival disclosed by modeled period analysis
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    J Clin Oncol 25:3274-80. 2007
    ..To disclose most recent trends in long-term cancer patient survival...
  33. pmc Improvement in survival of older adults with multiple myeloma: results of an updated period analysis of SEER data
    Dianne Pulte
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Oncologist 16:1600-3. 2011
    ..Here, we update survival estimates for patients with myeloma in the early 21st century to determine whether continued improvement can be seen on a population level and whether or not it now extends to older patients...
  34. doi request reprint Survival expectations of patients diagnosed with Hodgkin's lymphoma in 2006-2010
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Oncologist 14:806-13. 2009
    ..The 10-year survival expectations are now close to or exceed 90% in all age groups up to age 45, and exceed 80% and 70% in the 45-54 and 55-64 age groups, respectively...
  35. doi request reprint Low risk of colorectal cancer and advanced adenomas more than 10 years after negative colonoscopy
    Hermann Brenner
    Division of Clinical Epidemiology of Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Gastroenterology 138:870-6. 2010
    ..There is little empirical evidence available about the optimal interval for screening, making this a subject of debate. We associated the prevalence of advanced colorectal neoplasms with time since negative colonoscopies...
  36. pmc Eight years of colonoscopic bowel cancer screening in Germany: initial findings and projections
    Hermann Brenner
    Abteilung Klinische Epidemiologie und Alternsforschung, Deutsches Kresbforschungszentrum, Bergheimer Str 20, 69115 Heidelberg, Germany
    Dtsch Arztebl Int 107:753-9. 2010
    ..Screening colonoscopy has been offered in Germany since the end of 2002. Our aim was to estimate numbers of colorectal cancers prevented or detected early by screening colonoscopy in 2003-2010...
  37. doi request reprint Protection from colorectal cancer after colonoscopy: a population-based, case-control study
    Hermann Brenner
    German Cancer Research Center, University Clinic Heidelberg, University of Heidelberg, Germany
    Ann Intern Med 154:22-30. 2011
    ..However, the degree of protection achievable in a population setting with high-quality colonoscopy resources remains to be quantified...
  38. ncbi request reprint Dopamine-related genes and spontaneous smoking cessation in ever-heavy smokers
    Lutz P Breitling
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, TP4 INF581, 69120 Heidelberg, Germany
    Pharmacogenomics 12:1099-106. 2011
    ..Several studies have provided evidence for associations of polymorphisms located in and near dopamine-related genes and nicotine dependence and other smoking-related phenotypes, including pharmacogenetic interactions...
  39. doi request reprint Inverse association between a pro-inflammatory genetic profile and Helicobacter pylori seropositivity among patients with chronic atrophic gastritis: enhanced elimination of the infection during disease progression?
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, Heidelberg D 69115, Germany
    Eur J Cancer 45:2860-6. 2009
    ..There is increasing evidence of frequent clearance of the infection during progression of CAG. We aimed to assess the association between host inflammatory polymorphisms and H. pylori seropositivity among CAG patients from Germany...
  40. doi request reprint The association of cyclin D1 G870A and E-cadherin C-160A polymorphisms with the risk of colorectal cancer in a case control study and meta-analysis
    Xiang Lin Tan
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 122:2573-80. 2008
    ..However, the CCND1 G870A polymorphism may modify the protective effect of postmenopausal hormone use on the development of CRC...
  41. ncbi request reprint Atopic diseases, immunoglobulin E and risk of cancer of the prostate, breast, lung and colorectum
    Hao Wang
    Department of Clinical Social Medicine, University of Heidelberg, and Unit of Health Monitoring, Saarland Cancer Registry, Saarbrucken, Germany
    Int J Cancer 119:695-701. 2006
    ..The effect on cancer risk by atopy, defined by IgE reactivity, may differ from the effect by atopy-related clinically defined diseases such as asthma, hay fever and atopic dermatitis...
  42. pmc Gender disparities in diabetes and coronary heart disease medication among patients with type 2 diabetes: results from the DIANA study
    Heike U Krämer
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, D 69120, Heidelberg, Germany
    Cardiovasc Diabetol 11:88. 2012
    ..Coronary heart disease (CHD) is one of the most common long-term complications in people with type 2 diabetes. We analyzed whether or not gender differences exist in diabetes and CHD medication among people with type 2 diabetes...
  43. ncbi request reprint Cancer survival in Germany and the United States at the beginning of the 21st century: an up-to-date comparison by period analysis
    Adam Gondos
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 121:395-400. 2007
    ..Among these, differences between patients with breast and prostate cancer are probably due to more intensive screening activities...
  44. doi request reprint Serum 25-hydroxyvitamin D levels and incident diabetes mellitus type 2: a competing risk analysis in a large population-based cohort of older adults
    Ben Schöttker
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany
    Eur J Epidemiol 28:267-75. 2013
    ..In this large cohort study of older adults, serum 25(OH)D levels were inversely associated with incident diabetes in women but not in men. The association was particularly strong in subjects with renal dysfunction...
  45. doi request reprint Kidney graft survival in Europe and the United States: strikingly different long-term outcomes
    Adam Gondos
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Transplantation 95:267-74. 2013
    ..Kidney graft survival has never been systematically compared between Europe and the United States...
  46. doi request reprint Evaluation of serum and urinary myeloid related protein-14 as a marker for early detection of prostate cancer
    Heiko Muller
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    J Urol 180:1309-12; discussion 1312-3. 2008
    ..In diagnostic studies promising results were shown for myeloid related protein-14 in serum and urine. However, confirmation in longitudinal population based studies is needed...
  47. ncbi request reprint SULT1A1 genotype and susceptibility to colorectal cancer
    Carmen Lilla
    Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 120:201-6. 2007
    ....
  48. ncbi request reprint Prevalence and determinants of exocrine pancreatic insufficiency among older adults: results of a population-based study
    Dietrich Rothenbacher
    Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
    Scand J Gastroenterol 40:697-704. 2005
    ..The prevalence and main determinants of exocrine pancreatic insufficiency were investigated in a large population-based sample of older adults by measuring pancreatic elastase-1 in stool...
  49. ncbi request reprint Cigarette smoking and colorectal cancer risk in Germany: a population-based case-control study
    Emaculate Verla-Tebit
    Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 119:630-5. 2006
    ..This study supports the hypothesis that smoking for a long duration at a high cumulative dose increases the risk for colorectal cancer, particularly among women, and suggests that there is risk reduction after longterm smoking cessation...
  50. ncbi request reprint Household contacts were key factor for children's colonization with resistant Escherichia coli in community setting
    Susanne Lietzau
    Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
    J Clin Epidemiol 60:1149-55. 2007
    ..coli) can lead to life-threatening situations. Epidemiological data on the prevalence and major determinants of carriage of antibiotic resistant E. coli among children in the community setting are sparse...
  51. doi request reprint Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM
    Bernd Frank
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, 69115 Heidelberg, Germany
    Carcinogenesis 31:442-5. 2010
    ..Although none of them showed a significant association with CRC, the association of BLM P868L with rectal cancer risk requires further investigation...
  52. pmc Sex differences in colorectal cancer survival: population-based analysis of 164,996 colorectal cancer patients in Germany
    Ondrej Majek
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    PLoS ONE 8:e68077. 2013
    ..The effect of sex hormones, either endogenous or through hormonal replacement therapy, might be the most plausible explanation for the observed patterns. ..
  53. doi request reprint Vitamin D receptor genotype rs731236 (Taq1) and breast cancer prognosis
    Laura Perna
    Corresponding Author Laura Perna, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, INF 581 TP4, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 22:437-42. 2013
    ....
  54. doi request reprint Strong associations of 25-hydroxyvitamin D concentrations with all-cause, cardiovascular, cancer, and respiratory disease mortality in a large cohort study
    Ben Schöttker
    Divisions of Clinical Epidemiology and Aging Research and Preventive Oncology, German Cancer Research Center, Heidelberg, Germany
    Am J Clin Nutr 97:782-93. 2013
    ..Serum 25-hydroxyvitamin D [25(OH)D] concentration has been linked to mortality in several studies, but appropriate cutoffs to define risk categories are under debate...
  55. doi request reprint Copy number variations of GSTT1 and GSTM1, colorectal cancer risk and possible effect modification of cigarette smoking and menopausal hormone therapy
    Anja Rudolph
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 131:E841-8. 2012
    ..18) for GSTM1. No significant interaction with smoking and MHT use was observed. Our study does not provide evidence for a strong association between CRC risk and CNVs of GSTT1 or GSTM1 or for an effect modification of smoking or MHT use...
  56. ncbi request reprint Mutant-enriched PCR and allele-specific hybridization reaction to detect K-ras mutations in stool DNA: high prevalence in a large sample of older adults
    Ulrike Haug
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Clin Chem 53:787-90. 2007
    ..We investigated the prevalence and potential determinants of mutant K-ras in stool in a large sample of unselected older adults and assessed the association with colonoscopic findings...
  57. ncbi request reprint Death receptor 4 variants and colorectal cancer risk
    Bernd Frank
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 15:2002-5. 2006
    ..37; 95% CI, 0.98-5.76). The score statistic yielded an empirical P of 0.03 of the haplotype-specific test for 626C-683C based on 20,000 simulations, suggesting that DR4 626C-683C may affect colorectal cancer predisposition...
  58. ncbi request reprint Synergism between smoking and alcohol consumption with respect to serum gamma-glutamyltransferase
    Lutz Philipp Breitling
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Hepatology 49:802-8. 2009
    ..9 (1.1-7.6) in women and to 3.8 (2.2-6.6) in men (test for interaction between alcohol consumption and smoking: P(females) = 0.12, P(males) = 0.0017)...
  59. doi request reprint Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer
    Bernd Frank
    German Cancer Research Center, Heidelberg, Germany
    Carcinogenesis 31:1381-6. 2010
    ..However, our results provide evidence that CRC subsets may be affected. If confirmed, this knowledge may be used to assess individual susceptibility and to target potential measures of cancer prevention...
  60. doi request reprint Using rate advancement periods for communicating the benefits of quitting smoking to older smokers
    Carolin Gellert
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Tob Control 22:227-30. 2013
    ..We provide empirical evidence on the impact of smoking, and the benefits of quitting on all-cause mortality and RAPs for people aged 60 years and older in a large cohort of older adults...
  61. doi request reprint Genetic variations in the vitamin D binding protein and season-specific levels of vitamin D among older adults
    Laura Perna
    German Cancer Research Center DKFZ, Division of Clinical Epidemiology and Aging Research, Im Neuenheimer Feld 581, Heidelberg, Germany
    Epidemiology 24:104-9. 2013
    ..The quantification of this association among older women and men and its potential variation by season remain unexplored...
  62. ncbi request reprint Interval cancers after negative colonoscopy: population-based case-control study
    Hermann Brenner
    Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Heidelberg, Germany
    Gut 61:1576-82. 2012
    ..The risk of colorectal cancer after a previous negative colonoscopy is very low. Nevertheless, interval cancers occur. We aimed to assess the characteristics and predictors of interval cancers after negative colonoscopy...
  63. doi request reprint Gender specific temporal and cross-sectional associations between BMI-class and symptoms of depression in the elderly
    Beate Wild
    Department of General Internal Medicine and Psychosomatics, Medical University Hospital, Heidelberg, Germany
    J Psychosom Res 72:376-82. 2012
    ..The aim of the study was the gender specific analysis of cross-sectional and longitudinal associations between body mass index class (BMI-class) and symptoms of depression in a representative sample of elderly German people...
  64. doi request reprint Helicobacter pylori infection, chronic atrophic gastritis and major cardiovascular events: a population-based cohort study
    Ben Schöttker
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Atherosclerosis 220:569-74. 2012
    ..There is debate whether infection with Helicobacter (H.) pylori, the main inducer of chronic atrophic gastritis (CAG), is a risk factor for cardiovascular disease and premature mortality...
  65. pmc Inter-country and ethnic variation in colorectal cancer survival: comparisons between a Philippine population, Filipino-Americans and Caucasians
    Maria Theresa Redaniel
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    BMC Cancer 10:100. 2010
    ....
  66. doi request reprint Alcohol consumption, serum gamma-glutamyltransferase, and helicobacter pylori infection in a population-based study among 9733 older adults
    Lei Gao
    German Cancer Research Center, Heidelberg, Germany
    Ann Epidemiol 20:122-8. 2010
    ..pylori infection in a large population-based study...
  67. doi request reprint Alcohol consumption and chronic atrophic gastritis: population-based study among 9,444 older adults from Germany
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 125:2918-22. 2009
    ..pylori. However, the observed patterns suggest that other mechanisms are likely to contribute to the association as well...
  68. doi request reprint Exposure to environmental tobacco smoke and the risk of colorectal cancer in a case-control study from Germany
    Emaculate Verla-Tebit
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Eur J Cancer Prev 18:9-12. 2009
    ..03-12.15) and for women exposed to >23 pack-years of spousal smoking (OR: 3.02; 95% CI: 0.99-9.28). Our findings do not indicate a major impact of ETS on CRC risk but suggest that risk may be increased following spousal exposure...
  69. doi request reprint Genetic polymorphisms in GST genes and survival of colorectal cancer patients treated with chemotherapy
    Silvia Funke
    German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Pharmacogenomics 11:33-41. 2010
    ..Genetic polymorphisms in GST genes (GSTP1 Ile105Val, copy-number variants of GSTM1 and GSTT1) that lead to diminished enzyme activity have been associated with increased chemotherapeutic treatment benefit in colorectal cancer patients...
  70. doi request reprint Epidemiology of chronic kidney disease: results from a population of older adults in Germany
    Qiu Li Zhang
    German Cancer Research Center, Heidelberg, Germany
    Prev Med 48:122-7. 2009
    ..To determine prevalences and stages of chronic kidney disease (CKD), and evaluate association of CKD with related covariables in a large population of older adults...
  71. ncbi request reprint Changes of cardiovascular risk factors and their implications in subsequent birth cohorts of older adults in Germany: a life course approach
    Elke Raum
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Eur J Cardiovasc Prev Rehabil 14:809-14. 2007
    ....
  72. doi request reprint Serum parathyroid hormone and risk of adverse outcomes in patients with stable coronary heart disease
    Norma Christine Grandi
    Division of Clinical Epidemiology and Ageing Research C070, German Cancer Research Center, Heidelberg, Germany
    Heart 97:1215-21. 2011
    ..This study presents analyses of the prognostic value of baseline PTH for subsequent cardiovascular events and all-cause mortality in a high-risk population with stable coronary heart disease...
  73. doi request reprint Sibship size, Helicobacter pylori infection and chronic atrophic gastritis: a population-based study among 9444 older adults from Germany
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Epidemiol 39:129-34. 2010
    ..We aimed to assess the association of sibship size with H. pylori infection and chronic atrophic gastritis (CAG) in a population-based study from Germany...
  74. ncbi request reprint Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumption
    Carmen Lilla
    Division of Clinical Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 15:99-107. 2006
    ....
  75. doi request reprint Longitudinal predictors of health-related quality of life in middle-aged and older adults with hypertension: results of a population-based study
    Imad Maatouk
    Department of General Internal Medicine and Psychosomatics, Medical University Hospital Heidelberg, Heidelberg, Germany
    J Hypertens 30:1364-72. 2012
    ..g. awareness of hypertension, number of types of antihypertensive drugs, comorbidity), and health-related quality of life (HRQOL) in a large cohort of patients with hypertension, over a follow-up period of 5 years...
  76. doi request reprint Calcium, phosphate and the risk of cardiovascular events and all-cause mortality in a population with stable coronary heart disease
    Norma Christine Grandi
    Division of Clinical Epidemiology and Aging Research C070, German Cancer Research Centre, POB 10 19 49, D 69009 Heidelberg, Germany
    Heart 98:926-33. 2012
    ..The association between baseline calcium and phosphate and prognosis was examined in a cohort study of patients with stable coronary heart disease...
  77. doi request reprint Effect of type 2 diabetes predisposing genetic variants on colorectal cancer risk
    Juan Sainz
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Clin Endocrinol Metab 97:E845-51. 2012
    ..The link between colorectal cancer (CRC) and type 2 diabetes mellitus (T2D) has been extensively studied. Although it is commonly accepted that T2D is a risk factor for CRC, the underlying mechanisms are still poorly understood...
  78. pmc Temporal predictors of health-related quality of life in elderly people with diabetes: results of a German cohort study
    Imad Maatouk
    Department of General Internal Medicine and Psychosomatics, Medical University Hospital Heidelberg, Heidelberg, Germany
    PLoS ONE 7:e31088. 2012
    ..The aim of the study was to determine predictors that influence health-related quality of life (HRQOL) in a large cohort of elderly diabetes patients from primary care over a follow-up period of five years...
  79. doi request reprint Model-based projections for deriving up-to-date cancer survival estimates: an international evaluation
    Adam Gondos
    Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 125:2666-72. 2009
    ..Projections from model-based analysis may contribute to improved timeliness of monitoring of concurrent trends in population-based cancer survival in cancer registries operating in different populations and socioeconomic environments...
  80. doi request reprint Population-based prevalence estimates of history of colonoscopy or sigmoidoscopy: review and analysis of recent trends
    Christian Stock
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Gastrointest Endosc 71:366-381.e2. 2010
    ..We aimed to review prevalence estimates of history of colonoscopy or sigmoidoscopy in the general population and to analyze recent trends...
  81. ncbi request reprint Helicobacter pylori infection, interleukin-1 gene polymorphisms and the risk of colorectal cancer: evidence from a case-control study in Germany
    Natalia Zumkeller
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Eur J Cancer 43:1283-9. 2007
    ..Additionally, a pro-inflammatory genotype did not increase the colorectal cancer risk associated with H. pylori infection. H. pylori positive subjects carrying the pro-inflammatory genotypes even had a lower risk...
  82. ncbi request reprint Genotype combinations of plasminogen activator inhibitor-1 and angiotensin-converting enzyme genes and risk for early onset of coronary heart disease
    Michael Loew
    Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
    Eur J Cardiovasc Prev Rehabil 13:449-56. 2006
    ....
  83. pmc Age-specific administration of chemotherapy and long-term quality of life in stage II and III colorectal cancer patients: a population-based prospective cohort
    Lina Jansen
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Heidelberg, Germany
    Oncologist 16:1741-51. 2011
    ..To investigate the age-specific pattern of administration of chemotherapy and its association with long-term survival and quality of life (QoL) in stage II and III colorectal cancer patients...
  84. doi request reprint Association between a pro-inflammatory genetic profile and the risk of chronic atrophic gastritis among older adults from Germany
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Eur J Cancer 45:428-34. 2009
    ..We aimed to assess their impact on the risk of chronic atrophic gastritis (CAG) in a population-based study...
  85. ncbi request reprint Helicobacter pylori infection and gastric cancer risk: evaluation of 15 H. pylori proteins determined by novel multiplex serology
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Cancer Res 69:6164-70. 2009
    ..001). In conclusion, GroEL was identified as a new independent risk marker that may contribute to enhanced quantification of H. pylori-related GC risk...
  86. ncbi request reprint The mother as source of Helicobacter pylori infection
    Maria Weyermann
    Department of Epidemiology, The German Centre for Research on Ageing, Heidelberg, Germany
    Epidemiology 17:332-4. 2006
    ..To further elucidate the intrafamilial transmission of Helicobacter pylori infection, we investigated the occurrence of infection by parental infection status in a large community-based birth cohort of children from Germany...
  87. doi request reprint Grb2-associated binder 1 (Gab1) genetic polymorphism, Helicobacter pylori infection, and chronic atrophic gastritis among older adults from Germany
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Mol Carcinog 49:869-73. 2010
    ..pylori infection and CAG in this study population from Germany. Further studies with larger sample size are needed to clarify a potential modest effect of Gab1 genetic polymorphisms...
  88. ncbi request reprint Validity of self-reported endoscopies of the large bowel and implications for estimates of colorectal cancer risk
    Michael Hoffmeister
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Am J Epidemiol 166:130-6. 2007
    ..58), and reasonable for year of examination (kappa = 0.70). Self-reports of previous colorectal endoscopies agreed well with medical records, but validation appears to be essential with respect to details of the examination...
  89. ncbi request reprint Quality of life in patients with colorectal cancer 1 year after diagnosis compared with the general population: a population-based study
    Volker Arndt
    Department of Epidemiology, German Centre for Research on Aging, Heidelberg, Germany
    J Clin Oncol 22:4829-36. 2004
    ....
  90. ncbi request reprint Helicobacter pylori and hepatitis A virus infections and the cardiovascular risk profile in patients with diabetes mellitus: results of a population-based study
    Mercy Ongey
    Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
    Eur J Cardiovasc Prev Rehabil 11:471-6. 2004
    ....
  91. ncbi request reprint Sex, age, and birth cohort effects in colorectal neoplasms: a cohort analysis
    Hermann Brenner
    German Cancer Research Center, Heidelberg, Germany
    Ann Intern Med 152:697-703. 2010
    ..Cross-sectional analyses estimated that men reach an equivalent prevalence at a much younger age than women. However, cross-sectional estimates may be confounded by birth cohort effects...
  92. ncbi request reprint History of breastfeeding and Helicobacter pylori infection in pre-school children: results of a population-based study from Germany
    Dietrich Rothenbacher
    Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
    Int J Epidemiol 31:632-7. 2002
    ..However, there are few current data from developed countries to elucidate this association. We investigated the relation between history of breastfeeding and H. pylori infection in a large population-based sample...
  93. ncbi request reprint Short-term benefit of smoking cessation in patients with coronary heart disease: estimates based on self-reported smoking data and serum cotinine measurements
    Dorothee Twardella
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Eur Heart J 25:2101-8. 2004
    ..To assess the short-term impact of smoking and smoking cessation measured by self-report and by serum cotinine on the risk of secondary cardiovascular disease events (CVD events)...
  94. ncbi request reprint Role of infected parents in transmission of helicobacter pylori to their children
    Dietrich Rothenbacher
    Department of Epidemiology, The German Centre for Research on Ageing, Heidelberg
    Pediatr Infect Dis J 21:674-9. 2002
    ..The aim of this population-based study was to determine the role of parental infection status in transmission of H. pylori to the child by taking into consideration the infection status of both parents simultaneously...
  95. doi request reprint Quantitative immunochemical fecal occult blood testing for colorectal adenoma detection: evaluation in the target population of screening and comparison with qualitative tests
    Ulrike Haug
    German Cancer Research Center, Heidelberg, Germany
    Am J Gastroenterol 105:682-90. 2010
    ....
  96. doi request reprint Improvements in survival of adults diagnosed with acute myeloblastic leukemia in the early 21st century
    Dianne Pulte
    Div of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Haematologica 93:594-600. 2008
    ....
  97. doi request reprint Ethnicity and health care in cervical cancer survival: comparisons between a Filipino resident population, Filipino-Americans, and Caucasians
    Maria Theresa Redaniel
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 18:2228-34. 2009
    ..01-1.47). The differences in cervical cancer survival between patients in the Philippines and in the United States highlight the importance of enhanced health care and access to diagnostic and treatment facilities in the Philippines...
  98. doi request reprint Trends in 5- and 10-year survival after diagnosis with childhood hematologic malignancies in the United States, 1990-2004
    Dianne Pulte
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    J Natl Cancer Inst 100:1301-9. 2008
    ....
  99. ncbi request reprint Long-term survival rates of patients with prostate cancer in the prostate-specific antigen screening era: population-based estimates for the year 2000 by period analysis
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    J Clin Oncol 23:441-7. 2005
    ..In this study, we applied a new method for up-to-date analysis of long-term survival to evaluate if and to what extent these patients still have any excess mortality compared to the general population...
  100. ncbi request reprint Are patients diagnosed with breast cancer before age 50 years ever cured?
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Aging, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    J Clin Oncol 22:432-8. 2004
    ..The aim of this study was to assess long-term survival in a large population-based sample of patients diagnosed with breast cancer before age 50 years...