Hermann Brenner

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. ncbi request reprint Interval cancers after negative colonoscopy: population-based case-control study
    Hermann Brenner
    Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Heidelberg, Germany
    Gut 61:1576-82. 2012
  2. pmc Effect of screening sigmoidoscopy and screening colonoscopy on colorectal cancer incidence and mortality: systematic review and meta-analysis of randomised controlled trials and observational studies
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, INF 581, 69120 Heidelberg, Germany German Cancer Consortium, Heidelberg, Germany
    BMJ 348:g2467. 2014
  3. pmc Sex differences in colorectal cancer survival: population-based analysis of 164,996 colorectal cancer patients in Germany
    Ondrej Majek
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    PLoS ONE 8:e68077. 2013
  4. ncbi request reprint Colorectal cancer
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Heidelberg, Germany German Cancer Consortium DKTK, Heidelberg, Germany Electronic address
    Lancet 383:1490-502. 2014
  5. pmc Identification and evaluation of plasma microRNAs for early detection of colorectal cancer
    Xiaoya Luo
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 8:e62880. 2013
  6. pmc Survival from colorectal cancer in Germany in the early 21st century
    O Majek
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, D 69120, Heidelberg, Germany
    Br J Cancer 106:1875-80. 2012
  7. pmc Comparison and combination of blood-based inflammatory markers with faecal occult blood tests for non-invasive colorectal cancer screening
    S Tao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre, Heidelberg, Germany
    Br J Cancer 106:1424-30. 2012
  8. pmc F2RL3 Methylation as a Biomarker of Current and Lifetime Smoking Exposures
    Yan Zhang
    Division of Clinical Epidemiology and Aging Research, and
    Environ Health Perspect 122:131-7. 2014
  9. pmc Standard errors of non-standardised and age-standardised relative survival of cancer patients
    L Jansen
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, POB 10 19 49, Heidelberg D 69009, Germany
    Br J Cancer 106:569-74. 2012
  10. ncbi request reprint Reduced risk of colorectal cancer up to 10 years after screening, surveillance, or diagnostic colonoscopy
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany German Cancer Consortium, Heidelberg, Germany Electronic address
    Gastroenterology 146:709-17. 2014

Collaborators

Detail Information

Publications222 found, 100 shown here

  1. ncbi request reprint Interval cancers after negative colonoscopy: population-based case-control study
    Hermann Brenner
    Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Heidelberg, Germany
    Gut 61:1576-82. 2012
    ..The risk of colorectal cancer after a previous negative colonoscopy is very low. Nevertheless, interval cancers occur. We aimed to assess the characteristics and predictors of interval cancers after negative colonoscopy...
  2. pmc Effect of screening sigmoidoscopy and screening colonoscopy on colorectal cancer incidence and mortality: systematic review and meta-analysis of randomised controlled trials and observational studies
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, INF 581, 69120 Heidelberg, Germany German Cancer Consortium, Heidelberg, Germany
    BMJ 348:g2467. 2014
    ..To review, summarise, and compare the evidence for effectiveness of screening sigmoidoscopy and screening colonoscopy in the prevention of colorectal cancer occurrence and deaths...
  3. pmc Sex differences in colorectal cancer survival: population-based analysis of 164,996 colorectal cancer patients in Germany
    Ondrej Majek
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    PLoS ONE 8:e68077. 2013
    ..The effect of sex hormones, either endogenous or through hormonal replacement therapy, might be the most plausible explanation for the observed patterns. ..
  4. ncbi request reprint Colorectal cancer
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Heidelberg, Germany German Cancer Consortium DKTK, Heidelberg, Germany Electronic address
    Lancet 383:1490-502. 2014
    ..Screening has been shown to reduce colorectal cancer incidence and mortality, but organised screening programmes are still to be implemented in most countries...
  5. pmc Identification and evaluation of plasma microRNAs for early detection of colorectal cancer
    Xiaoya Luo
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 8:e62880. 2013
    ..Circulating microRNAs (miRNAs) have been suggested as potentially promising markers for early detection of CRC. We aimed to identify and evaluate a panel of miRNAs that might be suitable for CRC early detection...
  6. pmc Survival from colorectal cancer in Germany in the early 21st century
    O Majek
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, D 69120, Heidelberg, Germany
    Br J Cancer 106:1875-80. 2012
    ..The aim of this study is to provide detailed analysis of recent developments in survival of colorectal cancer patients using newly available data on a national basis...
  7. pmc Comparison and combination of blood-based inflammatory markers with faecal occult blood tests for non-invasive colorectal cancer screening
    S Tao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre, Heidelberg, Germany
    Br J Cancer 106:1424-30. 2012
    ..Faecal occult blood tests (FOBTs) are widely used for colorectal cancer (CRC) screening. Blood-based inflammatory markers have been suggested as alternative or supplementary non-invasive CRC screening tests...
  8. pmc F2RL3 Methylation as a Biomarker of Current and Lifetime Smoking Exposures
    Yan Zhang
    Division of Clinical Epidemiology and Aging Research, and
    Environ Health Perspect 122:131-7. 2014
    ..Citation: Zhang Y, Yang R, Burwinkel B, Breitling LP, Brenner H. 2014. F2RL3 methylation as a biomarker of current and lifetime smoking exposures. Environ Health Perspect 122:131-137; http://dx.doi.org/10.1289/ehp.1306937. ..
  9. pmc Standard errors of non-standardised and age-standardised relative survival of cancer patients
    L Jansen
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, POB 10 19 49, Heidelberg D 69009, Germany
    Br J Cancer 106:569-74. 2012
    ..Here, we provide a more comprehensive evaluation of the accuracy of standard errors including age-standardised survival and estimation by the Ederer II method...
  10. ncbi request reprint Reduced risk of colorectal cancer up to 10 years after screening, surveillance, or diagnostic colonoscopy
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany German Cancer Consortium, Heidelberg, Germany Electronic address
    Gastroenterology 146:709-17. 2014
    ..Observational studies have suggested that colonoscopies strongly reduce the risk of CRC, but there is little specific evidence on the effects of screening colonoscopies...
  11. doi request reprint Comparisons of colorectal cancer mortality between screening participants and the general population are strongly biased unless an incidence-based mortality approach is used
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany German Cancer Consortium DKTK, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany Electronic address
    J Clin Epidemiol 67:184-9. 2014
    ....
  12. doi request reprint In the era of widespread endoscopy use, randomized trials may strongly underestimate the effects of colorectal cancer screening
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelber, Germany
    J Clin Epidemiol 66:1144-50. 2013
    ..We aimed to quantify their potential impact in RCTs evaluating endoscopic screening for colorectal cancer (CRC)...
  13. ncbi request reprint Colorectal cancers occurring after colonoscopy with polyp detection: sites of polyps and sites of cancers
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, Heidelberg, Germany
    Int J Cancer 133:1672-9. 2013
    ..8%, 95% confidence interval 2.7%-19.3%). Our study suggests that less than one of nine CRCs occurring within 10 years after colonoscopy with polyp detection may be due to field effects or polyp recrudescence. ..
  14. pmc Assisted reproductive techniques and the risk of anorectal malformations: a German case-control study
    Nadine Zwink
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Orphanet J Rare Dis 7:65. 2012
    ..Therefore, we assessed the risk of anorectal malformations (ARM) after in-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI)...
  15. pmc Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases
    Stefanie Huhn
    Department of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Med Genet 13:94. 2012
    ..A two-stage case-control study on CRC susceptibility was conducted to assess the influence of the ancestral alleles in the polymorphisms previously associated with nutrition-related complex diseases...
  16. pmc Survival of endometrial cancer patients in Germany in the early 21st century: a period analysis by age, histology, and stage
    Tianhui Chen
    Institute of Social and Family Medicine, School of Public Health, Zhejiang University, Hangzhou, China
    BMC Cancer 12:128. 2012
    ..Population-based studies on endometrial cancer providing survival estimates by age, histology, and stage have been sparse. We aimed to derive most up-to-date and detailed survival estimates for endometrial cancer patients in Germany...
  17. doi request reprint Superior diagnostic performance of faecal immunochemical tests for haemoglobin in a head-to-head comparison with guaiac based faecal occult blood test among 2235 participants of screening colonoscopy
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld, 69120 Heidelberg, Germany
    Eur J Cancer 49:3049-54. 2013
    ..In conclusion, FITs can detect much larger proportions of colorectal neoplasms even if their cut-offs are set to levels that ensure equally low positivity rates as gFOBT...
  18. doi request reprint Natural history of colorectal adenomas: birth cohort analysis among 3.6 million participants of screening colonoscopy
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 22:1043-51. 2013
    ..Most colorectal cancers (CRC) develop from adenomas. Knowledge of the natural history of colorectal adenomas, which is not directly observable for ethical reasons, is crucial for designing cost-effective CRC screening strategies...
  19. doi request reprint Gastric parietal cell antibodies, Helicobacter pylori infection, and chronic atrophic gastritis: evidence from a large population-based study in Germany
    Yan Zhang
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 22:821-6. 2013
    ..pylori)-associated gastritis have suggested a potential link between these two pathologic conditions in the progression of chronic atrophic gastritis (CAG); however, evidence has remained conflicting...
  20. doi request reprint [Colorectal cancer screening]
    Hermann Brenner
    Abteilung Klinische Epidemiologie und Alternsforschung, Deutsches Krebsforschungszentrum, Heidelberg
    Ther Umsch 70:231-5; discussion 236. 2013
    ..Evidence from a range of countries shows that the highest participation rates are obtained when programs are designed to invite eligible individuals to come in for screening...
  21. doi request reprint Determinants and interpretation of death certificate only proportions in the initial years of newly established cancer registries
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, INF 581, D 69120 Heidelberg, Germany
    Eur J Cancer 49:931-7. 2013
    ....
  22. doi request reprint Matching of controls may lead to biased estimates of specificity in the evaluation of cancer screening tests
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, INF 581, D 69120 Heidelberg, Germany
    J Clin Epidemiol 66:202-8. 2013
    ..We assessed the potential merits and pitfalls of such matching using an example from colorectal cancer (CRC) screening...
  23. ncbi request reprint Role of colonoscopy and polyp characteristics in colorectal cancer after colonoscopic polyp detection: a population-based case-control study
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Ann Intern Med 157:225-32. 2012
    ..Studies have identified characteristics of adenomas detected on colonoscopy to be predictive of adenoma recurrence...
  24. doi request reprint Progress in colorectal cancer survival in Europe from the late 1980s to the early 21st century: the EUROCARE study
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 131:1649-58. 2012
    ..There is a huge potential for reducing the burden of CRC in Europe by more widespread and equal delivery of existing options of effective early detection and curative treatment to the European population...
  25. ncbi request reprint Risk of colorectal cancer after detection and removal of adenomas at colonoscopy: population-based case-control study
    Hermann Brenner
    German Cancer Research Center, Heidelberg, Germany
    J Clin Oncol 30:2969-76. 2012
    ..We aimed to assess risk of colorectal cancer (CRC) according to time since polypectomy and factors that might be relevant for risk stratification...
  26. ncbi request reprint Gender differences in healthcare utilization of patients with diabetes
    Heike U Krämer
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Am J Manag Care 18:362-9. 2012
    ..To examine gender differences in healthcare utilization including outpatient and inpatient medical care for patients with type 2 diabetes mellitus (T2DM), despite participation in T2DM-specific disease management programs (DMP-DM)...
  27. doi request reprint Calcium, phosphate and the risk of cardiovascular events and all-cause mortality in a population with stable coronary heart disease
    Norma Christine Grandi
    Division of Clinical Epidemiology and Aging Research C070, German Cancer Research Centre, POB 10 19 49, D 69009 Heidelberg, Germany
    Heart 98:926-33. 2012
    ..The association between baseline calcium and phosphate and prognosis was examined in a cohort study of patients with stable coronary heart disease...
  28. pmc Parental risk factors and anorectal malformations: systematic review and meta-analysis
    Nadine Zwink
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Orphanet J Rare Dis 6:25. 2011
    ..Besides genetic factors, prenatal exposures of the parents to nicotine, alcohol, caffeine, illicit drugs, occupational hazards, overweight/obesity and diabetes mellitus are suspected as environmental risk factors...
  29. pmc Prognostic value of physicians' assessment of compliance regarding all-cause mortality in patients with type 2 diabetes: primary care follow-up study
    Dietrich Rothenbacher
    Dept of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
    BMC Fam Pract 7:42. 2006
    ..The objective of this prospective cohort study was to investigate the prognostic value of the physicians' assessment of patient compliance and other factors with respect to all-cause mortality during a one year follow-up period...
  30. ncbi request reprint Inter-test agreement and quantitative cross-validation of immunochromatographical fecal occult blood tests
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 127:1643-9. 2010
    ..Definition of cutoffs is a critical issue in the application of immunochromatographical tests and should be redefined for several of these tests...
  31. doi request reprint Low-dose aspirin use and performance of immunochemical fecal occult blood tests
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    JAMA 304:2513-20. 2010
    ..Low-dose aspirin use, which increases the likelihood of gastrointestinal bleeding, is common in the target population for colorectal cancer screening...
  32. doi request reprint Sex differences in performance of fecal occult blood testing
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Am J Gastroenterol 105:2457-64. 2010
    ..We aimed to assess potential sex differences in performance of iFOBTs and gFOBT in the screening setting...
  33. doi request reprint Long-term risk of colorectal cancer after negative colonoscopy
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany D 69120
    J Clin Oncol 29:3761-7. 2011
    ..We aimed to assess the risk of CRC according to time since negative colonoscopy, overall, and by sex, smoking, and family history of CRC, in a large population-based case-control study...
  34. doi request reprint Deriving valid population-based cancer survival estimates in the presence of nonnegligible proportions of cancers notified by death certificates only
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 20:2480-6. 2011
    ..Patients notified by death certificates only (DCO) are commonly excluded from such studies. The validity of this "exclude DCO" approach has been questioned and an alternative "correct for DCO" approach has been proposed...
  35. doi request reprint Sojourn time of preclinical colorectal cancer by sex and age: estimates from the German national screening colonoscopy database
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer ResearchCenter, Im Neuenheimer Feld 581, Heidelberg, Germany
    Am J Epidemiol 174:1140-6. 2011
    ..This study provides, for the first time, precise estimates of sojourn time by age and sex, and it suggests that sojourn times are remarkably consistent across age groups and in both sexes...
  36. doi request reprint Long-term survival expectations of cancer patients in Europe in 2000-2002
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Eur J Cancer 45:1028-41. 2009
    ..Furthermore, relative survival was also better in female than in male patients and decreased with age for most cancer sites...
  37. ncbi request reprint Effect of APOE genotype on lipid levels in patients with coronary heart disease during a 3-week inpatient rehabilitation program
    C Y Vossen
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Clin Pharmacol Ther 84:222-7. 2008
    ..We therefore found no evidence that APOE genotyping will be useful in guiding dietary or pharmacological lipid-lowering treatment decisions...
  38. doi request reprint Efficacy, effectiveness and cost-effectiveness of endoscopic screening methods
    H Brenner
    Div of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Z Gastroenterol 46:S20-2. 2008
    ..Even higher cost-effectiveness is to be expected if screening intervals can be extended to 20 or more years, as suggested by recent epidemiological evidence...
  39. ncbi request reprint Dopamine-related genes and spontaneous smoking cessation in ever-heavy smokers
    Lutz P Breitling
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, TP4 INF581, 69120 Heidelberg, Germany
    Pharmacogenomics 12:1099-106. 2011
    ..Several studies have provided evidence for associations of polymorphisms located in and near dopamine-related genes and nicotine dependence and other smoking-related phenotypes, including pharmacogenetic interactions...
  40. ncbi request reprint Inverse association between a pro-inflammatory genetic profile and Helicobacter pylori seropositivity among patients with chronic atrophic gastritis: enhanced elimination of the infection during disease progression?
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, Heidelberg D 69115, Germany
    Eur J Cancer 45:2860-6. 2009
    ..There is increasing evidence of frequent clearance of the infection during progression of CAG. We aimed to assess the association between host inflammatory polymorphisms and H. pylori seropositivity among CAG patients from Germany...
  41. ncbi request reprint SULT1A1 genotype and susceptibility to colorectal cancer
    Carmen Lilla
    Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 120:201-6. 2007
    ....
  42. doi request reprint The association of cyclin D1 G870A and E-cadherin C-160A polymorphisms with the risk of colorectal cancer in a case control study and meta-analysis
    Xiang Lin Tan
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 122:2573-80. 2008
    ..However, the CCND1 G870A polymorphism may modify the protective effect of postmenopausal hormone use on the development of CRC...
  43. ncbi request reprint Protection from right- and left-sided colorectal neoplasms after colonoscopy: population-based study
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    J Natl Cancer Inst 102:89-95. 2010
    ....
  44. ncbi request reprint Cancer survival in Germany and the United States at the beginning of the 21st century: an up-to-date comparison by period analysis
    Adam Gondos
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 121:395-400. 2007
    ..Among these, differences between patients with breast and prostate cancer are probably due to more intensive screening activities...
  45. ncbi request reprint Frailty prevalence and 10-year survival in community-dwelling older adults: results from the ESTHER cohort study
    Kai Uwe Saum
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany
    Eur J Epidemiol 29:171-9. 2014
    ..We found sex differences in the FI and its increase with age, along with a consistent strong association of the FI with mortality in both sexes, even for age group 50-64...
  46. doi request reprint Serum 25-hydroxyvitamin D levels and incident diabetes mellitus type 2: a competing risk analysis in a large population-based cohort of older adults
    Ben Schöttker
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany
    Eur J Epidemiol 28:267-75. 2013
    ..In this large cohort study of older adults, serum 25(OH)D levels were inversely associated with incident diabetes in women but not in men. The association was particularly strong in subjects with renal dysfunction...
  47. pmc Gender disparities in diabetes and coronary heart disease medication among patients with type 2 diabetes: results from the DIANA study
    Heike U Krämer
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, D 69120, Heidelberg, Germany
    Cardiovasc Diabetol 11:88. 2012
    ..Coronary heart disease (CHD) is one of the most common long-term complications in people with type 2 diabetes. We analyzed whether or not gender differences exist in diabetes and CHD medication among people with type 2 diabetes...
  48. doi request reprint Kidney graft survival in Europe and the United States: strikingly different long-term outcomes
    Adam Gondos
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Transplantation 95:267-74. 2013
    ..Kidney graft survival has never been systematically compared between Europe and the United States...
  49. ncbi request reprint Cigarette smoking and colorectal cancer risk in Germany: a population-based case-control study
    Emaculate Verla-Tebit
    Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 119:630-5. 2006
    ..This study supports the hypothesis that smoking for a long duration at a high cumulative dose increases the risk for colorectal cancer, particularly among women, and suggests that there is risk reduction after longterm smoking cessation...
  50. doi request reprint Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM
    Bernd Frank
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, 69115 Heidelberg, Germany
    Carcinogenesis 31:442-5. 2010
    ..Although none of them showed a significant association with CRC, the association of BLM P868L with rectal cancer risk requires further investigation...
  51. doi request reprint Low risk of colorectal cancer and advanced adenomas more than 10 years after negative colonoscopy
    Hermann Brenner
    Division of Clinical Epidemiology of Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Gastroenterology 138:870-6. 2010
    ..There is little empirical evidence available about the optimal interval for screening, making this a subject of debate. We associated the prevalence of advanced colorectal neoplasms with time since negative colonoscopies...
  52. ncbi request reprint Is vitamin D deficiency a cause of increased morbidity and mortality at older age or simply an indicator of poor health?
    Ben Schöttker
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany
    Eur J Epidemiol 29:199-210. 2014
    ..In conclusion, vitamin D deficiency may not cause frailty or poor general health but may nevertheless be a prognostic marker for mortality, independent of the individual's morbidity. ..
  53. ncbi request reprint Vitamin D receptor polymorphism and colorectal cancer-specific and all-cause mortality
    Laura Perna
    German Cancer Research Center DKFZ Division of Clinical Epidemiology and Aging Research, Im Neuenheimer Feld, 581 69120 Heidelberg, Germany Electronic address
    Cancer Epidemiol 37:905-7. 2013
    ..The vitamin D receptor (VDR) gene is present in colorectal cancer (CRC) cells and its genetic variants have been associated with an increased risk of CRC. The association with colorectal cancer prognosis remains widely unexplored...
  54. doi request reprint Cancer survival in Eastern and Western Germany after the fall of the iron curtain
    Lina Jansen
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Eur J Epidemiol 27:689-93. 2012
    ....
  55. doi request reprint Vitamin D receptor genotype rs731236 (Taq1) and breast cancer prognosis
    Laura Perna
    Corresponding Author Laura Perna, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, INF 581 TP4, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 22:437-42. 2013
    ....
  56. doi request reprint Strong associations of 25-hydroxyvitamin D concentrations with all-cause, cardiovascular, cancer, and respiratory disease mortality in a large cohort study
    Ben Schöttker
    Divisions of Clinical Epidemiology and Aging Research and Preventive Oncology, German Cancer Research Center, Heidelberg, Germany
    Am J Clin Nutr 97:782-93. 2013
    ..Serum 25-hydroxyvitamin D [25(OH)D] concentration has been linked to mortality in several studies, but appropriate cutoffs to define risk categories are under debate...
  57. doi request reprint Evaluation of serum and urinary myeloid related protein-14 as a marker for early detection of prostate cancer
    Heiko Muller
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    J Urol 180:1309-12; discussion 1312-3. 2008
    ..In diagnostic studies promising results were shown for myeloid related protein-14 in serum and urine. However, confirmation in longitudinal population based studies is needed...
  58. doi request reprint Copy number variations of GSTT1 and GSTM1, colorectal cancer risk and possible effect modification of cigarette smoking and menopausal hormone therapy
    Anja Rudolph
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 131:E841-8. 2012
    ..18) for GSTM1. No significant interaction with smoking and MHT use was observed. Our study does not provide evidence for a strong association between CRC risk and CNVs of GSTT1 or GSTM1 or for an effect modification of smoking or MHT use...
  59. ncbi request reprint Synergism between smoking and alcohol consumption with respect to serum gamma-glutamyltransferase
    Lutz Philipp Breitling
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Hepatology 49:802-8. 2009
    ..9 (1.1-7.6) in women and to 3.8 (2.2-6.6) in men (test for interaction between alcohol consumption and smoking: P(females) = 0.12, P(males) = 0.0017)...
  60. ncbi request reprint Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer
    Bernd Frank
    German Cancer Research Center, Heidelberg, Germany
    Carcinogenesis 31:1381-6. 2010
    ..However, our results provide evidence that CRC subsets may be affected. If confirmed, this knowledge may be used to assess individual susceptibility and to target potential measures of cancer prevention...
  61. ncbi request reprint Mutant-enriched PCR and allele-specific hybridization reaction to detect K-ras mutations in stool DNA: high prevalence in a large sample of older adults
    Ulrike Haug
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Clin Chem 53:787-90. 2007
    ..We investigated the prevalence and potential determinants of mutant K-ras in stool in a large sample of unselected older adults and assessed the association with colonoscopic findings...
  62. doi request reprint Using rate advancement periods for communicating the benefits of quitting smoking to older smokers
    Carolin Gellert
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Tob Control 22:227-30. 2013
    ..We provide empirical evidence on the impact of smoking, and the benefits of quitting on all-cause mortality and RAPs for people aged 60 years and older in a large cohort of older adults...
  63. ncbi request reprint Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumption
    Carmen Lilla
    Division of Clinical Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 15:99-107. 2006
    ....
  64. doi request reprint Impact of smoking and quitting on cardiovascular outcomes and risk advancement periods among older adults
    Carolin Gellert
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany
    Eur J Epidemiol 28:649-58. 2013
    ..Smoking is a strong risk factor for cardiovascular events even at older age. Smoking cessation is highly and rapidly beneficial also at advanced age. ..
  65. doi request reprint Asymmetric and symmetric dimethylarginine and risk of secondary cardiovascular disease events and mortality in patients with stable coronary heart disease: the KAROLA follow-up study
    Bob Siegerink
    German Cancer Research Center DKFZ, Division of Clinical Epidemiology and Aging Research C070, Heidelberg, Germany
    Clin Res Cardiol 102:193-202. 2013
    ..This study aimed to determine the associations of both ADMA and SDMA levels with secondary cardiovascular disease events and all-cause mortality in patients with stable coronary heart disease (CHD)...
  66. doi request reprint Genetic variations in the vitamin D binding protein and season-specific levels of vitamin D among older adults
    Laura Perna
    German Cancer Research Center DKFZ, Division of Clinical Epidemiology and Aging Research, Im Neuenheimer Feld 581, Heidelberg, Germany
    Epidemiology 24:104-9. 2013
    ..The quantification of this association among older women and men and its potential variation by season remain unexplored...
  67. doi request reprint Gender specific temporal and cross-sectional associations between BMI-class and symptoms of depression in the elderly
    Beate Wild
    Department of General Internal Medicine and Psychosomatics, Medical University Hospital, Heidelberg, Germany
    J Psychosom Res 72:376-82. 2012
    ..The aim of the study was the gender specific analysis of cross-sectional and longitudinal associations between body mass index class (BMI-class) and symptoms of depression in a representative sample of elderly German people...
  68. ncbi request reprint Helicobacter pylori infection, chronic atrophic gastritis and major cardiovascular events: a population-based cohort study
    Ben Schöttker
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Atherosclerosis 220:569-74. 2012
    ..There is debate whether infection with Helicobacter (H.) pylori, the main inducer of chronic atrophic gastritis (CAG), is a risk factor for cardiovascular disease and premature mortality...
  69. doi request reprint Serum parathyroid hormone and risk of adverse outcomes in patients with stable coronary heart disease
    Norma Christine Grandi
    Division of Clinical Epidemiology and Ageing Research C070, German Cancer Research Center, Heidelberg, Germany
    Heart 97:1215-21. 2011
    ..This study presents analyses of the prognostic value of baseline PTH for subsequent cardiovascular events and all-cause mortality in a high-risk population with stable coronary heart disease...
  70. doi request reprint Exposure to environmental tobacco smoke and the risk of colorectal cancer in a case-control study from Germany
    Emaculate Verla-Tebit
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Eur J Cancer Prev 18:9-12. 2009
    ..03-12.15) and for women exposed to >23 pack-years of spousal smoking (OR: 3.02; 95% CI: 0.99-9.28). Our findings do not indicate a major impact of ETS on CRC risk but suggest that risk may be increased following spousal exposure...
  71. doi request reprint Sibship size, Helicobacter pylori infection and chronic atrophic gastritis: a population-based study among 9444 older adults from Germany
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Epidemiol 39:129-34. 2010
    ..We aimed to assess the association of sibship size with H. pylori infection and chronic atrophic gastritis (CAG) in a population-based study from Germany...
  72. ncbi request reprint Alcohol consumption and chronic atrophic gastritis: population-based study among 9,444 older adults from Germany
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 125:2918-22. 2009
    ..pylori. However, the observed patterns suggest that other mechanisms are likely to contribute to the association as well...
  73. pmc Inter-country and ethnic variation in colorectal cancer survival: comparisons between a Philippine population, Filipino-Americans and Caucasians
    Maria Theresa Redaniel
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    BMC Cancer 10:100. 2010
    ....
  74. doi request reprint Alcohol consumption, serum gamma-glutamyltransferase, and helicobacter pylori infection in a population-based study among 9733 older adults
    Lei Gao
    German Cancer Research Center, Heidelberg, Germany
    Ann Epidemiol 20:122-8. 2010
    ..pylori infection in a large population-based study...
  75. ncbi request reprint Changes of cardiovascular risk factors and their implications in subsequent birth cohorts of older adults in Germany: a life course approach
    Elke Raum
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Eur J Cardiovasc Prev Rehabil 14:809-14. 2007
    ....
  76. ncbi request reprint Household contacts were key factor for children's colonization with resistant Escherichia coli in community setting
    Susanne Lietzau
    Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
    J Clin Epidemiol 60:1149-55. 2007
    ..coli) can lead to life-threatening situations. Epidemiological data on the prevalence and major determinants of carriage of antibiotic resistant E. coli among children in the community setting are sparse...
  77. doi request reprint Genetic polymorphisms in GST genes and survival of colorectal cancer patients treated with chemotherapy
    Silvia Funke
    German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Pharmacogenomics 11:33-41. 2010
    ..Genetic polymorphisms in GST genes (GSTP1 Ile105Val, copy-number variants of GSTM1 and GSTT1) that lead to diminished enzyme activity have been associated with increased chemotherapeutic treatment benefit in colorectal cancer patients...
  78. pmc Risk of progression of advanced adenomas to colorectal cancer by age and sex: estimates based on 840,149 screening colonoscopies
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Gut 56:1585-9. 2007
    ..To derive age and sex specific estimates of transition rates from advanced adenomas to colorectal cancer by combining data of a nationwide screening colonoscopy registry and national data on colorectal cancer (CRC) incidence...
  79. ncbi request reprint Genotype combinations of plasminogen activator inhibitor-1 and angiotensin-converting enzyme genes and risk for early onset of coronary heart disease
    Michael Loew
    Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
    Eur J Cardiovasc Prev Rehabil 13:449-56. 2006
    ....
  80. ncbi request reprint Epidemiologic findings on serologically defined chronic atrophic gastritis strongly depend on the choice of the cutoff-value
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 121:2782-6. 2007
    ..The association of age and H. pylori infection with CAG may be strongly underestimated in studies in which CAG is defined by pepsinogen I only...
  81. doi request reprint Population-based prevalence estimates of history of colonoscopy or sigmoidoscopy: review and analysis of recent trends
    Christian Stock
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Gastrointest Endosc 71:366-381.e2. 2010
    ..We aimed to review prevalence estimates of history of colonoscopy or sigmoidoscopy in the general population and to analyze recent trends...
  82. ncbi request reprint Survival of stomach and esophagus cancer patients in Germany in the early 21st century
    Eva Hiripi
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Acta Oncol 51:906-14. 2012
    ..The aim of this study was to provide up-to-date survival estimates and trends for patients with stomach and esophagus cancer in Germany...
  83. ncbi request reprint Prevalence and determinants of exocrine pancreatic insufficiency among older adults: results of a population-based study
    Dietrich Rothenbacher
    Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
    Scand J Gastroenterol 40:697-704. 2005
    ..The prevalence and main determinants of exocrine pancreatic insufficiency were investigated in a large population-based sample of older adults by measuring pancreatic elastase-1 in stool...
  84. doi request reprint Longitudinal predictors of health-related quality of life in middle-aged and older adults with hypertension: results of a population-based study
    Imad Maatouk
    Department of General Internal Medicine and Psychosomatics, Medical University Hospital Heidelberg, Heidelberg, Germany
    J Hypertens 30:1364-72. 2012
    ..g. awareness of hypertension, number of types of antihypertensive drugs, comorbidity), and health-related quality of life (HRQOL) in a large cohort of patients with hypertension, over a follow-up period of 5 years...
  85. ncbi request reprint Death receptor 4 variants and colorectal cancer risk
    Bernd Frank
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 15:2002-5. 2006
    ..37; 95% CI, 0.98-5.76). The score statistic yielded an empirical P of 0.03 of the haplotype-specific test for 626C-683C based on 20,000 simulations, suggesting that DR4 626C-683C may affect colorectal cancer predisposition...
  86. doi request reprint Effect of type 2 diabetes predisposing genetic variants on colorectal cancer risk
    Juan Sainz
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Clin Endocrinol Metab 97:E845-51. 2012
    ..The link between colorectal cancer (CRC) and type 2 diabetes mellitus (T2D) has been extensively studied. Although it is commonly accepted that T2D is a risk factor for CRC, the underlying mechanisms are still poorly understood...
  87. ncbi request reprint Potential for colorectal cancer prevention of sigmoidoscopy versus colonoscopy: population-based case control study
    Hermann Brenner
    Department of Epidemiology, German Cancer Research Center, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 16:494-9. 2007
    ..Among men, this regimen may be almost as effective as colonoscopy, at least at previous performance levels of colonoscopy...
  88. doi request reprint Model-based projections for deriving up-to-date cancer survival estimates: an international evaluation
    Adam Gondos
    Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 125:2666-72. 2009
    ..Projections from model-based analysis may contribute to improved timeliness of monitoring of concurrent trends in population-based cancer survival in cancer registries operating in different populations and socioeconomic environments...
  89. ncbi request reprint Expected reduction of colorectal cancer incidence within 8 years after introduction of the German screening colonoscopy programme: estimates based on 1,875,708 screening colonoscopies
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, D 69115 Heidelberg, Germany
    Eur J Cancer 45:2027-33. 2009
    ..Our results forecast a major rapid reduction of the CRC burden in Germany by screening colonoscopy...
  90. doi request reprint Epidemiology of chronic kidney disease: results from a population of older adults in Germany
    Qiu Li Zhang
    German Cancer Research Center, Heidelberg, Germany
    Prev Med 48:122-7. 2009
    ..To determine prevalences and stages of chronic kidney disease (CKD), and evaluate association of CKD with related covariables in a large population of older adults...
  91. doi request reprint Prognostic value of haemoglobin A1c and fasting plasma glucose for incident diabetes and implications for screening
    Ben Schöttker
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Eur J Epidemiol 26:779-87. 2011
    ..FPG and HbA(1c) have comparable (yet insufficient) abilities in identifying individuals at high risk for diabetes. Effectiveness of a diabetes screening program could be improved by a risk score including FPG and HbA(1c)...
  92. doi request reprint Type 2 diabetes mellitus and gender-specific risk for colorectal neoplasia
    Heike Ursula Krämer
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, INF 581, 69120 Heidelberg, Germany
    Eur J Epidemiol 27:341-7. 2012
    ..01; 95 % CI 0.71-1.43). T2DM might have a stronger impact on CN among women than among men. Further research should examine possible reasons for these differences...
  93. pmc Temporal predictors of health-related quality of life in elderly people with diabetes: results of a German cohort study
    Imad Maatouk
    Department of General Internal Medicine and Psychosomatics, Medical University Hospital Heidelberg, Heidelberg, Germany
    PLoS ONE 7:e31088. 2012
    ..The aim of the study was to determine predictors that influence health-related quality of life (HRQOL) in a large cohort of elderly diabetes patients from primary care over a follow-up period of five years...
  94. pmc Age-specific administration of chemotherapy and long-term quality of life in stage II and III colorectal cancer patients: a population-based prospective cohort
    Lina Jansen
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Heidelberg, Germany
    Oncologist 16:1741-51. 2011
    ..To investigate the age-specific pattern of administration of chemotherapy and its association with long-term survival and quality of life (QoL) in stage II and III colorectal cancer patients...
  95. doi request reprint Association between a pro-inflammatory genetic profile and the risk of chronic atrophic gastritis among older adults from Germany
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Eur J Cancer 45:428-34. 2009
    ..We aimed to assess their impact on the risk of chronic atrophic gastritis (CAG) in a population-based study...
  96. ncbi request reprint Validity of self-reported endoscopies of the large bowel and implications for estimates of colorectal cancer risk
    Michael Hoffmeister
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Am J Epidemiol 166:130-6. 2007
    ..58), and reasonable for year of examination (kappa = 0.70). Self-reports of previous colorectal endoscopies agreed well with medical records, but validation appears to be essential with respect to details of the examination...
  97. doi request reprint Low-to-moderate alcohol consumption and smoking cessation rates: retrospective analysis of 4576 elderly ever-smokers
    Lutz Philipp Breitling
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Drug Alcohol Depend 108:122-9. 2010
    ..We aimed to elucidate the association of concurrent alcohol consumption with the probability of smoking cessation in non-clinical populations...
  98. ncbi request reprint Quality of life over 5 years in women with breast cancer after breast-conserving therapy versus mastectomy: a population-based study
    Volker Arndt
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Bergheimer Strasse 20, 69115 Heidelberg, Germany
    J Cancer Res Clin Oncol 134:1311-8. 2008
    ..Therefore we compared QOL in women with breast cancer undergoing BCT versus women undergoing mastectomy over a 5-year period following primary surgery...
  99. doi request reprint Grb2-associated binder 1 (Gab1) genetic polymorphism, Helicobacter pylori infection, and chronic atrophic gastritis among older adults from Germany
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Mol Carcinog 49:869-73. 2010
    ..pylori infection and CAG in this study population from Germany. Further studies with larger sample size are needed to clarify a potential modest effect of Gab1 genetic polymorphisms...
  100. doi request reprint Male sex and smoking have a larger impact on the prevalence of colorectal neoplasia than family history of colorectal cancer
    Michael Hoffmeister
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Clin Gastroenterol Hepatol 8:870-6. 2010
    ..Screening recommendations for colorectal cancer (CRC) commonly take family history but no other risk factors into account. We compared and assessed risk factors of colorectal polyps in a large population undergoing screening colonoscopy...
  101. ncbi request reprint Variants in COMT and spontaneous smoking cessation: retrospective cohort analysis of 925 cessation events
    Lutz Philipp Breitling
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Pharmacogenet Genomics 19:657-9. 2009
    ....