Hermann Brenner

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. ncbi Gastric Parietal Cell Antibodies, Helicobacter Pylori Infection, and Chronic Atrophic Gastritis: Evidence from a Large Population-based Study in Germany
    Yan Zhang
    Corresponding Author Hermann Brenner, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 22:821-6. 2013
  2. ncbi [Colorectal cancer screening]
    Hermann Brenner
    Abteilung Klinische Epidemiologie und Alternsforschung, Deutsches Krebsforschungszentrum, Heidelberg
    Ther Umsch 70:231-5; discussion 236. 2013
  3. ncbi Determinants and interpretation of death certificate only proportions in the initial years of newly established cancer registries
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, INF 581, D 69120 Heidelberg, Germany
    Eur J Cancer 49:931-7. 2013
  4. ncbi Matching of controls may lead to biased estimates of specificity in the evaluation of cancer screening tests
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, INF 581, D 69120 Heidelberg, Germany
    J Clin Epidemiol 66:202-8. 2013
  5. ncbi Role of colonoscopy and polyp characteristics in colorectal cancer after colonoscopic polyp detection: a population-based case-control study
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Ann Intern Med 157:225-32. 2012
  6. ncbi Interval cancers after negative colonoscopy: population-based case-control study
    Hermann Brenner
    Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Heidelberg, Germany
    Gut 61:1576-82. 2012
  7. ncbi Progress in colorectal cancer survival in Europe from the late 1980s to the early 21st century: the EUROCARE study
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 131:1649-58. 2012
  8. ncbi Risk of colorectal cancer after detection and removal of adenomas at colonoscopy: population-based case-control study
    Hermann Brenner
    German Cancer Research Center, Heidelberg, Germany
    J Clin Oncol 30:2969-76. 2012
  9. ncbi Gender differences in healthcare utilization of patients with diabetes
    Heike U Krämer
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Am J Manag Care 18:362-9. 2012
  10. ncbi Calcium, phosphate and the risk of cardiovascular events and all-cause mortality in a population with stable coronary heart disease
    Norma Christine Grandi
    Division of Clinical Epidemiology and Aging Research C070, German Cancer Research Centre, POB 10 19 49, D 69009 Heidelberg, Germany
    Heart 98:926-33. 2012

Collaborators

Detail Information

Publications196 found, 100 shown here

  1. ncbi Gastric Parietal Cell Antibodies, Helicobacter Pylori Infection, and Chronic Atrophic Gastritis: Evidence from a Large Population-based Study in Germany
    Yan Zhang
    Corresponding Author Hermann Brenner, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 22:821-6. 2013
    ..pylori)-associated gastritis have suggested a potential link between these two pathologic conditions in the progression of chronic atrophic gastritis (CAG); however, evidence has remained conflicting...
  2. ncbi [Colorectal cancer screening]
    Hermann Brenner
    Abteilung Klinische Epidemiologie und Alternsforschung, Deutsches Krebsforschungszentrum, Heidelberg
    Ther Umsch 70:231-5; discussion 236. 2013
    ..Evidence from a range of countries shows that the highest participation rates are obtained when programs are designed to invite eligible individuals to come in for screening...
  3. ncbi Determinants and interpretation of death certificate only proportions in the initial years of newly established cancer registries
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, INF 581, D 69120 Heidelberg, Germany
    Eur J Cancer 49:931-7. 2013
    ....
  4. ncbi Matching of controls may lead to biased estimates of specificity in the evaluation of cancer screening tests
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, INF 581, D 69120 Heidelberg, Germany
    J Clin Epidemiol 66:202-8. 2013
    ..We assessed the potential merits and pitfalls of such matching using an example from colorectal cancer (CRC) screening...
  5. ncbi Role of colonoscopy and polyp characteristics in colorectal cancer after colonoscopic polyp detection: a population-based case-control study
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Ann Intern Med 157:225-32. 2012
    ..Studies have identified characteristics of adenomas detected on colonoscopy to be predictive of adenoma recurrence...
  6. ncbi Interval cancers after negative colonoscopy: population-based case-control study
    Hermann Brenner
    Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Heidelberg, Germany
    Gut 61:1576-82. 2012
    ..The risk of colorectal cancer after a previous negative colonoscopy is very low. Nevertheless, interval cancers occur. We aimed to assess the characteristics and predictors of interval cancers after negative colonoscopy...
  7. ncbi Progress in colorectal cancer survival in Europe from the late 1980s to the early 21st century: the EUROCARE study
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 131:1649-58. 2012
    ..There is a huge potential for reducing the burden of CRC in Europe by more widespread and equal delivery of existing options of effective early detection and curative treatment to the European population...
  8. ncbi Risk of colorectal cancer after detection and removal of adenomas at colonoscopy: population-based case-control study
    Hermann Brenner
    German Cancer Research Center, Heidelberg, Germany
    J Clin Oncol 30:2969-76. 2012
    ..We aimed to assess risk of colorectal cancer (CRC) according to time since polypectomy and factors that might be relevant for risk stratification...
  9. ncbi Gender differences in healthcare utilization of patients with diabetes
    Heike U Krämer
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Am J Manag Care 18:362-9. 2012
    ..To examine gender differences in healthcare utilization including outpatient and inpatient medical care for patients with type 2 diabetes mellitus (T2DM), despite participation in T2DM-specific disease management programs (DMP-DM)...
  10. ncbi Calcium, phosphate and the risk of cardiovascular events and all-cause mortality in a population with stable coronary heart disease
    Norma Christine Grandi
    Division of Clinical Epidemiology and Aging Research C070, German Cancer Research Centre, POB 10 19 49, D 69009 Heidelberg, Germany
    Heart 98:926-33. 2012
    ..The association between baseline calcium and phosphate and prognosis was examined in a cohort study of patients with stable coronary heart disease...
  11. ncbi Parental risk factors and anorectal malformations: systematic review and meta-analysis
    Nadine Zwink
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Orphanet J Rare Dis 6:25. 2011
    ..Besides genetic factors, prenatal exposures of the parents to nicotine, alcohol, caffeine, illicit drugs, occupational hazards, overweight/obesity and diabetes mellitus are suspected as environmental risk factors...
  12. ncbi Prognostic value of physicians' assessment of compliance regarding all-cause mortality in patients with type 2 diabetes: primary care follow-up study
    Dietrich Rothenbacher
    Dept of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
    BMC Fam Pract 7:42. 2006
    ..The objective of this prospective cohort study was to investigate the prognostic value of the physicians' assessment of patient compliance and other factors with respect to all-cause mortality during a one year follow-up period...
  13. ncbi Sex differences in performance of fecal occult blood testing
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Am J Gastroenterol 105:2457-64. 2010
    ..We aimed to assess potential sex differences in performance of iFOBTs and gFOBT in the screening setting...
  14. ncbi Low-dose aspirin use and performance of immunochemical fecal occult blood tests
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    JAMA 304:2513-20. 2010
    ..Low-dose aspirin use, which increases the likelihood of gastrointestinal bleeding, is common in the target population for colorectal cancer screening...
  15. ncbi Long-term risk of colorectal cancer after negative colonoscopy
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany D 69120
    J Clin Oncol 29:3761-7. 2011
    ..We aimed to assess the risk of CRC according to time since negative colonoscopy, overall, and by sex, smoking, and family history of CRC, in a large population-based case-control study...
  16. ncbi Sojourn time of preclinical colorectal cancer by sex and age: estimates from the German national screening colonoscopy database
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer ResearchCenter, Im Neuenheimer Feld 581, Heidelberg, Germany
    Am J Epidemiol 174:1140-6. 2011
    ..This study provides, for the first time, precise estimates of sojourn time by age and sex, and it suggests that sojourn times are remarkably consistent across age groups and in both sexes...
  17. ncbi Inter-test agreement and quantitative cross-validation of immunochromatographical fecal occult blood tests
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 127:1643-9. 2010
    ..Definition of cutoffs is a critical issue in the application of immunochromatographical tests and should be redefined for several of these tests...
  18. ncbi Long-term survival expectations of cancer patients in Europe in 2000-2002
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Eur J Cancer 45:1028-41. 2009
    ..Furthermore, relative survival was also better in female than in male patients and decreased with age for most cancer sites...
  19. ncbi Effect of APOE genotype on lipid levels in patients with coronary heart disease during a 3-week inpatient rehabilitation program
    C Y Vossen
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Clin Pharmacol Ther 84:222-7. 2008
    ..We therefore found no evidence that APOE genotyping will be useful in guiding dietary or pharmacological lipid-lowering treatment decisions...
  20. ncbi Efficacy, effectiveness and cost-effectiveness of endoscopic screening methods
    H Brenner
    Div of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Z Gastroenterol 46:S20-2. 2008
    ..Even higher cost-effectiveness is to be expected if screening intervals can be extended to 20 or more years, as suggested by recent epidemiological evidence...
  21. ncbi Deriving valid population-based cancer survival estimates in the presence of nonnegligible proportions of cancers notified by death certificates only
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 20:2480-6. 2011
    ..The validity of this "exclude DCO" approach has been questioned and an alternative "correct for DCO" approach has been proposed...
  22. ncbi Dopamine-related genes and spontaneous smoking cessation in ever-heavy smokers
    Lutz P Breitling
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, TP4 INF581, 69120 Heidelberg, Germany
    Pharmacogenomics 12:1099-106. 2011
    ..Several studies have provided evidence for associations of polymorphisms located in and near dopamine-related genes and nicotine dependence and other smoking-related phenotypes, including pharmacogenetic interactions...
  23. ncbi Inverse association between a pro-inflammatory genetic profile and Helicobacter pylori seropositivity among patients with chronic atrophic gastritis: enhanced elimination of the infection during disease progression?
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, Heidelberg D 69115, Germany
    Eur J Cancer 45:2860-6. 2009
    ..There is increasing evidence of frequent clearance of the infection during progression of CAG. We aimed to assess the association between host inflammatory polymorphisms and H. pylori seropositivity among CAG patients from Germany...
  24. ncbi The association of cyclin D1 G870A and E-cadherin C-160A polymorphisms with the risk of colorectal cancer in a case control study and meta-analysis
    Xiang Lin Tan
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 122:2573-80. 2008
    ..However, the CCND1 G870A polymorphism may modify the protective effect of postmenopausal hormone use on the development of CRC...
  25. ncbi Protection from right- and left-sided colorectal neoplasms after colonoscopy: population-based study
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    J Natl Cancer Inst 102:89-95. 2010
    ....
  26. ncbi Gender disparities in diabetes and coronary heart disease medication among patients with type 2 diabetes: results from the DIANA study
    Heike U Krämer
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, D 69120, Heidelberg, Germany
    Cardiovasc Diabetol 11:88. 2012
    ..Coronary heart disease (CHD) is one of the most common long-term complications in people with type 2 diabetes. We analyzed whether or not gender differences exist in diabetes and CHD medication among people with type 2 diabetes...
  27. ncbi Kidney graft survival in europe and the United States: strikingly different long-term outcomes
    Adam Gondos
    1 Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany 2 Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany 3 Address correspondence to Adam Gondos, Ph D, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, PO Box 101909, 69009 Heidelberg, Germany
    Transplantation 95:267-74. 2013
    ..Kidney graft survival has never been systematically compared between Europe and the United States...
  28. ncbi Cigarette smoking and colorectal cancer risk in Germany: a population-based case-control study
    Emaculate Verla-Tebit
    Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 119:630-5. 2006
    ..This study supports the hypothesis that smoking for a long duration at a high cumulative dose increases the risk for colorectal cancer, particularly among women, and suggests that there is risk reduction after longterm smoking cessation...
  29. ncbi Low risk of colorectal cancer and advanced adenomas more than 10 years after negative colonoscopy
    Hermann Brenner
    Division of Clinical Epidemiology of Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Gastroenterology 138:870-6. 2010
    ..There is little empirical evidence available about the optimal interval for screening, making this a subject of debate. We associated the prevalence of advanced colorectal neoplasms with time since negative colonoscopies...
  30. ncbi Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM
    Bernd Frank
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, 69115 Heidelberg, Germany
    Carcinogenesis 31:442-5. 2010
    ..Although none of them showed a significant association with CRC, the association of BLM P868L with rectal cancer risk requires further investigation...
  31. ncbi SULT1A1 genotype and susceptibility to colorectal cancer
    Carmen Lilla
    Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 120:201-6. 2007
    ....
  32. ncbi Strong associations of 25-hydroxyvitamin D concentrations with all-cause, cardiovascular, cancer, and respiratory disease mortality in a large cohort study
    Ben Schöttker
    Divisions of Clinical Epidemiology and Aging Research and Preventive Oncology, German Cancer Research Center, Heidelberg, Germany
    Am J Clin Nutr 97:782-93. 2013
    ..Serum 25-hydroxyvitamin D [25(OH)D] concentration has been linked to mortality in several studies, but appropriate cutoffs to define risk categories are under debate...
  33. ncbi Evaluation of serum and urinary myeloid related protein-14 as a marker for early detection of prostate cancer
    Heiko Muller
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    J Urol 180:1309-12; discussion 1312-3. 2008
    ..In diagnostic studies promising results were shown for myeloid related protein-14 in serum and urine. However, confirmation in longitudinal population based studies is needed...
  34. ncbi Copy number variations of GSTT1 and GSTM1, colorectal cancer risk and possible effect modification of cigarette smoking and menopausal hormone therapy
    Anja Rudolph
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 131:E841-8. 2012
    ..18) for GSTM1. No significant interaction with smoking and MHT use was observed. Our study does not provide evidence for a strong association between CRC risk and CNVs of GSTT1 or GSTM1 or for an effect modification of smoking or MHT use...
  35. ncbi Cancer survival in Germany and the United States at the beginning of the 21st century: an up-to-date comparison by period analysis
    Adam Gondos
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 121:395-400. 2007
    ..Among these, differences between patients with breast and prostate cancer are probably due to more intensive screening activities...
  36. ncbi Mutant-enriched PCR and allele-specific hybridization reaction to detect K-ras mutations in stool DNA: high prevalence in a large sample of older adults
    Ulrike Haug
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Clin Chem 53:787-90. 2007
    ..We investigated the prevalence and potential determinants of mutant K-ras in stool in a large sample of unselected older adults and assessed the association with colonoscopic findings...
  37. ncbi Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer
    Bernd Frank
    German Cancer Research Center, Heidelberg, Germany
    Carcinogenesis 31:1381-6. 2010
    ..However, our results provide evidence that CRC subsets may be affected. If confirmed, this knowledge may be used to assess individual susceptibility and to target potential measures of cancer prevention...
  38. ncbi Synergism between smoking and alcohol consumption with respect to serum gamma-glutamyltransferase
    Lutz Philipp Breitling
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Hepatology 49:802-8. 2009
    ..12, P(males) = 0.0017). CONCLUSION: Our results support the notion of a detrimental interaction between cigarette smoking and alcohol consumption as determinants of elevated serum gamma-GT, especially in men...
  39. ncbi Epidemiologic findings on serologically defined chronic atrophic gastritis strongly depend on the choice of the cutoff-value
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 121:2782-6. 2007
    ..The association of age and H. pylori infection with CAG may be strongly underestimated in studies in which CAG is defined by pepsinogen I only...
  40. ncbi Gender specific temporal and cross-sectional associations between BMI-class and symptoms of depression in the elderly
    Beate Wild
    Department of General Internal Medicine and Psychosomatics, Medical University Hospital, Heidelberg, Germany
    J Psychosom Res 72:376-82. 2012
    ..The aim of the study was the gender specific analysis of cross-sectional and longitudinal associations between body mass index class (BMI-class) and symptoms of depression in a representative sample of elderly German people...
  41. ncbi Helicobacter pylori infection, chronic atrophic gastritis and major cardiovascular events: a population-based cohort study
    Ben Schöttker
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Atherosclerosis 220:569-74. 2012
    ..There is debate whether infection with Helicobacter (H.) pylori, the main inducer of chronic atrophic gastritis (CAG), is a risk factor for cardiovascular disease and premature mortality...
  42. ncbi Inter-country and ethnic variation in colorectal cancer survival: comparisons between a Philippine population, Filipino-Americans and Caucasians
    Maria Theresa Redaniel
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    BMC Cancer 10:100. 2010
    ....
  43. ncbi Genotype combinations of plasminogen activator inhibitor-1 and angiotensin-converting enzyme genes and risk for early onset of coronary heart disease
    Michael Loew
    Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
    Eur J Cardiovasc Prev Rehabil 13:449-56. 2006
    ....
  44. ncbi Serum parathyroid hormone and risk of adverse outcomes in patients with stable coronary heart disease
    Norma Christine Grandi
    Division of Clinical Epidemiology and Ageing Research C070, German Cancer Research Center, Heidelberg, Germany
    Heart 97:1215-21. 2011
    ..This study presents analyses of the prognostic value of baseline PTH for subsequent cardiovascular events and all-cause mortality in a high-risk population with stable coronary heart disease...
  45. ncbi Genetic polymorphisms in GST genes and survival of colorectal cancer patients treated with chemotherapy
    Silvia Funke
    German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Pharmacogenomics 11:33-41. 2010
    ..Genetic polymorphisms in GST genes (GSTP1 Ile105Val, copy-number variants of GSTM1 and GSTT1) that lead to diminished enzyme activity have been associated with increased chemotherapeutic treatment benefit in colorectal cancer patients...
  46. ncbi Alcohol consumption, serum gamma-glutamyltransferase, and helicobacter pylori infection in a population-based study among 9733 older adults
    Lei Gao
    German Cancer Research Center, Heidelberg, Germany
    Ann Epidemiol 20:122-8. 2010
    ..pylori infection in a large population-based study...
  47. ncbi Exposure to environmental tobacco smoke and the risk of colorectal cancer in a case-control study from Germany
    Emaculate Verla-Tebit
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Eur J Cancer Prev 18:9-12. 2009
    ..03-12.15) and for women exposed to >23 pack-years of spousal smoking (OR: 3.02; 95% CI: 0.99-9.28). Our findings do not indicate a major impact of ETS on CRC risk but suggest that risk may be increased following spousal exposure...
  48. ncbi Household contacts were key factor for children's colonization with resistant Escherichia coli in community setting
    Susanne Lietzau
    Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
    J Clin Epidemiol 60:1149-55. 2007
    ..coli) can lead to life-threatening situations. Epidemiological data on the prevalence and major determinants of carriage of antibiotic resistant E. coli among children in the community setting are sparse...
  49. ncbi Changes of cardiovascular risk factors and their implications in subsequent birth cohorts of older adults in Germany: a life course approach
    Elke Raum
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Eur J Cardiovasc Prev Rehabil 14:809-14. 2007
    ....
  50. ncbi Alcohol consumption and chronic atrophic gastritis: population-based study among 9,444 older adults from Germany
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 125:2918-22. 2009
    ..pylori. However, the observed patterns suggest that other mechanisms are likely to contribute to the association as well...
  51. ncbi Sibship size, Helicobacter pylori infection and chronic atrophic gastritis: a population-based study among 9444 older adults from Germany
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Epidemiol 39:129-34. 2010
    ..We aimed to assess the association of sibship size with H. pylori infection and chronic atrophic gastritis (CAG) in a population-based study from Germany...
  52. ncbi Risk of progression of advanced adenomas to colorectal cancer by age and sex: estimates based on 840,149 screening colonoscopies
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Gut 56:1585-9. 2007
    ..To derive age and sex specific estimates of transition rates from advanced adenomas to colorectal cancer by combining data of a nationwide screening colonoscopy registry and national data on colorectal cancer (CRC) incidence...
  53. ncbi Population-based prevalence estimates of history of colonoscopy or sigmoidoscopy: review and analysis of recent trends
    Christian Stock
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Gastrointest Endosc 71:366-381.e2. 2010
    ..We aimed to review prevalence estimates of history of colonoscopy or sigmoidoscopy in the general population and to analyze recent trends...
  54. ncbi Survival of stomach and esophagus cancer patients in Germany in the early 21st century
    Eva Hiripi
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Acta Oncol 51:906-14. 2012
    ..The aim of this study was to provide up-to-date survival estimates and trends for patients with stomach and esophagus cancer in Germany...
  55. ncbi Cancer survival in Eastern and Western Germany after the fall of the iron curtain
    Lina Jansen
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, POB 10 19 49, 69009, Heidelberg, Germany
    Eur J Epidemiol 27:689-93. 2012
    ....
  56. ncbi Prevalence and determinants of exocrine pancreatic insufficiency among older adults: results of a population-based study
    Dietrich Rothenbacher
    Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
    Scand J Gastroenterol 40:697-704. 2005
    ..The prevalence and main determinants of exocrine pancreatic insufficiency were investigated in a large population-based sample of older adults by measuring pancreatic elastase-1 in stool...
  57. ncbi Longitudinal predictors of health-related quality of life in middle-aged and older adults with hypertension: results of a population-based study
    Imad Maatouk
    Department of General Internal Medicine and Psychosomatics, Medical University Hospital Heidelberg, Heidelberg, Germany
    J Hypertens 30:1364-72. 2012
    ..g. awareness of hypertension, number of types of antihypertensive drugs, comorbidity), and health-related quality of life (HRQOL) in a large cohort of patients with hypertension, over a follow-up period of 5 years...
  58. ncbi Death receptor 4 variants and colorectal cancer risk
    Bernd Frank
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 15:2002-5. 2006
    ..37; 95% CI, 0.98-5.76). The score statistic yielded an empirical P of 0.03 of the haplotype-specific test for 626C-683C based on 20,000 simulations, suggesting that DR4 626C-683C may affect colorectal cancer predisposition...
  59. ncbi Effect of type 2 diabetes predisposing genetic variants on colorectal cancer risk
    Juan Sainz
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Clin Endocrinol Metab 97:E845-51. 2012
    ..The link between colorectal cancer (CRC) and type 2 diabetes mellitus (T2D) has been extensively studied. Although it is commonly accepted that T2D is a risk factor for CRC, the underlying mechanisms are still poorly understood...
  60. ncbi Potential for colorectal cancer prevention of sigmoidoscopy versus colonoscopy: population-based case control study
    Hermann Brenner
    Department of Epidemiology, German Cancer Research Center, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 16:494-9. 2007
    ..Among men, this regimen may be almost as effective as colonoscopy, at least at previous performance levels of colonoscopy...
  61. ncbi Model-based projections for deriving up-to-date cancer survival estimates: an international evaluation
    Adam Gondos
    Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 125:2666-72. 2009
    ..Projections from model-based analysis may contribute to improved timeliness of monitoring of concurrent trends in population-based cancer survival in cancer registries operating in different populations and socioeconomic environments...
  62. ncbi Epidemiology of chronic kidney disease: results from a population of older adults in Germany
    Qiu Li Zhang
    German Cancer Research Center, Heidelberg, Germany
    Prev Med 48:122-7. 2009
    ..To determine prevalences and stages of chronic kidney disease (CKD), and evaluate association of CKD with related covariables in a large population of older adults...
  63. ncbi Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumption
    Carmen Lilla
    Division of Clinical Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 15:99-107. 2006
    ....
  64. ncbi Expected reduction of colorectal cancer incidence within 8 years after introduction of the German screening colonoscopy programme: estimates based on 1,875,708 screening colonoscopies
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, D 69115 Heidelberg, Germany
    Eur J Cancer 45:2027-33. 2009
    ..Our results forecast a major rapid reduction of the CRC burden in Germany by screening colonoscopy...
  65. ncbi Prognostic value of haemoglobin A1c and fasting plasma glucose for incident diabetes and implications for screening
    Ben Schöttker
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Eur J Epidemiol 26:779-87. 2011
    ..FPG and HbA(1c) have comparable (yet insufficient) abilities in identifying individuals at high risk for diabetes. Effectiveness of a diabetes screening program could be improved by a risk score including FPG and HbA(1c)...
  66. ncbi Type 2 diabetes mellitus and gender-specific risk for colorectal neoplasia
    Heike Ursula Krämer
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, INF 581, 69120 Heidelberg, Germany
    Eur J Epidemiol 27:341-7. 2012
    ..01; 95 % CI 0.71-1.43). T2DM might have a stronger impact on CN among women than among men. Further research should examine possible reasons for these differences...
  67. ncbi Temporal predictors of health-related quality of life in elderly people with diabetes: results of a German cohort study
    Imad Maatouk
    Department of General Internal Medicine and Psychosomatics, Medical University Hospital Heidelberg, Heidelberg, Germany
    PLoS ONE 7:e31088. 2012
    ..The aim of the study was to determine predictors that influence health-related quality of life (HRQOL) in a large cohort of elderly diabetes patients from primary care over a follow-up period of five years...
  68. ncbi Age-specific administration of chemotherapy and long-term quality of life in stage II and III colorectal cancer patients: a population-based prospective cohort
    Lina Jansen
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Heidelberg, Germany
    Oncologist 16:1741-51. 2011
    ..To investigate the age-specific pattern of administration of chemotherapy and its association with long-term survival and quality of life (QoL) in stage II and III colorectal cancer patients...
  69. ncbi Low-to-moderate alcohol consumption and smoking cessation rates: retrospective analysis of 4576 elderly ever-smokers
    Lutz Philipp Breitling
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Drug Alcohol Depend 108:122-9. 2010
    ..We aimed to elucidate the association of concurrent alcohol consumption with the probability of smoking cessation in non-clinical populations...
  70. ncbi Quality of life over 5 years in women with breast cancer after breast-conserving therapy versus mastectomy: a population-based study
    Volker Arndt
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Bergheimer Strasse 20, 69115 Heidelberg, Germany
    J Cancer Res Clin Oncol 134:1311-8. 2008
    ..Therefore we compared QOL in women with breast cancer undergoing BCT versus women undergoing mastectomy over a 5-year period following primary surgery...
  71. ncbi Male sex and smoking have a larger impact on the prevalence of colorectal neoplasia than family history of colorectal cancer
    Michael Hoffmeister
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Clin Gastroenterol Hepatol 8:870-6. 2010
    ..Screening recommendations for colorectal cancer (CRC) commonly take family history but no other risk factors into account. We compared and assessed risk factors of colorectal polyps in a large population undergoing screening colonoscopy...
  72. ncbi Validity of self-reported endoscopies of the large bowel and implications for estimates of colorectal cancer risk
    Michael Hoffmeister
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Am J Epidemiol 166:130-6. 2007
    ..58), and reasonable for year of examination (kappa = 0.70). Self-reports of previous colorectal endoscopies agreed well with medical records, but validation appears to be essential with respect to details of the examination...
  73. ncbi Grb2-associated binder 1 (Gab1) genetic polymorphism, Helicobacter pylori infection, and chronic atrophic gastritis among older adults from Germany
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Mol Carcinog 49:869-73. 2010
    ..pylori infection and CAG in this study population from Germany. Further studies with larger sample size are needed to clarify a potential modest effect of Gab1 genetic polymorphisms...
  74. ncbi Association between a pro-inflammatory genetic profile and the risk of chronic atrophic gastritis among older adults from Germany
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Eur J Cancer 45:428-34. 2009
    ..We aimed to assess their impact on the risk of chronic atrophic gastritis (CAG) in a population-based study...
  75. ncbi Association between the prevalence of depression and age in a large representative German sample of people aged 53 to 80 years
    Beate Wild
    Department of General Internal Medicine and Psychosomatics, Medical University Hospital, Heidelberg, Germany
    Int J Geriatr Psychiatry 27:375-81. 2012
    ..The aim of the study was to determine the association between the prevalence of clinically significant depression and age in a large representative sample of elderly German people...
  76. ncbi Variants in COMT and spontaneous smoking cessation: retrospective cohort analysis of 925 cessation events
    Lutz Philipp Breitling
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Pharmacogenet Genomics 19:657-9. 2009
    ....
  77. ncbi DNA repair gene polymorphisms and risk of chronic atrophic gastritis: a case-control study
    Bernd Frank
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    BMC Cancer 11:440. 2011
    ..Recent studies have reported associations of DNA repair pathway gene variants and risk of various cancers and precancerous lesions, such as chronic atrophic gastritis (CAG)...
  78. ncbi Sex, age, and birth cohort effects in colorectal neoplasms: a cohort analysis
    Hermann Brenner
    German Cancer Research Center, Heidelberg, Germany
    Ann Intern Med 152:697-703. 2010
    ..Cross-sectional analyses estimated that men reach an equivalent prevalence at a much younger age than women. However, cross-sectional estimates may be confounded by birth cohort effects...
  79. ncbi Serum uric acid and risk of occupational disability: findings from a cohort study of male construction workers in Germany
    Heiner Claessen
    German Cancer Research Center, Heidelberg, Germany
    Arthritis Care Res (Hoboken) 62:1278-86. 2010
    ....
  80. ncbi Association of diabetes and body mass index with levels of prostate-specific antigen: implications for correction of prostate-specific antigen cutoff values?
    Heiko Muller
    German Cancer Research Center, Division of Clinical Epidemiology and Aging Research, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 18:1350-6. 2009
    ..However, all of the studies were conducted in populations with intensive PSA screening and the role of diabetes severity, duration, and therapy are yet to be explored...
  81. ncbi Association between chronic atrophic gastritis and serum antibodies to 15 Helicobacter pylori proteins measured by multiplex serology
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Cancer Res 69:2973-80. 2009
    ..In conclusion, HcpC and GroEL were identified as new independent virulence factors, and in combination with the established virulence factors, CagA and VacA, were strongly associated with CAG...
  82. ncbi Polymorphisms in the insulin like growth factor 1 and IGF binding protein 3 genes and risk of colorectal cancer
    Sonali Pechlivanis
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Cancer Detect Prev 31:408-16. 2007
    ..We wanted to study if these polymorphisms or any haplotypes of the IGF1 and the IGFBP3 genes are associated with CRC...
  83. ncbi Quantitative immunochemical fecal occult blood testing for colorectal adenoma detection: evaluation in the target population of screening and comparison with qualitative tests
    Ulrike Haug
    German Cancer Research Center, Heidelberg, Germany
    Am J Gastroenterol 105:682-90. 2010
    ....
  84. ncbi Recent trends in cancer survival across Europe between 2000 and 2004: a model-based period analysis from 12 cancer registries
    A Gondos
    Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Bergheimer Strasse 20, 69115 Heidelberg, Germany
    Eur J Cancer 44:1463-75. 2008
    ..Monitoring population-based cancer survival is an essential component in the evaluation of cancer control, but subject to an inherent delay in the reporting of the most recent survival estimates with traditional techniques of analysis...
  85. ncbi Ovarian cancer survival population differences: a "high resolution study" comparing Philippine residents, and Filipino-Americans and Caucasians living in the US
    Maria Theresa M Redaniel
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    BMC Cancer 9:340. 2009
    ..We aimed to compare ovarian cancer survival in Philippine residents, Filipino-Americans and Caucasians living in the US, using a high resolution approach, taking potential differences in prognostic factors into account...
  86. ncbi Smoking cessation and variations in nicotinic acetylcholine receptor subunits alpha-5, alpha-3, and beta-4 genes
    Lutz Philipp Breitling
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Biol Psychiatry 65:691-5. 2009
    ..We aimed to determine whether these genetic variations are also predictive of smoking cessation...
  87. ncbi Case-control study supports extension of surveillance interval after colonoscopic polypectomy to at least 5 yr
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany, and Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Am J Gastroenterol 102:1739-44. 2007
    ..Whereas previous evidence is mainly based on observations of adenoma recurrence, we aimed to assess risk of CRC occurrence according to time since polypectomy...
  88. ncbi The mother as source of Helicobacter pylori infection
    Maria Weyermann
    Department of Epidemiology, The German Centre for Research on Ageing, Heidelberg, Germany
    Epidemiology 17:332-4. 2006
    ..The number of older siblings was not a risk factor for H. pylori infection of the child. CONCLUSIONS: This longitudinal study suggests that infected mothers are the main source of H. pylori infection of their children...
  89. ncbi Helicobacter pylori infection, interleukin-1 gene polymorphisms and the risk of colorectal cancer: evidence from a case-control study in Germany
    Natalia Zumkeller
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Eur J Cancer 43:1283-9. 2007
    ..Additionally, a pro-inflammatory genotype did not increase the colorectal cancer risk associated with H. pylori infection. H. pylori positive subjects carrying the pro-inflammatory genotypes even had a lower risk...
  90. ncbi Quality of life in patients with colorectal cancer 1 year after diagnosis compared with the general population: a population-based study
    Volker Arndt
    Department of Epidemiology, German Centre for Research on Aging, Heidelberg, Germany
    J Clin Oncol 22:4829-36. 2004
    ....
  91. ncbi Association of hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD) variants and colorectal cancer risk
    Bernd Frank
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Carcinogenesis 32:190-6. 2011
    ..82, 95% CI = 0.70, 0.95, P = 0.01) as well as among smokers (OR = 0.74, 95% CI = 0.61, 0.90, P = 0.003). Yet, our data do not support the previously reported associations of HPGD tagSNPs and risk of CRC...
  92. ncbi Trends in 5- and 10-year survival after diagnosis with childhood hematologic malignancies in the United States, 1990-2004
    Dianne Pulte
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    J Natl Cancer Inst 100:1301-9. 2008
    ....
  93. ncbi Family history and age at initiation of colorectal cancer screening
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Am J Gastroenterol 103:2326-31. 2008
    ....
  94. ncbi Individual and joint use of statins and low-dose aspirin and risk of colorectal cancer: a population-based case-control study
    Michael Hoffmeister
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 121:1325-30. 2007
    ....
  95. ncbi Breast cancer survival in different country settings: comparisons between a Filipino resident population, Filipino-Americans and Caucasians
    Maria Theresa Redaniel
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Breast 19:109-14. 2010
    ..Access to, utilization and affordability of cancer care facilities are important for reducing breast cancer deaths in developing countries...
  96. ncbi Helicobacter pylori infection and gastric cancer risk: evaluation of 15 H. pylori proteins determined by novel multiplex serology
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Cancer Res 69:6164-70. 2009
    ..001). In conclusion, GroEL was identified as a new independent risk marker that may contribute to enhanced quantification of H. pylori-related GC risk...
  97. ncbi Comparative evaluation of immunochemical fecal occult blood tests for colorectal adenoma detection
    Sabrina Hundt
    The German Cancer Research Center, Heidelberg, Germany
    Ann Intern Med 150:162-9. 2009
    ..Large-scale, colonoscopy-based screening studies that allow evaluation of these tests for the detection of precursor lesions are scarce...
  98. ncbi Long-term survival rates of cancer patients achieved by the end of the 20th century: a period analysis
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Str 20, 69115, Heidelberg, Germany
    Lancet 360:1131-5. 2002
    ..I aimed to assess achievements in cancer patients' survival by an alternative method of survival analysis,known as period analysis, which provides more up-to-date estimates of long-term survival rates than do conventional methods...
  99. ncbi MicroRNA signatures: novel biomarker for colorectal cancer?
    Xiaoya Luo
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 20:1272-86. 2011
    ..The expression of miRNAs in plasma may be indicative of presence of CRC. Larger diagnostic studies are needed to evaluate potential use of miRNA expression in early detection and diagnosis of CRC...
  100. ncbi Up-to-date and precise estimates of cancer patient survival: model-based period analysis
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
    Am J Epidemiol 164:689-96. 2006
    ..The modeling approach may further enhance the use of period analysis for deriving up-to-date cancer survival rates...
  101. ncbi Effects of practitioner education, practitioner payment and reimbursement of patients' drug costs on smoking cessation in primary care: a cluster randomised trial
    Dorothee Twardella
    Department of Epidemiology, German Center for Research on Ageing, Heidelberg, Germany
    Tob Control 16:15-21. 2007
    ..To evaluate new strategies to enhance the promotion of smoking cessation in general practice...