Klaus Braun

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. pmc BioShuttle mobility in living cells studied with high-resolution FCS & CLSM methodologies
    Klaus Braun
    Dept of Imaging and Radiooncology, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany
    Int J Med Sci 9:339-52. 2012
  2. pmc A cyclic-RGD-BioShuttle functionalized with TMZ by DARinv "Click Chemistry" targeted to αvβ3 integrin for therapy
    Klaus Braun
    German Cancer Research Center, Dept of Imaging and Radiooncology, INF 280, D 69120 Heidelberg, Germany
    Int J Med Sci 7:326-39. 2010
  3. ncbi request reprint The enhancement of neutron irradiation of HeLa-S cervix carcinoma cells by cell-nucleus-addressed deca-p-boronophenylalanine
    Klaus Braun
    Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur J Med Chem 38:587-95. 2003
  4. pmc BioShuttle-mediated plasmid transfer
    Klaus Braun
    Division of Molecular Toxicology, German Cancer Research Center, INF 280, D 69120 Heidelberg, Germany
    Int J Med Sci 4:267-77. 2007
  5. pmc Gain of a 500-fold sensitivity on an intravital MR contrast agent based on an endohedral gadolinium-cluster-fullerene-conjugate: a new chance in cancer diagnostics
    Klaus Braun
    Department of Medical Physics in Radiology, German Cancer Research Center, INF 280, D 69120 Heidelberg, Germany
    Int J Med Sci 7:136-46. 2010
  6. ncbi request reprint HPV18 E6 and E7 genes affect cell cycle, pRB and p53 of cervical tumor cells and represent prominent candidates for intervention by use peptide nucleic acids (PNAs)
    Klaus Braun
    Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Cancer Lett 209:37-49. 2004
  7. ncbi request reprint Development and characterization of drug delivery systems for targeting mammalian cells and tissues: a review
    K Braun
    German Cancer Research Center, Clinical Cooperation Unit Radiation Oncology, Heidelberg, Germany
    Curr Med Chem 12:1841-58. 2005
  8. pmc High-resolution flow cytometry: a suitable tool for monitoring aneuploid prostate cancer cells after TMZ and TMZ-BioShuttle treatment
    Klaus Braun
    German Cancer Research Center, Dept of Medical Physics in Radiooncology, INF 280, D 69120 Heidelberg, Germany
    Int J Med Sci 6:338-47. 2009
  9. pmc TMZ-BioShuttle--a reformulated temozolomide
    Waldemar Waldeck
    German Cancer Research Center, Division of Biophysics of Macromolecules, INF 580, D 69120 Heidelberg, Germany
    Int J Med Sci 5:273-84. 2008
  10. pmc Transporter molecules influence the gene expression in HeLa cells
    Waldemar Waldeck
    German Cancer Research Center, Division of Biophysics of Macromolecules, INF 580, D 69120 Heidelberg, Germany
    Int J Med Sci 6:18-27. 2009

Collaborators

Detail Information

Publications32

  1. pmc BioShuttle mobility in living cells studied with high-resolution FCS & CLSM methodologies
    Klaus Braun
    Dept of Imaging and Radiooncology, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany
    Int J Med Sci 9:339-52. 2012
    ..The modular design of BioShuttle-based formulations results in a multi-faceted field of applications, also as a theranostic tool...
  2. pmc A cyclic-RGD-BioShuttle functionalized with TMZ by DARinv "Click Chemistry" targeted to αvβ3 integrin for therapy
    Klaus Braun
    German Cancer Research Center, Dept of Imaging and Radiooncology, INF 280, D 69120 Heidelberg, Germany
    Int J Med Sci 7:326-39. 2010
    ..The ligation was carried out by the Diels Alder Reaction with inverse electron demand (DAR(inv))...
  3. ncbi request reprint The enhancement of neutron irradiation of HeLa-S cervix carcinoma cells by cell-nucleus-addressed deca-p-boronophenylalanine
    Klaus Braun
    Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur J Med Chem 38:587-95. 2003
    ..No cells were alive 72 h after the incubation with 'Bioshuttle'-p-BPA(10) followed by neutron irradiation. A post-mitotic cell death could be assumed based on flow cytometrical data...
  4. pmc BioShuttle-mediated plasmid transfer
    Klaus Braun
    Division of Molecular Toxicology, German Cancer Research Center, INF 280, D 69120 Heidelberg, Germany
    Int J Med Sci 4:267-77. 2007
    ..The results demonstrate that the "BioShuttle"-Technology is an appropriate tool for an effective transfer of genetic material carried by a plasmid...
  5. pmc Gain of a 500-fold sensitivity on an intravital MR contrast agent based on an endohedral gadolinium-cluster-fullerene-conjugate: a new chance in cancer diagnostics
    Klaus Braun
    Department of Medical Physics in Radiology, German Cancer Research Center, INF 280, D 69120 Heidelberg, Germany
    Int J Med Sci 7:136-46. 2010
    ..Using the Gd-cluster@-BioShuttle as MRI contrast agent allows an improved evaluation of radio- or chemotherapy treated tissues...
  6. ncbi request reprint HPV18 E6 and E7 genes affect cell cycle, pRB and p53 of cervical tumor cells and represent prominent candidates for intervention by use peptide nucleic acids (PNAs)
    Klaus Braun
    Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Cancer Lett 209:37-49. 2004
    ..These data could demonstrate a promising approach for development of new 'anti-gene therapeutics' against papillomavirus-induced human cancers...
  7. ncbi request reprint Development and characterization of drug delivery systems for targeting mammalian cells and tissues: a review
    K Braun
    German Cancer Research Center, Clinical Cooperation Unit Radiation Oncology, Heidelberg, Germany
    Curr Med Chem 12:1841-58. 2005
    ..However, the design and development of successful therapies based on this technology still remains a great challenge...
  8. pmc High-resolution flow cytometry: a suitable tool for monitoring aneuploid prostate cancer cells after TMZ and TMZ-BioShuttle treatment
    Klaus Braun
    German Cancer Research Center, Dept of Medical Physics in Radiooncology, INF 280, D 69120 Heidelberg, Germany
    Int J Med Sci 6:338-47. 2009
    ....
  9. pmc TMZ-BioShuttle--a reformulated temozolomide
    Waldemar Waldeck
    German Cancer Research Center, Division of Biophysics of Macromolecules, INF 580, D 69120 Heidelberg, Germany
    Int J Med Sci 5:273-84. 2008
    ....
  10. pmc Transporter molecules influence the gene expression in HeLa cells
    Waldemar Waldeck
    German Cancer Research Center, Division of Biophysics of Macromolecules, INF 580, D 69120 Heidelberg, Germany
    Int J Med Sci 6:18-27. 2009
    ..The PKN1 gene was induced and two genes (ZCD1 and BSG) were slightly repressed. The genes and the chromosomes are described, the moderate differential gene expression graphed, and the ontology is listed...
  11. pmc Improved synthesis strategy for peptide nucleic acids (PNA) appropriate for cell-specific fluorescence imaging
    Rudiger Pipkorn
    DKFZ, Central Peptide Synthesis Unit, INF 580, D 69120 Heidelberg, Germany
    Int J Med Sci 9:1-10. 2012
    ..After ligation to the modular peptide-based BioShuttle carrier, which was utilized to facilitate the delivery of the functional modules into the cells' cytoplasm, the modules were scrutinized...
  12. doi request reprint Inverse-electron-demand Diels-Alder reaction as a highly efficient chemoselective ligation procedure: synthesis and function of a BioShuttle for temozolomide transport into prostate cancer cells
    Rudiger Pipkorn
    German Cancer Research Center, Peptide Synthesis Unit, INF 580, 69120 Heidelberg, Germany
    J Pept Sci 15:235-41. 2009
    ..This TMZ-BioShuttle may be well suited for combining chemotherapy with other cytostatic agents or radiation therapy...
  13. pmc HIV-1 capsid assembly inhibitor (CAI) peptide: structural preferences and delivery into human embryonic lung cells and lymphocytes
    Klaus Braun
    Division of Molecular Toxicology, German Cancer Research Center, Heidelberg, Germany
    Int J Med Sci 5:230-9. 2008
    ..Under the conditions described, the HIV-1 CAI peptide was transported into living cells and could be localized in the vicinity of the mitochondria...
  14. ncbi request reprint CNN-Gd(3+) enables cell nucleus molecular imaging of prostate cancer cells: the last 600 nm
    Stefan Heckl
    Department of Oncological Diagnostics and Therapy, German Cancer Research Center, Heidelberg, Germany
    Cancer Res 62:7018-24. 2002
    ..Therefore, our method seems promising for in vivo application in molecular imaging...
  15. doi request reprint ROS-mediated killing efficiency with visible light of bacteria carrying different red fluorochrome proteins
    Waldemar Waldeck
    German Cancer Research Center, Division of Biophysics of Macromolecules, INF 580, D 69120 Heidelberg, Germany
    J Photochem Photobiol B 109:28-33. 2012
    ..Their application and a possible bactericide role is discussed...
  16. pmc Autofluorescent proteins as photosensitizer in eukaryontes
    Waldemar Waldeck
    German Cancer Research Center, Department of Biophysics of Macromolecules, Heidelberg, Germany
    Int J Med Sci 6:365-73. 2009
    ..Therefore the H2A-KRED fusion protein can be considered as an appropriate candidate for the photodynamic therapy (PDT). This finding can be transferred to current photodynamic approaches and can enhance their therapeutic outcome...
  17. pmc Positioning effects of KillerRed inside of cells correlate with DNA strand breaks after activation with visible light
    Waldemar Waldeck
    German Cancer Research Center, Dept of Biophysics of Macromolecules, INF 580, D 69120 Heidelberg, Germany
    Int J Med Sci 8:97-105. 2011
    ..These findings are not restricted to the detection of programmed cell death processes in the therapeutic field like PDT, but they can also contribute to a better understanding of the structure-function relations in the epigenomic world...
  18. pmc Enhancement of the click chemistry for the inverse Diels Alder technology by functionalization of amide-based monomers
    Ruediger Pipkorn
    German Cancer Research Center, Central Peptide Synthesis Unit, INF 580, 69120 Heidelberg, Germany
    Int J Med Sci 8:387-96. 2011
    ..It is important to point out that this technology is not restricted to ligation of medicament material; it is also a candidate to develop new and highly efficient active compounds for a "sustainable pharmacy"...
  19. ncbi request reprint Comparison of different methods to assess the cytotoxic effects of cytosine deaminase and thymidine kinase gene therapy
    Heike Corban-Wilhelm
    Clinical Cooperation Unit Radiotherapeutical Oncology, Deutsches Krebsforschungszentrum DKFZ, Heidelberg, Germany
    Cancer Gene Ther 11:208-14. 2004
    ..On the other hand, a significant S-phase block could be observed after 24 hours incubation with GCV. This short time is enough to incorporate the genotoxic GCV metabolites in the nascent DNA to impair the cell cycle...
  20. pmc Extension of the PNA world by functionalized PNA monomers eligible candidates for inverse Diels Alder Click Chemistry
    Manfred Wiessler
    German Cancer Research Center, Dept of Imaging and Radiooncology, INF 280, D 69120 Heidelberg, Germany
    Int J Med Sci 7:213-23. 2010
    ..This system is not restricted to medicament material, but appropriate for the development of new and highly efficient drugs for a sustainable pharmacy...
  21. pmc Theranostic cRGD-BioShuttle Constructs Containing Temozolomide- and Cy7 For NIR-Imaging and Therapy
    Manfred Wiessler
    1 DKFZ, Dept of Imaging and Radiooncology, INF 280, D 69120 Heidelberg, Germany
    Theranostics 1:381-94. 2011
    ..Therefore, these targeted theranostic agents are considered to be highly suitable systems for improving disease diagnosis and therapy...
  22. ncbi request reprint Induced and repressed genes after irradiation sensitizing by pentoxyphylline
    Waldemar Waldeck
    Division of Biophysics of Macromolecules, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Int J Cancer 120:1198-207. 2007
    ..Radiation combined with PTX may lead to a better prognosis by down regulation of the Her-2/neu, which will be proven by clinical studies in the near future...
  23. pmc The Diels-Alder-reaction with inverse-electron-demand, a very efficient versatile click-reaction concept for proper ligation of variable molecular partners
    Manfred Wiessler
    German Cancer Research Center, Dept of Imaging and Radiooncology, INF 280, D 69120 Heidelberg, Germany
    Int J Med Sci 7:19-28. 2009
    ..With this report we would like to stimulate scientists working with the focus on "Click chemistry" to intensify research with this expanding DAR(inv )able to open the door for new solutions inconceivable so far...
  24. pmc Spatial localization of genes determined by intranuclear DNA fragmentation with the fusion proteins lamin KRED and histone KRED und visible light
    Waldemar Waldeck
    German Cancer Research Center, Dept of Biophysics of Macromolecules, INF 580, D 69120 Heidelberg, Germany
    Int J Med Sci 10:1136-48. 2013
    ..A connection between the damaged gene sequences and some diseases was found. ..
  25. ncbi request reprint Delivery of substances and their target-specific topical activation
    Rudiger Pipkorn
    Peptide Synthesis Facility, German Cancer Research Center, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Biochim Biophys Acta 1758:606-10. 2006
    ..As shown here for glioma cells and the cathepsin B cleavable site, living cells can be treated with high specificity and selectivity for diagnostic and therapeutic purposes...
  26. pmc SPPS resins impact the PNA-syntheses' improvement
    Rudiger Pipkorn
    German Cancer Research Center, Peptide Synthesis Core Facility, INF 280, D 69120 Heidelberg, Germany
    Int J Med Sci 10:331-7. 2013
    ..Here we demonstrate the solid phase synthesis effects dependent on the choice of resin and of the deprotection agent...
  27. ncbi request reprint A biological transporter for the delivery of peptide nucleic acids (PNAs) to the nuclear compartment of living cells
    Klaus Braun
    Division of Radiooncology, Klinische Kooperationseinheit Strahlentherapeutische Onkologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Mol Biol 318:237-43. 2002
    ..Our results clearly demonstrate efficient compartment-directed transport using a synthetic, non-toxic modular transporter in living cells...
  28. doi request reprint From green to red--To more dead? Autofluorescent proteins as photosensitizers
    Gabriele Mueller
    German Cancer Research Center, Division of Biophysics of Macromolecules, INF 580, D 69120 Heidelberg, Germany
    J Photochem Photobiol B 98:95-8. 2010
    ..We outline some possibilities for use the protein's properties for treatment of antibiotic multi-resistant and difficult to treat bacteria like the methicillin-resistant Staphylococcus aureus (MRSA)...
  29. ncbi request reprint Generation, application and quantification of clamp-BioShuttle carriers for plasmid delivery into nuclei of prostate cancer cells
    R Pipkorn
    Central Section for Peptide Synthesis, German Cancer Research Center, INF 580, D 69120 Heidelberg, Germany
    Biochem Soc Trans 35:829-32. 2007
    ..Finally, attempts have been made to solve some of the issues surrounding the efficiency of transfer of therapeutic or diagnostic agents and their later activity in the cell...
  30. ncbi request reprint Synthesis and application of functional peptides as cell nucleus-directed molecules in the treatment of malignant diseases
    R Pipkorn
    German Cancer Research Center, Heidelberg, Germany
    J Mol Recognit 16:240-7. 2003
    ..This article provides an overview of previous work on the BioShuttle technology and outlines the promising use of this approach in combinatorial peptide synthesis and drug discovery...
  31. ncbi request reprint Thermal properties and changes of acoustic parameters in an egg white phantom during heating and coagulation by high intensity focused ultrasound
    Gabriela Wilzbach Divkovic
    German Cancer Research Center, Heidelberg, Germany
    Ultrasound Med Biol 33:981-6. 2007
    ..In comparison with the noncoagulated phantom, the coagulated phantom material showed an enhanced absorption and a threefold higher attenuation coefficient at a frequency of 1 MHz...
  32. ncbi request reprint Intracellular visualization of prostate cancer using magnetic resonance imaging
    Stefan Heckl
    Department of Neuroradiology, University of Tubingen Medical School, Germany
    Cancer Res 63:4766-72. 2003
    ....