Jan C Brase

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. doi request reprint Circulating miRNAs are correlated with tumor progression in prostate cancer
    Jan C Brase
    Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 128:608-16. 2011
  2. doi request reprint ERBB2 and TOP2A in breast cancer: a comprehensive analysis of gene amplification, RNA levels, and protein expression and their influence on prognosis and prediction
    Jan C Brase
    Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
    Clin Cancer Res 16:2391-401. 2010
  3. doi request reprint Antibody-mediated signal amplification for reverse phase protein array-based protein quantification
    Jan C Brase
    Division of Molecular Genome Analysis, German Cancer Research Center DKFZ, Heidelberg, Germany
    Methods Mol Biol 785:55-64. 2011
  4. pmc Serum microRNAs as non-invasive biomarkers for cancer
    Jan C Brase
    Working Group Cancer Genome Research, German Cancer Research Center, Heidelberg, Germany
    Mol Cancer 9:306. 2010
  5. pmc Graph based fusion of miRNA and mRNA expression data improves clinical outcome prediction in prostate cancer
    Stephan Gade
    German Cancer Research Center, Cancer Genome Research, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany
    BMC Bioinformatics 12:488. 2011
  6. doi request reprint Serum miR-142-3p is associated with early relapse in operable lung adenocarcinoma patients
    Sajo Kaduthanam
    Unit Cancer Genome Research, Division of Molecular Genetics, German Cancer Research Center and National Center for Tumor Diseases, Im Neuenheimer Feld 460, Heidelberg, Germany
    Lung Cancer 80:223-7. 2013
  7. doi request reprint microRNA biomarkers in body fluids of prostate cancer patients
    Ruprecht Kuner
    Unit Cancer Genome Research, Division of Molecular Genetics, German Cancer Research Center and National Center of Tumor Diseases, Heidelberg, Germany
    Methods 59:132-7. 2013
  8. pmc ERG induces epigenetic activation of Tudor domain-containing protein 1 (TDRD1) in ERG rearrangement-positive prostate cancer
    Lukasz A Kacprzyk
    Unit Cancer Genome Research, Division of Molecular Genetics, National Center for Tumor Diseases NCT and German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 8:e59976. 2013
  9. doi request reprint The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer
    Ruprecht Kuner
    Unit Cancer Genome Research, Division of Molecular Genetics, German Cancer Research Center and National Center of Tumor Diseases, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany
    J Mol Med (Berl) 91:237-48. 2013
  10. pmc Increasing the sensitivity of reverse phase protein arrays by antibody-mediated signal amplification
    Jan C Brase
    Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
    Proteome Sci 8:36. 2010

Collaborators

Detail Information

Publications11

  1. doi request reprint Circulating miRNAs are correlated with tumor progression in prostate cancer
    Jan C Brase
    Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 128:608-16. 2011
    ..Overall, our observations suggest that miRNA-375 and miRNA-141 expression is enhanced in prostate cancer specimens and their release into the blood is further associated with advanced cancer disease...
  2. doi request reprint ERBB2 and TOP2A in breast cancer: a comprehensive analysis of gene amplification, RNA levels, and protein expression and their influence on prognosis and prediction
    Jan C Brase
    Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
    Clin Cancer Res 16:2391-401. 2010
    ..However, the correlation of DNA amplification, RNA levels, and protein expression and their prognostic role and association with anthracycline responses in node-negative breast cancer have not yet been evaluated...
  3. doi request reprint Antibody-mediated signal amplification for reverse phase protein array-based protein quantification
    Jan C Brase
    Division of Molecular Genome Analysis, German Cancer Research Center DKFZ, Heidelberg, Germany
    Methods Mol Biol 785:55-64. 2011
    ..In this chapter, we present the amplification protocol and application examples for the time-resolved analysis of signaling pathways as well as protein profiling of clinical samples...
  4. pmc Serum microRNAs as non-invasive biomarkers for cancer
    Jan C Brase
    Working Group Cancer Genome Research, German Cancer Research Center, Heidelberg, Germany
    Mol Cancer 9:306. 2010
    ..Although several challenges remain to be addressed, circulating microRNAs have the potential to be useful for the diagnosis and prognosis of cancer diseases...
  5. pmc Graph based fusion of miRNA and mRNA expression data improves clinical outcome prediction in prostate cancer
    Stephan Gade
    German Cancer Research Center, Cancer Genome Research, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany
    BMC Bioinformatics 12:488. 2011
    ....
  6. doi request reprint Serum miR-142-3p is associated with early relapse in operable lung adenocarcinoma patients
    Sajo Kaduthanam
    Unit Cancer Genome Research, Division of Molecular Genetics, German Cancer Research Center and National Center for Tumor Diseases, Im Neuenheimer Feld 460, Heidelberg, Germany
    Lung Cancer 80:223-7. 2013
    ..007; AUC=0.78). In conclusion, circulating miR-142-3p was found to be associated with a high risk of recurrence in early-stage lung adenocarcinoma patients, and a putative serum marker for risk assessment...
  7. doi request reprint microRNA biomarkers in body fluids of prostate cancer patients
    Ruprecht Kuner
    Unit Cancer Genome Research, Division of Molecular Genetics, German Cancer Research Center and National Center of Tumor Diseases, Heidelberg, Germany
    Methods 59:132-7. 2013
    ..We reflect the critical steps to translate miRNA biomarker into clinical routine diagnostics and present future aspects for the fast, robust and standardized quantification of miRNAs in body fluids...
  8. pmc ERG induces epigenetic activation of Tudor domain-containing protein 1 (TDRD1) in ERG rearrangement-positive prostate cancer
    Lukasz A Kacprzyk
    Unit Cancer Genome Research, Division of Molecular Genetics, National Center for Tumor Diseases NCT and German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 8:e59976. 2013
    ..The aim of our study was to provide a mechanistic explanation for the transcriptional activation of TDRD1 in ERG rearrangement-positive prostate tumors...
  9. doi request reprint The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer
    Ruprecht Kuner
    Unit Cancer Genome Research, Division of Molecular Genetics, German Cancer Research Center and National Center of Tumor Diseases, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany
    J Mol Med (Berl) 91:237-48. 2013
    ....
  10. pmc Increasing the sensitivity of reverse phase protein arrays by antibody-mediated signal amplification
    Jan C Brase
    Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
    Proteome Sci 8:36. 2010
    ..Increasing the sensitivity of RPPA approaches is important since many signaling proteins or posttranslational modifications are present at a low level...
  11. doi request reprint Loss of EpCAM expression in breast cancer derived serum exosomes: role of proteolytic cleavage
    Anne Kathleen Rupp
    Tumor Immunology Programme, D015, German Cancer Research Center, D 69120 Heidelberg, Germany
    Gynecol Oncol 122:437-46. 2011
    ..However, marker proteins that allow enrichment of tumor-derived exosomes over normal exosomes are less well defined...