P Boukamp

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. ncbi request reprint Ageing mechanisms: the role of telomere loss
    P Boukamp
    DKFZ, Abt Genetik der Hautcarcinogenese, Heidelberg, Germany
    Clin Exp Dermatol 26:562-5. 2001
  2. pmc The three-dimensional organization of telomeres in the nucleus of mammalian cells
    Tony Chih Yuan Chuang
    Manitoba Institute of Cell Biology, CancerCare Manitoba, University of Manitoba, 675 McDermot Avenue, Winnipeg, MB, R3E 0V9, Canada
    BMC Biol 2:12. 2004
  3. ncbi request reprint Non-melanoma skin cancer: what drives tumor development and progression?
    Petra Boukamp
    Division of Genetics of Skin Carcinogenesis, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Carcinogenesis 26:1657-67. 2005
  4. ncbi request reprint Telomere-dependent chromosomal instability
    Petra Boukamp
    German Cancer Research Center, Division of Genetics of Skin Carcinogensis, Im Neuenheimer Feld, Heidelberg, Germany
    J Investig Dermatol Symp Proc 10:89-94. 2005
  5. ncbi request reprint Skin aging: a role for telomerase and telomere dynamics?
    Petra Boukamp
    Division of Genetics of Skin Carcinogenesis, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Curr Mol Med 5:171-7. 2005
  6. ncbi request reprint UV-induced skin cancer: similarities--variations
    Petra Boukamp
    Division of Genetics of Skin Carcinogenesis, German Cancer Research Center Heidelberg, Germany
    J Dtsch Dermatol Ges 3:493-503. 2005
  7. doi request reprint UVA radiation causes DNA strand breaks, chromosomal aberrations and tumorigenic transformation in HaCaT skin keratinocytes
    K Wischermann
    Division of Genetics of Skin Carcinogenesis, German Cancer Research Center DKFZ, Heidelberg, Germany
    Oncogene 27:4269-80. 2008
  8. ncbi request reprint UV-B-type mutations and chromosomal imbalances indicate common pathways for the development of Merkel and skin squamous cell carcinomas
    Susanne Popp
    Division of Genetics of Skin Carcinogenesis, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Int J Cancer 99:352-60. 2002
  9. pmc Tumor progression of skin carcinoma cells in vivo promoted by clonal selection, mutagenesis, and autocrine growth regulation by granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor
    M M Mueller
    Division of Carcinogenesis and Differentiation, German Cancer Research Center (Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Am J Pathol 159:1567-79. 2001
  10. ncbi request reprint The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1
    Bettina Burnworth
    Division of Genetics of Skin Carcinogenesis, Deutsches Krebsforschungszentrum DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Eur J Cell Biol 86:763-80. 2007

Collaborators

  • Dirk Breitkreutz
  • A Rapp
  • P Schmezer
  • M M Mueller
  • Ingrid Moll
  • Jackie Bickenbach
  • Wolfgang Wagner
  • S Joos
  • S Werner
  • S Mai
  • Thomas K Hoffmann
  • Gernot Herrmann
  • J Arturo Londono-Vallejo
  • Peter Brenneisen
  • Ethel Michele de Villiers
  • Eniko Sonkoly
  • Hans Jürgen Stark
  • Nicolae Mirancea
  • Karsten Boehnke
  • Norbert E Fusenig
  • Sharareh Moshir
  • Ana Cerezo
  • Karin M Greulich-Bode
  • Alessandra Pavesio
  • Michael J Willhauck
  • Heiko Büth
  • Sonja Muffler
  • Damir Krunic
  • Susanne Popp
  • Stefan Wörz
  • Peter Lichter
  • Thibaud Jegou
  • Wolfgang Hartschuh
  • K Wischermann
  • Anne Sophie Gabet
  • Andor Pivarcsi
  • Katrin Wischermann
  • Roswitha Nischt
  • W Hartschuh
  • S Popp
  • Bettina Burnworth
  • Sabine Rosenberger
  • B Burnworth
  • Klaudia Brix
  • Norbert Schaschke
  • Massimo Tommasino
  • Rosita Accardi
  • Rita Narath
  • Sherif F Louis
  • Yuval Garini
  • Virginie Mougey
  • Ian T Young
  • Paul Donald Kerr
  • Thierry Fest
  • Sibylle Ermler
  • Tony Chih Yuan Chuang
  • Sandra Caldeira
  • Wenjian Ma
  • Gunhild Mechtersheimer
  • Ralf J Rieker
  • Karl Rohr
  • Petra Sander
  • Martin Pfannmöller
  • Reynel Figueroa
  • Sabine M Görisch
  • Gerrit Heuvelman
  • Steven G Gray
  • Kirsten Vang Nielsen
  • Malte Wachsmuth
  • Inn Chung
  • Karsten Rippe
  • Hermann Stammer
  • Mara Amoros
  • Angelica Bellopede
  • M Wlaschek
  • K Scharfetter-Kochanek
  • B Volkmer
  • F De Gruijl
  • Alexander Marme
  • Bakary S Sylla
  • Hans Jorg Buhring
  • S Moshir
  • R Greinert
  • Berit Falkowska-Hansen
  • A Faust
  • Ruediger Liersch
  • Pier Luigi Buttigieg
  • Rainer Haas
  • Sharada Mokkapati
  • Bernd Nurnberg

Detail Information

Publications36

  1. ncbi request reprint Ageing mechanisms: the role of telomere loss
    P Boukamp
    DKFZ, Abt Genetik der Hautcarcinogenese, Heidelberg, Germany
    Clin Exp Dermatol 26:562-5. 2001
    ..As telomerase is expressed in about 90% of all tumours while expression is absent in many somatic tissues, it is not surprising that the causal role of telomere erosion is presently the most favoured hypothesis of cellular ageing...
  2. pmc The three-dimensional organization of telomeres in the nucleus of mammalian cells
    Tony Chih Yuan Chuang
    Manitoba Institute of Cell Biology, CancerCare Manitoba, University of Manitoba, 675 McDermot Avenue, Winnipeg, MB, R3E 0V9, Canada
    BMC Biol 2:12. 2004
    ..It is, therefore, essential to analyze the 3D genome organization of the interphase nucleus in both normal and cancer cells...
  3. ncbi request reprint Non-melanoma skin cancer: what drives tumor development and progression?
    Petra Boukamp
    Division of Genetics of Skin Carcinogenesis, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Carcinogenesis 26:1657-67. 2005
    ..However, the complexity of the genetic alterations (numerical and structural aberration profiles) in SCCs argues for several levels of genomic instability involved in the generation and progression of skin cancer...
  4. ncbi request reprint Telomere-dependent chromosomal instability
    Petra Boukamp
    German Cancer Research Center, Division of Genetics of Skin Carcinogensis, Im Neuenheimer Feld, Heidelberg, Germany
    J Investig Dermatol Symp Proc 10:89-94. 2005
    ..In addition, we provide evidence that in a length-independent manner telomeres can confer to genomic instability by forming telomericaggregates which through chromosomal dys-locations contribute to chromosomal aberrations...
  5. ncbi request reprint Skin aging: a role for telomerase and telomere dynamics?
    Petra Boukamp
    Division of Genetics of Skin Carcinogenesis, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Curr Mol Med 5:171-7. 2005
    ....
  6. ncbi request reprint UV-induced skin cancer: similarities--variations
    Petra Boukamp
    Division of Genetics of Skin Carcinogenesis, German Cancer Research Center Heidelberg, Germany
    J Dtsch Dermatol Ges 3:493-503. 2005
    ....
  7. doi request reprint UVA radiation causes DNA strand breaks, chromosomal aberrations and tumorigenic transformation in HaCaT skin keratinocytes
    K Wischermann
    Division of Genetics of Skin Carcinogenesis, German Cancer Research Center DKFZ, Heidelberg, Germany
    Oncogene 27:4269-80. 2008
    ..Since normal keratinocytes responded similarly, UVA may likewise contribute to the complex karyotype characteristic for human skin carcinomas...
  8. ncbi request reprint UV-B-type mutations and chromosomal imbalances indicate common pathways for the development of Merkel and skin squamous cell carcinomas
    Susanne Popp
    Division of Genetics of Skin Carcinogenesis, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Int J Cancer 99:352-60. 2002
    ..Taken together, in addition to the common UV-B-specific mutations in the p53 and Ha-ras gene, MCCs and SCCs also share chromosomal imbalances that may point to a common environmental-derived (e.g., UV-A) oxidative damage...
  9. pmc Tumor progression of skin carcinoma cells in vivo promoted by clonal selection, mutagenesis, and autocrine growth regulation by granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor
    M M Mueller
    Division of Carcinogenesis and Differentiation, German Cancer Research Center (Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Am J Pathol 159:1567-79. 2001
    ..Thus, malignant progression favored by the in vivo microenvironment requires both clonal selection of subpopulations adapted to in vivo growth and mutational events leading to stable functional alterations...
  10. ncbi request reprint The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1
    Bettina Burnworth
    Division of Genetics of Skin Carcinogenesis, Deutsches Krebsforschungszentrum DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Eur J Cell Biol 86:763-80. 2007
    ..e. the angiogenic switch) required for malignant growth...
  11. doi request reprint Tissue context-activated telomerase in human epidermis correlates with little age-dependent telomere loss
    Damir Krunic
    Division of Genetics of Skin Carcinogenesis, German Cancer Research Center, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Biochim Biophys Acta 1792:297-308. 2009
    ....
  12. ncbi request reprint Reversion of tumor phenotype in surface transplants of skin SCC cells by scaffold-induced stroma modulation
    Michael J Willhauck
    Division of Carcinogenesis and Differentiation, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Carcinogenesis 28:595-610. 2007
    ..These novel findings underline the controlling function of tumor stroma and open new strategies of cancer therapy by targeting tumor stroma elements...
  13. ncbi request reprint Telomeres rather than telomerase a key target for anti-cancer therapy?
    Petra Boukamp
    Department of Genetics and Skin Carcinogenesis, German Cancer Research Center, Heidelberg, Germany
    Exp Dermatol 16:71-9. 2007
    ..This review aims to critically throw light on different therapeutical approaches and comes to the conclusion that telomeres may be the better targets for cancer therapeutics...
  14. pmc Dynamics of telomeres and promyelocytic leukemia nuclear bodies in a telomerase-negative human cell line
    Thibaud Jegou
    Research Group Genome Organization and Function, Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany
    Mol Biol Cell 20:2070-82. 2009
    ..Based on these studies, a model is proposed in which the shortening of telomeres results in an increased mobility that could facilitate the formation of complexes between telomeres and PML-NBs...
  15. ncbi request reprint Gain of 11q/cyclin D1 overexpression is an essential early step in skin cancer development and causes abnormal tissue organization and differentiation
    B Burnworth
    Genetics of Skin Carcinogenesis, Heidelberg, Germany
    Oncogene 25:4399-412. 2006
    ....
  16. ncbi request reprint Effects of fibroblasts and microenvironment on epidermal regeneration and tissue function in long-term skin equivalents
    Karsten Boehnke
    Division of Genetics of Skin Carcinogenesis, German Cancer Research Center DKFZ, Heidelberg, Germany
    Eur J Cell Biol 86:731-46. 2007
    ....
  17. doi request reprint A stable niche supports long-term maintenance of human epidermal stem cells in organotypic cultures
    Sonja Muffler
    Division of Genetics of Skin Carcinogenesis, German Cancer Research Center, Heidelberg, Germany
    Stem Cells 26:2506-15. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  18. ncbi request reprint Epidermal homeostasis in long-term scaffold-enforced skin equivalents
    Hans Jürgen Stark
    Division of Genetics of Skin Carcinogenesis, German Cancer Research Center, Heidelberg, Germany
    J Investig Dermatol Symp Proc 11:93-105. 2006
    ..Therefore, these scaffold-based SEs not only allow for studying homeostasis control but also for the first time provide proper experimental conditions for establishing a stem cell niche in vitro...
  19. ncbi request reprint Cell cycle-dependent 3D distribution of telomeres and telomere repeat-binding factor 2 (TRF2) in HaCaT and HaCaT-myc cells
    Sibylle Ermler
    German Cancer Research Center, Heidelberg, Germany
    Eur J Cell Biol 83:681-90. 2004
    ..Thus, we propose that TAs, which subsequently also cluster their respective chromosomes, contribute to genomic instability by forcing an abnormal chromosome segregation during mitosis...
  20. pmc Aging and replicative senescence have related effects on human stem and progenitor cells
    Wolfgang Wagner
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 4:e5846. 2009
    ..Changes upon aging of MSC and HPC are related to those of replicative senescence of MSC in vitro and this indicates that our stem and progenitor cells undergo a similar process also in vivo...
  21. ncbi request reprint A novel regulator of telomerase. S100A8 mediates differentiation-dependent and calcium-induced inhibition of telomerase activity in the human epidermal keratinocyte line HaCaT
    Sabine Rosenberger
    Genetics of Skin Carcinogenesis, German Cancer Research Center Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Biol Chem 282:6126-35. 2007
    ..We hypothesize that calcium binds to S100A8/S100A9 complexes and alters their composition, thus enabling S100A8 to interact with the telomerase complex and inhibit its activity...
  22. ncbi request reprint Improved alkaline comet assay protocol for adherent HaCaT keratinocytes to study UVA-induced DNA damage
    Katrin Wischermann
    Division of Genetics of Skin Carcinogenesis, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Mutat Res 630:122-8. 2007
    ....
  23. ncbi request reprint Junctional basement membrane anomalies of skin and mucosa in lipoid proteinosis (hyalinosis cutis et mucosae)
    Nicolae Mirancea
    German Cancer Research Center, Division Genetics of Skin Cancer, Heidelberg, Germany
    J Dermatol Sci 45:175-85. 2007
    ..According to ultrastructure there are striking differences between junctional and microvascular BM...
  24. doi request reprint 3D geometry-based quantification of colocalizations in multichannel 3D microscopy images of human soft tissue tumors
    Stefan Wörz
    Department Bioinformatics and Functional Genomics, Biomedical Computer Vision Group, University of Heidelberg, IPMB, BIOQUANT, and DKFZ Heidelberg, 69120 Heidelberg, Germany
    IEEE Trans Med Imaging 29:1474-84. 2010
    ..A statistical analysis was performed to assess the significance of the determined colocalizations. This approach was used to successfully analyze about 500 three-channel 3D microscopy images of human soft tissue tumors and controls...
  25. ncbi request reprint Dual regulation of telomerase activity through c-Myc-dependent inhibition and alternative splicing of hTERT
    Ana Cerezo
    Deutsches Krebsforschungszentrum, Division of Skin Carcinogenesis, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    J Cell Sci 115:1305-12. 2002
    ..Thus alternative splicing may not be restricted to TGF-beta1 but may add a more general mechanism of hTERT regulation in epidermal cells...
  26. ncbi request reprint Authentic fibroblast matrix in dermal equivalents normalises epidermal histogenesis and dermoepidermal junction in organotypic co-culture
    Hans Jürgen Stark
    German Cancer Research Center DKFZ, Heidelberg, Germany
    Eur J Cell Biol 83:631-45. 2004
    ....
  27. ncbi request reprint Human dermal fibroblasts escape from the long-term phenocopy of senescence induced by psoralen photoactivation
    Wenjian Ma
    Department of Dermatology, University of Cologne, Joseph Stelzmann Strasse 9, Germany
    Exp Cell Res 274:299-309. 2002
    ..The model reported here is particularly suited to elucidating mechanisms underlying long-term transient growth arrest, the related functional changes, and the release of cells thereof...
  28. pmc The E6 and E7 proteins of the cutaneous human papillomavirus type 38 display transforming properties
    Sandra Caldeira
    Angewandte Tumorvirologie Genetik der Hautcarcinogenese, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany Istituto di Dermatologia, Facolta di Medicina, Universita di Bari, Bari, Italy
    J Virol 77:2195-206. 2003
    ..In further support of such a role, we detected HPV38 DNA in approximately 50% of nonmelanoma skin cancers, but only in 10% of healthy skin specimens (P < 0.001)...
  29. pmc Tumor immune escape by the loss of homeostatic chemokine expression
    Andor Pivarcsi
    Department of Dermatology, Heinrich Heine University, D 40255 Düsseldorf, Germany
    Proc Natl Acad Sci U S A 104:19055-60. 2007
    ..Collectively, our data identify a mechanism of skin tumors to evade host antitumor immune responses...
  30. ncbi request reprint Impairment of the telomere/telomerase system and genomic instability are associated with keratinocyte immortalization induced by the skin human papillomavirus type 38
    Anne Sophie Gabet
    Infections and Cancer Biology Group, International Agency for Research on Cancer, World Health Organization, 150 cours Albert Thomas, 69372 Lyon, France
    FASEB J 22:622-32. 2008
    ....
  31. pmc c-Myc induces chromosomal rearrangements through telomere and chromosome remodeling in the interphase nucleus
    Sherif F Louis
    Manitoba Institute of Cell Biology, University of Manitoba, 675 McDermot Avenue, Winnipeg, MB, Canada R3E 0V9
    Proc Natl Acad Sci U S A 102:9613-8. 2005
    ..Our findings reveal that c-Myc possesses the ability to structurally modify chromosomes through telomeric fusions, thereby reorganizing the genetic information...
  32. ncbi request reprint Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes
    Heiko Büth
    School of Engineering and Science, Jacobs University Bremen formerly International University Bremen, Campus Ring 6, Research II 107, D 28759 Bremen, Germany
    Eur J Cell Biol 86:747-61. 2007
    ....
  33. ncbi request reprint Constitutive overexpression of human telomerase reverse transcriptase but not c-myc blocks terminal differentiation in human HaCaT skin keratinocytes
    Ana Cerezo
    German Cancer Research Center DKFZ
    J Invest Dermatol 121:110-9. 2003
    ....
  34. ncbi request reprint HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration
    Heiko Büth
    School of Engineering and Science, International University Bremen, Bremen, Germany
    Eur J Cell Biol 83:781-95. 2004
    ..Thus, our results strongly suggest that cell surface-associated cathepsin B is a protease that contributes to the remodelling of the extracellular matrix and thereby promotes keratinocyte migration during wound healing...
  35. ncbi request reprint Automatic telomere length measurements in interphase nuclei by IQ-FISH
    Rita Narath
    Children s Cancer Research Institute CCRI, St Anna Kinderspital, A 1090 Vienna, Austria
    Cytometry A 68:113-20. 2005
    ..The automatic measurement of large cell numbers allows the measurement of statistically relevant cell populations...
  36. ncbi request reprint Lack of nidogen-1 and -2 prevents basement membrane assembly in skin-organotypic coculture
    Roswitha Nischt
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Invest Dermatol 127:545-54. 2007
    ....