Affiliation: German Institute of Human Nutrition
Behrens M, Meyerhof W. Oral and extraoral bitter taste receptors. Results Probl Cell Differ. 2010;52:87-99 pubmed publisher
Behrens M, Born S, Redel U, Voigt N, Schuh V, Raguse J, et al
. Immunohistochemical detection of TAS2R38 protein in human taste cells. PLoS ONE. 2012;7:e40304 pubmed publisher
Lossow K, Hübner S, Roudnitzky N, Slack J, Pollastro F, Behrens M, et al
. Comprehensive Analysis of Mouse Bitter Taste Receptors Reveals Different Molecular Receptive Ranges for Orthologous Receptors in Mice and Humans. J Biol Chem. 2016;291:15358-77 pubmed publisher
..Moreover, we have demonstrated that sequence-orthologous bitter taste receptors have distinct agonist profiles. Species-specific gene expansions have enabled further diversification of bitter substance recognition spectra. ..
Behrens M, Korsching S, Meyerhof W. Tuning properties of avian and frog bitter taste receptors dynamically fit gene repertoire sizes. Mol Biol Evol. 2014;31:3216-27 pubmed publisher
..In sum, we show that variability in tuning breadth, overlapping agonist profiles, and staggered effective agonist concentration ranges are shared features of human and other vertebrate Tas2rs. ..
Cheled Shoval S, Behrens M, Korb A, Di Pizio A, Meyerhof W, Uni Z, et al
. From Cell to Beak: In-Vitro and In-Vivo Characterization of Chicken Bitter Taste Thresholds. Molecules. 2017;22: pubmed publisher
..In-vivo thresholds were similar or up to two orders of magnitude higher than the in-vitro ones. ..
Prandi S, Voigt A, Meyerhof W, Behrens M. Expression profiling of Tas2r genes reveals a complex pattern along the mouse GI tract and the presence of Tas2r131 in a subset of intestinal Paneth cells. Cell Mol Life Sci. 2018;75:49-65 pubmed publisher
..We discovered that the number and expression level of Tas2r genes profoundly vary along the alimentary canal, with the stomach and the colon expressing the largest subsets. ..
Behrens M, Blank K, Meyerhof W. Blends of Non-caloric Sweeteners Saccharin and Cyclamate Show Reduced Off-Taste due to TAS2R Bitter Receptor Inhibition. Cell Chem Biol. 2017;24:1199-1204.e2 pubmed publisher
..Intriguingly, also saccharin inhibits cyclamate-activated bitter receptors. Our experiments demonstrate that heterologous assays are useful for understanding perceptual phenomena and the development of novel tastant formulations. ..
Behrens M, Buck F, Meyerhof W. Substrate specificity of rat DESC4, a type II transmembrane serine protease. Protein Pept Lett. 2009;16:1-6 pubmed
..For further analyses a homology-based model of the DESC4 catalytic domain was generated enabling us to investigate protease-substrate interaction in more detail. ..
Behrens M, Meyerhof W. Gustatory and extragustatory functions of mammalian taste receptors. Physiol Behav. 2011;105:4-13 pubmed publisher
..The present article summarizes current knowledge on mammalian G protein-coupled taste receptors as well as various aspects of their proposed role in gastrointestinal tissues. ..