Research Topics
Genomes and Genes
Species | Stephanie BechtelSummaryAffiliation: German Cancer Research Center Country: Germany Publications
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Detail Information
Publications
An anthropoid-specific segmental duplication on human chromosome 1q22Vladimir Yu Kuryshev
Department of Molecular Genome Analysis, DKFZ German Cancer Research Center, INF 580, D 69120 Heidelberg, Germany
Genomics 88:143-51. 2006..Moreover, we provide detailed information regarding structure and evolution of the SD1q22 region that is a prerequisite for future studies of its anthropoid-specific functions and possible linkage to human genetic disorders...
Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migrationSiau Wei Baï
Randall Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, London SE11UL, UK
BMC Biol 9:54. 2011..Cell migration is essential during development and in human disease progression including cancer. Most cell migration studies concentrate on known or predicted components of migration pathways...
The full-ORF clone resource of the German cDNA ConsortiumStephanie Bechtel
Department of Molecular Genome Analysis, German Cancer Research Center DKFZ, Heidelberg, Germany
BMC Genomics 8:399. 2007..In combination with a unique and versatile cloning system, these will provide the tools for genome-wide systematic functional analyses, to achieve a deeper insight into complex biological processes...
Time-resolved human kinome RNAi screen identifies a network regulating mitotic-events as early regulators of cell proliferationJitao David Zhang
Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
PLoS ONE 6:e22176. 2011..Our work establishes RTCA technology as a novel robust tool with biological and pharmacological relevance amenable for high-throughput screening...
Large-scale protein expression for proteome researchUlrike Korf
Molecular Genome Analysis, DKFZ, Heidelberg, Germany
Proteomics 5:3571-80. 2005..Affinity-purified fusion proteins were confirmed by MALDI-TOF MS...
High-throughput flow cytometry-based assay to identify apoptosis-inducing proteinsMamatha Sauermann
Division of Molecular Genome Analysis, German Cancer Research Centre, Heidelberg, Germany
J Biomol Screen 12:510-20. 2007..The candidate proteins were all verified in an independent microscopy-based nuclear fragmentation assay, finally resulting in the identification of 6 apoptosis inducers...
The German cDNA network: cDNAs, functional genomics and proteomicsStefan Wiemann
Molecular Genome Analysis, German Cancer Research Center, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
J Struct Funct Genomics 4:87-96. 2003....
The LIFEdb database in 2006Alexander Mehrle
Division Molecular Genome Analysis, German Cancer Research Center, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
Nucleic Acids Res 34:D415-8. 2006..LIFEdb enables researchers to systematically select and characterize genes and proteins of interest, and presents data and information via its user-friendly web-based interface...
From ORFeome to biology: a functional genomics pipelineStefan Wiemann
Molecular Genome Analysis, German Cancer Research Center, 69120 Heidelberg, Germany
Genome Res 14:2136-44. 2004..All information is presented in a Web database (http://www.dkfz.de/LIFEdb). It is exploited for the identification of disease-relevant genes and proteins for diagnosis and therapy...
CDNAs for functional genomics and proteomics: the German ConsortiumStefan Wiemann
Molecular Genome Analysis, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
C R Biol 326:1003-9. 2003..The resulting information is integrated with functional genomics and proteomics data for further understanding of protein functions in the cellular context...
The systematic functional characterisation of Xq28 genes prioritises candidate disease genesAnja Kolb-Kokocinski
Division of Molecular Genome Analysis, German Cancer Research Centre DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
BMC Genomics 7:29. 2006..To expedite disease gene identification, we have initiated the functional characterisation of all known Xq28 genes...
