Helmut Bartsch

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. ncbi request reprint Oxidative stress and lipid peroxidation-derived DNA-lesions in inflammation driven carcinogenesis
    Helmut Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im NeuenheimerFeld280, D 69120 Heidelberg, Germany
    Cancer Detect Prev 28:385-91. 2004
  2. ncbi request reprint Accumulation of lipid peroxidation-derived DNA lesions: potential lead markers for chemoprevention of inflammation-driven malignancies
    Helmut Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Mutat Res 591:34-44. 2005
  3. ncbi request reprint Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair
    Helmut Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Langenbecks Arch Surg 391:499-510. 2006
  4. ncbi request reprint Hunting for electrophiles that harm human DNA: Frits Sobels Award Lecture
    Helmut Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mutagenesis 17:281-7. 2002
  5. ncbi request reprint Ultrasensitive and specific detection methods for exocylic DNA adducts: markers for lipid peroxidation and oxidative stress
    H Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120, Heidelberg, Germany
    Toxicology 153:105-14. 2000
  6. ncbi request reprint Potential role of lipid peroxidation derived DNA damage in human colon carcinogenesis: studies on exocyclic base adducts as stable oxidative stress markers
    Helmut Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Cancer Detect Prev 26:308-12. 2002
  7. doi request reprint Dr Jagadeesan Nair, Senior Scientist at the German Cancer Research Center (DKFZ) 1953-2007
    Helmut Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 290, Heidelberg, Germany
    Carcinogenesis 29:887-8. 2008
  8. ncbi request reprint Association between the risk for lung adenocarcinoma and a (-4) G-to-A polymorphism in the XPA gene
    Dorota Butkiewicz
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 13:2242-6. 2004
  9. doi request reprint Accumulation of lipid peroxidation-derived DNA lesions in iron-overloaded thalassemic mouse livers: comparison with levels in the lymphocytes of thalassemia patients
    Mayura Meerang
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 125:759-66. 2009
  10. doi request reprint Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer
    Maria Timofeeva
    Department of Epigenomics and Cancer Risk Factors, German Cancer Research Centre DKFZ, Heidelberg, Germany
    Int J Cancer 127:1547-61. 2010

Collaborators

Detail Information

Publications102 found, 100 shown here

  1. ncbi request reprint Oxidative stress and lipid peroxidation-derived DNA-lesions in inflammation driven carcinogenesis
    Helmut Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im NeuenheimerFeld280, D 69120 Heidelberg, Germany
    Cancer Detect Prev 28:385-91. 2004
    ..Mechanisms and host-factors that influence the steady-state levels of epsilon-DNA adducts in cancer prone tissues are under investigation...
  2. ncbi request reprint Accumulation of lipid peroxidation-derived DNA lesions: potential lead markers for chemoprevention of inflammation-driven malignancies
    Helmut Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Mutat Res 591:34-44. 2005
    ..If so, the efficacy of human chemopreventive interventions for malignant disease prevention could be verified...
  3. ncbi request reprint Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair
    Helmut Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Langenbecks Arch Surg 391:499-510. 2006
    ..Steady-state levels of LPO-derived (etheno-) DNA adducts in organs affected by persistent inflammatory processes were investigated as potential lead markers for assessing progression of inflammatory cancer-prone diseases...
  4. ncbi request reprint Hunting for electrophiles that harm human DNA: Frits Sobels Award Lecture
    Helmut Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mutagenesis 17:281-7. 2002
    ..Etheno-DNA adducts are thus promising markers to verify the efficiency of chemopreventive measures in humans...
  5. ncbi request reprint Ultrasensitive and specific detection methods for exocylic DNA adducts: markers for lipid peroxidation and oxidative stress
    H Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120, Heidelberg, Germany
    Toxicology 153:105-14. 2000
    ....
  6. ncbi request reprint Potential role of lipid peroxidation derived DNA damage in human colon carcinogenesis: studies on exocyclic base adducts as stable oxidative stress markers
    Helmut Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Cancer Detect Prev 26:308-12. 2002
    ..g. [Lancet Oncol. 1 (2000) 107]) and chemopreventive agents in lowering oxidative stress and related cancer risk...
  7. doi request reprint Dr Jagadeesan Nair, Senior Scientist at the German Cancer Research Center (DKFZ) 1953-2007
    Helmut Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 290, Heidelberg, Germany
    Carcinogenesis 29:887-8. 2008
  8. ncbi request reprint Association between the risk for lung adenocarcinoma and a (-4) G-to-A polymorphism in the XPA gene
    Dorota Butkiewicz
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 13:2242-6. 2004
    ..The underlying mechanisms as to why AA homozygotes are predisposed to lung adenocarcinoma and which specific carcinogens are involved remains to be determined...
  9. doi request reprint Accumulation of lipid peroxidation-derived DNA lesions in iron-overloaded thalassemic mouse livers: comparison with levels in the lymphocytes of thalassemia patients
    Mayura Meerang
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 125:759-66. 2009
    ..We conclude that promutagenic LPO-derived DNA lesions are involved in the onset of hepatocellular carcinoma in these patients...
  10. doi request reprint Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer
    Maria Timofeeva
    Department of Epigenomics and Cancer Risk Factors, German Cancer Research Centre DKFZ, Heidelberg, Germany
    Int J Cancer 127:1547-61. 2010
    ..To confirm these observations and to eliminate possible bias in our analyses, larger studies are warranted...
  11. ncbi request reprint Genotype relationships in the CYP3A locus in Caucasians
    Heike Dally
    Deutsches Krebsforschungszentrum, Abteilung Toxikologie und Krebsrisikofaktoren, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Cancer Lett 207:95-9. 2004
    ....
  12. ncbi request reprint The CYP3A4*1B allele increases risk for small cell lung cancer: effect of gender and smoking dose
    Heike Dally
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Pharmacogenetics 13:607-18. 2003
    ..To confirm our observation that the CYP3A4*1B allele increases SCLC risk and modifies the smoking-related lung cancer risk in a gender-specific manner, further studies, including CYP3A haplotype analysis, will be necessary...
  13. ncbi request reprint Laryngeal cancer risk in Caucasians is associated with alcohol and tobacco consumption but not modified by genetic polymorphisms in class I alcohol dehydrogenases ADH1B and ADH1C, and glutathione-S-transferases GSTM1 and GSTT1
    Angela Risch
    Division of Toxicology and Cancer Risk Factors German Cancer Research Center DKFZ, Heidelberg, Germany
    Pharmacogenetics 13:225-30. 2003
    ..As part of the Rhein-Neckar Larynx-case-control study, this study investigated the potential risk-modifying effect of genetic polymorphisms in enzymes involved in ethanol and tobacco carcinogen metabolism for laryngeal cancer in Germany...
  14. doi request reprint A distinct ERCC1 haplotype is associated with mRNA expression levels in prostate cancer patients
    Andreas Woelfelschneider
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Carcinogenesis 29:1758-64. 2008
    ..Our study further revealed a modulating effect by nutritional factors...
  15. ncbi request reprint Elevated risk of squamous-cell carcinoma of the lung in heavy smokers carrying the variant alleles of the TP53 Arg72Pro and p21 Ser31Arg polymorphisms
    Odilia Popanda
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Lung Cancer 55:25-34. 2007
    ..Nevertheless, confirmation by further molecular and epidemiological studies is warranted...
  16. doi request reprint Lipid peroxidation and DNA adduct formation in lymphocytes of premenopausal women: Role of estrogen metabolites and fatty acid intake
    Xin Sun
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, DKFZ, Heidelberg 69120, Germany
    Int J Cancer 131:1983-90. 2012
    ..Similar studies in human breast epithelial tissue and on amplification of DNA-damage in breast cancer patients are in progress...
  17. ncbi request reprint Specific combinations of DNA repair gene variants and increased risk for non-small cell lung cancer
    Odilia Popanda
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Carcinogenesis 25:2433-41. 2004
    ..Analyses of additional DNA repair gene interactions in larger population-based studies are warranted for identification of high-risk subjects...
  18. ncbi request reprint In vitro radiation-induced expression of XPC mRNA as a possible biomarker for developing adverse reactions during radiotherapy
    Katrin Wiebalk
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 121:2340-5. 2007
    ..The predictive value of DNA damage-induced XPC levels as a possible biomarker for radiosensitivity has to be further investigated...
  19. doi request reprint Quantifying etheno-DNA adducts in human tissues, white blood cells, and urine by ultrasensitive (32)P-postlabeling and immunohistochemistry
    Jagadeesan Nair
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Methods Mol Biol 682:189-205. 2011
    ..The described methods are useful in diagnosis and monitoring of chronic degenerative diseases, including cancer, atherosclerosis, and neurodegenerative disorders...
  20. doi request reprint High urinary excretion of lipid peroxidation-derived DNA damage in patients with cancer-prone liver diseases
    Jagadeesan Nair
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Mutat Res 683:23-8. 2010
    ....
  21. ncbi request reprint Lipid peroxidation-induced DNA damage in cancer-prone inflammatory diseases: a review of published adduct types and levels in humans
    Urmila Nair
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Free Radic Biol Med 43:1109-20. 2007
    ....
  22. doi request reprint CYP450 polymorphisms as risk factors for early-onset lung cancer: gender-specific differences
    Maria N Timofeeva
    Department of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Carcinogenesis 30:1161-9. 2009
    ..63 and P = 0.42 for CYP1B1 and CYP2A13, respectively). Our results suggest that the CYP1B1 and the CYP2A13 genotypes may contribute to individual susceptibility to early-onset lung cancer in women...
  23. ncbi request reprint Constitutive mRNA expression of DNA repair-related genes as a biomarker for clinical radio-resistance: A pilot study in prostate cancer patients receiving radiotherapy
    Jörg Hümmerich
    Division of Toxicology and Cancer Risk Factors, Heidelberg, Germany
    Int J Radiat Biol 82:593-604. 2006
    ..Constitutive mRNA expression of repair genes was investigated in such patients to analyze whether expression patterns are predictive for therapy-related acute side effects...
  24. doi request reprint Polymorphisms in ABCG2, ABCC3 and CNT1 genes and their possible impact on chemotherapy outcome of lung cancer patients
    Phillip J Müller
    Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 124:1669-74. 2009
    ..04-2.47; n = 256). In conclusion, this study prioritizes ABCC3 C-211T and ABCG2 C421A as candidate transporter SNPs to be further investigated as possible predictors of the clinical outcome of chemotherapy in lung cancer patients...
  25. doi request reprint Identification of 3,N(4)-etheno-5-methyl-2'-deoxycytidine in human DNA: a new modified nucleoside which may perturb genome methylation
    Jagadeesan Nair
    German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Chem Res Toxicol 25:162-9. 2012
    ..Our new detection method can now be used to explore the hypothesis that this DNA lesion perturbs the DNA methylation status...
  26. ncbi request reprint Decreased levels of lipid peroxidation-induced DNA damage in the onset of atherogenesis in apolipoprotein E deficient mice
    Roger W L Godschalk
    German Cancer Research Center DKFZ, Division of Toxicology and Cancer Risk Factors, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mutat Res 621:87-94. 2007
    ..Although these data suggest no role for increased LPO derived DNA damage in the onset of atherogenesis in ApoE-KO mice, the potentially modulating role of Ape1/Ref1 in the arterial wall deserves further attention...
  27. pmc Biomarkers for hazard identification in humans
    Helmut Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Environ Health 10:S11. 2011
    ..Exocyclic etheno-DNA adducts, which are formed by LPO-products such as 4-hydroxy -2-nonenal, are strongly pro-mutagenic DNA lesions...
  28. ncbi request reprint Prevention of degenerative diseases; clues from studies investigating oxidative stress, Brussels, 13 November 2002
    Urmila Nair
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, 280 Im Neuenheimer Feld, 69120 Heidelberg, Germany
    Mutagenesis 18:477-83. 2003
    ..The European Commission held a major conference from 11 to 13 November 2002 in the Palais du Heysel in Brussels to mark the launch of the European Union's Sixth Framework Programme (FP-6) for research, which covers the period 2002-2006...
  29. ncbi request reprint Apoptosis and age-dependant induction of nuclear and mitochondrial etheno-DNA adducts in Long-Evans Cinnamon (LEC) rats: enhanced DNA damage by dietary curcumin upon copper accumulation
    Jagadeesan Nair
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Carcinogenesis 26:1307-15. 2005
    ..LPO-induced adduct formation in nuclear and mitochondrial DNA appear as early lesions in LEC rat liver carcinogenesis and are discussed in relation to apoptotic events in the progression of malignant disease...
  30. ncbi request reprint Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention
    Elisabeth Bertl
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, C010 2 Chemoprevention, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mol Cancer Ther 5:575-85. 2006
    ..These novel antiangiogenic activities of sulforaphane are likely to contribute to its cancer chemopreventive and therapeutic potential...
  31. ncbi request reprint Etheno-DNA adduct formation in rats gavaged with linoleic acid, oleic acid and coconut oil is organ- and gender specific
    Qingming Fang
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280 69120 Heidelberg, Germany
    Mutat Res 624:71-9. 2007
    ..Colon was a target for LPO-derived DNA-adducts in both LA-treated male and female rats, supporting their role in omega-6 PUFA induced colon carcinogenesis...
  32. ncbi request reprint Biphasic modulation of cell proliferation by sulforaphane at physiologically relevant exposure times in a human colon cancer cell line
    Gerlinde Pappa
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Mol Nutr Food Res 51:977-84. 2007
    ..Depletion of GSH does not seem to play a role in SFN-mediated apoptosis induction. Our data clearly contribute to a better understanding of the kinetics of antiproliferative activity of SFN...
  33. ncbi request reprint Radiation-induced DNA damage and repair in lymphocytes from breast cancer patients and their correlation with acute skin reactions to radiotherapy
    Odilia Popanda
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 55:1216-25. 2003
    ..The study objective was to evaluate whether DNA repair data determined in vitro are correlated with the occurrence of acute side effects during radiotherapy...
  34. ncbi request reprint Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers
    H Bartsch
    Division of Toxicology and Cancer Risk Factors, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 9:3-28. 2000
    ..Future strategies in molecular cancer epidemiology for identifying such susceptible individuals are discussed with emphasis on well-designed larger studies...
  35. ncbi request reprint Quantitative combination effects between sulforaphane and 3,3'-diindolylmethane on proliferation of human colon cancer cells in vitro
    Gerlinde Pappa
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, C010 2 Chemoprevention, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Carcinogenesis 28:1471-7. 2007
    ..These data stress the need for elucidating mechanistic interactions for better predicting beneficial health effects of bioactive food components...
  36. ncbi request reprint Benzo[a]pyrene enhances lipid peroxidation induced DNA damage in aorta of apolipoprotein E knockout mice
    Roger Godschalk
    German Cancer Research Center DKFZ, Div Toxicology and Cancer Risk Factors, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Free Radic Res 37:1299-305. 2003
    ..This study further indicates that etheno-DNA adducts are useful biomarkers for in vivo oxidative stress in atherosclerosis...
  37. ncbi request reprint Lipid peroxidation-derived etheno-DNA adducts in human atherosclerotic lesions
    Jagadeesan Nair
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Mutat Res 621:95-105. 2007
    ....
  38. doi request reprint Polymorphisms in the apoptotic pathway gene BCL-2 and survival in small cell lung cancer
    Lena Franziska Knoefel
    Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    J Thorac Oncol 6:183-9. 2011
    ..Such a marker might help optimize lung cancer treatment in a tailored approach...
  39. ncbi request reprint Gene expression profiles in rat liver slices exposed to hepatocarcinogenic enzyme inducers, peroxisome proliferators, and 17alpha-ethinylestradiol
    Gisela Werle-Schneider
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, DKFZ, Heidelberg, Germany
    Int J Toxicol 25:379-95. 2006
    ..In conclusion, gene expression profiles induced by compounds that act via similar mechanisms showed common effects on transcription upon treatment in vivo and in rat liver slices in vitro...
  40. ncbi request reprint Genetic risk profiles for cancer susceptibility and therapy response
    Helmut Bartsch
    Deutsches Krebsforschungszentrum, Toxicology and Cancer Risk Factors, Heidelberg, Germany
    Recent Results Cancer Res 174:19-36. 2007
    ..Before translating these findings into clinical use and application for public health measures, large population-based studies and validation of the results will be required...
  41. ncbi request reprint Content of polyphenolic compounds in the Nigerian stimulants Cola nitida ssp. alba, Cola nitida ssp. rubra A. Chev, and Cola acuminata Schott & Endl and their antioxidant capacity
    Sunday Ene Ojo Atawodi
    Division of Toxicology, German Cancer Research Center, Heidelberg, Germany
    J Agric Food Chem 55:9824-8. 2007
    ....
  42. doi request reprint Increased urinary 1,N6-ethenodeoxyadenosine and 3,N4-ethenodeoxycytidine excretion in thalassemia patients: markers for lipid peroxidation-induced DNA damage
    Mayura Meerang
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Free Radic Biol Med 44:1863-8. 2008
    ..These highly promutagenic lesions may contribute to the increased risk of thalassemia patients to develop hepatocellular carcinoma...
  43. ncbi request reprint Age-dependent increase of etheno-DNA-adducts in liver and brain of ROS overproducing OXYS rats
    Jagadeesan Nair
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Biochem Biophys Res Commun 336:478-82. 2005
    ..Our results demonstrate increased LPO-induced DNA damage in organs of OXYS rats which correlates with their known shorter life-span and elevated frequency of chronic degenerative diseases...
  44. doi request reprint Ethanol-mediated carcinogenesis in the human esophagus implicates CYP2E1 induction and the generation of carcinogenic DNA-lesions
    Gunda Millonig
    Department of Medicine, Salem Medical Centre and Centre of Alcohol Research, Liver Disease and Nutrition, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 128:533-40. 2011
    ..Our data demonstrate for the first time an induction of CYP2E1 in the esophageal mucosa by ethanol in a dose dependent manner in man and may explain, at least in part, the generation of carcinogenic DNA lesions in this target organ...
  45. ncbi request reprint Genetic cancer susceptibility and DNA adducts: studies in smokers, tobacco chewers, and coke oven workers
    H Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Cancer Detect Prev 23:445-53. 1999
    ....
  46. pmc The role of individual susceptibility in cancer burden related to environmental exposure
    H Bartsch
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Environ Health Perspect 104:569-77. 1996
    ....
  47. ncbi request reprint Influence of dietary fatty acid, vegetable, and vitamin intake on etheno-DNA adducts in white blood cells of healthy female volunteers: a pilot study
    T Hagenlocher
    Division of Toxicology, German Cancer Research Center (Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 10:1187-91. 2001
    ..This pilot study also indicated a protective effect of dietary vitamin E and vegetables against miscoding, lipid peroxidation-induced DNA lesions...
  48. ncbi request reprint Relevance of N-acetyltransferase 1 and 2 (NAT1, NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility
    H Wikman
    German Cancer Research Centre DKFZ, Division of Toxicology and Cancer Risk Factors, Heidelberg
    Pharmacogenetics 11:157-68. 2001
    ..These data clearly show the importance of separating different histological lung tumour subtypes in studies on genetic susceptibility factors and implicate the NAT1*10 allele as a risk factor for adenocarcinoma...
  49. ncbi request reprint Identification and functional characterization of the natural variant MRP3-Arg1297His of human multidrug resistance protein 3 (MRP3/ABCC3)
    Young Min A Lee
    Division of Tumour Biochemistry, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    Pharmacogenetics 14:213-23. 2004
    ..This experimental setup provides a useful tool to analyse the functional consequences of polymorphic variants of MRP3...
  50. ncbi request reprint Optimization of an isotope dilution gas chromatography/mass spectrometry method for the detection of endogenous estrogen metabolites in urine samples
    Ulrike Knust
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Rapid Commun Mass Spectrom 21:2245-54. 2007
    ..The modified method described is less complex, amenable to use with commercially available SPE columns and fulfils all the reliability criteria, resulting in highly specific and accurate results...
  51. ncbi request reprint Alert for an epidemic of oral cancer due to use of the betel quid substitutes gutkha and pan masala: a review of agents and causative mechanisms
    Urmila Nair
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Mutagenesis 19:251-62. 2004
    ..Further, education to reduce or eliminate home-made preparations needs to be accelerated...
  52. ncbi request reprint CYP1A1 and GSTM1 genotypes affect benzo[a]pyrene DNA adducts in smokers' lung: comparison with aromatic/hydrophobic adduct formation
    Kroum Alexandrov
    German Cancer Research Center DKFZ, Division of Toxicology and Cancer Risk Factors, P O Box 101949, D 69009 Heidelberg, Germany
    Carcinogenesis 23:1969-77. 2002
    ....
  53. ncbi request reprint DNA repair capacity after gamma-irradiation and expression profiles of DNA repair genes in resting and proliferating human peripheral blood lymphocytes
    Claudia Mayer
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    DNA Repair (Amst) 1:237-50. 2002
    ....
  54. ncbi request reprint Exocyclic DNA adducts as oxidative stress markers in colon carcinogenesis: potential role of lipid peroxidation, dietary fat and antioxidants
    Helmut Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Biol Chem 383:915-21. 2002
    ..As epsilon-DNA adducts are biomarkers for oxidative stress and LPO induced DNA damage, they can verify the efficacy of newly identified antioxidants, e.g. from olive oil, as chemopreventive agents against colon carcinogenesis...
  55. ncbi request reprint Inhibition of endothelial cell functions by novel potential cancer chemopreventive agents
    Elisabeth Bertl
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Biochem Biophys Res Commun 325:287-95. 2004
    ..Overall, our data indicate that inhibition of endothelial cell function contributes to various extents to the chemopreventive or anti-angiogenic potential of these lead compounds...
  56. ncbi request reprint Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae
    Gerlinde Pappa
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, DKFZ, 69120 Heidelberg, Germany
    Mutat Res 599:76-87. 2006
    ....
  57. ncbi request reprint No prevention of liver and kidney tumors in Long-Evans Cinnamon rats by dietary curcumin, but inhibition at other sites and of metastases
    Norbert Frank
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, lm Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mutat Res 523:127-35. 2003
    ..We conclude that curcumin should be contra-indicated for patients suffering from inherited and acquired metal storage diseases that include patients with hepatitis C virus infection...
  58. ncbi request reprint Development of novel cancer chemopreventive agents in Europe--neglected Cinderella or rising phoenix? A critical commentary. ESF Workshop on Cancer Chemoprevention, DKFZ, Heidelberg, September 18-20, 2005
    Clarissa Gerhauser
    German Cancer Research Center, Toxicology and Cancer Risk Factors, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur J Cancer 42:1338-43. 2006
    ..Overall the workshop aimed at raising awareness among European clinical and laboratory researchers of the importance of the development of novel, efficacious and safe cancer preventive agents...
  59. ncbi request reprint Immunohistochemical detection of 1,N6-ethenodeoxyadenosine in nuclei of human liver affected by diseases predisposing to hepato-carcinogenesis
    Alexander Frank
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Carcinogenesis 25:1027-31. 2004
    ..In cancer-prone liver diseases (fatty liver, cirrhosis/fibrosis) such damage may act as a driving force towards malignancy...
  60. ncbi request reprint A modified immuno-enriched 32P-postlabeling method for analyzing the malondialdehyde-deoxyguanosine adduct, 3-(2-deoxy-beta-D-erythro-pentofuranosyl)- pyrimido[1,2-alpha]purin-10(3H)one in human tissue samples
    Xin Sun
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Chem Res Toxicol 17:268-72. 2004
    ..This ultrasensitive detection method is thus suitable for applications in human biomonitoring and molecular epidemiology studies...
  61. ncbi request reprint Comparison of multiple DNA adduct types in tumor adjacent human lung tissue: effect of cigarette smoking
    R Godschalk
    German Cancer Research Center DKFZ, Division of Toxicology and Cancer Risk Factors, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Carcinogenesis 23:2081-6. 2002
    ....
  62. ncbi request reprint [Cancer prevention with green tea: reality and wishful thinking]
    Barbara Bertram
    Abteilung für Toxikologie und Krebsrisikofaktoren, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Deutschland
    Wien Med Wochenschr 152:153-8. 2002
    ..By inactivation of proteolytic enzymes they inhibit the development of metastases. This short review summarizes relevant recent findings on the protective effects of green tea constituents...
  63. ncbi request reprint Glutathione-S-transferase M1, M3, T1 and P1 polymorphisms and susceptibility to non-small-cell lung cancer subtypes and hamartomas
    A Risch
    German Cancer Research Centre DKFZ, Division of Toxicology and Cancer Risk Factors, Heidelberg, Germany
    Pharmacogenetics 11:757-64. 2001
    ..The latter role for GSTT1 would explain the observed lower risk of SCC and hamartoma associated with GSTT1 null. Further confirmatory studies are required...
  64. ncbi request reprint New DNA-based biomarkers for oxidative stress and cancer chemoprevention studies
    H Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Centre DKFZ, Im Neuenheimer Feld 280, D 69120, Heidelberg, Germany
    Eur J Cancer 36:1229-34. 2000
    ..Therefore, exocyclic DNA adducts offer new tools in cancer aetiological research and in verifying the efficacy of chemopreventive agents...
  65. doi request reprint Typical signature of DNA damage in white blood cells: a pilot study on etheno adducts in Danish mother-newborn child pairs
    K Arab
    Division of Epigenomics, German Cancer Research Center DKFZ, Heidelberg, Germany
    Carcinogenesis 30:282-5. 2009
    ..Prospective cohort studies have to reveal whether these two WBC-DNA adducts could serve as risk indicator for developing hematopoietic cancers and other disorders later in life...
  66. ncbi request reprint Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop
    Clarissa Gerhauser
    Deutsches Krebstforschungszentrum, Abteilung Toxikologie und Krebsrisikofaktoren, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mol Cancer Ther 1:959-69. 2002
    ..Together, our data provide evidence for the potential application of XN as a novel, readily available chemopreventive agent, and clinical investigations are warranted once efficacy and safety in animal models have been established...
  67. ncbi request reprint Myeloperoxidase (MPO) genotype and lung cancer histologic types: the MPO -463 A allele is associated with reduced risk for small cell lung cancer in smokers
    Heike Dally
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 102:530-5. 2002
    ..We confirm that the MPO -463 A variant affords a protective effect against lung cancer risk in smokers, which was strongest for SCLC patients...
  68. ncbi request reprint Increased etheno-DNA adducts in affected tissues of patients suffering from Crohn's disease, ulcerative colitis, and chronic pancreatitis
    Jagadeesan Nair
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Antioxid Redox Signal 8:1003-10. 2006
    ..The conclusion is that promutagenic etheno-DNA adducts are generated as a consequence of chronic inflammation, acting as a driving force to malignancy in cancer-prone inflammatory diseases...
  69. ncbi request reprint New ultrasensitive 32P-postlabelling method for the analysis of 3,N4-etheno-2'-deoxycytidine in human urine
    X Sun
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Biomarkers 11:329-40. 2006
    ..49+/-1.76 (SD) fmol micromol-1 creatinine (range 0.66-6.42). By this non-invasive method, epsilondC in human urine could be explored as a biomarker for oxidative stress-related human diseases...
  70. ncbi request reprint Rapid screening assay for mutagen sensitivity and DNA repair capacity in human peripheral blood lymphocytes
    P Schmezer
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Mutagenesis 16:25-30. 2001
    ....
  71. ncbi request reprint Altered DNA repair capacity and bleomycin sensitivity as risk markers for non-small cell lung cancer
    N Rajaee-Behbahani
    Division of Toxicology and Cancer Risk Factors, Deutsches Krebsforschungszentrum (DKFZ, Heidelberg, Germany
    Int J Cancer 95:86-91. 2001
    ..Validation of this assay in large prospective studies for the identification of subjects at high risk for non-small cell lung cancer is now warranted...
  72. ncbi request reprint Pharmacogenomics of a traditional Japanese herbal medicine (Kampo) for cancer therapy
    Thomas Efferth
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Cancer Genomics Proteomics 4:81-91. 2007
    ..Kampo-derived natural products represent a valuable reservoir for individual tumour treatment strategies in the future...
  73. ncbi request reprint Differential effect of NAT2 on the association between active and passive smoke exposure and breast cancer risk
    Jenny Chang-Claude
    Division of Clinical Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 11:698-704. 2002
    ....
  74. ncbi request reprint Modified immunoenriched (32)P-HPLC assay for the detection of O(4)-ethylthymidine in human biomonitoring studies
    Roger Godschalk
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Chem Res Toxicol 15:433-7. 2002
    ..Our improved assay was found to be sufficiently sensitive and specific to detect O(4)-etT in surrogate cells from cigarette smoke exposed humans...
  75. ncbi request reprint Polycyclic aromatic hydrocarbon-DNA adducts in humans: relevance as biomarkers for exposure and cancer risk
    E Kriek
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Mutat Res 400:215-31. 1998
    ..e., adduct formation (preferably at specific sites), mutational spectra in cancer-relevant genes, and genetic markers of (cancer) susceptibility in a number of cancer-predisposing genes...
  76. ncbi request reprint Studies on biomarkers in cancer etiology and prevention: a summary and challenge of 20 years of interdisciplinary research
    H Bartsch
    German Cancer Research Center DKFZ, Division of Toxicology and Cancer Risk Factors, Im Neuenheimer Feld 280, D 69120, Heidelberg, Germany
    Mutat Res 462:255-79. 2000
    ..Advances in the application of selected biomarkers in human studies are reviewed and illustrated by examples from the author's research conducted during the past two decades...
  77. pmc Analysis of radon-associated squamous cell carcinomas of the lung for a p53 gene hotspot mutation
    Q Yang
    Deutsches Krebsforschungszentrum German Cancer Research Center Im Neuenheimer Feld 280, Heidelberg, Germany
    Br J Cancer 82:763-6. 2000
    ....
  78. ncbi request reprint Metabolic polymorphisms as susceptibility markers for lung and oral cavity cancer
    U Nair
    Division of Toxicology and Cancer Risk Factors- C0200, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    IARC Sci Publ 154:271-90. 2001
    ..The possible interaction of chemopreventive agents with metabolic polymorphisms as biomarkers in chemoprevention trials is discussed...
  79. ncbi request reprint Lipid peroxidation-induced etheno-DNA adducts in the liver of patients with the genetic metal storage disorders Wilson's disease and primary hemochromatosis
    J Nair
    Division of Toxicology and Cancer Risk Factors, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 7:435-40. 1998
    ..Thus, the etheno adducts are implicated as initiating DNA damage in copper/iron-induced carcinogenesis in humans and should also be explored as biomarkers in disease progression and prevention trials...
  80. ncbi request reprint Reduced poly(ADP-ribosyl)ation in lymphocytes of laryngeal cancer patients: results of a case-control study
    Nahid Rajaee-Behbahani
    Division of Toxicology and Cancer Risk Factors, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Int J Cancer 98:780-4. 2002
    ..Our results suggest that a reduced capacity of somatic cells to synthesize poly(ADP-ribose) might be associated with an increased risk for laryngeal cancer. The underlying mechanism remains to be investigated...
  81. ncbi request reprint Identification and quantitation of phenolic compounds in faecal matrix by capillary gas chromatography and nano-electrospray mass spectrometry
    Ulrike Knust
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Rapid Commun Mass Spectrom 20:3119-29. 2006
    ..The new method should enable large epidemiologic, case-control and intervention studies on the relevance of phenolic antioxidants in the aetiology of colorectal cancer to be conducted in the future...
  82. ncbi request reprint Lipid peroxidation status, somatic mutations and micronuclei in peripheral lymphocytes: a case observation on a possible interrelationship
    C Mayer
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Cancer Lett 152:169-73. 2000
    ..A possible association between these biomarkers, particularly in relation to dietary fat intake and antioxidant status, should now be studied in a larger trial...
  83. ncbi request reprint Myeloperoxidase--463A variant reduces benzo[a]pyrene diol epoxide DNA adducts in skin of coal tar treated patients
    M Rojas
    German Cancer Research Center (DKFZ, Division of Toxicology and Cancer Risk Factors, PO Box 101949, D-69009 Heidelberg, Germany
    Carcinogenesis 22:1015-8. 2001
    ..In conclusion, these data show for the first time: (i) the in vivo formation of BPDE-DNA adducts in human skin treated with coal tar; (ii) that the MPO-463AA/AG genotype reduced BPDE-DNA adduct levels in human skin...
  84. ncbi request reprint Laryngeal mucosa of head and neck cancer patients shows increased DNA damage as detected by single cell microgel electrophoresis
    P Schmezer
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Centre DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Toxicology 144:149-54. 2000
    ....
  85. ncbi request reprint p53 gene mutation analysis in tumors of patients exposed to alpha-particles
    M Hollstein
    Division of Toxicology and Cancer Risk Factors, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Carcinogenesis 18:511-6. 1997
    ....
  86. ncbi request reprint Isolation, purification and identification of ellagic acid derivatives, catechins, and procyanidins from the root bark of Anisophyllea dichostyla R. Br
    F Khallouki
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Food Chem Toxicol 45:472-85. 2007
    ....
  87. ncbi request reprint Lack of evidence for tamoxifen- and toremifene-DNA adducts in lymphocytes of treated patients
    H Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Carcinogenesis 21:845-7. 2000
    ..In conclusion, lymphocyte DNA from female patients treated at therapeutic levels did not show evidence of the formation of TAM- or TOR-DNA adducts...
  88. ncbi request reprint New approaches to understanding p53 gene tumor mutation spectra
    M Hollstein
    Deutsches Krebsforschungszentrum DKFZ, Heidelberg, Germany
    Mutat Res 431:199-209. 1999
    ..P53-specific laboratory models, combined with DNA microchips designed for high through-put mutation screening promise to unmask information currently hidden in the compilation of human tumor p53 mutations...
  89. ncbi request reprint Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms
    E Heiss
    Deutsches Krebsforschungszentrum Heidelberg, Division of Toxicology and Cancer Risk Factors, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Biol Chem 276:32008-15. 2001
    ..Our data provide novel evidence that anti-inflammatory mechanisms contribute to sulforaphane-mediated cancer chemoprevention...
  90. ncbi request reprint Olives and olive oil in cancer prevention
    R W Owen
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Eur J Cancer Prev 13:319-26. 2004
    ..It seems probable that olive and olive oil consumption in southern Europe represents an important contribution to the beneficial effects on health of the Mediterranean diet...
  91. ncbi request reprint Correspondence re: Feyler et al., Point: Myeloperoxidase (-463)G --> a polymorphism and lung cancer risk. Cancer Epidemiol. Biomark. Prev., 11: 1550-1554, 2002, and Xu et al., Counterpoint: The myeloperoxidase (-463)G --> a polymorphism does not decrease
    Heike Dally
    Cancer Epidemiol Biomarkers Prev 12:683. 2003
  92. ncbi request reprint A critical evaluation of DNA adducts as biological markers for human exposure to polycyclic aromatic compounds
    Roger W L Godschalk
    Department of Health Risk Analysis and Toxicology, University of Maastricht, 6200 MD Maastricht, The Netherlands
    J Biochem Mol Biol 36:1-11. 2003
    ..Their use in risk-assessment, however, requires further investigation...
  93. ncbi request reprint Urinary level of 1,N(6) -ethenodeoxyadenosine, a marker of oxidative stress, is associated with salt excretion and omega 6-polyunsaturated fatty acid intake in postmenopausal Japanese women
    Tomoyuki Hanaoka
    Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, Chiba, Japan
    Int J Cancer 100:71-5. 2002
    ..08). Results from this pilot study suggest urinary epsilon dA as a potential biomarker of DNA damage possibly derived from salt-induced inflammation and LPO; further exploration of epsilon dA in human biomonitoring studies is warranted...
  94. ncbi request reprint Ochratoxin study
    Marcel Castegnaro
    Int J Cancer 112:1083. 2004
  95. ncbi request reprint Effect of short-term fasting on urinary excretion of primary lipid peroxidation products and on markers of oxidative DNA damage in healthy women
    Kyoung Ho Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, Institute for Environmental Medicine, SNUMRC, Seoul 110 799, Korea
    Carcinogenesis 27:1398-403. 2006
    ..51, n = 27, P = 0.02). Our results demonstrate that the short-term fasting reduces lipid peroxidation products but does not affect oxidative stress-induced DNA damage...
  96. ncbi request reprint Moderate G6PD deficiency increases mutation rates in the brain of mice
    Klaus Felix
    Laboratory of Genetics, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892 4255, USA
    Free Radic Biol Med 32:663-73. 2002
    ..These findings suggested a critical function for G6PD in limiting oxidative mutagenesis in the mouse brain...
  97. ncbi request reprint The XRCC3 Thr241Met polymorphism and breast cancer risk: a case-control study in a Thai population
    Suleeporn Sangrajrang
    Research Division, National Cancer Institute, Bangkok, Thailand
    Biomarkers 12:523-32. 2007
    ..48, 95% CI 0.82-2.69). Our findings suggest that the XRCC3 Thr241Met polymorphism is likely to play a modifying role in the individual susceptibility to breast cancer among Thai women as already shown for women of European ancestry...
  98. ncbi request reprint Polymorphisms in three base excision repair genes and breast cancer risk in Thai women
    Suleeporn Sangrajrang
    Research Division, National Cancer Institute, Bangkok, 10400, Thailand
    Breast Cancer Res Treat 111:279-88. 2008
    ..26-2.82). In conclusion, our data suggest that Thai women with a certain XRCC1 diplotype or homozygous for two or three variant alleles of XRCC1, OGG1, and APEX1 are likely to have an increased susceptibility to breast cancer...
  99. ncbi request reprint 32nd annual meeting of European Environmental Mutagen Society. DNA damage and repair fundamental aspects and contribution to human disorders
    Barbara Tudek
    Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02 106 Warsaw, Poland
    DNA Repair (Amst) 2:765-81. 2003
  100. ncbi request reprint [Hazardous natural products. Are there carcinogens in herbal teas?]
    Helmut Bartsch
    MMW Fortschr Med 144:14. 2002
  101. ncbi request reprint Conflicts of interest: the responsibility of the authors and editors of the International Journal of Cancer
    Harald zur Hausen
    Int J Cancer 118:2919. 2006