H Bartsch

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. pmc The role of individual susceptibility in cancer burden related to environmental exposure
    H Bartsch
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Environ Health Perspect 104:569-77. 1996
  2. ncbi request reprint New DNA-based biomarkers for oxidative stress and cancer chemoprevention studies
    H Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Centre DKFZ, Im Neuenheimer Feld 280, D 69120, Heidelberg, Germany
    Eur J Cancer 36:1229-34. 2000
  3. ncbi request reprint Studies on biomarkers in cancer etiology and prevention: a summary and challenge of 20 years of interdisciplinary research
    H Bartsch
    German Cancer Research Center DKFZ, Division of Toxicology and Cancer Risk Factors, Im Neuenheimer Feld 280, D 69120, Heidelberg, Germany
    Mutat Res 462:255-79. 2000
  4. ncbi request reprint Lack of evidence for tamoxifen- and toremifene-DNA adducts in lymphocytes of treated patients
    H Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Carcinogenesis 21:845-7. 2000
  5. ncbi request reprint Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers
    H Bartsch
    Division of Toxicology and Cancer Risk Factors, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 9:3-28. 2000
  6. ncbi request reprint Dietary polyunsaturated fatty acids and cancers of the breast and colorectum: emerging evidence for their role as risk modifiers
    H Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Carcinogenesis 20:2209-18. 1999
  7. ncbi request reprint Genetic cancer susceptibility and DNA adducts: studies in smokers, tobacco chewers, and coke oven workers
    H Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Cancer Detect Prev 23:445-53. 1999
  8. ncbi request reprint Glutathione-S-transferase M1, M3, T1 and P1 polymorphisms and susceptibility to non-small-cell lung cancer subtypes and hamartomas
    A Risch
    German Cancer Research Centre DKFZ, Division of Toxicology and Cancer Risk Factors, Heidelberg, Germany
    Pharmacogenetics 11:757-64. 2001
  9. ncbi request reprint Rapid screening assay for mutagen sensitivity and DNA repair capacity in human peripheral blood lymphocytes
    P Schmezer
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Mutagenesis 16:25-30. 2001
  10. ncbi request reprint Phenolic compounds and squalene in olive oils: the concentration and antioxidant potential of total phenols, simple phenols, secoiridoids, lignansand squalene
    R W Owen
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Food Chem Toxicol 38:647-59. 2000

Collaborators

Detail Information

Publications48

  1. pmc The role of individual susceptibility in cancer burden related to environmental exposure
    H Bartsch
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Environ Health Perspect 104:569-77. 1996
    ....
  2. ncbi request reprint New DNA-based biomarkers for oxidative stress and cancer chemoprevention studies
    H Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Centre DKFZ, Im Neuenheimer Feld 280, D 69120, Heidelberg, Germany
    Eur J Cancer 36:1229-34. 2000
    ..Therefore, exocyclic DNA adducts offer new tools in cancer aetiological research and in verifying the efficacy of chemopreventive agents...
  3. ncbi request reprint Studies on biomarkers in cancer etiology and prevention: a summary and challenge of 20 years of interdisciplinary research
    H Bartsch
    German Cancer Research Center DKFZ, Division of Toxicology and Cancer Risk Factors, Im Neuenheimer Feld 280, D 69120, Heidelberg, Germany
    Mutat Res 462:255-79. 2000
    ..Advances in the application of selected biomarkers in human studies are reviewed and illustrated by examples from the author's research conducted during the past two decades...
  4. ncbi request reprint Lack of evidence for tamoxifen- and toremifene-DNA adducts in lymphocytes of treated patients
    H Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Carcinogenesis 21:845-7. 2000
    ..In conclusion, lymphocyte DNA from female patients treated at therapeutic levels did not show evidence of the formation of TAM- or TOR-DNA adducts...
  5. ncbi request reprint Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers
    H Bartsch
    Division of Toxicology and Cancer Risk Factors, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 9:3-28. 2000
    ..Future strategies in molecular cancer epidemiology for identifying such susceptible individuals are discussed with emphasis on well-designed larger studies...
  6. ncbi request reprint Dietary polyunsaturated fatty acids and cancers of the breast and colorectum: emerging evidence for their role as risk modifiers
    H Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Carcinogenesis 20:2209-18. 1999
    ....
  7. ncbi request reprint Genetic cancer susceptibility and DNA adducts: studies in smokers, tobacco chewers, and coke oven workers
    H Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Cancer Detect Prev 23:445-53. 1999
    ....
  8. ncbi request reprint Glutathione-S-transferase M1, M3, T1 and P1 polymorphisms and susceptibility to non-small-cell lung cancer subtypes and hamartomas
    A Risch
    German Cancer Research Centre DKFZ, Division of Toxicology and Cancer Risk Factors, Heidelberg, Germany
    Pharmacogenetics 11:757-64. 2001
    ..The latter role for GSTT1 would explain the observed lower risk of SCC and hamartoma associated with GSTT1 null. Further confirmatory studies are required...
  9. ncbi request reprint Rapid screening assay for mutagen sensitivity and DNA repair capacity in human peripheral blood lymphocytes
    P Schmezer
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    Mutagenesis 16:25-30. 2001
    ....
  10. ncbi request reprint Phenolic compounds and squalene in olive oils: the concentration and antioxidant potential of total phenols, simple phenols, secoiridoids, lignansand squalene
    R W Owen
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Food Chem Toxicol 38:647-59. 2000
    ..29 +/- 2.56). All classes of phenolics were shown to be potent antioxidants. In future epidemiologic studies, both the nature and source of olive oil consumed should be differentiated in ascertaining cancer risk...
  11. ncbi request reprint hOGG1 polymorphism and loss of heterozygosity (LOH): significance for lung cancer susceptibility in a caucasian population
    H Wikman
    German Cancer Research Center DKFZ, Division of Toxicology and Cancer Risk Factors, Heidelberg, Germany
    Int J Cancer 88:932-7. 2000
    ..However, the hOGG1 polymorphisms studied are probably not major contributors to individual lung cancer susceptibility in Caucasians...
  12. ncbi request reprint The antioxidant/anticancer potential of phenolic compounds isolated from olive oil
    R W Owen
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Centre, Im Neuenheimer Feld 280, D 69120, Heidelberg, Germany
    Eur J Cancer 36:1235-47. 2000
    ....
  13. ncbi request reprint Altered DNA repair capacity and bleomycin sensitivity as risk markers for non-small cell lung cancer
    N Rajaee-Behbahani
    Division of Toxicology and Cancer Risk Factors, Deutsches Krebsforschungszentrum (DKFZ, Heidelberg, Germany
    Int J Cancer 95:86-91. 2001
    ..Validation of this assay in large prospective studies for the identification of subjects at high risk for non-small cell lung cancer is now warranted...
  14. ncbi request reprint p53 gene mutation analysis in tumors of patients exposed to alpha-particles
    M Hollstein
    Division of Toxicology and Cancer Risk Factors, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Carcinogenesis 18:511-6. 1997
    ....
  15. doi request reprint Evaluation of the polyphenol composition and antioxidant activity of African variety of Dacryodes edulis (G.Don) H.J Lam fruit
    S E Atawodi
    Institute for Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    J Med Food 12:1321-5. 2009
    ..These results suggest that consumption of D. edulis could contribute to prevention of diseases that are related to oxidative stress...
  16. ncbi request reprint Identification of lignans as major components in the phenolic fraction of olive oil
    R W Owen
    Division of Toxicology and Cancer Risk Factors, Central Spectroscopy Department, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Clin Chem 46:976-88. 2000
    ..Because olive oil is an important component of the Mediterranean diet, it is necessary to establish unequivocal identification of the major potential antioxidant phenolic compounds it contains...
  17. ncbi request reprint Comparison of multiple DNA adduct types in tumor adjacent human lung tissue: effect of cigarette smoking
    R Godschalk
    German Cancer Research Center DKFZ, Division of Toxicology and Cancer Risk Factors, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Carcinogenesis 23:2081-6. 2002
    ....
  18. ncbi request reprint Characterization of alkyl phenols in cashew (Anacardium occidentale) products and assay of their antioxidant capacity
    M T S Trevisan
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Food Chem Toxicol 44:188-97. 2006
    ....
  19. doi request reprint Polyphenol composition and antioxidant potential of Hibiscus esculentus L. fruit cultivated in Nigeria
    S E Atawodi
    Institute for Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
    J Med Food 12:1316-20. 2009
    ..esculentus, popular especially during the rainy season in Nigeria and many tropical West, Central, and Eastern African countries, is a good contributor to the antioxidant status and disease chemoprevention of people in these countries...
  20. ncbi request reprint Polycyclic aromatic hydrocarbon-DNA adducts in humans: relevance as biomarkers for exposure and cancer risk
    E Kriek
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Mutat Res 400:215-31. 1998
    ..e., adduct formation (preferably at specific sites), mutational spectra in cancer-relevant genes, and genetic markers of (cancer) susceptibility in a number of cancer-predisposing genes...
  21. ncbi request reprint Olive-oil consumption and health: the possible role of antioxidants
    R W Owen
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Heidelberg
    Lancet Oncol 1:107-12. 2000
    ....
  22. ncbi request reprint Olives and olive oil in cancer prevention
    R W Owen
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Eur J Cancer Prev 13:319-26. 2004
    ..It seems probable that olive and olive oil consumption in southern Europe represents an important contribution to the beneficial effects on health of the Mediterranean diet...
  23. ncbi request reprint Isolation, purification and identification of ellagic acid derivatives, catechins, and procyanidins from the root bark of Anisophyllea dichostyla R. Br
    F Khallouki
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Food Chem Toxicol 45:472-85. 2007
    ....
  24. doi request reprint Typical signature of DNA damage in white blood cells: a pilot study on etheno adducts in Danish mother-newborn child pairs
    K Arab
    Division of Epigenomics, German Cancer Research Center DKFZ, Heidelberg, Germany
    Carcinogenesis 30:282-5. 2009
    ..Prospective cohort studies have to reveal whether these two WBC-DNA adducts could serve as risk indicator for developing hematopoietic cancers and other disorders later in life...
  25. ncbi request reprint Myeloperoxidase--463A variant reduces benzo[a]pyrene diol epoxide DNA adducts in skin of coal tar treated patients
    M Rojas
    German Cancer Research Center (DKFZ, Division of Toxicology and Cancer Risk Factors, PO Box 101949, D-69009 Heidelberg, Germany
    Carcinogenesis 22:1015-8. 2001
    ..In conclusion, these data show for the first time: (i) the in vivo formation of BPDE-DNA adducts in human skin treated with coal tar; (ii) that the MPO-463AA/AG genotype reduced BPDE-DNA adduct levels in human skin...
  26. ncbi request reprint Isolation and structure elucidation of the major individual polyphenols in carob fibre
    R W Owen
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Food Chem Toxicol 41:1727-38. 2003
    ..9% and 10%, respectively). These data indicate that carob fibre is rich in both amount and variety of phenolic antioxidant substances, and its inclusion in the diet may have chemopreventive properties...
  27. ncbi request reprint Lipid peroxidation status, somatic mutations and micronuclei in peripheral lymphocytes: a case observation on a possible interrelationship
    C Mayer
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Cancer Lett 152:169-73. 2000
    ..A possible association between these biomarkers, particularly in relation to dietary fat intake and antioxidant status, should now be studied in a larger trial...
  28. ncbi request reprint Ultrasensitive and specific detection methods for exocylic DNA adducts: markers for lipid peroxidation and oxidative stress
    H Bartsch
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120, Heidelberg, Germany
    Toxicology 153:105-14. 2000
    ....
  29. ncbi request reprint Metabolic polymorphisms as susceptibility markers for lung and oral cavity cancer
    U Nair
    Division of Toxicology and Cancer Risk Factors- C0200, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    IARC Sci Publ 154:271-90. 2001
    ..The possible interaction of chemopreventive agents with metabolic polymorphisms as biomarkers in chemoprevention trials is discussed...
  30. ncbi request reprint Lipid peroxidation-induced etheno-DNA adducts in the liver of patients with the genetic metal storage disorders Wilson's disease and primary hemochromatosis
    J Nair
    Division of Toxicology and Cancer Risk Factors, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 7:435-40. 1998
    ..Thus, the etheno adducts are implicated as initiating DNA damage in copper/iron-induced carcinogenesis in humans and should also be explored as biomarkers in disease progression and prevention trials...
  31. ncbi request reprint Relevance of N-acetyltransferase 1 and 2 (NAT1, NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility
    H Wikman
    German Cancer Research Centre DKFZ, Division of Toxicology and Cancer Risk Factors, Heidelberg
    Pharmacogenetics 11:157-68. 2001
    ..These data clearly show the importance of separating different histological lung tumour subtypes in studies on genetic susceptibility factors and implicate the NAT1*10 allele as a risk factor for adenocarcinoma...
  32. pmc Analysis of radon-associated squamous cell carcinomas of the lung for a p53 gene hotspot mutation
    Q Yang
    Deutsches Krebsforschungszentrum German Cancer Research Center Im Neuenheimer Feld 280, Heidelberg, Germany
    Br J Cancer 82:763-6. 2000
    ....
  33. ncbi request reprint Analysis of enterolignan glucuronides in serum and urine by HPLC-ESI-MS
    U Knust
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Food Chem Toxicol 44:1038-49. 2006
    ....
  34. ncbi request reprint New ultrasensitive 32P-postlabelling method for the analysis of 3,N4-etheno-2'-deoxycytidine in human urine
    X Sun
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Biomarkers 11:329-40. 2006
    ..49+/-1.76 (SD) fmol micromol-1 creatinine (range 0.66-6.42). By this non-invasive method, epsilondC in human urine could be explored as a biomarker for oxidative stress-related human diseases...
  35. ncbi request reprint Laryngeal mucosa of head and neck cancer patients shows increased DNA damage as detected by single cell microgel electrophoresis
    P Schmezer
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Centre DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Toxicology 144:149-54. 2000
    ....
  36. ncbi request reprint New approaches to understanding p53 gene tumor mutation spectra
    M Hollstein
    Deutsches Krebsforschungszentrum DKFZ, Heidelberg, Germany
    Mutat Res 431:199-209. 1999
    ..P53-specific laboratory models, combined with DNA microchips designed for high through-put mutation screening promise to unmask information currently hidden in the compilation of human tumor p53 mutations...
  37. ncbi request reprint Isolation, structure elucidation and antioxidant potential of the major phenolic and flavonoid compounds in brined olive drupes
    R W Owen
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Food Chem Toxicol 41:703-17. 2003
    ..Brined olives contain even higher concentrations of phenolic antioxidants than olive oil and may, therefore, be more important modulators of cancer chemopreventive activity...
  38. ncbi request reprint Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms
    E Heiss
    Deutsches Krebsforschungszentrum Heidelberg, Division of Toxicology and Cancer Risk Factors, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Biol Chem 276:32008-15. 2001
    ..Our data provide novel evidence that anti-inflammatory mechanisms contribute to sulforaphane-mediated cancer chemoprevention...
  39. ncbi request reprint Low-molecular-weight hormonal factors that affect head formation in Hydra
    W A Muller
    Zoological Institute, Physiology University, Heidelberg, Germany
    Int J Dev Biol 42:825-8. 1998
    ....
  40. ncbi request reprint [Cancer prevention with green tea: reality and wishful thinking]
    Barbara Bertram
    Abteilung für Toxikologie und Krebsrisikofaktoren, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Deutschland
    Wien Med Wochenschr 152:153-8. 2002
    ..By inactivation of proteolytic enzymes they inhibit the development of metastases. This short review summarizes relevant recent findings on the protective effects of green tea constituents...
  41. ncbi request reprint Isolation and structure elucidation of phenolic antioxidants from Tamarind (Tamarindus indica L.) seeds and pericarp
    Y Sudjaroen
    Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Food Chem Toxicol 43:1673-82. 2005
    ..The antioxidant capacities of the Soxhlet methanolic extracts were determined, and indicates that Tamarind may be an important source of cancer chemopreventive natural products in tropical regions...
  42. ncbi request reprint Consumption of argan oil (Morocco) with its unique profile of fatty acids, tocopherols, squalene, sterols and phenolic compounds should confer valuable cancer chemopreventive effects
    F Khallouki
    Laboratoire D Ingénierie Moléculaire et de Biochimie Pharmalogique, Universite de Metz, Campus Bridoux, rue Claude Bernard, 57070, Metz, France
    Eur J Cancer Prev 12:67-75. 2003
    ..0 mg/kg). Nevertheless, argan oil with its high content of the vitamer -tocopherol, squalene and oleic acid is likely to enhance the cancer prevention effects of the Moroccan diet...
  43. ncbi request reprint Editors' comments, "Epidemiologic studies of nutrition and cancer"
    H Bartsch
    Int J Cancer 116:661. 2005
  44. ncbi request reprint [Search for agents responsible for DNA damaging and hazardous for humans: certain achievements in cancer etiology research]
    H Bartsch
    Vopr Onkol 50:261-5. 2004
  45. ncbi request reprint The twentieth international symposium of the Sapporo Cancer Seminar Foundation: gene environment interaction and cancer prevention
    E Mihich
    Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 61:2788-92. 2001
    ....
  46. ncbi request reprint Influence of dietary fatty acid, vegetable, and vitamin intake on etheno-DNA adducts in white blood cells of healthy female volunteers: a pilot study
    T Hagenlocher
    Division of Toxicology, German Cancer Research Center (Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 10:1187-91. 2001
    ..This pilot study also indicated a protective effect of dietary vitamin E and vegetables against miscoding, lipid peroxidation-induced DNA lesions...
  47. ncbi request reprint Modulation of DNA and protein adducts in smokers by genetic polymorphisms in GSTM1,GSTT1, NAT1 and NAT2
    R W Godschalk
    Department of Health Risk Analysis and Toxicology, Maastricht University, Maastricht, The Netherlands
    Pharmacogenetics 11:389-98. 2001
    ....
  48. ncbi request reprint Oxidative stress related DNA adducts in the liver of female rats fed with sunflower-, rapeseed-, olive- or coconut oil supplemented diets
    E Eder
    Department of Toxicology, University of Wurzburg, 97078 Wurzburg, Germany
    Chem Biol Interact 159:81-9. 2006
    ..Our results indicate that a high linoleic acid diet may contribute to oxidative stress in the liver of female rats leading to a marginal increase in oxidative DNA-damage...