Peter Angel

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. ncbi request reprint Function of AP-1 target genes in mesenchymal-epithelial cross-talk in skin
    Peter Angel
    Deutsches Krebsforschungszentrum, Division of Signal Transduction and Growth Control, Im Neuenheimer Feld 280, Heidelberg, Germany
    Biochem Pharmacol 64:949-56. 2002
  2. ncbi request reprint Increased keratinocyte proliferation by JUN-dependent expression of PTN and SDF-1 in fibroblasts
    Lore Florin
    Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Cell Sci 118:1981-9. 2005
  3. pmc The DNA binding-independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skin
    J P Tuckermann
    Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    J Cell Biol 147:1365-70. 1999
  4. pmc The receptor RAGE: Bridging inflammation and cancer
    Astrid Riehl
    German Cancer Research Center, DKFZ ZMBH Alliance, Division of Signal Transduction and Growth Control A100, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Cell Commun Signal 7:12. 2009
  5. pmc A novel aspartic proteinase-like gene expressed in stratified epithelia and squamous cell carcinoma of the skin
    Verena Rhiemeier
    Division of Signal Transduction and Growth Control, German Cancer Research Center, Heidelberg, Germany
    Am J Pathol 168:1354-64. 2006
  6. doi request reprint S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis
    Julia Nemeth
    Division of Signal Transduction and Growth Control A100, German Cancer Research Center DKFZ, DKFZ ZMBH Alliance, Heidelberg, Germany
    Hepatology 50:1251-62. 2009
  7. ncbi request reprint Delayed wound healing and epidermal hyperproliferation in mice lacking JunB in the skin
    Lore Florin
    Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Invest Dermatol 126:902-11. 2006
  8. pmc c-Fos-dependent induction of the small ras-related GTPase Rab11a in skin carcinogenesis
    Christoffer Gebhardt
    Division of Signal Transduction and Growth Control, German Cancer Research Center, Heidelberg, Germany
    Am J Pathol 167:243-53. 2005
  9. ncbi request reprint JunB is required for IgE-mediated degranulation and cytokine release of mast cells
    Björn Textor
    Deutsches Krebsforschungszentrum Heidelberg, Division of Signal Transduction and Growth Control A100, Heidelberg, Germany
    J Immunol 179:6873-80. 2007
  10. pmc Critical role for NF-kappaB-induced JunB in VEGF regulation and tumor angiogenesis
    Dirk Schmidt
    Division of Signal Transduction and Growth Control, DKFZ German Cancer Research Center, Heidelberg, Germany
    EMBO J 26:710-9. 2007

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Function of AP-1 target genes in mesenchymal-epithelial cross-talk in skin
    Peter Angel
    Deutsches Krebsforschungszentrum, Division of Signal Transduction and Growth Control, Im Neuenheimer Feld 280, Heidelberg, Germany
    Biochem Pharmacol 64:949-56. 2002
    ....
  2. ncbi request reprint Increased keratinocyte proliferation by JUN-dependent expression of PTN and SDF-1 in fibroblasts
    Lore Florin
    Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Cell Sci 118:1981-9. 2005
    ....
  3. pmc The DNA binding-independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skin
    J P Tuckermann
    Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    J Cell Biol 147:1365-70. 1999
    ..Thus, these data suggest that the DNA binding-independent function of the GR is dispensable for repression of AP-1 activity in vivo and responsible for the antitumor promoting activity of GCs...
  4. pmc The receptor RAGE: Bridging inflammation and cancer
    Astrid Riehl
    German Cancer Research Center, DKFZ ZMBH Alliance, Division of Signal Transduction and Growth Control A100, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Cell Commun Signal 7:12. 2009
    ..Moreover, we will review recent findings that provide genetic evidence for an important role of RAGE in bridging inflammation and cancer...
  5. pmc A novel aspartic proteinase-like gene expressed in stratified epithelia and squamous cell carcinoma of the skin
    Verena Rhiemeier
    Division of Signal Transduction and Growth Control, German Cancer Research Center, Heidelberg, Germany
    Am J Pathol 168:1354-64. 2006
    ..Similar expression was observed in squamous skin tumors of patients, suggesting that detection of Taps levels represents a novel strategy to discriminate the progression state of squamous skin cancers...
  6. doi request reprint S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis
    Julia Nemeth
    Division of Signal Transduction and Growth Control A100, German Cancer Research Center DKFZ, DKFZ ZMBH Alliance, Heidelberg, Germany
    Hepatology 50:1251-62. 2009
    ..Finally, we found a synergistic function for S100A8 and S100A9 in Hep3B cells resulting in a significant induction of reactive oxygen species (ROS), accompanied by enhanced cell survival...
  7. ncbi request reprint Delayed wound healing and epidermal hyperproliferation in mice lacking JunB in the skin
    Lore Florin
    Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Invest Dermatol 126:902-11. 2006
    ....
  8. pmc c-Fos-dependent induction of the small ras-related GTPase Rab11a in skin carcinogenesis
    Christoffer Gebhardt
    Division of Signal Transduction and Growth Control, German Cancer Research Center, Heidelberg, Germany
    Am J Pathol 167:243-53. 2005
    ..These data identify Rab11a as a novel, tumor-associated c-Fos/AP-1 target and may point to an as yet unrecognized function of Rab11a in the development of skin cancer...
  9. ncbi request reprint JunB is required for IgE-mediated degranulation and cytokine release of mast cells
    Björn Textor
    Deutsches Krebsforschungszentrum Heidelberg, Division of Signal Transduction and Growth Control A100, Heidelberg, Germany
    J Immunol 179:6873-80. 2007
    ..Thus, JunB is a critical regulator of intrinsic mast cell functions including cross-talk with endothelial cells...
  10. pmc Critical role for NF-kappaB-induced JunB in VEGF regulation and tumor angiogenesis
    Dirk Schmidt
    Division of Signal Transduction and Growth Control, DKFZ German Cancer Research Center, Heidelberg, Germany
    EMBO J 26:710-9. 2007
    ..In support of these findings, tumor angiogenesis was impaired in junB(-/-) teratocarcinomas because of severely impaired paracrine-acting VEGF and the subsequent inability to efficiently recruit host-derived vessels...
  11. ncbi request reprint Kallikrein 6 induces E-cadherin shedding and promotes cell proliferation, migration, and invasion
    Britta Klucky
    Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Cancer Res 67:8198-206. 2007
    ..Finally, enhanced epidermal keratinocyte proliferation and migration in concert with decreased E-cadherin protein levels are confirmed in an in vivo Klk6 transgenic mouse model...
  12. ncbi request reprint Impaired skin regeneration and remodeling after cutaneous injury and chemically induced hyperplasia in taps-transgenic mice
    Maike Hildenbrand
    Division of Signal Transduction and Growth Control A100, DKFZ ZMBH Alliance, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Invest Dermatol 130:1922-30. 2010
    ..In summary, these data show that aberrant Taps expression causes impaired skin regeneration and skin remodeling after cutaneous injury and chemically induced hyperplasia...
  13. pmc Identification of the Rage-dependent gene regulatory network in a mouse model of skin inflammation
    Astrid Riehl
    Signal Transduction and Growth Control, German Cancer Research Center DKFZ, DKFZ ZMBH Alliance, Heidelberg, Germany
    BMC Genomics 11:537. 2010
    ....
  14. ncbi request reprint Calcium-binding proteins S100A8 and S100A9 as novel diagnostic markers in human prostate cancer
    Alexander Hermani
    Research Group Hormones and Signal Transduction, German Cancer Research Center, Heidelberg, Germany
    Clin Cancer Res 11:5146-52. 2005
    ....
  15. ncbi request reprint Cutting edge: the AP-1 subunit JunB determines NK cell-mediated target cell killing by regulation of the NKG2D-ligand RAE-1epsilon
    Norman Nausch
    Division of Innate Immunity, German Cancer Research Center, Heidelberg, Germany
    J Immunol 176:7-11. 2006
    ..Thus, up-regulated RAE-1epsilon expression due to low levels of JunB could alert immune cells to tumors and stressed cells...
  16. pmc JunB is required for endothelial cell morphogenesis by regulating core-binding factor beta
    Alexander H Licht
    Division of Signal Transduction and Growth Control, German Cancer Research Center, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    J Cell Biol 175:981-91. 2006
    ..Reintroduction of CBFbeta into JunB-deficient ECs rescued the tube formation defect and MMP-13 expression, indicating an important role for CBFbeta in EC morphogenesis...
  17. doi request reprint AP-1-controlled hepatocyte growth factor activation promotes keratinocyte migration via CEACAM1 and urokinase plasminogen activator/urokinase plasminogen receptor
    Stephanie Schnickmann
    Institute of Pathology, University Hospital of Heidelberg, Heidelberg, Germany
    J Invest Dermatol 129:1140-8. 2009
    ..In conclusion, the distinct spatiotemporal regulation of genes by HGF is essential for proper epidermal cell migration in cutaneous wound healing...
  18. ncbi request reprint Up-regulation of insulin-like growth factor axis components in human primary prostate cancer correlates with tumor grade
    Yongde Liao
    Hormones and Signal Transduction Group, German Cancer Research Centre, D 69120 Heidelberg, Germany
    Hum Pathol 36:1186-96. 2005
    ..Expression of IGFs, especially IGF-II, may be predictors of the outcome of prostate cancer...
  19. ncbi request reprint Identification of novel AP-1 target genes in fibroblasts regulated during cutaneous wound healing
    Lore Florin
    Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg D 69120, Germany
    Oncogene 23:7005-17. 2004
    ..The identification of novel Jun target genes should provide a basis for understanding the molecular mechanisms underlying mesenchymal-epithelial interactions and the critical contribution of AP-1 to tissue homeostasis and repair...
  20. pmc RAGE signaling sustains inflammation and promotes tumor development
    Christoffer Gebhardt
    Division of Signal Transduction and Growth Control, German Cancer Research Center, 69120 Heidelberg, Germany
    J Exp Med 205:275-85. 2008
    ..We show that RAGE signaling drives the strength and maintenance of an inflammatory reaction during tumor promotion and provide direct genetic evidence for a novel role for RAGE in linking chronic inflammation and cancer...
  21. doi request reprint Podoplanin is a novel fos target gene in skin carcinogenesis
    Moritz Durchdewald
    Division of Transduction and Growth Control, German Cancer Research Center, Heidelberg, Germany
    Cancer Res 68:6877-83. 2008
    ..Systematic analysis of these novel target genes will guide us in elucidating the molecular mechanisms of AP-1-regulated pathways that are critically implicated in neoplastic transformation and/or malignant progression...
  22. ncbi request reprint Profile of gene expression induced by the tumour promotor TPA in murine epithelial cells
    Joerg Schlingemann
    Division of Molecular Genetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Int J Cancer 104:699-708. 2003
    ....
  23. ncbi request reprint c-Jun and JunB are essential for hypoglycemia-mediated VEGF induction
    Björn Textor
    Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Ann N Y Acad Sci 1091:310-8. 2006
    ..In contrast, JunB is activated by the MAP kinase ERK for the AP-1 subunits c-Jun and JunB to mediate VEGF regulaltion of hypoglycemia...
  24. ncbi request reprint Defective endochondral ossification in mice with strongly compromised expression of JunB
    Jochen Hess
    Deutsches Krebsforschungszentrum Heidelberg DKFZ, Division of Signal Transduction and Growth Control A100, Im Neuenheimer Feld 280, D 69120 Heidelberg
    J Cell Sci 116:4587-96. 2003
    ..Our data demonstrate that JunB plays a crucial role in endochondral ossification by regulating proliferation and function of chondrocytes and osteoblasts...
  25. ncbi request reprint Efficient Keratinocyte Differentiation Strictly Depends on JNK-Induced Soluble Factors in Fibroblasts
    Marion Schumacher
    Division of Signal Transduction and Growth Control, DKFZ ZMBH Alliance, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Invest Dermatol 134:1332-41. 2014
    ..Taken together, our results imply that mesenchymal JNK has a pivotal role in the paracrine cross talk between dermal fibroblasts and epidermal keratinocytes during wound healing. ..
  26. ncbi request reprint Loss of stromal JUNB does not affect tumor growth and angiogenesis
    Jennifer Braun
    Division of Signal Transduction and Growth Control DKFZ DKFZ ZMBH Alliance, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 134:1511-6. 2014
    ..Taken together, these results indicate that the pro-angiogenic functions of stromal JUNB are well compensated with regard to tumor angiogenesis and tumor growth. ..
  27. ncbi request reprint Preeclampsia: increased expression of soluble ADAM 12
    Sabine Gack
    Division for Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum Heidelberg, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    J Mol Med (Berl) 83:887-96. 2005
    ..Thus, ADAM 12 could serve as an early biomarker for preeclampsia that may be of predictive and/or functional significance...
  28. doi request reprint Receptor for advanced glycation endproducts (RAGE) is a key regulator of oval cell activation and inflammation-associated liver carcinogenesis in mice
    Tobias Pusterla
    Division of Signal Transduction and Growth Control, DKFZ ZMBH Alliance, German Cancer Research Center DKFZ, Heidelberg, Germany
    Hepatology 58:363-73. 2013
    ..Conclusion: Our data identified a novel function of RAGE in regulating oval cell activation and tumor development in inflammation-associated liver carcinogenesis...
  29. pmc Junb regulates arterial contraction capacity, cellular contractility, and motility via its target Myl9 in mice
    Alexander H Licht
    Division of Signal Transduction and Growth Control A100, German Cancer Research Center DKFZ, DKFZ ZMBH Alliance, 69120 Heidelberg, Germany
    J Clin Invest 120:2307-18. 2010
    ..Our data establish a molecular link between the activator protein-1 transcription factor subunit Junb and actomyosin-based cellular motility as well as cellular and vascular contractility by governing Myl9 transcription...
  30. pmc MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma
    Wiltrud Lederle
    German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Carcinogenesis 31:1175-84. 2010
    ....
  31. pmc Epidermal development and wound healing in matrix metalloproteinase 13-deficient mice
    Bettina Hartenstein
    Division of Signal Transduction and Growth Control A100, Deutsches Krebsforschungszentrum Heidelberg DKFZ, Heidelberg, Germany
    J Invest Dermatol 126:486-96. 2006
    ....
  32. ncbi request reprint Early activation and induction of apoptosis in T cells is independent of c-Fos
    Hanna Bierbaum
    Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum Heidelberg, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Ann N Y Acad Sci 1010:225-31. 2003
    ..Our data provide clear evidence that c-Fos is not required for apoptosis regulation in activated T cells as well as in thymocytes...
  33. ncbi request reprint AP-1 subunits: quarrel and harmony among siblings
    Jochen Hess
    Deutsches Krebsforschungszentrum, Division of Signal Transduction and Growth Control, 69120 Heidelberg, Germany
    J Cell Sci 117:5965-73. 2004
    ....
  34. ncbi request reprint Two-hybrid fluorescence cross-correlation spectroscopy detects protein-protein interactions in vivo
    Nina Baudendistel
    Division Biophysics of Macromolecules B040, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Chemphyschem 6:984-90. 2005
    ..The technique has rich potential applications for the rapid screening of protein-protein interactions in vivo, which are able to clarify events during the whole life of cells...
  35. ncbi request reprint An unexpected role for FosB in activation-induced cell death of T cells
    Sven Baumann
    Tumor Immunology Program, Heidelberg, Germany
    Oncogene 22:1333-9. 2003
    ..Thus, our results demonstrate an important novel function for FosB dimerized with c-Jun in TCR/CD3-mediated AICD in human T cells...
  36. doi request reprint Keratinocyte-specific deletion of the receptor RAGE modulates the kinetics of skin inflammation in vivo
    Julia S Leibold
    Division Signal Transduction and Growth Control, German Cancer Research Center DKFZ, DKFZ ZMBH Alliance, Heidelberg, Germany
    J Invest Dermatol 133:2400-6. 2013
    ....
  37. ncbi request reprint S100A8 and S100A9 in inflammation and cancer
    Christoffer Gebhardt
    Division of Signal Transduction and Growth Control, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Biochem Pharmacol 72:1622-31. 2006
    ..Altogether, its expression and potential cytokine-like function in inflammation and in cancer suggests that S100A8/A9 may play a key role in inflammation-associated cancer...
  38. ncbi request reprint TAF7 (TAFII55) plays a role in the transcription activation by c-Jun
    Christine Munz
    Division of Signal Transduction and Growth Control, Deutsches Krebforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    J Biol Chem 278:21510-6. 2003
    ..TAF7 interacts preferentially with DNA-bound phosphorylated c-Jun, suggesting that TAF7 represents a novel c-Jun co-activator mediating activation of AP-1 target genes in response to extracellular signals...
  39. doi request reprint Overexpression of far upstream element binding proteins: a mechanism regulating proliferation and migration in liver cancer cells
    Mona Malz
    Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany
    Hepatology 50:1130-9. 2009
    ..Accordingly, analyzing nuclear and cytoplasmic areas of HCC cells revealed that reduced FBP-1 levels affected cell morphology and were associated with a less malignant phenotype...
  40. pmc Expression and function of the kallikrein-related peptidase 6 in the human melanoma microenvironment
    Stefanie Krenzer
    Division of Signal Transduction and Growth Control A100, DKFZ ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany
    J Invest Dermatol 131:2281-8. 2011
    ..Our data provide experimental evidence that specific inhibition of the KLK6-PAR1 axis may interfere with the deleterious effect of tumor-microenvironment interaction and represent a potential option for translational melanoma research...
  41. ncbi request reprint Differential enhancement of a cutaneous HPV promoter by DeltaNP63alpha, Jun and mutant p53
    Jian Wei Fei
    Division for the Characterization of Tumorviruses, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
    Cell Cycle 4:689-96. 2005
    ..The data presented in this study provide insight into a possible mechanism through which these cellular proteins may modulate a cutaneous papillomavirus genome to induce viral replication, latent infection or malignant transformation...
  42. pmc Expression of podoplanin in human astrocytic brain tumors is controlled by the PI3K-AKT-AP-1 signaling pathway and promoter methylation
    Heike Peterziel
    Divisions of Signal Transduction and Growth Control, DKFZ ZMBH Alliance, Heidelberg, Germany
    Neuro Oncol 14:426-39. 2012
    ..Thus, specific targeting of PDPN expression and/or function could be a promising strategy for the treatment of patients with primary GB...
  43. pmc Gene network dynamics controlling keratinocyte migration
    Hauke Busch
    B080 Division of Theoretical Bioinformatics, German Cancer Research Center DKFZ, Heidelberg, Germany
    Mol Syst Biol 4:199. 2008
    ..Context information for enhancing, delaying or stopping migration is provided by the activity of the protein kinase A signaling pathway. Our study reveals the complex orchestration of multiple pathways controlling cell migration...
  44. pmc Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB
    Bettina Hartenstein
    Deutsches Krebsforschungszentrum Heidelberg, Department of Signal Transduction and Growth Control, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    EMBO J 21:6321-9. 2002
    ..This study demonstrates novel functions of JunB in the development of Th2 effector cells, for a normal Th2 cytokine expression pattern and for a complete Th2-dependent immune response in mice...
  45. ncbi request reprint CEBPbeta, JunD and c-Jun contribute to the transcriptional activation of the metastasis-associated C4.4A gene
    Frank Fries
    Departments of Tumor Progression and Immune Defense, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Int J Cancer 120:2135-47. 2007
    ..4A-negative tumor cell line after cotransfection with C/EBPbeta plus JunD or c-Jun. Thus, upregulation of C/EBPbeta during tumor progression and wound repair may well provide a sufficient trigger for transcription of the C4.4A gene...
  46. ncbi request reprint The receptor for advanced glycation end products is dispensable in a mouse model of oral and esophageal carcinogenesis
    Regina Mark
    Experimental Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery, University Hospital Heidelberg, and Division of Signal Transduction and Growth Control A100, DKFZ ZMBH Alliance, German Cancer Research Center Heidelberg, Heidelberg, Germany
    Histol Histopathol 28:1585-94. 2013
    ..Our data demonstrate that RAGE is dispensable in the onset of genotoxic induced oral and esophageal squamous cell carcinoma and provide evidence for an alternative pathway of S100-Calgranulin signaling via Tlr4...
  47. pmc Opposing function of MYBBP1A in proliferation and migration of head and neck squamous cell carcinoma cells
    Gustavo A Acuña Sanhueza
    Department of Otolaryngology, Head and Neck Surgery, University Hospital Heidelberg, Heidelberg, Germany
    BMC Cancer 12:72. 2012
    ..Despite its significance, our knowledge on molecular, cellular and environmental mechanisms that drive disease pathogenesis remains largely elusive, and there are limited therapeutic options, with only negligible clinical benefit...
  48. doi request reprint Loss of matrix metalloproteinase-13 attenuates murine radiation-induced pulmonary fibrosis
    Paul Flechsig
    Department of Molecular Pathology, German Cancer Research Center, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 77:582-90. 2010
    ..Matrix metalloproteinases (MMPs) constitute a family of proteases that degrade extracellular matrix with roles in fibrosis. Here we studied the role of MMP13 in a radiation-induced lung fibrosis model using a MMP13 knockout mouse...
  49. pmc Stathmin regulates keratinocyte proliferation and migration during cutaneous regeneration
    Sabrina Schmitt
    Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany
    PLoS ONE 8:e75075. 2013
    ..Thus, activation of stathmin may stimulate keratinocyte proliferation, while basal stathmin levels are sufficient for keratinocyte migration during cutaneous regeneration. ..
  50. ncbi request reprint Calgranulins S100A8 and S100A9 are negatively regulated by glucocorticoids in a c-Fos-dependent manner and overexpressed throughout skin carcinogenesis
    Christoffer Gebhardt
    Deutsches Krebsforschungszentrum, Division of Signal Transduction and Growth Control, 69120 Heidelberg, Germany
    Oncogene 21:4266-76. 2002
    ..These data identify S100A8 and S100A9 as novel, tumor-associated genes and may point to an as yet unrecognized function of both genes in the development of epithelial skin tumors...
  51. ncbi request reprint The transcription factor Fos: a Janus-type regulator in health and disease
    Moritz Durchdewald
    German Cancer Research Center DKFZ, DKFZ ZMBH Alliance, Division of Signal Transduction and Growth Control, Heidelberg, Germany
    Histol Histopathol 24:1451-61. 2009
    ..Finally, selective inhibition of its function with a small molecule inhibitor in a preclinical mouse model of arthritis demonstrated that targeting Fos/AP-1 activity could be an auspicious new option for clinical use...
  52. ncbi request reprint Increase of AKT/PKB expression correlates with gleason pattern in human prostate cancer
    Yongde Liao
    Research Group Hormones and Signal Transduction, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Int J Cancer 107:676-80. 2003
    ..0325). These data show that AKT is upregulated in prostate cancer and that expression is correlated with tumor progression...
  53. ncbi request reprint Cre recombinase-mediated gene targeting of mesenchymal cells
    Lore Florin
    Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Genesis 38:139-44. 2004
    ....
  54. pmc Hepatocyte-specific S100a8 and S100a9 transgene expression in mice causes Cxcl1 induction and systemic neutrophil enrichment
    Lars Wiechert
    Junior Group Molecular Mechanisms of Head and Neck Tumors, DKFZ ZMBH Alliance, German Cancer Research Center DKFZ, Heidelberg, Germany
    Cell Commun Signal 10:40. 2012
    ..abstract:..
  55. ncbi request reprint Cell cycle promoting activity of JunB through cyclin A activation
    Sven Andrecht
    Division for Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum Heidelberg, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    J Biol Chem 277:35961-8. 2002
    ..Thus, cyclin A is a direct transcriptional target of JunB driving cell proliferation...
  56. ncbi request reprint High invasive melanoma cells induce matrix metalloproteinase-1 synthesis in fibroblasts by interleukin-1alpha and basic fibroblast growth factor-mediated mechanisms
    Stefanie Löffek
    Department of Dermatology, Center of Molecular Medicine CMMC, University of Cologne, Cologne, Germany
    J Invest Dermatol 124:638-43. 2005
    ..Taken together, our results indicate an essential role for soluble factors, mainly IL-1alpha and bFGF, in the stimulation of dermal fibroblasts by human melanoma cells to secrete MMP-1...
  57. ncbi request reprint Hyaluronan-oligosaccharide-induced transcription of metalloproteases
    Christina Fieber
    Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, and University of Karlsruhe, Institute of Genetics, PO Box 3640, 76021 Karlsruhe, Germany
    J Cell Sci 117:359-67. 2004
    ..Finally, we show that HA fragment-induced MMP-9 transcription is mediated via NF-kappa B. Our results suggest that the metastasis-associated HA degradation in tumours might promote invasion by inducing MMP expression...
  58. ncbi request reprint p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis
    Christine Bourcier
    Institute of Signaling, Developmental Biology and Cancer Research, UMR Centre National de la Recherche Scientifique, Nice, France
    Cancer Res 66:2700-7. 2006
    ..These results highlight the importance of ERK1 in skin homeostasis and in the process of skin tumor development...