Genomes and Genes
Affiliation: German Cancer Research Center
- Familial risk for non-Hodgkin lymphoma and other lymphoproliferative malignancies by histopathologic subtype: the Swedish Family-Cancer DatabaseAndrea Altieri
Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany
Blood 106:668-72. 2005..The patterns of risks in parents and siblings support the hypothesis of an autosomal-dominant component for diffuse large B-cell NHL and a recessive one for follicular NHL...
- Familial risks and temporal incidence trends of multiple myelomaAndrea Altieri
Division of Molecular Genetic Epidemiology, German Cancer Research Centre, DKFZ, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
Eur J Cancer 42:1661-70. 2006..If environmental factors can be excluded, the pattern of familial risk of MM is consistent with an autosomal dominant mode of inheritance...
- Polymorphisms in the transforming growth factor beta 1 pathway in relation to colorectal cancer progressionAsta Forsti
Department of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
Genes Chromosomes Cancer 49:270-81. 2010..63, 95%CI: 1.08-2.46). As this is the first study about the influence of the polymorphisms in the TGFB1 pathway on CRC progression, further studies in large independent cohorts are warranted...
- PAI-1 -675 4G/5G polymorphism as a prognostic biomarker in breast cancerHaixin Lei
Division of Molecular Genetic Epidemiology C050, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120, Heidelberg, Germany
Breast Cancer Res Treat 109:165-75. 2008..5G/5G homozygotes were also the group with worse survival among lymph node negative cases. Our finding suggests that genotyping PAI-1 -675 4G/5G may help in clinical prognosis of breast cancer...
- Interleukin promoter polymorphisms and prognosis in colorectal cancerStefan Wilkening
Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
Carcinogenesis 29:1202-6. 2008..The predicted biological effect of these SNPs in relation to promotion of cancer progression is consistent with the observed increased survival time...
- Association between number of siblings and nervous system tumors suggests an infectious etiologyAndrea Altieri
Deutsches Krebsforschungszentrum DKFZ, Division of Molecular Genetic Epidemiology, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
Neurology 67:1979-83. 2006..To estimate the effect of the number of siblings on the risk of histopathologic subtypes of tumors of the nervous system using large population-based data...
- Number of siblings and the risk of lymphoma, leukemia, and myeloma by histopathologyAndrea Altieri
Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg
Cancer Epidemiol Biomarkers Prev 15:1281-6. 2006..The remarkable protective effect of number of older siblings on acute monocytic leukemia is a novel finding of potential interest. Possible interpretations of our findings in the context of a putative infectious etiology are discussed...
- Promoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progressionHaixin Lei
Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
Breast Cancer Res Treat 103:61-9. 2007..34, 95% CI 1.08-5.08). Although our study suggests some correlations between the studied SNPs and the progression of breast cancer, the rarity of the risk genotypes limits their usefulness in the clinic...
- Sun exposure, phenotypic characteristics, and cutaneous malignant melanoma. An analysis according to different clinico-pathological variants and anatomic locations (Italy)Luigi Naldi
Clinica Dermatologica, Ospedali Riuniti di Bergamo, , Bergamo, Italy
Cancer Causes Control 16:893-9. 2005..A higher level of education and sunburn episodes in early childhood appeared to be more strongly related to SSM than to other variants...
- Single nucleotide polymorphisms in the DMBT1 promoter and the progression of breast cancerHaixin Lei
Int J Cancer 120:447-9. 2007
- Number of siblings and risk of hodgkin's and other lymphoid neoplasmsLiliane Chatenoud
Cancer Epidemiol Biomarkers Prev 14:552. 2005
- Occupational and leisure time physical activity and the risk of nonfatal acute myocardial infarction in ItalyAndrea Altieri
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
Ann Epidemiol 14:461-6. 2004..However, the quantitative estimates of the possible protective role of physical activity appear to vary across studies and populations...
- Influence of education level on breast cancer risk and survival in Sweden between 1990 and 2004Shehnaz K Hussain
Center for Family and Community Medicine, Karolinska Institute, Huddinge, Sweden
Int J Cancer 122:165-9. 2008..68, 95% CI: 0.61-0.75. Further research is warranted to elucidate possible behaviors or characteristics associated with education that could explain the differences in incidence and survival, such as compliance with cancer screening...
- Marital status and cancer risk in ItalyGiorgia Randi
Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
Prev Med 38:523-8. 2004..Marital status has long been related to cancer incidence and mortality rates. However, only few analytical studies have been conducted on this issue considering known or potential confounding factors...
- Epidemiology and aetiology of gestational trophoblastic diseasesAndrea Altieri
Laboratory of Epidemiology at the Mario Negri Institute of Pharmacological Research, Milan, Italy
Lancet Oncol 4:670-8. 2003....