Peter Altevogt

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. pmc Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins
    S Mechtersheimer
    Tumor Immunology Program, G0100, German Cancer Research Center, D-69120 Heidelberg, Germany
    J Cell Biol 155:661-73. 2001
  2. pmc L1CAM protein expression is associated with poor prognosis in non-small cell lung cancer
    Verena Tischler
    Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
    Mol Cancer 10:127. 2011
  3. pmc Interaction and uptake of exosomes by ovarian cancer cells
    Cristina Escrevente
    Instituto de Tecnologia Quimica e Biologica, Apartado 127, 2781 901 Oeiras, Portugal
    BMC Cancer 11:108. 2011
  4. doi request reprint CD24 controls Src/STAT3 activity in human tumors
    Niko P Bretz
    Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany
    Cell Mol Life Sci 69:3863-79. 2012
  5. doi request reprint The RGD integrin binding site in human L1-CAM is important for nuclear signaling
    Daniela Gast
    Tumor Immunology Programme, D010, German Cancer Research Center, Heidelberg, Germany
    Exp Cell Res 314:2411-8. 2008
  6. pmc L1CAM: a major driver for tumor cell invasion and motility
    Helena Kiefel
    Translational Immunology, German Cancer Research Center, Heidelberg, Germany
    Cell Adh Migr 6:374-84. 2012
  7. ncbi request reprint L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells
    Alexander Stoeck
    Tumor Immunology Programme, D010, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Gynecol Oncol 104:461-9. 2007
  8. doi request reprint Systemic presence and tumor-growth promoting effect of ovarian carcinoma released exosomes
    Sascha Keller
    Tumor Immunology Programme, D015, German Cancer Research Center, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Cancer Lett 278:73-81. 2009
  9. ncbi request reprint The adhesion molecule L1 (CD171) promotes melanoma progression
    Friedegund Meier
    Department of Dermatology, Section of Dermatologic Oncology, University of Tuebingen, Tuebingen, and Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 119:549-55. 2006
  10. doi request reprint Enhanced L1CAM expression on pancreatic tumor endothelium mediates selective tumor cell transmigration
    Yasmin Issa
    Tumor Immunology Programme, D015, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    J Mol Med (Berl) 87:99-112. 2009

Collaborators

Detail Information

Publications28

  1. pmc Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins
    S Mechtersheimer
    Tumor Immunology Program, G0100, German Cancer Research Center, D-69120 Heidelberg, Germany
    J Cell Biol 155:661-73. 2001
    ..We propose that ectodomain-released L1 promotes migration by autocrine/paracrine stimulation via alpha v beta 5. This regulatory loop could be relevant for migratory processes under physiological and pathophysiological conditions...
  2. pmc L1CAM protein expression is associated with poor prognosis in non-small cell lung cancer
    Verena Tischler
    Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
    Mol Cancer 10:127. 2011
    ..We investigated the protein expression of L1CAM in a cohort of NSCLC patients. L1CAM protein expression was correlated with clinico-pathological parameters including survival and markers of epithelial-mesenchymal transition...
  3. pmc Interaction and uptake of exosomes by ovarian cancer cells
    Cristina Escrevente
    Instituto de Tecnologia Quimica e Biologica, Apartado 127, 2781 901 Oeiras, Portugal
    BMC Cancer 11:108. 2011
    ..Exosomes interact with other cells and may serve as vehicles for the transfer of protein and RNA among cells...
  4. doi request reprint CD24 controls Src/STAT3 activity in human tumors
    Niko P Bretz
    Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany
    Cell Mol Life Sci 69:3863-79. 2012
    ..Our results provide evidence that CD24 regulates STAT3 and FAK activity and suggest an important role of Src in this process. Finally, the targeting of CD24 by antibodies could represent a novel route for tumor therapy...
  5. doi request reprint The RGD integrin binding site in human L1-CAM is important for nuclear signaling
    Daniela Gast
    Tumor Immunology Programme, D010, German Cancer Research Center, Heidelberg, Germany
    Exp Cell Res 314:2411-8. 2008
    ..Mutant L1 was unable to translocate to the nucleus. Our findings highlight the importance of the RGD site in L1 for human tumors and suggest that nuclear signaling of L1 is dependent on integrins...
  6. pmc L1CAM: a major driver for tumor cell invasion and motility
    Helena Kiefel
    Translational Immunology, German Cancer Research Center, Heidelberg, Germany
    Cell Adh Migr 6:374-84. 2012
    ....
  7. ncbi request reprint L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells
    Alexander Stoeck
    Tumor Immunology Programme, D010, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Gynecol Oncol 104:461-9. 2007
    ..We reported previously, that L1 adhesion molecule (CD171) is overexpressed in ovarian and endometrial carcinomas and that L1 expression is a predictor of poor outcome. We investigated a possible role of L1 in apoptosis resistance...
  8. doi request reprint Systemic presence and tumor-growth promoting effect of ovarian carcinoma released exosomes
    Sascha Keller
    Tumor Immunology Programme, D015, German Cancer Research Center, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Cancer Lett 278:73-81. 2009
    ..Exosomes from the serum of tumor patients could be isolated from only one ml of blood and this analysis could serve for diagnostic purposes. We propose that tumor-derived exosomes could play a role in tumor progression...
  9. ncbi request reprint The adhesion molecule L1 (CD171) promotes melanoma progression
    Friedegund Meier
    Department of Dermatology, Section of Dermatologic Oncology, University of Tuebingen, Tuebingen, and Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 119:549-55. 2006
    ..Altogether, L1 plays a critical role in melanoma invasion and progression and offers therapeutic potential in combination with conventional anticancer agents...
  10. doi request reprint Enhanced L1CAM expression on pancreatic tumor endothelium mediates selective tumor cell transmigration
    Yasmin Issa
    Tumor Immunology Programme, D015, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    J Mol Med (Berl) 87:99-112. 2009
    ..Our data demonstrate a functional role of L1CAM expression on tumor endothelium that could favor metastasis and angiogenesis during tumor progression...
  11. ncbi request reprint Blockade of natural killer cell-mediated lysis by NCAM140 expressed on tumor cells
    Mostafa Jarahian
    Department of Molecular Immunology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 120:2625-34. 2007
    ..We conclude that aberrant expression of NCAM on tumor cells of different histogenetic origin can lead to inhibition of target cell recognition and lysis by NK cells...
  12. ncbi request reprint Malignant ascites-derived exosomes of ovarian carcinoma patients contain CD24 and EpCAM
    Steffen Runz
    Tumor Immunology Programme D010, German Cancer Research Center, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Gynecol Oncol 107:563-71. 2007
    ..Given the emerging role of exosomes in tumor progression, we investigated whether cytoplasmic CD24 expression is correlated with the secretion of CD24 in exosomes...
  13. doi request reprint Loss of EpCAM expression in breast cancer derived serum exosomes: role of proteolytic cleavage
    Anne Kathleen Rupp
    Tumor Immunology Programme, D015, German Cancer Research Center, D 69120 Heidelberg, Germany
    Gynecol Oncol 122:437-46. 2011
    ..However, marker proteins that allow enrichment of tumor-derived exosomes over normal exosomes are less well defined...
  14. ncbi request reprint CD24 induces localization of beta1 integrin to lipid raft domains
    Steffen Runz
    Tumor Immunology Programme, D010, German Cancer Research Center, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Biochem Biophys Res Commun 365:35-41. 2008
    ..We suggest that CD24 acts as a gate-keeper for lipid rafts, thereby regulating the activity of integrins and other proteins...
  15. doi request reprint Therapeutic antibodies to human L1CAM: functional characterization and application in a mouse model for ovarian carcinoma
    Silke Wolterink
    Tumor Immunology Program, Translational Immunology Unit D015, German Cancer Research Center, Heidelberg, Germany
    Cancer Res 70:2504-15. 2010
    ..Our results establish that anti-L1 mAb therapy acts via immunologic and nonimmunologic effector mechanism to block tumor growth. The novel antibodies to L1CAM could become helpful tools for the therapy of L1-positive human carcinomas...
  16. pmc Body fluid exosomes promote secretion of inflammatory cytokines in monocytic cells via Toll-like receptor signaling
    Niko P Bretz
    From the Tumor Immunology Programme, D015, German Cancer Research Center, 69120 Heidelberg, Germany
    J Biol Chem 288:36691-702. 2013
    ..This process could be important for the induction of immunosuppressive mechanisms during cancer progression and inflammatory diseases. ..
  17. doi request reprint Linking L1CAM-mediated signaling to NF-κB activation
    Helena Kiefel
    Translational Immunology, D015, German Cancer Research Center, 69120 Heidelberg, Germany
    Trends Mol Med 17:178-87. 2011
    ..Taken together, these findings lead to a new understanding of L1CAM downstream signaling that is fundamental for the development of anti-L1CAM antibody-mediated therapeutics in human tumor cells...
  18. ncbi request reprint Generation of novel, secreted epidermal growth factor receptor (EGFR/ErbB1) isoforms via metalloprotease-dependent ectodomain shedding and exosome secretion
    Michael P Sanderson
    Tumor Immunology Program, German Cancer Research Center DKFZ, D010 TP3, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    J Cell Biochem 103:1783-97. 2008
    ..Our results provide new insights into the proteolysis, trafficking and fate of ErbB1 receptors and suggest that the novel ErbB1 isoforms may have functions distinct from the plasma membrane receptor...
  19. pmc Epigenetic regulation of L1CAM in endometrial carcinoma: comparison to cancer-testis (CT-X) antigens
    Uwe Schirmer
    Department of Translational Immunology, German Cancer Research Center, D015, Heidelberg, D 69120, Germany
    BMC Cancer 13:156. 2013
    ..We also studied the relationship to cancer testis (CT-X) antigens that co-localize with L1CAM on chromosome Xq28, a region that is often activated in human tumors...
  20. ncbi request reprint L1 on ovarian carcinoma cells is a binding partner for Neuropilin-1 on mesothelial cells
    Alexander Stoeck
    Tumor Immunology Programme, German Cancer Research Center, D010, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Cancer Lett 239:212-26. 2006
    ..The L1-NRP-1 binding pathway could contribute to the growth of ovarian carcinomas and to reciprocal signalling between mesothelial cells and tumors...
  21. pmc L1CAM expression in endometrial carcinomas is regulated by usage of two different promoter regions
    Marco Pfeifer
    German Cancer Research Center, Department of Translational Immunology, Heidelberg, Germany
    BMC Mol Biol 11:64. 2010
    ..Previous studies have implied the transcription factors Slug and/or β-catenin in L1CAM transcriptional regulation. However, the regulation of human L1CAM expression at the transcriptional level is not well understood...
  22. pmc A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44
    Alexander Stoeck
    Tumor Immunology Programme, D010, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Biochem J 393:609-18. 2006
    ..Our findings open up the possibility that exosomes serve as a platform for ectodomain shedding and as a vehicle for the cellular export of soluble molecules...
  23. ncbi request reprint Glucocorticoid-mediated inhibition of chemotherapy in ovarian carcinomas
    Chengwen Zhang
    Molecular Urooncology, German Cancer Research Center, Heidelberg, Germany
    Int J Oncol 28:551-8. 2006
    ..These data show that glucocorticoid-induced resistance is common in ovarian carcinomas implicating that the use of glucocorticoids may be harmful for cancer patients...
  24. doi request reprint CD24 promotes tumor cell invasion by suppressing tissue factor pathway inhibitor-2 (TFPI-2) in a c-Src-dependent fashion
    Niko Bretz
    Tumor Immunology Programme D015, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Clin Exp Metastasis 29:27-38. 2012
    ..Our results provide evidence that CD24 can regulate cell invasion via TFPI-2 and suggests a role of c-Src in this process...
  25. ncbi request reprint Cleavage of L1 in exosomes and apoptotic membrane vesicles released from ovarian carcinoma cells
    Paul Gutwein
    Tumor Immunology Programme, D010, German Cancer Research Center, Heidelberg, Germany
    Clin Cancer Res 11:2492-501. 2005
    ..Soluble L1 is present in serum and ascites of ovarian carcinoma patients. We investigated the mode of L1 cleavage and the function of soluble L1...
  26. ncbi request reprint CD24 affects CXCR4 function in pre-B lymphocytes and breast carcinoma cells
    Heidi Schabath
    Tumor Immunology Programme, D010, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Cell Sci 119:314-25. 2006
    ..These results demonstrate a novel role for CD24 as a regulator of CXCR4 function that could be relevant for breast cancer growth and metastasis...
  27. ncbi request reprint Exosomes: from biogenesis and secretion to biological function
    Sascha Keller
    German Cancer Research Center DKFZ, Tumor Immunology Program, D010 TP3, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Immunol Lett 107:102-8. 2006
    ....
  28. pmc Body fluid derived exosomes as a novel template for clinical diagnostics
    Sascha Keller
    Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany
    J Transl Med 9:86. 2011
    ..They can be found in various body fluids including plasma, malignant ascites, urine, amniotic fluid and saliva. Exosomes contain proteins, miRNAs and mRNAs (exosome shuttle RNA, esRNA) that could serve as novel platform for diagnosis...