P Altevogt

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. pmc Antibody targeting of CD24 efficiently retards growth and influences cytokine milieu in experimental carcinomas
    A V Salnikov
    Department of Translational Immunology, German Cancer Research Center and National Center for Tumor Diseases, Heidelberg, Germany
    Br J Cancer 108:1449-59. 2013
  2. pmc Role of miR-34a as a suppressor of L1CAM in endometrial carcinoma
    Uwe Schirmer
    Department of Translational Immunology, German Cancer Research Center
    Oncotarget 5:462-72. 2014
  3. pmc Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity
    Svenja Riedle
    Translational Immunology, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Federal Republic of Germany
    Biochem J 420:391-402. 2009
  4. pmc Epigenetic regulation of L1CAM in endometrial carcinoma: comparison to cancer-testis (CT-X) antigens
    Uwe Schirmer
    Department of Translational Immunology, German Cancer Research Center, D015, Heidelberg, D 69120, Germany
    BMC Cancer 13:156. 2013
  5. pmc Body fluid derived exosomes as a novel template for clinical diagnostics
    Sascha Keller
    Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany
    J Transl Med 9:86. 2011
  6. pmc ADAM10 is expressed in human podocytes and found in urinary vesicles of patients with glomerular kidney diseases
    Paul Gutwein
    Pharmazentrum frankfurt ZAFES, University Hospital Goethe University Frankfurt, Frankfurt am Main, Germany
    J Biomed Sci 17:3. 2010
  7. pmc L1CAM expression in endometrial carcinomas is regulated by usage of two different promoter regions
    Marco Pfeifer
    German Cancer Research Center, Department of Translational Immunology, Heidelberg, Germany
    BMC Mol Biol 11:64. 2010
  8. ncbi request reprint The role of L1 in the progression of ovarian carcinomas
    P Altevogt
    Tumor Immunology Programme, D010, German Cancer Research Center, Heidelberg, Germany
    Zentralbl Gynakol 126:323-5. 2004
  9. pmc Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins
    S Mechtersheimer
    Tumor Immunology Program, G0100, German Cancer Research Center, D-69120 Heidelberg, Germany
    J Cell Biol 155:661-73. 2001
  10. doi request reprint L1CAM-integrin interaction induces constitutive NF-kappaB activation in pancreatic adenocarcinoma cells by enhancing IL-1beta expression
    H Kiefel
    Translational Immunology, German Cancer Research Center, Heidelberg, Germany
    Oncogene 29:4766-78. 2010

Collaborators

Detail Information

Publications29

  1. pmc Antibody targeting of CD24 efficiently retards growth and influences cytokine milieu in experimental carcinomas
    A V Salnikov
    Department of Translational Immunology, German Cancer Research Center and National Center for Tumor Diseases, Heidelberg, Germany
    Br J Cancer 108:1449-59. 2013
    ..We have shown before that monotherapy with monoclonal antibody (mAb) SWA11 to CD24 effectively retarded tumour growth in xenotransplanted mice...
  2. pmc Role of miR-34a as a suppressor of L1CAM in endometrial carcinoma
    Uwe Schirmer
    Department of Translational Immunology, German Cancer Research Center
    Oncotarget 5:462-72. 2014
    ..Our data suggest that miR-34a can regulate L1CAM expression by targeting L1CAM mRNA for degradation. These findings shed new light on the complex regulation of L1CAM in human tumors. ..
  3. pmc Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity
    Svenja Riedle
    Translational Immunology, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Federal Republic of Germany
    Biochem J 420:391-402. 2009
    ..Our results establish for the first time that regulated proteolytic processing by ADAM10 and PS/gamma-secretase is essential for the nuclear signalling of L1 in human carcinoma cell lines...
  4. pmc Epigenetic regulation of L1CAM in endometrial carcinoma: comparison to cancer-testis (CT-X) antigens
    Uwe Schirmer
    Department of Translational Immunology, German Cancer Research Center, D015, Heidelberg, D 69120, Germany
    BMC Cancer 13:156. 2013
    ..We also studied the relationship to cancer testis (CT-X) antigens that co-localize with L1CAM on chromosome Xq28, a region that is often activated in human tumors...
  5. pmc Body fluid derived exosomes as a novel template for clinical diagnostics
    Sascha Keller
    Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany
    J Transl Med 9:86. 2011
    ..They can be found in various body fluids including plasma, malignant ascites, urine, amniotic fluid and saliva. Exosomes contain proteins, miRNAs and mRNAs (exosome shuttle RNA, esRNA) that could serve as novel platform for diagnosis...
  6. pmc ADAM10 is expressed in human podocytes and found in urinary vesicles of patients with glomerular kidney diseases
    Paul Gutwein
    Pharmazentrum frankfurt ZAFES, University Hospital Goethe University Frankfurt, Frankfurt am Main, Germany
    J Biomed Sci 17:3. 2010
    ..The importance of the Notch signaling in the development of glomerular diseases has been recently described. Therefore we analyzed in podocytes the expression and activity of ADAM10, one important component of the Notch signaling complex...
  7. pmc L1CAM expression in endometrial carcinomas is regulated by usage of two different promoter regions
    Marco Pfeifer
    German Cancer Research Center, Department of Translational Immunology, Heidelberg, Germany
    BMC Mol Biol 11:64. 2010
    ..Previous studies have implied the transcription factors Slug and/or β-catenin in L1CAM transcriptional regulation. However, the regulation of human L1CAM expression at the transcriptional level is not well understood...
  8. ncbi request reprint The role of L1 in the progression of ovarian carcinomas
    P Altevogt
    Tumor Immunology Programme, D010, German Cancer Research Center, Heidelberg, Germany
    Zentralbl Gynakol 126:323-5. 2004
    ..We address the question how L1 determination in tumor tissue samples and in serum and ascites could potentially improve the disease management...
  9. pmc Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins
    S Mechtersheimer
    Tumor Immunology Program, G0100, German Cancer Research Center, D-69120 Heidelberg, Germany
    J Cell Biol 155:661-73. 2001
    ..We propose that ectodomain-released L1 promotes migration by autocrine/paracrine stimulation via alpha v beta 5. This regulatory loop could be relevant for migratory processes under physiological and pathophysiological conditions...
  10. doi request reprint L1CAM-integrin interaction induces constitutive NF-kappaB activation in pancreatic adenocarcinoma cells by enhancing IL-1beta expression
    H Kiefel
    Translational Immunology, German Cancer Research Center, Heidelberg, Germany
    Oncogene 29:4766-78. 2010
    ..The unravelling of this novel mechanism sheds new light on the important role of L1CAM expression in PDAC cells...
  11. ncbi request reprint CD24, a mucin-type glycoprotein, is a ligand for P-selectin on human tumor cells
    S Aigner
    Tumor Immunology Programme, German Cancer Research Center, Heidelberg
    Blood 89:3385-95. 1997
    ..The CD24/P-selectin binding pathway could be important in the dissimination of tumor cells by facilitating the interaction with platelets or endothelial cells...
  12. pmc The alpha 4 integrin chain is a ligand for alpha 4 beta 7 and alpha 4 beta 1
    P Altevogt
    Tumor Immunology Programme, German Cancer Research Center, Heidelberg
    J Exp Med 182:345-55. 1995
    ....
  13. ncbi request reprint Critical amino acid residues of the alpha4 subunit for alpha4beta7 integrin function
    Y Zeller
    Tumor Immunology Programme, G0100, German Cancer Research Center, D-69120 Heidelberg, Germany
    J Cell Biochem 83:304-19. 2001
    ..Our results indicate: (i) that LDV-3, located proximal to the cell membrane, is important for alpha4beta7 integrin-triggered functions and for lateral clustering and (ii) that LDV-2 affects alpha4beta7 heterodimer stability...
  14. ncbi request reprint Mouse CD24 as a signaling molecule for integrin-mediated cell binding: functional and physical association with src-kinases
    M Sammar
    Tumor Immunology Programme, German Cancer Research Center, Heidelberg
    Biochem Biophys Res Commun 234:330-4. 1997
    ..It is suggested that the CD24-associated kinases are involved in the activation of cell aggregation...
  15. ncbi request reprint Characterization of the L1-neurocan-binding site. Implications for L1-L1 homophilic binding
    M Oleszewski
    Tumor Immunology Programme, G0100, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Biol Chem 275:34478-85. 2000
    ..We find that the C-terminal portion of neurocan is sufficient to mediate binding to the first Ig domain of L1, and we suggest that the sushi domain cooperates with a glycosaminoglycan side chain in forming the binding site for L1...
  16. ncbi request reprint The cytoplasmic part of L1-CAM controls growth and gene expression in human tumors that is reversed by therapeutic antibodies
    D Gast
    Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany
    Oncogene 27:1281-9. 2008
    ..These findings provide a rationale for the mode of action of L1 antibodies and suggest that interference with L1 function could become a valuable target for therapy...
  17. ncbi request reprint CD24 is a marker of exosomes secreted into urine and amniotic fluid
    S Keller
    Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany
    Kidney Int 72:1095-102. 2007
    ..Our studies suggest that exosomal secretion from the embryonic kidney could play a biological role at the fetal-maternal interphase...
  18. ncbi request reprint Integrin leukocyte function-associated antigen-1-mediated cell binding can be activated by clustering of membrane rafts
    K Krauss
    Tumor Immunology Programme, G0100, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Biol Chem 274:36921-7. 1999
    ..Our results support the notion that rafts as preformed adhesion platforms could be important for the rapid regulation of lymphocyte adhesion...
  19. doi request reprint Prognostic significance of L1CAM in ovarian cancer and its role in constitutive NF-κB activation
    S Bondong
    Department of Translational Immunology, German Cancer Research Center, Heidelberg, Germany
    Ann Oncol 23:1795-802. 2012
    ..We tested L1CAM and interleukin-1 beta (IL-1β) expression in tumor samples and ascitic fluid from ovarian carcinoma patients to examine its role as a prognostic marker...
  20. ncbi request reprint The cell adhesion molecule L1: species- and cell-type-dependent multiple binding mechanisms
    G Kadmon
    Department of Cellular Immunology 0710, German Cancer Research Centre, Heidelberg, Germany
    Differentiation 61:143-50. 1997
    ..The model of L1 binding seems to be governed by the cell, but it does not correlate with known alternative splicing or glycosylation patterns of L1...
  21. ncbi request reprint Heat-stable antigen (mouse CD24) in the brain: dual but distinct interaction with P-selectin and L1
    M Sammar
    Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany
    Biochim Biophys Acta 1337:287-94. 1997
    ..Treatment of HSA with OSGE significantly reduced binding of both P-selectin and I.1. Our data suggest that HSA can bind P-selectin and I.1 by distinct mechanism and that the binding epitopes on HSA are in close proximity...
  22. ncbi request reprint L1 adhesion molecule on human lymphocytes and monocytes: expression and involvement in binding to alpha v beta 3 integrin
    O Ebeling
    Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany
    Eur J Immunol 26:2508-16. 1996
    ..MED-B1 cells could also be stained with the 6.L1-Fc fusion protein. Our results suggest that human L1 binds predominantly to alpha v beta 3 and that its presence on leukocytes could be important for adhesion and migration...
  23. doi request reprint Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling
    G Kallifatidis
    Molecular OncoSurgery Group, University of Heidelberg and German Cancer Research Center, Heidelberg, Germany
    Gut 58:949-63. 2009
    ..The aim of the study was to identify TICs in pancreatic carcinoma for analysis of resistance mechanisms and for definition of sensitising agents...
  24. pmc The L1 adhesion molecule is a cellular ligand for VLA-5
    M Ruppert
    Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany
    J Cell Biol 131:1881-91. 1995
    ..Given its rapid downregulation on lymphocytes after induction of cell proliferation, L1 may be important in integrin-mediated and activation-regulated cell-cell interactions...
  25. ncbi request reprint Expression and function of the neural cell adhesion molecule L1 in mouse leukocytes
    A Kowitz
    Institute for Immunology and Genetics, German Cancer Research Center, Heidelberg
    Eur J Immunol 22:1199-205. 1992
    ..A possible role of L1 on lymphocytes in stimulating the innervation of lymphoid organs is discussed...
  26. ncbi request reprint Tumour biological aspects of CD24, a mucin-like adhesion molecule
    G Kristiansen
    Institute of Pathology, Charite University Hospital, Schumannstrasse 20 21, 10117 Berlin, Germany
    J Mol Histol 35:255-62. 2004
    ..The aim of this review is to summarize relevant work covering these aspects of CD24...
  27. ncbi request reprint Adhesive hierarchy involving the cell adhesion molecules L1, CD24, and alpha 6 integrin in murine neuroblastoma N2A cells
    G Kadmon
    Department of Cellular Immunology 710, German Cancer Research Centre, Heidelberg
    Biochem Biophys Res Commun 214:94-101. 1995
    ..These results indicate that neural cells might employ a strategy of adhesion cascade in establishing stable contacts...
  28. ncbi request reprint Different expression levels of alpha3/4 fucosyltransferases and Lewis determinants in ovarian carcinoma tissues and cell lines
    C Escrevente
    Instituto de Tecnologia Quimica e Biologica, 2781 901 Oeiras, Portugal
    Int J Oncol 29:557-66. 2006
    ..The GG and m130 cell lines are adequate models to investigate the role of Lex, Ley, sLea and Leb in ovarian carcinoma development...
  29. ncbi request reprint The role of L1-CAM immunohistochemial staining in the diagnosis of abdominal-pelvic cancer of uncertain primary site in women
    A Ben-Arie
    Department of Gynecology Oncology, Kaplan Medical Center, 76100 Rehovot, Israel
    Eur J Surg Oncol 34:795-9. 2008
    ..Here we evaluated whether L1-CAM could serve as a novel tumor marker for the diagnosis of metastatic abdominal-pelvic cancers of uncertain origin in women...