Gunther Gerisch

Summary

Country: Germany

Publications

  1. Helenius J, Ecke M, Muller D, Gerisch G. Oscillatory Switches of Dorso-Ventral Polarity in Cells Confined between Two Surfaces. Biophys J. 2018;115:150-162 pubmed publisher
    ..These data provide evidence for a cell-autonomous oscillator that switches dorso-ventral polarity in a cell simultaneously exposed to multiple substrate surfaces. ..
  2. Gerisch G, Ecke M, Schroth Diez B, Gerwig S, Engel U, Maddera L, et al. Self-organizing actin waves as planar phagocytic cup structures. Cell Adh Migr. 2009;3:373-82 pubmed
    ..We suggest that actin waves enable a phagocyte to scan a surface for particles that might be engulfed. ..
  3. Gerisch G. Self-organizing actin waves that simulate phagocytic cup structures. PMC Biophys. 2010;3:7 pubmed publisher
    ..5) The actin wave and PIP3 patterns resemble 2-dimensional projections of phagocytic cups, suggesting that they are involved in the scanning of surfaces for particles to be taken up.PACS Codes: 87.16.Ln, 87.19.lp, 89.75.Fb. ..
  4. Gerisch G, Schroth Diez B, Müller Taubenberger A, Ecke M. PIP3 waves and PTEN dynamics in the emergence of cell polarity. Biophys J. 2012;103:1170-8 pubmed publisher
    ..Actin clusters were remodeled into a ring along the perimeter of the expanding PIP3 wave. The reverse transition of PIP3 to PTEN was linked to the previous site of wave initiation: where PIP3 decayed first, the entry of PTEN was primed. ..
  5. Jasnin M, Ecke M, Baumeister W, Gerisch G. Actin Organization in Cells Responding to a Perforated Surface, Revealed by Live Imaging and Cryo-Electron Tomography. Structure. 2016;24:1031-43 pubmed publisher
    ..Branches identified at later stages suggested that formin-based nucleation of filaments was followed by Arp2/3-mediated network stabilization, which prevented buckling of the force-generating filaments. ..
  6. Gerisch G, Ecke M, Wischnewski D, Schroth Diez B. Different modes of state transitions determine pattern in the Phosphatidylinositide-Actin system. BMC Cell Biol. 2011;12:42 pubmed publisher
    ..The PTEN oscillations are related to motility patterns of chemotaxing cells. ..
  7. Gerisch G, Ecke M. Wave Patterns in Cell Membrane and Actin Cortex Uncoupled from Chemotactic Signals. Methods Mol Biol. 2016;1407:79-96 pubmed publisher
    ..Here, we describe imaging techniques using fluorescent proteins to probe for the state of the membrane, the reorganization of the actin network, and the dynamics of wave patterns. ..
  8. Lange M, Prassler J, Ecke M, Müller Taubenberger A, Gerisch G. Local Ras activation, PTEN pattern, and global actin flow in the chemotactic responses of oversized cells. J Cell Sci. 2016;129:3462-72 pubmed publisher
    ..But even in large cells, the front communicates with the tail through an actin flow that might act as carrier of a protrusion inhibitor. ..