Gerd Geerling

....

..the recommendations of the Subcommittee are based on a modification of the ITF severity grading scheme, and suggested treatments were chosen from a menu of therapies for which evidence of therapeutic effect had been presented...

....

..In the presence of these problems, surgical attempts of ocular surface reconstruction frequently fail. Here we review established and evolving new techniques in the field of adnexal surgery to specifically address these problems...

..It is particularly helpful for lamellar dissection techniques such as deep anterior lamellar keratoplasty and trabeculectomy...

..In view of legislative restrictions and based upon the literature reviewed here a preliminary standard operating procedure for the manufacture of serum eye drops is proposed...

..We describe our complex surgical techniques in the management of a patient with end-stage ocular surface disease from Stevens-Johnson syndrome...

..Platelet releasate may be suitable as a novel treatment option for ocular surface disease with a superior effect on cell growth...

..To evaluate a serum-free system where mitotically active subconjunctival fibroblasts were co-cultured with conjunctival epithelial cells to mimic a niche environment for conjunctival progenitor cells...

....

..To investigate therapeutic ocular surface medium (TOSM), a potential physiological tear replacement therapy, for moderate to severe dry eye...

..Investigation of slit-lamp-adapted 1310-nm optical coherence tomography (OCT) as an in vivo imaging device in the postoperative course of glaucoma surgery...

..The authors aimed to produce a new tear substitute capable of providing both lubrication and nutrition, based on a novel nutrient-containing therapeutic ocular surface medium (TOSM)...

..To assess intraobserver and interobserver variability of anterior segment optical coherence tomography (AS-OCT) as an objective diagnostic tool to quantify the anterior chamber angle and opening width...

....

..We report six eyes (five patients) which were all treated with autologous serum eye drops in combination with an FDA group IV hydrogel contact lens...

..To evaluate the radioprotective effect of lidocaine, amifostine and pilocarpine on lacrimal glands...

..In this group of patients the three major salivary glands, the parotid, the submandibular and the sublingual gland, have been used to lubricate the ocular surface...

....

..This article reviews the present approaches for reconstruction of the conjunctival surface, considering the established strategies and new potential methodologies...

..These changes may represent objective surrogate parameters for radiogenic dysfunction and prerequisites for further investigations on radioprotection of lachrymal glands during radiotherapy of the periorbital region...

..Here we review current irreversible and reversible techniques to occlude the lacrimal drainage and describe a new surgical technique, termed 'punctum switch', which has the advantage of being permanent and yet potentially is reversible...

..They can be transplanted together with the overlying mucosa as a complex graft to the posterior lamella of the eyelids to increase ocular surface lubrication and reduce discomfort in dry eyes...

..This shows that submandibular glands can remain viable despite complete separation from their normal nerve supply and are capable of regaining a substantial secretory activity for years...

..However material modifications are requested before KF may represent a feasible alternative for ocular surface reconstruction...

..Understanding the characteristics and limitations of these models will help researchers choose the right models to address specific problems and develop new treatment modalities in dry eye...

..Based on the type and severity of dry eye, we propose a structured approach to the surgical management of the disease...

..Platelets (PLTs) are rich in growth factors and easily available as PLT concentrates (PCs) from blood banks. Therefore, growth factor preparations from PCs may serve as a new and superior therapeutic agent for such defects...

..In this review, we formulate a consensus on the unmet medical needs in the management of corneal neovascularisation and outline a framework for the clinical research that is needed to identify suitable agents to meet these needs...

..Although it is very rare, ophthalmologists should consider leiomyolipoma in the differential diagnosis of orbital tumors. The long-term prognosis for patients affected by this benign tumor is good...

..This study was conducted to investigate whether CXL influences ablation rate, flap thickness, and refractive results of excimer laser procedures ex vivo...

..This study demonstrates matrix metalloproteinase expression in epithelial and fibroblast-like cells following wounding of human corneal tissue in culture where the cells remain in contact with their natural matrices...

..A temporary block is usually induced by implants to tamponade on the level of the lacrimal puncta or canaliculi...

..A new option is the implantable pump dacryoreservoir...

..Moreover, the results suggest that VEGF might play an active role in the physiology of conjunctival epithelial cells...

..Our aim was to investigate the efficiency of adenoviral gene transfer via direct injection into the Schlemm canal ex vivo in human donor eyes and to examine the effect of human MMP-3 transgene expression in a rat model in vivo...