Joanna Gawinecka

Summary

Country: Germany

Publications

  1. pmc Sporadic Creutzfeldt-Jakob disease subtype-specific alterations of the brain proteome: impact on Rab3a recycling
    Joanna Gawinecka
    National Reference Center for TSE Surveillance, Medical Center Georg August University, Goettingen, Germany
    Proteomics 12:3610-20. 2012
  2. pmc Cerebrospinal fluid biomarker supported diagnosis of Creutzfeldt-Jakob disease and rapid dementias: a longitudinal multicentre study over 10 years
    Katharina Stoeck
    Department of Neurology, National Reference Centre for Transmissible Spongiform Encephalopathies, Georg August University, 37075 Gottingen, Germany
    Brain 135:3051-61. 2012
  3. doi Desmoplakin as a potential candidate for cerebrospinal fluid marker to rule out 14-3-3 false positive rates in sporadic Creutzfeldt-Jakob disease differential diagnosis
    Joanna Gawinecka
    National Reference Center for TSE Surveillance, Department of Neurology, Medical Center Georg August University, Gottingen, Germany
    Neurodegener Dis 9:139-44. 2012
  4. doi MRI and clinical syndrome in dura mater-related Creutzfeldt-Jakob disease
    B Meissner
    National TSE Reference Center, Dept of Neurology, University of Gottingen, Robert Koch Str 40, 37075, Gottingen, Germany
    J Neurol 256:355-63. 2009
  5. doi Genetic prion disease with codon 196 PRNP mutation: clinical and pathological findings
    Gabi Schelzke
    National Reference Centre for Transmissible Spongiform Encephalopathies, Department of Neurology, Georg August University, Goettingen, Germany
    Neurobiol Aging 32:756.e1-9. 2011
  6. pmc Cerebrospinal fluid biomarkers in human genetic transmissible spongiform encephalopathies
    Anna Ladogana
    Department of Cellular Biology and Neurosciences, Instituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Neurol 256:1620-8. 2009
  7. doi Codon 129 polymorphism and the E200K mutation do not affect the cellular prion protein isoform composition in the cerebrospinal fluid from patients with Creutzfeldt-Jakob disease
    Matthias Schmitz
    National TSE Reference Center, Department of Neurology, Georg August University Gottingen, Gottingen, Germany
    Eur J Neurosci 31:2024-31. 2010
  8. doi Subtype-specific synaptic proteome alterations in sporadic creutzfeldt-jakob disease
    Joanna Gawinecka
    National Reference Center for TSE, Medical Center Georg August University, Goettingen, Germany
    J Alzheimers Dis 37:51-61. 2013
  9. doi Low-abundant cerebrospinal fluid proteome alterations in dementia with lewy bodies
    Jana Katharina Dieks
    Department of Neurology, Clinical Dementia Center, Medical Center Georg August University, Gottingen, Germany
    J Alzheimers Dis 34:387-97. 2013
  10. doi Codon 129 polymorphism specific cerebrospinal fluid proteome pattern in sporadic Creutzfeldt-Jakob disease and the implication of glycolytic enzymes in prion-induced pathology
    Joanna Gawinecka
    Department of Clinical Chemistry, Medical Center Georg August University, Goettingen, Germany
    J Proteome Res 9:5646-57. 2010

Collaborators

Detail Information

Publications13

  1. pmc Sporadic Creutzfeldt-Jakob disease subtype-specific alterations of the brain proteome: impact on Rab3a recycling
    Joanna Gawinecka
    National Reference Center for TSE Surveillance, Medical Center Georg August University, Goettingen, Germany
    Proteomics 12:3610-20. 2012
    ..Indeed, we found an accumulation of the membrane-associated form, thus the active one, which suggests that dysfunction of the Rab3a-mediated exocytosis might be implicated in sCJD pathology...
  2. pmc Cerebrospinal fluid biomarker supported diagnosis of Creutzfeldt-Jakob disease and rapid dementias: a longitudinal multicentre study over 10 years
    Katharina Stoeck
    Department of Neurology, National Reference Centre for Transmissible Spongiform Encephalopathies, Georg August University, 37075 Gottingen, Germany
    Brain 135:3051-61. 2012
    ..The spectrum of differential diagnosis of rapid progressive dementia varied from neurodegenerative dementias to dementia due to acute neurological conditions such as inflammatory diseases and non-neurological origin...
  3. doi Desmoplakin as a potential candidate for cerebrospinal fluid marker to rule out 14-3-3 false positive rates in sporadic Creutzfeldt-Jakob disease differential diagnosis
    Joanna Gawinecka
    National Reference Center for TSE Surveillance, Department of Neurology, Medical Center Georg August University, Gottingen, Germany
    Neurodegener Dis 9:139-44. 2012
    ..However, some pathological conditions associated with acute neuronal damage may result in a positive 14-3-3 test and thereby reduce test specificity in sCJD...
  4. doi MRI and clinical syndrome in dura mater-related Creutzfeldt-Jakob disease
    B Meissner
    National TSE Reference Center, Dept of Neurology, University of Gottingen, Robert Koch Str 40, 37075, Gottingen, Germany
    J Neurol 256:355-63. 2009
    ..Data on disease course in DM-CJD are limited. We describe the clinical and diagnostic findings in this patient group with special emphasis on MRI signal alterations...
  5. doi Genetic prion disease with codon 196 PRNP mutation: clinical and pathological findings
    Gabi Schelzke
    National Reference Centre for Transmissible Spongiform Encephalopathies, Department of Neurology, Georg August University, Goettingen, Germany
    Neurobiol Aging 32:756.e1-9. 2011
    ..Four patients underwent autopsy-pathological lesions revealed striking similarity to sporadic Creutzfeldt-Jakob disease but also involvement of the white matter...
  6. pmc Cerebrospinal fluid biomarkers in human genetic transmissible spongiform encephalopathies
    Anna Ladogana
    Department of Cellular Biology and Neurosciences, Instituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Neurol 256:1620-8. 2009
    ..Disease duration and codon 129 genotype influence the findings in a different way than in sporadic CJD...
  7. doi Codon 129 polymorphism and the E200K mutation do not affect the cellular prion protein isoform composition in the cerebrospinal fluid from patients with Creutzfeldt-Jakob disease
    Matthias Schmitz
    National TSE Reference Center, Department of Neurology, Georg August University Gottingen, Gottingen, Germany
    Eur J Neurosci 31:2024-31. 2010
    ....
  8. doi Subtype-specific synaptic proteome alterations in sporadic creutzfeldt-jakob disease
    Joanna Gawinecka
    National Reference Center for TSE, Medical Center Georg August University, Goettingen, Germany
    J Alzheimers Dis 37:51-61. 2013
    ..Moreover, several of them have been already linked to the pathophysiological processes occurring in Alzheimer's disease. ..
  9. doi Low-abundant cerebrospinal fluid proteome alterations in dementia with lewy bodies
    Jana Katharina Dieks
    Department of Neurology, Clinical Dementia Center, Medical Center Georg August University, Gottingen, Germany
    J Alzheimers Dis 34:387-97. 2013
    ..The identification of DLB-associated proteome changes will help to further understand pathological processes occurring in DLB and may provide future prospects to diagnostic and therapeutic options...
  10. doi Codon 129 polymorphism specific cerebrospinal fluid proteome pattern in sporadic Creutzfeldt-Jakob disease and the implication of glycolytic enzymes in prion-induced pathology
    Joanna Gawinecka
    Department of Clinical Chemistry, Medical Center Georg August University, Goettingen, Germany
    J Proteome Res 9:5646-57. 2010
    ..The identification of sCJD-regulated proteins in CSF of living symptomatic patients in our study can broaden our knowledge about pathological processes occurring in sCJD, as they are still not fully understood...
  11. doi Amyloid-β 1-42 levels are modified by apolipoprotein E ε4 in Creutzfeldt-Jakob disease in a similar manner as in Alzheimer's disease
    Daniela Varges
    National Reference Center for TSE Surveillance at Department of Neurology, University Medical School, Gottingen, Germany
    J Alzheimers Dis 23:717-26. 2011
    ..Based on our results in sCJD patients, we hypothesize that the ApoE ε4 effect on Aβ1-42 values might not be disease-specific...
  12. doi Filtration of protein aggregates increases the accuracy for diagnosing prion diseases in brain biopsies
    Wiebke M Wemheuer
    Department of Neuropathology, Prion and Dementia Research Unit, University Medical Center Gottingen, Germany
    J Neuropathol Exp Neurol 72:758-67. 2013
    ..With this standard and the availability of unfixed tissue, a diagnosis was possible in all 16 biopsies examined. ..
  13. pmc Similarities between forms of sheep scrapie and Creutzfeldt-Jakob disease are encoded by distinct prion types
    Wiebke M Wemheuer
    Prion and Dementia Research Unit, Department of Neuropathology, University Medical Center Goettingen, Goettingen, Germany
    Am J Pathol 175:2566-73. 2009
    ..This should be taken into consideration when discussing interspecies transmission...