Meinrad Gawaz

Summary

Country: Germany

Publications

  1. ncbi request reprint Implications of glycoprotein VI for theranostics
    M Gawaz
    Meinrad Gawaz, MD, Department of Cardiology, University of Tubingen, Otfried Müller Straße 10, 72076 Tubingen, Germany, Tel 49 7071 29 83688, Fax 49 7071 29 5749, E mail
    Thromb Haemost 112:26-31. 2014
  2. pmc The GPVI-Fc fusion protein Revacept improves cerebral infarct volume and functional outcome in stroke
    Silvia Goebel
    AdvanceCOR GmbH, Martinsried, Germany
    PLoS ONE 8:e66960. 2013
  3. pmc Macrophage migration inhibitory factor is enhanced in acute coronary syndromes and is associated with the inflammatory response
    Iris I Müller
    Kardiologie und Kreislauferkrankungen, Medizinische Klinik III, Eberhard Karls Universitat, Tubingen, Germany
    PLoS ONE 7:e38376. 2012
  4. pmc Thrombus Aspiration in ThrOmbus containing culpRiT lesions in Non-ST-Elevation Myocardial Infarction (TATORT-NSTEMI): study protocol for a randomized controlled trial
    Suzanne de Waha
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Struempellstr 39, Leipzig 04289, Germany
    Trials 14:110. 2013
  5. pmc Student tutors for hands-on training in focused emergency echocardiography--a randomized controlled trial
    Matthias Kuhl
    University Hospital Tubingen, Department of Internal Medicine, Division of Cardiology, University Hospital of Tubingen, Otfried Muller Str 10, 72076, Tubingen, Germany
    BMC Med Educ 12:101. 2012
  6. doi request reprint Elinogrel, an orally and intravenously available ADP-receptor antagonist. How does elinogrel affect a personalized antiplatelet therapy?
    K A L Müller
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Universitatsklinikum Tubingen, Germany
    Hamostaseologie 32:191-4. 2012
  7. pmc Platelets in inflammation and atherogenesis
    Meinrad Gawaz
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    J Clin Invest 115:3378-84. 2005
  8. ncbi request reprint Platelets in the onset of atherosclerosis
    Meinrad Gawaz
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    Blood Cells Mol Dis 36:206-10. 2006
  9. ncbi request reprint Non-invasive imaging of glycoprotein VI binding to injured arterial lesions
    Meinrad Gawaz
    Medizinische Klink III, Universitatsklinikum Tubingen, Germany
    Thromb Haemost 93:910-3. 2005
  10. ncbi request reprint CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation
    Tobias Geisler
    Department of Cardiology, University Hospital Tuebingen, Otfried Mueller Strasse 10, Tuebingen, Germany
    Pharmacogenomics 9:1251-9. 2008

Detail Information

Publications161 found, 100 shown here

  1. ncbi request reprint Implications of glycoprotein VI for theranostics
    M Gawaz
    Meinrad Gawaz, MD, Department of Cardiology, University of Tubingen, Otfried Müller Straße 10, 72076 Tubingen, Germany, Tel 49 7071 29 83688, Fax 49 7071 29 5749, E mail
    Thromb Haemost 112:26-31. 2014
    ..This review summarises the potential of GPVI for diagnostic and therapeutic options based on novel non-invasive molecular imaging modalities to ameliorate care of patients with cardiovascular diseases. ..
  2. pmc The GPVI-Fc fusion protein Revacept improves cerebral infarct volume and functional outcome in stroke
    Silvia Goebel
    AdvanceCOR GmbH, Martinsried, Germany
    PLoS ONE 8:e66960. 2013
    ..We examined the effect of Revacept, an Fc fusion protein which is specifically linked to the extracellular domain of glycoprotein VI (GPVI), on thrombus formation after vessel wall injury and on experimental stroke in mice...
  3. pmc Macrophage migration inhibitory factor is enhanced in acute coronary syndromes and is associated with the inflammatory response
    Iris I Müller
    Kardiologie und Kreislauferkrankungen, Medizinische Klinik III, Eberhard Karls Universitat, Tubingen, Germany
    PLoS ONE 7:e38376. 2012
    ..Little is known to date about the clinical impact of MIF in patients with symptomatic coronary artery disease (CAD)...
  4. pmc Thrombus Aspiration in ThrOmbus containing culpRiT lesions in Non-ST-Elevation Myocardial Infarction (TATORT-NSTEMI): study protocol for a randomized controlled trial
    Suzanne de Waha
    Department of Internal Medicine Cardiology, University of Leipzig Heart Center, Struempellstr 39, Leipzig 04289, Germany
    Trials 14:110. 2013
    ..Current guidelines recommend thrombus aspiration in patients with ST-elevation myocardial infarction (STEMI); however, there are insufficient data to unequivocally support thrombectomy in patients with non-STEMI (NSTEMI)...
  5. pmc Student tutors for hands-on training in focused emergency echocardiography--a randomized controlled trial
    Matthias Kuhl
    University Hospital Tubingen, Department of Internal Medicine, Division of Cardiology, University Hospital of Tubingen, Otfried Muller Str 10, 72076, Tubingen, Germany
    BMC Med Educ 12:101. 2012
    ..There is a shortage of experienced echocardiographers who can supervise the second step, the hands-on training. We thus investigated whether student tutors can perform the hands-on training for focused emergency echocardiography...
  6. doi request reprint Elinogrel, an orally and intravenously available ADP-receptor antagonist. How does elinogrel affect a personalized antiplatelet therapy?
    K A L Müller
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Universitatsklinikum Tubingen, Germany
    Hamostaseologie 32:191-4. 2012
    ..This review gives an overview over the investigational drug elinogrel for use in a personalized antiplatelet approach...
  7. pmc Platelets in inflammation and atherogenesis
    Meinrad Gawaz
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    J Clin Invest 115:3378-84. 2005
    ..This Review highlights the molecular machinery and inflammatory pathways used by platelets to initiate and accelerate atherothrombosis...
  8. ncbi request reprint Platelets in the onset of atherosclerosis
    Meinrad Gawaz
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    Blood Cells Mol Dis 36:206-10. 2006
    ..Inhibition of platelet interaction with the arterial wall results in attenuation of atherosclerosis and may be a novel therapeutic strategy in treatment of high-risk patients...
  9. ncbi request reprint Non-invasive imaging of glycoprotein VI binding to injured arterial lesions
    Meinrad Gawaz
    Medizinische Klink III, Universitatsklinikum Tubingen, Germany
    Thromb Haemost 93:910-3. 2005
    ..Because GPVI is the critical collagen receptor that mediates platelet adhesion to vascular lesions, soluble radiolabeled GPVI may be an agent for non-invasive imaging of thrombogenic thus, vulnerable atherosclerotic plaques...
  10. ncbi request reprint CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation
    Tobias Geisler
    Department of Cardiology, University Hospital Tuebingen, Otfried Mueller Strasse 10, Tuebingen, Germany
    Pharmacogenomics 9:1251-9. 2008
    ..To investigate an association of responsiveness to clopidogrel loading dose with genotypes of cytochrome P450 (CYP) 2C19, other CYP isozymes and nongenetic factors in patients with coronary artery disease...
  11. ncbi request reprint Platelets modulate atherogenesis and progression of atherosclerotic plaques via interaction with progenitor and dendritic cells
    M Gawaz
    Medizinische Klinik III, Klinik für Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    J Thromb Haemost 6:235-42. 2008
    ..This review describes recent findings on platelet interaction with progenitor cells or dendritic cells and discusses potential consequences of this interaction in atherosclerosis...
  12. ncbi request reprint Junctional adhesion molecule A expressed on human CD34+ cells promotes adhesion on vascular wall and differentiation into endothelial progenitor cells
    Konstantinos Stellos
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Otfried Muller Strasse 10, 72076 Tubingen, Germany
    Arterioscler Thromb Vasc Biol 30:1127-36. 2010
    ..To investigate the role of junctional adhesion molecule A (JAM-A) on adhesion and differentiation of human CD34(+) cells into endothelial progenitor cells...
  13. ncbi request reprint Capture of endothelial progenitor cells by a bispecific protein/monoclonal antibody molecule induces reendothelialization of vascular lesions
    Harald F Langer
    Medical Clini III, Department of Cardiovascular Medicine, Eberhard Karls University of Tubingen, Tubingen, Germany
    J Mol Med (Berl) 88:687-99. 2010
    ..In vivo, GPVI-CD133 augments reendothelialization of vascular lesions. Thus, this bifunctional protein could be a potential new therapeutic option for cardiovascular diseases...
  14. ncbi request reprint EMMPRIN (CD147) is a novel receptor for platelet GPVI and mediates platelet rolling via GPVI-EMMPRIN interaction
    Peter Seizer
    Medizinische Klinik III, Universitatsklinikum Tubingen, Tubingen, Germany
    Thromb Haemost 101:682-6. 2009
    ..Platelet GPVI is a novel receptor for EMMPRIN and can mediate platelet rolling via GPVI-EMMPRIN interaction...
  15. doi request reprint Skepinone-L, a novel potent and highly selective inhibitor of p38 MAP kinase, effectively impairs platelet activation and thrombus formation
    Oliver Borst
    Department of Physiology, University of Tubingen, Gmelinstrasse 5, Tubingen, Germany
    Cell Physiol Biochem 31:914-24. 2013
    ..The present study examined the impact of Skepinone-L, a novel and highly selective inhibitor of p38 mitogen-activated protein kinase (p38 MAPK), on platelet activation and thrombus formation...
  16. ncbi request reprint Impact of glycoprotein VI and platelet adhesion on atherosclerosis--a possible role of fibronectin
    Andreas Bültmann
    Corimmun GmbH, Martinsried, Germany
    J Mol Cell Cardiol 49:532-42. 2010
    ..This novel mechanism of GPVI-mediated platelet adhesion-possibly via fibronectin-could relevantly contribute to platelet-triggered atheroprogression...
  17. doi request reprint Platelet aggregates-induced human CD34+ progenitor cell proliferation and differentiation to macrophages and foam cells is mediated by stromal cell derived factor 1 in vitro
    Konstantinos Stellos
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Semin Thromb Hemost 36:139-45. 2010
    ....
  18. doi request reprint Thrombin-sensitive expression of the store operated Ca(2+) channel Orai1 in platelets
    Patrick Münzer
    Department of Physiology, University of Tubingen, Germany
    Biochem Biophys Res Commun 436:25-30. 2013
    ..In conclusion, activation of platelets stimulates the translational expression of Orai1, thus augmenting platelet Ca(2+) signaling...
  19. doi request reprint Local catheter-based delivery of antithrombotic or antiproliferative drugs: a new concept for prevention of restenosis
    Christian Herdeg
    Medizinische Klinik III, Eberhard Karls Universitaet Tuebingen, Germany
    Thromb Res 123:236-43. 2008
    ....
  20. doi request reprint Oxidized LDL-activated platelets induce vascular inflammation
    Karin Daub
    Medizinische Klinik, Klinik für Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Germany
    Semin Thromb Hemost 36:146-56. 2010
    ..Platelet oxLDL contributes significantly to vascular inflammation and is able to promote atherosclerosis...
  21. ncbi request reprint 1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca2+ signaling and thrombus formation in klotho-deficient mice
    Oliver Borst
    2Department of Physiology, University of Tubingen, Gmelinstr 5, 72076 Tubingen, Germany
    FASEB J 28:2108-19. 2014
    ..Leibrock, C., Szteyn, K., Schmidt, S., Elvers, M., Faggio, C., Shumilina, E., Kuro-o, M., Gawaz, M., Lang, F. 1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca(2+) signaling and thrombus formation in klotho-deficient mice. ..
  22. doi request reprint Dynamic adhesion of eryptotic erythrocytes to immobilized platelets via platelet phosphatidylserine receptors
    Britta Walker
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Am J Physiol Cell Physiol 306:C291-7. 2014
    ..Thus platelet-mediated erythrocyte adhesion may foster thromboocclusive complications in diseases with stimulated phosphatidylserine exposure of erythrocytes. ..
  23. doi request reprint Intracellular cyclophilin A is an important Ca(2+) regulator in platelets and critically involved in arterial thrombus formation
    Margitta Elvers
    Medizinische Klinik III, Department of Cardiology and Cardiovascular Diseases, Eberhard Karls University, Tubingen, Germany
    Blood 120:1317-26. 2012
    ..The results of the present study identified CyPA as an important Ca(2+) regulator in platelets, a critical mechanism for arterial thrombosis...
  24. ncbi request reprint Platelets recruit human dendritic cells via Mac-1/JAM-C interaction and modulate dendritic cell function in vitro
    Harald F Langer
    Innere Medizin, Abteilung III, Eberhard Karls Universitat Tubingen, Otfried Muller Str 10, 72076 Tubingen, Germany
    Arterioscler Thromb Vasc Biol 27:1463-70. 2007
    ..Thrombotic events and immunoinflammatory processes take place next to each other during vascular remodeling in atherosclerotic lesions. In this study we investigated the interaction of platelets with dendritic cells (DCs)...
  25. doi request reprint Catheter-based delivery of fluid paclitaxel for prevention of restenosis in native coronary artery lesions after stent implantation
    Christian Herdeg
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Germany
    Circ Cardiovasc Interv 2:294-301. 2009
    ..We assessed the safety and efficacy of catheter-based local delivery of fluid paclitaxel in patients with coronary de novo stenoses after implantation of a bare metal stent...
  26. pmc Gremlin-1 is an inhibitor of macrophage migration inhibitory factor and attenuates atherosclerotic plaque growth in ApoE-/- Mice
    Iris Muller
    From the Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat, 72076 Tubingen, Germany
    J Biol Chem 288:31635-45. 2013
    ..The present data disclose that Gremlin-1 is an endogenous antagonist of MIF and define a role for Gremlin-1/MIF interaction in atherosclerosis. ..
  27. doi request reprint The dimeric platelet collagen receptor GPVI-Fc reduces platelet adhesion to activated endothelium and preserves myocardial function after transient ischemia in mice
    Tanja Schonberger
    DVM, Medizinische Klinik III, Universitatsklinikum Tubingen, Tubingen, Germany
    Am J Physiol Cell Physiol 303:C757-66. 2012
    ..Taken together, administration of GPVI-Fc offers a novel strategy to control platelet-mediated inflammation and to preserve myocardial function following myocardial infarction...
  28. doi request reprint EMMPRIN and its ligand cyclophilin A as novel diagnostic markers in inflammatory cardiomyopathy
    Peter Seizer
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Universitatsklinikum Tubingen, Otfried Muller Strasse 10, Tubingen, Germany
    Int J Cardiol 163:299-304. 2013
    ..Therefore, a series of 102 human endomyocardial biopsies were analyzed for the expression of EMMPRIN and CyPA and correlated with histological and immunohistological findings...
  29. ncbi request reprint Influence of platelet count on the expression of platelet collagen receptor glycoprotein VI (GPVI) in patients with acute coronary syndrome
    Boris Bigalke
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Otfried Muller Str 10, 72076 Tubingen, Germany
    Thromb Haemost 101:911-5. 2009
    ....
  30. pmc Predictive value of platelet activation for the rate of cognitive decline in Alzheimer's disease patients
    Konstantinos Stellos
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Otfried Mueller Straße 10, Tubingen, Germany
    J Cereb Blood Flow Metab 30:1817-20. 2010
    ..These results suggest that platelet activation could be a putative prognostic biomarker for the rate of cognitive decline and a potential new treatment target in AD patients...
  31. ncbi request reprint Inhibition of foam cell formation using a soluble CD68-Fc fusion protein
    Karin Daub
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Otfried Muller Str 10, 72076 Tubingen, Germany
    J Mol Med (Berl) 88:909-20. 2010
    ..Thus, CD68-Fc might offer a novel therapeutic strategy for patients with acute coronary syndrome by modulating the generation of vulnerable plaques...
  32. doi request reprint Platelet collagen receptor glycoprotein VI as a possible novel indicator for the acute coronary syndrome
    Boris Bigalke
    Medizinische Klinik, Klinik für Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Am Heart J 156:193-200. 2008
    ....
  33. doi request reprint Impact of inflammatory markers on platelet inhibition and cardiovascular outcome including stent thrombosis in patients with symptomatic coronary artery disease
    Karin Muller
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat, Tubingen, Germany
    Atherosclerosis 213:256-62. 2010
    ..The aim of the present analysis was to evaluate the association of inflammatory markers and effects of dual antiplatelet therapy on platelet function and outcome in patients undergoing PCI...
  34. pmc Green fluorescent protein (GFP) color reporter gene visualizes parvovirus B19 non-structural segment 1 (NS1) transfected endothelial modification
    Thomas Wurster
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    PLoS ONE 7:e33602. 2012
    ..Whether PVB19 infects endothelial cells and causes a modification of endothelial function and inflammation and, thus, disturbance of microcirculation has not been elucidated and could not be visualized so far...
  35. ncbi request reprint Stimulation of platelet death by vancomycin
    Syeda T Towhid
    Department of Physiology, University of Tubingen, Germany
    Cell Physiol Biochem 31:102-12. 2013
    ..An effect of vancomycin on platelet apoptosis has, however, never been tested. The present study thus explored the effect of vancomycin on platelet activation and apoptosis...
  36. doi request reprint Sphingomyelinase-induced adhesion of eryptotic erythrocytes to endothelial cells
    Majed Abed
    Physiologisches Institut, Eberhard Karls Universitat Tubingen, Gmelinstr 5, D 72076 Tubingen, Germany
    Am J Physiol Cell Physiol 303:C991-9. 2012
    ..Thus exposure to sphingomyelinase or C6-ceramide triggers eryptosis followed by phosphatidylserine- and CXCL16-sensitive adhesion of eryptotic erythrocytes to HUVEC...
  37. doi request reprint SGK1 sensitivity of platelet migration
    Eva Maria Schmidt
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 30:259-68. 2012
    ..In conclusion, SGK1 is a powerful regulator of platelet migration...
  38. pmc Disrupting the EMMPRIN (CD147)-cyclophilin A interaction reduces infarct size and preserves systolic function after myocardial ischemia and reperfusion
    Peter Seizer
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Germany
    Arterioscler Thromb Vasc Biol 31:1377-86. 2011
    ..The aim of the study was to characterize the role of the CD147 and CyPA interplay in myocardial ischemia/reperfusion (I/R) injury...
  39. pmc Low responsiveness to clopidogrel increases risk among CKD patients undergoing coronary intervention
    Patrik Htun
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Universitätsklinikum der Eberhard Karls Universität Tübingen, Otfried Muller Strasse 10, 72076 Tubingen, Germany
    J Am Soc Nephrol 22:627-33. 2011
    ..In summary, a low response to clopidogrel might be an additional risk factor for the poorer outcomes in patients with stage 3 to 5 CKD compared with patients with better renal function...
  40. ncbi request reprint Platelet derived bFGF mediates vascular integrative mechanisms of mesenchymal stem cells in vitro
    Harald F Langer
    Medizinische Klinik III, Department of Cardiovascular Medicine, Eberhard Karls Universitat Tubingen, Germany
    J Mol Cell Cardiol 47:315-25. 2009
    ..We conclude that platelets may play a critical part in the recruitment of MSCs to the endothelium, influence MSC function and promote integration of MSCs into the endothelium...
  41. doi request reprint EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation
    Peter Seizer
    Medizinische Klinik III, Eberhard Karls University Tuebingen, Germany
    Atherosclerosis 209:51-7. 2010
    ..Thus, we investigated the role of EMMPRIN (CD147) and its ligand cyclophilin A (CyPA) during foam cell formation originating from both monocytes/macrophages and CD34(+) progenitor cells...
  42. pmc The GPVI-Fc fusion protein Revacept reduces thrombus formation and improves vascular dysfunction in atherosclerosis without any impact on bleeding times
    Martin Ungerer
    AdvanceCOR GmbH, Martinsried, Germany
    PLoS ONE 8:e71193. 2013
    ..Therefore, interference in GPVI-mediated platelet activation has the potential to combine short-term and long-term beneficial effects, specificity and safety especially regarding bleeding complications...
  43. doi request reprint Circulating platelet-progenitor cell coaggregate formation is increased in patients with acute coronary syndromes and augments recruitment of CD34+ cells in the ischaemic microcirculation
    Konstantinos Stellos
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Otfried Muller Str 10, 72076 Tubingen, Germany
    Eur Heart J 34:2548-56. 2013
    ....
  44. doi request reprint Impact of inflammatory state and metabolic control on responsiveness to dual antiplatelet therapy in type 2 diabetics after PCI: prognostic relevance of residual platelet aggregability in diabetics undergoing coronary interventions
    Tobias Geisler
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat, Tubingen, Germany
    Clin Res Cardiol 99:743-52. 2010
    ..We aimed to characterize the relationship of inflammation and residual platelet aggregability (RPA) under antiplatelet therapy with regard to prognosis in an unselected PCI-cohort of diabetics...
  45. doi request reprint Novel antiplatelet drug revacept (Dimeric Glycoprotein VI-Fc) specifically and efficiently inhibited collagen-induced platelet aggregation without affecting general hemostasis in humans
    Martin Ungerer
    Martinsried, Germany
    Circulation 123:1891-9. 2011
    ..A dose-escalating clinical phase I study was performed to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of Revacept in humans...
  46. doi request reprint The inflammatory chemokine CXC motif ligand 16 triggers platelet activation and adhesion via CXC motif receptor 6-dependent phosphatidylinositide 3-kinase/Akt signaling
    Oliver Borst
    Medizinische Klinik III, Department of Cardiology and Cardiovascular Medicine, University of Tubingen, Otfried Müller St 10, 72076 Tubingen, Germany
    Circ Res 111:1297-307. 2012
    ..The recently discovered chemokine CXC motif ligand 16 (CXCL16) is highly expressed in atherosclerotic lesions and is a potential pathogenic mediator in coronary artery disease...
  47. doi request reprint Statins do not adversely affect post-interventional residual platelet aggregation and outcomes in patients undergoing coronary stenting treated by dual antiplatelet therapy
    Tobias Geisler
    Medizinische Klinik III, University Hospital Tubingen, Otfried Müller Strasse 10 72076, Tubingen, Germany
    Eur Heart J 29:1635-43. 2008
    ....
  48. doi request reprint Cyclophilin A predicts clinical outcome in patients with congestive heart failure undergoing endomyocardial biopsy
    Christine S Zuern
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Universitatsklinikum Tubingen, Germany
    Eur J Heart Fail 15:176-84. 2013
    ..The aim of this study was to evaluate the prognostic relevance of CyPA expression in endomyocardial biopsies of consecutive patients with congestive heart failure...
  49. doi request reprint Severe autonomic failure in moderate to severe aortic stenosis: prevalence and association with hemodynamics and biomarkers
    Christine S Zuern
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Germany
    Clin Res Cardiol 101:565-72. 2012
    ..Here, we investigated SAF in patients with AS and tested its correlation with hemodynamic and biochemical markers...
  50. ncbi request reprint Platelets induce differentiation of human CD34+ progenitor cells into foam cells and endothelial cells
    Karin Daub
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    FASEB J 20:2559-61. 2006
    ..The understanding and modulation of these mechanisms may offer new treatment strategies for patients at high risk for atherosclerotic diseases...
  51. doi request reprint Ex vivoimaging of injured arteries in rabbits using fluorescence-labelled glycoprotein VI-Fc
    Boris Bigalke
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Germany
    Platelets 23:1-6. 2012
    ..021) and carotid (30.2 ± 7.6 vs. 7.9 ± 3.9; P = 0.005) arteries. This preclinical GPVI-Fc-based vascular lesion imaging approach may be the first step towards a method that allows identification of vascular lesions in vivo...
  52. ncbi request reprint Platelet-derived stromal cell-derived factor-1 regulates adhesion and promotes differentiation of human CD34+ cells to endothelial progenitor cells
    Konstantinos Stellos
    Medizinische Klinik III, Eberhard Karls Universitätsklinikum Tübingen, Tubingen, Germany
    Circulation 117:206-15. 2008
    ..The chemokine stromal cell-derived factor-1 (SDF-1) regulates homing of CD34+ stem cells. We evaluated the role of platelet-derived SDF-1 in adhesion and differentiation of human CD34+ cells into endothelial progenitor cells...
  53. ncbi request reprint High shear flow induces migration of adherent human platelets
    Bjoern F Kraemer
    Universitatsklinikum Tubingen, Medizinische Klinik III für Herz und Kreislauferkrankungen, Tubingen, Germany
    Platelets 22:415-21. 2011
    ..Their migratory potential may enable platelets to cover intimal lesions and contribute to vascular repair...
  54. doi request reprint CD36 and macrophage scavenger receptor a modulate foam cell formation via inhibition of lipid-laden platelet phagocytosis
    Peter Seizer
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Germany
    Semin Thromb Hemost 36:157-62. 2010
    ..We conclude that CD36 and SR-A play an important role in platelet-induced foam cell formation from CD34(+) progenitor cells and thus represent a promising target to inhibit platelet-induced foam cell formation...
  55. doi request reprint The immunoadhesin glycoprotein VI-Fc regulates arterial remodelling after mechanical injury in ApoE-/- mice
    Tanja Schonberger
    DVM, Medizinische Klinik III, Abt Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Otfried Muller Str 10, 72076 Tubingen, Germany
    Cardiovasc Res 80:131-7. 2008
    ..In this study, we examined binding of soluble platelet collagen receptor GPVI-Fc to atherosclerotic lesions and its effect on platelet-triggered athero-progression and neointima formation after wire-induced carotid injury...
  56. doi request reprint Increased circulating progenitor cells in Alzheimer's disease patients with moderate to severe dementia: evidence for vascular repair and tissue regeneration?
    Konstantinos Stellos
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    J Alzheimers Dis 19:591-600. 2010
    ..Our findings suggest a stage-dependent upregulation of circulating CD34+/CD133+ and CD34+ progenitor cells in AD patients, which could take part in tissue healing processes of the brain in AD...
  57. doi request reprint Stimulation of platelet apoptosis by balhimycin
    Syeda T Towhid
    Department of Physiology, Eberhard Karls University Tuebingen, Tuebingen, Germany
    Biochem Biophys Res Commun 435:323-6. 2013
    ..In conclusion, balhimycin triggers cell membrane scrambling of platelets, an effect dependent on Ca(2+), but not on activation of caspases...
  58. ncbi request reprint Cyclophilin A affects inflammation, virus elimination and myocardial fibrosis in coxsackievirus B3-induced myocarditis
    Peter Seizer
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Germany
    J Mol Cell Cardiol 53:6-14. 2012
    ..In conclusion, in CVB3-induced myocarditis CyPA is important for macrophage and T cell recruitment and effective virus defense and may represent a pharmacological target to modulate myocardial remodeling in myocarditis...
  59. doi request reprint Diagnostic and therapeutic potentials of platelet glycoprotein VI
    Boris Bigalke
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Germany
    Semin Thromb Hemost 36:203-11. 2010
    ..Besides the therapeutical implication, radiolabeled GPVI gives us a valuable diagnostic means that may be used clinically for plaque imaging in the near future...
  60. ncbi request reprint Platelet response to clopidogrel is attenuated in diabetic patients undergoing coronary stent implantation
    Tobias Geisler
    Medizinische Klinik III, Universitatsklinikum Tubingen, Otfried Mullerstrasse 10, 72076 Tubingen, Germany
    Diabetes Care 30:372-4. 2007
  61. doi request reprint The serum- and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes
    Oliver Borst
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Blood 119:251-61. 2012
    ..The present observations unravel SGK1 as novel regulator of platelet function, effective at least in part by NF-κB-dependent transcriptional up-regulation of Orai1 in megakaryocytes and increasing platelet SOCE...
  62. doi request reprint Plasma levels of stromal cell-derived factor-1 in patients with coronary artery disease: effect of clinical presentation and cardiovascular risk factors
    Konstantinos Stellos
    Department of Cardiology, Centre of Internal Medicine III, Johann Wolfgang Goethe University Frankfurt am Main, Frankfurt, Germany
    Atherosclerosis 219:913-6. 2011
    ..To investigate the possible association of plasma levels of stromal cell-derived factor-1 (SDF-1; CXCL12) with clinical presentation of symptomatic coronary artery disease (CAD) and with cardiovascular risk factors...
  63. ncbi request reprint Platelet-leukocyte interactions in inflammation and atherothrombosis
    Andreas E May
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Semin Thromb Hemost 33:123-7. 2007
    ..They trigger autocrine and paracrine activation processes, leading to leukocyte recruitment (in)to the vascular wall. This article highlights the molecular basis and the inflammatory pathways initiated by platelet-leukocyte interactions...
  64. doi request reprint Copeptin as a prognostic factor for major adverse cardiovascular events in patients with coronary artery disease
    Stephan von Haehling
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Int J Cardiol 162:27-32. 2012
    ..The aim is to investigate the prognostic value of copeptin with regard to mortality and morbidity in patients with symptomatic coronary artery disease (CAD)...
  65. pmc Value of serum pregnancy-associated plasma protein A for predicting cardiovascular events among patients presenting with cardiac chest pain
    Stephan von Haehling
    Division of Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    CMAJ 185:E295-303. 2013
    ..We assessed the value of PAPP-A for predicting short-term cardiovascular events in a large cohort of patients presenting with cardiac chest pain...
  66. doi request reprint The bispecific SDF1-GPVI fusion protein preserves myocardial function after transient ischemia in mice
    Melanie Ziegler
    Innere Medizin III, Eberhard Karls Universitat, Tubingen, Otfried Muller Strasse 10, Tubingen, Germany
    Circulation 125:685-96. 2012
    ..After myocardial infarction, SDF-1 expression is rapidly upregulated and promotes myocardial repair...
  67. doi request reprint Glycoprotein VI for diagnosis of acute coronary syndrome when ECG is ambiguous
    Boris Bigalke
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Germany
    Int J Cardiol 149:164-8. 2011
    ....
  68. doi request reprint Expression of junctional adhesion molecule-C on the surface of platelets supports adhesion, but not differentiation, of human CD34 cells in vitro
    Konstantinos Stellos
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Cell Physiol Biochem 29:153-62. 2012
    ....
  69. doi request reprint Regulation of platelet glycoprotein VI (GPVI) surface expression and of soluble GPVI in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS)
    Boris Bigalke
    Medizinische Klinik III, Klinik für Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Basic Res Cardiol 104:352-7. 2009
    ..This study examined patients with both ACS and stable coronary artery disease (CAD), which presented with atrial fibrillation (AF) and sinus rhythm (SR)...
  70. ncbi request reprint Decreased plasma and cerebrospinal fluid levels of stem cell factor in patients with early Alzheimer's disease
    Christoph Laske
    Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany
    J Alzheimers Dis 15:451-60. 2008
    ..Further studies are needed to examine whether a manipulation of HGFs such as SCF could be a promising new therapeutic strategy for AD...
  71. ncbi request reprint Expression of stromal-cell-derived factor-1 on circulating platelets is increased in patients with acute coronary syndrome and correlates with the number of CD34+ progenitor cells
    Konstantinos Stellos
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Eur Heart J 30:584-93. 2009
    ..However, there are no clinical data available regarding platelet-bound SDF-1 in patients with acute coronary syndrome (ACS). The objective of this study was to evaluate the platelet-surface expression of SDF-1 in patients with ACS...
  72. doi request reprint Imaging of injured and atherosclerotic arteries in mice using fluorescence-labeled glycoprotein VI-Fc
    Boris Bigalke
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Germany
    Eur J Radiol 79:e63-9. 2011
    ..To assess endothelial injury and repair using fluorescence-labeled glycoprotein VI (GPVI)-Fc in a murine model...
  73. doi request reprint Management of perioperative stent thrombosis in patients undergoing surgery
    Boris Bigalke
    Medizinische Klinik III, Klinik für Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Platelets 21:578-82. 2010
    ..Our patients benefited from this individualized practical approach...
  74. doi request reprint Ion channels in the regulation of platelet migration
    Eva Maria Schmidt
    Department of Physiology, University of Tubingen, Germany
    Biochem Biophys Res Commun 415:54-60. 2011
    ..In conclusion, platelet migration requires activity of the Ca(2+) channel Orai1 and of the Ca(2+) activated K(+) channel SK4, but not of NPPB-sensitive Cl(-) channels...
  75. ncbi request reprint Platelet and soluble glycoprotein VI - novel applications in diagnosis and therapy
    Boris Bigalke
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Germany
    Curr Drug Targets 12:1821-30. 2011
    ..This therapeutic aspect could serve as a promising strategy for antithrombotic and antiatherosclerotic therapy in future...
  76. doi request reprint Binding of oxidized low-density lipoprotein on circulating platelets is increased in patients with acute coronary syndromes and induces platelet adhesion to vascular wall in vivo--brief report
    Konstantinos Stellos
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Otfried Muller Str 10, 72076 Tubingen, Germany
    Arterioscler Thromb Vasc Biol 32:2017-20. 2012
    ..Furthermore, the role of oxLDL binding on platelet adhesion to collagen and endothelial cells in vitro as well as after carotid ligation in mice was investigated...
  77. doi request reprint Early but not late stent thrombosis is influenced by residual platelet aggregation in patients undergoing coronary interventions
    Tobias Geisler
    Medizinische Klinik III, Abteilung für Kardiologie und Kreislauferkrankungen, Universitätsklinikum der Eberhard Karls Universität Tübingen, Otfried Muller Strasse 10, Tubingen 72076, Germany
    Eur Heart J 31:59-66. 2010
    ..The aim of this observational study was to investigate the impact of RPA on the incidence of ST within 3 months in patients treated with dual antiplatelet therapy...
  78. pmc Adipocytokines and CD34 progenitor cells in Alzheimer's disease
    Boris Bigalke
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    PLoS ONE 6:e20286. 2011
    ..Adipocytokines and CD34(+) progenitor cells are associated with the progression and prognosis of atherosclerotic diseases. Their role in AD is not adequately elucidated...
  79. ncbi request reprint PI3 kinase-dependent stimulation of platelet migration by stromal cell-derived factor 1 (SDF-1)
    Bjoern F Kraemer
    Abteilung III, Kardiologie und Kreislauferkrankungen, Medizinische Klinik, Universitatsklinikum Tubingen, Otfried Muller Strasse 10, 72076, Tubingen, Germany
    J Mol Med (Berl) 88:1277-88. 2010
    ..The potential of platelets to migrate in an SDF-1-mediated fashion may redefine the role of platelets in the pathophysiology of vascular inflammation, subsequent atherosclerotic degeneration, and vascular regeneration...
  80. doi request reprint Risk stratification by adenosine stress cardiac magnetic resonance in patients with coronary artery stenoses of intermediate angiographic severity
    Christina Doesch
    Department of Cardiology, Eberhard Karls University, Tubingen, Germany
    JACC Cardiovasc Imaging 2:424-33. 2009
    ..The purpose of this study was to determine the role of adenosine stress cardiac magnetic resonance (CMR) for risk stratification in patients with coronary artery stenoses of intermediate angiographic severity...
  81. doi request reprint Effect of comedication with proton pump inhibitors (PPIs) on post-interventional residual platelet aggregation in patients undergoing coronary stenting treated by dual antiplatelet therapy
    Christine S Zuern
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, University of Tuebingen, Otfried Mueller Strasse 10, 72076 Tuebingen, Germany
    Thromb Res 125:e51-4. 2010
    ..The aim of this study was to assess the impact of PPI treatment on clopidogrel response by measuring the ex vivo platelet aggregation in patients with coronary intervention...
  82. ncbi request reprint The evil in atherosclerosis: adherent platelets induce foam cell formation
    Karin Daub
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Semin Thromb Hemost 33:173-8. 2007
    ..These findings emphasize that the balance between endothelial cell regeneration and platelet-mediated foam cell generation derived from CD34 (+) progenitor cells may play a critical role in atherogenesis and atheroprogression...
  83. doi request reprint Sandwich immunoassay for soluble glycoprotein VI in patients with symptomatic coronary artery disease
    Boris Bigalke
    Medizinische Klinik, Klinik für Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Germany
    Clin Chem 57:898-904. 2011
    ..There is no reliable method available to measure pGPVI. Our aim was to develop a bead-based sandwich immunoassay to measure soluble GPVI (sGPVI)...
  84. doi request reprint Platelet-vessel wall interactions in atherosclerotic disease
    Harald F Langer
    Medizinische Klinik III, Klinik für Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Thromb Haemost 99:480-6. 2008
    ..Understanding interactions of platelets with other circulating cells and the vascular wall is a prerequisite to understand cardiovascular disease and to identify potential therapeutic targets...
  85. doi request reprint Adenosine stress cardiac magnetic resonance imaging for the assessment of ischemic heart disease
    Christina Doesch
    Department of Cardiology, Eberhard Karls University, Tubingen, Otfried Muller Str 10, 72076, Tubingen, Germany
    Clin Res Cardiol 97:905-12. 2008
    ..This prospective study was designed to determine the diagnostic value of adenosine stress cardiac magnetic resonance imaging (CMRI) in patients referred to elective coronary angiography...
  86. ncbi request reprint Platelet-monocyte interactions--a dangerous liaison linking thrombosis, inflammation and atherosclerosis
    Peter Seizer
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Otfried Muller Strasse 10, Tubingen, Germany
    Curr Med Chem 15:1976-80. 2008
    ..These processes promote monocyte recruitment (in)to the vascular wall--a key mechanism in atherogenesis. This article highlights the molecular basis and the inflammatory pathways initiated by platelet-monocyte interactions...
  87. doi request reprint Platelet lipoprotein interplay: trigger of foam cell formation and driver of atherosclerosis
    Dorothea Siegel-Axel
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Universitatsklinikum Tubingen, Otfried Muller Str 10, D 72076 Tubingen, Germany
    Cardiovasc Res 78:8-17. 2008
    ..New data about platelet-mediated lipoprotein transport and consequent foam cell formation, however, provide proof of how platelets might contribute to atheromatous lesion formation...
  88. ncbi request reprint Amyloid-β peptides in plasma and cognitive decline after 1 year follow-up in Alzheimer's disease patients
    Christoph Laske
    Department of Psychiatry and Psychotherapy Eberhard Karls Universität Tübingen, Tubingen, Germany
    J Alzheimers Dis 21:1263-9. 2010
    ..These results suggest that Aβ₁₋₄₂ plasma levels are associated with the rate of cognitive decline in AD patients and may be influenced by atherosclerotic vasculopathies such as stroke and myocardial infarction...
  89. doi request reprint Interaction of platelets and inflammatory endothelium in the development and progression of coronary artery disease
    Harald F Langer
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Semin Thromb Hemost 36:131-8. 2010
    ..Taken together, platelets may participate in the initiation, development, and total extent of atherosclerotic lesions...
  90. ncbi request reprint High plasma levels of adipocytokines are associated with platelet activation in patients with coronary artery disease
    Boris Bigalke
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Platelets 21:11-9. 2010
    ..Intriguingly, high plasma levels of both adipocytokines seem to modulate platelet activation. Further studies should elucidate the adipocytokine regulation in CAD...
  91. doi request reprint Glycoprotein VI as a prognostic biomarker for cardiovascular death in patients with symptomatic coronary artery disease
    Boris Bigalke
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Germany
    Clin Res Cardiol 99:227-33. 2010
    ..Platelets play a critical role in arterial thrombosis, acute coronary syndrome (ACS) and stroke. Platelet collagen receptor glycoprotein VI (GPVI) is associated with acute coronary events and a poor clinical outcome...
  92. doi request reprint Platelet glycoprotein VI (GPVI) for early identification of acute coronary syndrome in patients with chest pain
    Boris Bigalke
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Germany
    Thromb Res 125:e184-9. 2010
    ..GPVI may be helpful to distinguish an imminent ACS from non-coronary (NC) causes in patients with chest pain who were transferred to chest pain unit, before the myocardial necrosis is evident with classical biomarkers...
  93. ncbi request reprint Platelet-induced differentiation of endothelial progenitor cells
    Harald F Langer
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Semin Thromb Hemost 33:136-43. 2007
    ..The described interaction of EPCs with platelets represents a novel mechanism of vascular remodeling and healing of endothelial lesions...
  94. ncbi request reprint Platelet interaction with progenitor cells: vascular regeneration or inquiry?
    Konstantinos Stellos
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Otfried Müller 10, Tubingen, Germany
    Pharmacol Rep 60:101-8. 2008
    ..Although further studies are needed to describe the mechanisms that lie underneath these observations, it seems that platelet interaction with progenitor cells is an essential step in both vascular regeneration and injury...
  95. ncbi request reprint Platelets: inflammatory firebugs of vascular walls
    Andreas E May
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    Arterioscler Thromb Vasc Biol 28:s5-10. 2008
    ..This review highlights the molecular key components and pathways used by platelets to trigger and accelerate inflammation at the vascular wall and, thereby, atherosclerosis...
  96. ncbi request reprint Platelet glycoprotein VI: a novel marker for acute coronary syndrome
    Boris Bigalke
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Semin Thromb Hemost 33:179-84. 2007
    ..We conclude that the determination of the platelet-specific thrombotic marker GPVI may help to identify patients at risk before myocardial ischemia is evident...
  97. ncbi request reprint Platelets and endothelial cells
    Dorothea I Siegel-Axel
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Semin Thromb Hemost 33:128-35. 2007
    ..Understanding the specific interactions between platelets and the endothelium may lead to the development of novel therapeutic strategies...
  98. ncbi request reprint Low response to clopidogrel is associated with cardiovascular outcome after coronary stent implantation
    Tobias Geisler
    Medizinische Klinik III, Universitatsklinikum Tubingen, Eberhard Karls Universitat Tubingen, Otfried Muller Str 10, D 72076 Tubingen, Germany
    Eur Heart J 27:2420-5. 2006
    ..To assess whether low response to clopidogrel influences cardiovascular outcome after coronary stent implantation in a consecutively measured cohort of patients with coronary stent implantation...
  99. ncbi request reprint Platelet interaction with progenitor cells: potential implications for regenerative medicine
    Konstantinos Stellos
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Thromb Haemost 98:922-9. 2007
    ....
  100. ncbi request reprint Residual platelet activity is increased in clopidogrel- and ASA-treated patients with coronary stenting for acute coronary syndromes compared with stable coronary artery disease
    T Geisler
    Medizinische Klinik III, Universitatsklinikum Tubingen, Eberhard Karls Universitat Tubingen, Germany
    Heart 94:743-7. 2008
    ..To evaluate residual platelet activity in a consecutive cohort of patients treated with dual antiplatelet therapy after coronary stent implantation..
  101. ncbi request reprint Local delivery of soluble platelet collagen receptor glycoprotein VI inhibits thrombus formation in vivo
    Andreas Bültmann
    Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Thromb Haemost 95:763-6. 2006
    ....