Thomas Gasser

Summary

Country: Germany

Publications

  1. ncbi request reprint The transcription factor PITX3 is associated with sporadic Parkinson's disease
    Julia Fuchs
    Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tubingen, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    Neurobiol Aging 30:731-8. 2009
  2. pmc Genetic basis of Parkinson's disease: inheritance, penetrance, and expression
    Claudia Schulte
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, and German Center for Neurodegenerative Diseases, Tubingen, Germany
    Appl Clin Genet 4:67-80. 2011
  3. pmc Genome-wide association study reveals genetic risk underlying Parkinson's disease
    Javier Simon-Sanchez
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 41:1308-12. 2009
  4. doi request reprint Genomic and proteomic biomarkers for Parkinson disease
    Thomas Gasser
    Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, Tubingen, Germany
    Neurology 72:S27-31. 2009
  5. doi request reprint Milestones in PD genetics
    Thomas Gasser
    Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, and German Center for Neurodegenerative Diseases, Tubingen, Germany
    Mov Disord 26:1042-8. 2011
  6. doi request reprint EFNS guidelines on the molecular diagnosis of ataxias and spastic paraplegias
    T Gasser
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Eur J Neurol 17:179-88. 2010
  7. doi request reprint Identifying PD-causing genes and genetic susceptibility factors: current approaches and future prospects
    Thomas Gasser
    Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, Tubingen, Germany
    Prog Brain Res 183:3-20. 2010
  8. doi request reprint "Jerky" dystonia in children: spectrum of phenotypes and genetic testing
    Friedrich Asmus
    Department of Neurodegenerative Disease, Hertie Institute for Clinical Brain Research, Center of Neurology, University of Tuebingen, Tuebingen, Germany
    Mov Disord 24:702-9. 2009
  9. ncbi request reprint Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology
    Alexander Zimprich
    Department of Neurodegenerative Disease, Hertie Institute for Clinical Brain Research, University of Tubingen, 72076 Tubingen, Germany
    Neuron 44:601-7. 2004
  10. pmc SNCA variants are associated with increased risk for multiple system atrophy
    Sonja W Scholz
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA
    Ann Neurol 65:610-4. 2009

Collaborators

Detail Information

Publications76

  1. ncbi request reprint The transcription factor PITX3 is associated with sporadic Parkinson's disease
    Julia Fuchs
    Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tubingen, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    Neurobiol Aging 30:731-8. 2009
    ..004) with PD. The C-allele appears to be a recessive risk allele with an estimated population frequency of 83%. An allele-dependent dysregulation of PITX3 expression might contribute to the susceptibility to PD...
  2. pmc Genetic basis of Parkinson's disease: inheritance, penetrance, and expression
    Claudia Schulte
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, and German Center for Neurodegenerative Diseases, Tubingen, Germany
    Appl Clin Genet 4:67-80. 2011
    ..The identification of genes involved in the development of Parkinson's disease will improve our understanding of the underlying molecular mechanisms, and will hopefully lead to new drug targets and treatment strategies...
  3. pmc Genome-wide association study reveals genetic risk underlying Parkinson's disease
    Javier Simon-Sanchez
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 41:1308-12. 2009
    ..14, P = 1.55 x 10(-5)). These data demonstrate an unequivocal role for common genetic variants in the etiology of typical PD and suggest population-specific genetic heterogeneity in this disease...
  4. doi request reprint Genomic and proteomic biomarkers for Parkinson disease
    Thomas Gasser
    Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, Tubingen, Germany
    Neurology 72:S27-31. 2009
    ..However, because of the complex relationship of genotypes and phenotypes in neurodegenerative disorders, the development of useful biomarkers is still in an early phase...
  5. doi request reprint Milestones in PD genetics
    Thomas Gasser
    Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, and German Center for Neurodegenerative Diseases, Tubingen, Germany
    Mov Disord 26:1042-8. 2011
    ..These findings may provide the "genetic entry points" to identify molecular targets and readouts necessary to design rational disease-modifying treatments...
  6. doi request reprint EFNS guidelines on the molecular diagnosis of ataxias and spastic paraplegias
    T Gasser
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Eur J Neurol 17:179-88. 2010
    ..These EFNS guidelines on the molecular diagnosis of neurogenetic disorders are designed to provide practical help for the general neurologist to make appropriate use of molecular genetics in diagnosing neurogenetic disorders...
  7. doi request reprint Identifying PD-causing genes and genetic susceptibility factors: current approaches and future prospects
    Thomas Gasser
    Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, Tubingen, Germany
    Prog Brain Res 183:3-20. 2010
    ..These findings provide the 'genetic entry points' to identify molecular targets and readouts necessary to design rational disease-modifying treatments...
  8. doi request reprint "Jerky" dystonia in children: spectrum of phenotypes and genetic testing
    Friedrich Asmus
    Department of Neurodegenerative Disease, Hertie Institute for Clinical Brain Research, Center of Neurology, University of Tuebingen, Tuebingen, Germany
    Mov Disord 24:702-9. 2009
    ..A causative gene for D-PMM remains to be identified...
  9. ncbi request reprint Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology
    Alexander Zimprich
    Department of Neurodegenerative Disease, Hertie Institute for Clinical Brain Research, University of Tubingen, 72076 Tubingen, Germany
    Neuron 44:601-7. 2004
    ..Hence, LRRK2 may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism...
  10. pmc SNCA variants are associated with increased risk for multiple system atrophy
    Sonja W Scholz
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA
    Ann Neurol 65:610-4. 2009
    ..SNPs at the SNCA locus were significantly associated with risk for increased risk for the development of MSA (combined p = 5.5 x 10(-12); odds ratio 6.2) [corrected]...
  11. doi request reprint Genetic factors influencing age at onset in LRRK2-linked Parkinson disease
    Yulia Golub
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Germany
    Parkinsonism Relat Disord 15:539-41. 2009
    ....
  12. doi request reprint Clinical and brain imaging characteristics in leucine-rich repeat kinase 2-associated PD and asymptomatic mutation carriers
    Kathrin Brockmann
    Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Mov Disord 26:2335-42. 2011
    ..Substantia nigra hyperechogenicity in yet unaffected LRRK2 mutation carriers indicates morphologic alterations in an asymptomatic stage of disease...
  13. doi request reprint A single-nucleotide polymorphism of the osteopontin gene may contribute to a susceptibility to Lewy body disease
    Walter Maetzler
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tubingen, Germany
    J Neural Transm 116:599-605. 2009
    ..61, 95% CI 0.66-3.91, P = 0.29). Genotype prevalence and OPN levels were not significantly related. These findings suggest that OPN is associated with the occurrence of Lewy body disease and SNP-66 may be a susceptibility factor...
  14. pmc Identification of novel Angiogenin (ANG) gene missense variants in German patients with amyotrophic lateral sclerosis
    Rubén Fernández-Santiago
    Department for Neurodegenerative Disorders, Hertie Institute for Clinical Brain Research, Eberhard Karls University, Tuebingen, Germany
    J Neurol 256:1337-42. 2009
    ....
  15. doi request reprint GBA-associated PD. Neurodegeneration, altered membrane metabolism, and lack of energy failure
    Kathrin Brockmann
    Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Neurology 79:213-20. 2012
    ....
  16. ncbi request reprint Genomic deletion size at the epsilon-sarcoglycan locus determines the clinical phenotype
    Friedrich Asmus
    Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Center of Neurology, University of Tuebingen, Tuebingen, Germany
    Brain 130:2736-45. 2007
    ....
  17. doi request reprint SNCA: major genetic modifier of age at onset of Parkinson's disease
    Kathrin Brockmann
    Department of Neurodegenerative Diseases, University of Tubingen, Tubingen, Germany
    Mov Disord 28:1217-21. 2013
    ..2013 Movement Disorder Society. ..
  18. doi request reprint Further delineation of the association signal on chromosome 5 from the first whole genome association study in Parkinson's disease
    Manu Sharma
    Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen, Hoppe Seyler Strasse 3, 72076 Tuebingen, Germany
    Neurobiol Aging 30:1706-9. 2009
    ..In conclusion, our study did not lend support to the finding that the reported SNPs are directly influencing the susceptibility to sporadic form of PD at least in our population...
  19. doi request reprint Clinical and molecular characterisation of a Parkinson family with a novel PINK1 mutation
    Jügen Prestel
    Hertie Institute for Clinical Brain Research, Dept for Neurodegenerative Diseases, University of Tuebingen, Hoppe Seyler Str 3, 72076 Tuebingen, Germany
    J Neurol 255:643-8. 2008
    ..MR spectroscopy revealed raised myoinositol levels in the basal ganglia of both patients, reflecting possible astroglial proliferation...
  20. doi request reprint Rivastigmine for the treatment of dementia in patients with progressive supranuclear palsy: Clinical observations as a basis for power calculations and safety analysis
    Iuga Liepelt
    Center of Neurology, Department of Neurodegeneration, and Hertie Institute of Clinical Brain Research, University of Tubingen, Germany
    Alzheimers Dement 6:70-4. 2010
    ..In subtests, meaningful results can be obtained with even lower numbers (five patients for a verbal fluency test, and 14 patients for a logical memory task)...
  21. ncbi request reprint Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain
    Julia Fuchs
    University of Tubingen, Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    FASEB J 22:1327-34. 2008
    ..In conclusion, we provide evidence that alpha-synuclein levels are influenced by genetic variability in the promoter and 3' region of the SNCA gene in vivo...
  22. pmc A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants
    Manu Sharma
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research and DZNE German Center for Neurodegenerative Diseases, Tubingen, Hoppe Seyler Str 3, Tubingen 72076, Germany
    J Med Genet 49:721-6. 2012
    ..Asp620Asn) in the vacuolar protein sorting 35 gene as a cause for an autosomal dominant form of Parkinson disease . Although additional missense variants were described, their pathogenic role yet remains inconclusive...
  23. doi request reprint Deep-brain-stimulation does not impair deglutition in Parkinson's disease
    Sabrina Lengerer
    Department for Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Straße 3, 72076 Tubingen, Germany
    Parkinsonism Relat Disord 18:847-53. 2012
    ..e., aspirational pneumonia. So far, little is known on how deep-brain-stimulation of the subthalamic nucleus influences deglutition in PD...
  24. pmc Large-scale replication and heterogeneity in Parkinson disease genetic loci
    Manu Sharma
    Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Neurology 79:659-67. 2012
    ..The extent to which these genetic effects are consistent across different populations is unknown...
  25. doi request reprint A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease
    Rejko Kruger
    Laboratory of Functional Neurogenomics, Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Germany
    Neurobiol Aging 32:548.e9-18. 2011
    ..This largest association study performed to define the role of any gene in the pathogenesis of Parkinson's disease revealed no overall strong association of Omi/HtrA2 variants with PD in populations worldwide...
  26. doi request reprint Neprilysin activity in cerebrospinal fluid is associated with dementia and amyloid-β42 levels in Lewy body disease
    Walter Maetzler
    Center of Neurology, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
    J Alzheimers Dis 22:933-8. 2010
    ..Serum NEP activity levels were not significantly different between the groups. We conclude that, in Lewy body disease, CSF NEP activity levels are associated with dementia, probably via the Aβ pathway...
  27. ncbi request reprint Clinical differentiation of genetically proven benign hereditary chorea and myoclonus-dystonia
    Friedrich Asmus
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, Center of Neurology, University of Tuebingen, Tuebingen, Germany
    Mov Disord 22:2104-9. 2007
    ..TITF-1 mutations should be considered in choreiform movement disorders with onset in infancy even in the presence of dystonia and myoclonic jerks...
  28. pmc Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease
    Margaux F Keller
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 21:4996-5009. 2012
    ..Our results suggest that although GWASs are a useful tool in identifying the most common variants associated with complex disease, a great deal of common variants of small effect remain to be discovered...
  29. ncbi request reprint Influence of lithium treatment on GDNF serum and CSF concentrations in patients with early Alzheimer's disease
    Guido Straten
    Depatment of Anesthesiology and Intensive Care, University of Tubingen, Germany
    Curr Alzheimer Res 8:853-9. 2011
    ..3 ± 37.4 pg/ml versus 72.8 ± 43.9 pg/ml, p = 0.511). The findings of the present investigation indicated that beneficial effects of the lithium treatment might reduce the necessity of enhanced GDNF expression in the CNS in early AD...
  30. ncbi request reprint Role of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease
    Manu Sharma
    Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Tuebingen, Germany
    Neurobiol Aging 32:2108.e1-5. 2011
    ..However, taking the initial mapping of the PARK3 into account, the role of a population-specific effect warrants consideration in future studies...
  31. ncbi request reprint Transcranial ultrasound in different monogenetic subtypes of Parkinson's disease
    Katherine J Schweitzer
    Hertie Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler Str 3, 72076, Tuebingen, Germany
    J Neurol 254:613-6. 2007
    ..As SN hyperechogenicity could be related to an increased iron content of the SN, these findings suggest that iron may play a less significant role in the pathogenesis of monogenetically caused compared to idiopathic PD...
  32. doi request reprint Autoantibodies against amyloid and glial-derived antigens are increased in serum and cerebrospinal fluid of Lewy body-associated dementias
    Walter Maetzler
    Center of Neurology, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
    J Alzheimers Dis 26:171-9. 2011
    ..The potential of neural-derived IgG autoantibodies as part of a biomarker panel for the diagnosis of Lewy body-associated dementias should be further evaluated...
  33. doi request reprint No evidence of association of FLJ10986 and ITPR2 with ALS in a large German cohort
    Rubén Fernández-Santiago
    Department for Neurodegenerative Disorders, Hertie Institute for Clinical Brain Research, Eberhard Karls University, Otfried Muller Strasse 27, 72076, Tuebingen, Germany
    Neurobiol Aging 32:551.e1-4. 2011
    ..Our results did not provide evidence for the association of these SNPs with SALS, suggesting a possible population-specific effect for FLJ10986 and ITPR2 that do not modulate the risk for SALS in the German population...
  34. doi request reprint The specificity and sensitivity of transcranial ultrasound in the differential diagnosis of Parkinson's disease: a prospective blinded study
    Alexandra Gaenslen
    Center of Neurology, Department of Neurodegeneration and Hertie Institute of Clinical Brain Research, University of Tubingen, Germany
    Lancet Neurol 7:417-24. 2008
    ..We aimed to determine the diagnostic value of TCS in the early stages of parkinsonian syndromes, when the clinical symptoms often do not enable a definite diagnosis to be made...
  35. doi request reprint Update on the genetics of Parkinson's disease
    Thomas Gasser
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Mov Disord 22:S343-50. 2007
    ..Further, it is likely that the cellular pathways identified in rare monogenic variants of the disease also shed light on the molecular pathogenesis in typical sporadic PD...
  36. pmc Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway
    Iria Carballo-Carbajal
    Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Germany
    Cell Signal 22:821-7. 2010
    ..This pathway linking the two dominant PD genes LRRK2 and SNCA may offer an interesting target for drug therapy in both familial and sporadic disease...
  37. doi request reprint Enlarged hyperechogenic substantia nigra is related to motor performance and olfaction in the elderly
    Daniela Berg
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
    Mov Disord 25:1464-9. 2010
    ..Whether the association of SN+ with both impaired motor performance and hyposmia as seen in this study predicts an increased risk for the development of PD needs to be evaluated in the follow-up investigations...
  38. ncbi request reprint [11C]PIB binding in Parkinson's disease dementia
    Walter Maetzler
    Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany
    Neuroimage 39:1027-33. 2008
    ..Furthermore, we provide evidence that--in addition to nonspecific binding--PIB uptake in the brainstem may also reflect PDD related amyloid...
  39. doi request reprint Reduced but not oxidized cerebrospinal fluid glutathione levels are lowered in Lewy body diseases
    Walter Maetzler
    Department of Neurodegeneration, Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
    Mov Disord 26:176-81. 2011
    ..We hypothesize that alterations of the glutathione system occur in a very early stage of the disease or may even represent a risk marker for LBD...
  40. doi request reprint Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair
    Oliver Rothfuss
    Department for Neurodegenerative Diseases, Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Germany
    Hum Mol Genet 18:3832-50. 2009
    ..Our data indicate a novel role for parkin in directly supporting mitochondrial function and protecting mitochondrial genomic integrity from oxidative stress...
  41. ncbi request reprint Use of support vector machines for disease risk prediction in genome-wide association studies: concerns and opportunities
    Florian Mittag
    Center for Bioinformatics Tuebingen ZBIT, University of Tuebingen, Tubingen, Germany
    Hum Mutat 33:1708-18. 2012
    ..The used software is available at http://www.ra.cs.uni-tuebingen.de/software/MACLEAPS/...
  42. ncbi request reprint New aspects of genetic contributions to Parkinson's disease
    Anne Hofer
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen, 72076 Tuebingen, Germany
    J Mol Neurosci 24:417-24. 2004
    ..There is also accumulating evidence that genetic factors play a role in the common sporadic form of PD, however their precise nature remains unknown...
  43. doi request reprint DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders
    Philipp J Kahle
    Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, 72076 Tubingen, Germany
    Free Radic Biol Med 47:1354-61. 2009
    ..Augmenting DJ-1 activity might provide novel approaches to treating chronic neurodegenerative illnesses such as Parkinson's disease and acute damage such as stroke...
  44. ncbi request reprint Osteopontin is elevated in Parkinson's disease and its absence leads to reduced neurodegeneration in the MPTP model
    Walter Maetzler
    Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen, Otfried Mueller Strasse 27, 72076 Tuebingen, Germany
    Neurobiol Dis 25:473-82. 2007
    ..Loss of tyrosine-hydroxylase-positive cells in the SN and of dopaminergic fibers in the striatum was reduced 3 weeks after MPTP intoxication in OPN-null mice. These data suggest that OPN is involved in PD-associated neurodegeneration...
  45. doi request reprint Mendelian forms of Parkinson's disease
    Thomas Gasser
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Biochim Biophys Acta 1792:587-96. 2009
    ..Further, it is likely that the cellular pathways identified in rare monogenic variants of the disease also shed light on the molecular pathogenesis in typical sporadic PD...
  46. pmc A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies
    Michael A Nalls
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA
    JAMA Neurol 70:727-35. 2013
    ..While mutations in glucocerebrosidase (GBA1) are associated with an increased risk for Parkinson disease (PD), it is important to establish whether such mutations are also a common risk factor for other Lewy body disorders...
  47. ncbi request reprint PARK11 is not linked with Parkinson's disease in European families
    Jürgen Prestel
    Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen, Hoppe Seyler Str 3, 72076 Tuebingen, Germany
    Eur J Hum Genet 13:193-7. 2005
    ..Therefore, PARK11 does not seem to play a major role for familial PD in the European population...
  48. doi request reprint Genes associated with Parkinson syndrome
    Saskia Biskup
    Dept of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    J Neurol 255:8-17. 2008
    ..Here we add recent findings to a greatly challenging puzzle...
  49. doi request reprint Increased serum insulin-like growth factor 1 in early idiopathic Parkinson's disease
    Jana Godau
    Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    J Neurol Neurosurg Psychiatry 81:536-8. 2010
    ..The aim of this study was to measure serum IGF-1 in patients with PD and assess its correlation with the clinical presentation...
  50. ncbi request reprint Predictive value of transcranial sonography in the diagnosis of Parkinson's disease
    Jürgen Prestel
    Hertie Institute for Clinical Brain Research, Tubingen, Germany
    Mov Disord 21:1763-5. 2006
    ..7% and a negative predictive value of 82.9% in the diagnosis of PD solely by interpreting the results of TCS, indicating that TCS is a valuable additional tool in the diagnosis of PD...
  51. pmc Genetic comorbidities in Parkinson's disease
    Mike A Nalls
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Hum Mol Genet 23:831-41. 2014
    ..We show a strong genetically defined level of comorbidity between PD and Crohn's disease as well as between PD and schizophrenia, with likely functional consequences of associated variants occurring in brain. ..
  52. doi request reprint Kick and rush: paradoxical kinesia in Parkinson disease
    Friedrich Asmus
    Dystonia Genetics Unit, Hertie Institute for Clinical Brain Research, Center of Neurology, University of Tuebingen, Otfried Müller Str 27, 4th Floor, D 72076 Tuebingen, Germany
    Neurology 71:695. 2008
  53. doi request reprint Increase of BDNF serum concentration in lithium treated patients with early Alzheimer's disease
    Thomas Leyhe
    Department of Psychiatry and Psychotherapy, University of Tubingen, Tubingen, Germany
    J Alzheimers Dis 16:649-56. 2009
    ..The results of the present investigation encourage performing studies with longer treatment phases to observe potential positive long-term effects of lithium in AD patients...
  54. ncbi request reprint Genetics of Parkinson's disease
    Thomas Gasser
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Curr Opin Neurol 18:363-9. 2005
    ....
  55. doi request reprint Enlarged substantia nigra hyperechogenicity and risk for Parkinson disease: a 37-month 3-center study of 1847 older persons
    Daniela Berg
    Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center of Neurodegenerative Diseases, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Arch Neurol 68:932-7. 2011
    ..To evaluate whether enlarged substantia nigra hyperechogenicity (SN+) is associated with an increased risk for Parkinson disease (PD) in a healthy elderly population...
  56. ncbi request reprint State of the art review: molecular diagnosis of inherited movement disorders. Movement Disorders Society task force on molecular diagnosis
    Thomas Gasser
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Mov Disord 18:3-18. 2003
    ..Huntington's disease, Parkinson's disease and parkinsonian syndromes, ataxias, Wilson disease, essential tremor, dystonias, and other genetic diseases associated with a variety of movement disorders are considered separately...
  57. ncbi request reprint Sonographic abnormalities of brainstem structures in restless legs syndrome
    Jana Godau
    Hertie Institute for Clinical Brain Research and Center of Neurology, Department of Neurodegeneration, Hoppe Seyler Str 3, University of Tuebingen, 72076 Tuebingen, Germany
    Sleep Med 9:782-9. 2008
    ..The aim of this study was to validate SN hypoechogenicity as a morphological marker for RLS in a large patient cohort and to investigate further RLS-associated brain abnormalities using TCS...
  58. doi request reprint No differences of butyrylcholinesterase protein activity and allele frequency in Lewy body diseases
    Walter Maetzler
    Center of Neurology, Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tuebingen, Otfried Muller Strasse 27, Tuebingen D 72076, Germany
    Neurobiol Dis 35:296-301. 2009
    ..These data confirm and extend previous results on the relationship between BChE gene and BuChE activity, and argue rather against a major impact of BuChE on LBD-associated pathologies...
  59. doi request reprint The CST3 BB genotype and low cystatin C cerebrospinal fluid levels are associated with dementia in Lewy body disease
    Walter Maetzler
    Department of Neurodegeneration, University of Tuebingen, Germany
    J Alzheimers Dis 19:937-42. 2010
    ..We conclude that, in Lewy body disease, the CST3 BB genotype and low CSF CysC levels are associated with dementia, possibly through a disturbed elimination of soluble Abeta(42)...
  60. doi request reprint Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease
    Anne S Soehn
    Department of Medical Genetics, University of Tuebingen, Tuebingen, Germany
    Neurogenetics 11:203-15. 2010
    ..Searching for mutations in the periphilin gene, we detected a K69E substitution in two patients of a PD family. Taken together, these findings support for the first time an involvement of periphilin in PD...
  61. ncbi request reprint Alpha-synuclein and Parkinson's disease: implications from the screening of more than 1,900 patients
    Daniela Berg
    Institute for Medical Genetics, University of Tubingen, Germany
    Mov Disord 20:1191-4. 2005
    ..A53T mutation. These results demonstrate that mutations in the alpha-synuclein gene are rare and suggest that other factors contribute to alpha-synuclein aggregation in the majority of PD patients...
  62. ncbi request reprint New family with paroxysmal exercise-induced dystonia and epilepsy
    Christoph Kamm
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Mov Disord 22:873-7. 2007
    ....
  63. pmc Integrative pathway-based approach for genome-wide association studies: identification of new pathways for rheumatoid arthritis and type 1 diabetes
    Finja Büchel
    Center for Bioinformatics Tuebingen ZBIT, University of Tuebingen, Tubingen, Germany
    PLoS ONE 8:e78577. 2013
    ..These results provide new leads to understand the molecular underpinnings of these diseases. The developed software herein used is available at http://www.cogsys.cs.uni-tuebingen.de/software/GWASPathwayIdentifier/index.htm...
  64. doi request reprint Changing the research criteria for the diagnosis of Parkinson's disease: obstacles and opportunities
    Daniela Berg
    Department of Neurodegeneration, Hertie Institute of Clinical Brain Research, University of Tubingen, 72070 Tübingen, Germany
    Lancet Neurol 12:514-24. 2013
    ..Specific advances in each tier, bridged by neuroimaging and biochemical data, will eventually lead to a redefinition of Parkinson's disease...
  65. ncbi request reprint Treatment of dementia in parkinsonian syndromes with cholinesterase inhibitors
    Inga Liepelt
    Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Dement Geriatr Cogn Disord 23:351-67. 2007
    ..The effect of treatment with cholinesterase inhibitors in progressive supranuclear palsy and corticobasal degeneration warrants carefully designed studies including a sufficient number of patients and symptom-adopted dementia scales...
  66. doi request reprint Reverse sensory geste in cervical dystonia
    Friedrich Asmus
    Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, Tuebingen, Germany
    Mov Disord 24:297-300. 2009
    ..Assessment of rSG should be included in the routine examination of CD patients, since BTX treatment may have to beadjusted accordingly to be efficacious...
  67. doi request reprint Involuntary eyelid closure after STN-DBS: evidence for different pathophysiological entities
    Daniel Weiss
    Center of Neurology, Hertie Institute for Clinical Brain Research, and German Center for Neurodegenerative Diseases DZNE, University of Tubingen, Tubingen, Germany
    J Neurol Neurosurg Psychiatry 81:1002-7. 2010
    ..To gain insight into the hitherto undefined pathophysiology of IEC after STN-DBS, we performed a comprehensive clinical and electrophysiological characterisation of lid function in a total of six PD patients...
  68. doi request reprint Nutrition and the risk for Parkinson's disease: review of the literature
    Alexandra Gaenslen
    Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tubingen, Tubingen, Germany
    J Neural Transm 115:703-13. 2008
    ..However, dietary factors are difficult to assess. This review gives an overview on epidemiological studies addressing a possible relation of dietary compounds and the risk for PD...
  69. ncbi request reprint Myoclonus-dystonia due to genomic deletions in the epsilon-sarcoglycan gene
    Friedrich Asmus
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, Tubingen, Germany
    Ann Neurol 58:792-7. 2005
    ..SGCE exon dosage assays may identify additional families with SGCE mutation and thus reduce "genetic heterogeneity."..
  70. ncbi request reprint Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment
    Christian L Klein
    Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Germany
    J Neurochem 111:703-15. 2009
    ..Importantly, our finding of ROCO(LRRK2) fragment-mediated LRRK2 kinase inhibition offers a novel lead for drug design and thus might have important implications for new therapeutic avenues in PD...
  71. doi request reprint Ultrasound-guided injection of the iliopsoas muscle with botulinum toxin in camptocormia
    Rainer von Coelln
    Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
    Mov Disord 23:889-92. 2008
    ..In conclusion, injection of BTX into the iliopsoas does not appear to be a promising approach for the treatment of parkinsonism-associated camptocormia...
  72. ncbi request reprint Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration
    Daniela Rosenkranz
    Department of Cellular Neurology, Tubingen, Germany
    J Neuroimmunol 188:117-27. 2007
    ..The analysis of Treg from AD and PD patients as well as non-affected individuals, revealed that the frequency of Treg (CD4(+)Foxp3(+)) increases with age and is accompanied by intensified suppressive activity for Treg in patients...
  73. ncbi request reprint Molecular pathogenesis of Parkinson disease: insights from genetic studies
    Thomas Gasser
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Expert Rev Mol Med 11:e22. 2009
    ..These findings will allow the search for new treatment strategies that focus on the underlying molecular pathophysiology, rather than simply on ameliorating symptoms...
  74. ncbi request reprint Radicular and nonradicular back pain in Parkinson's disease: a controlled study
    Doris Broetz
    Center for Therapy, Hertie Institute for Clinical Brain Research, School of Medicine, University of Tubingen, Tubingen, Germany
    Mov Disord 22:853-6. 2007
    ..This suggests that back pain in PD patients is often neglected and insufficiently treated. Our results argue for the routine evaluation of back pain in every patient suffering from PD...
  75. pmc The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval
    Alexander Zimprich
    Hertie Institute for Clinical Brain Research, Department for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany
    Am J Hum Genet 74:11-9. 2004
    ..7 Mb). Our data provide evidence that the PARK8 locus is responsible for the disease in a subset of families of white ancestry with autosomal dominant parkinsonism, suggesting that it could be a more common locus...
  76. doi request reprint Genetic testing in neurological diseases
    Saskia Biskup
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, DZNE German Center for Neurodegenerative Diseases, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    J Neurol 259:1249-54. 2012
    ....