P Garcia

Summary

Country: Germany

Publications

  1. doi Low dose erythropoietin stimulates bone healing in mice
    P Garcia
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    J Orthop Res 29:165-72. 2011
  2. doi Temporal and spatial vascularization patterns of unions and nonunions: role of vascular endothelial growth factor and bone morphogenetic proteins
    P Garcia
    Department of Trauma, Hand and Reconstructive Surgery, Collaborative Research Center, AO Foundation, University of Saarland, D 66421 Homburg Saar, Germany
    J Bone Joint Surg Am 94:49-58. 2012
  3. ncbi Increased exercise after stable closed fracture fixation does not affect fracture healing in mice
    J H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    J Biomech 45:1299-304. 2012
  4. doi Erythropoietin stimulates bone formation, cell proliferation, and angiogenesis in a femoral segmental defect model in mice
    J H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrberger Strasse 1, 66421 Homburg Saar, Germany
    Bone 49:1037-45. 2011
  5. pmc Inhibition of angiotensin-converting enzyme stimulates fracture healing and periosteal callus formation - role of a local renin-angiotensin system
    P Garcia
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Br J Pharmacol 159:1672-80. 2010
  6. doi A new technique for internal fixation of femoral fractures in mice: impact of stability on fracture healing
    P Garcia
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrbergerstr 1, D 66421 Homburg, Saar, Germany
    J Biomech 41:1689-96. 2008
  7. doi Intravital microscopic studies of angiogenesis during bone defect healing in mice calvaria
    J H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Injury 42:765-71. 2011
  8. doi Deficiencies of folate and vitamin B12 do not affect fracture healing in mice
    J H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Bone 47:151-5. 2010
  9. doi Advances in the establishment of defined mouse models for the study of fracture healing and bone regeneration
    J H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    J Orthop Trauma 23:S31-8. 2009
  10. ncbi In vivo gait analysis in a mouse femur fracture model
    T Histing
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    J Biomech 43:3240-3. 2010

Detail Information

Publications18

  1. doi Low dose erythropoietin stimulates bone healing in mice
    P Garcia
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    J Orthop Res 29:165-72. 2011
    ..The herein shown acceleration of healing by EPO may represent a promising novel treatment strategy for fractures with delayed healing and non-union formation...
  2. doi Temporal and spatial vascularization patterns of unions and nonunions: role of vascular endothelial growth factor and bone morphogenetic proteins
    P Garcia
    Department of Trauma, Hand and Reconstructive Surgery, Collaborative Research Center, AO Foundation, University of Saarland, D 66421 Homburg Saar, Germany
    J Bone Joint Surg Am 94:49-58. 2012
    ..Because established nonunions are well vascularized, we hypothesized that lack of vascular endothelial growth factor (VEGF) expression and vascularization during the early time course of fracture-healing determine nonunion formation...
  3. ncbi Increased exercise after stable closed fracture fixation does not affect fracture healing in mice
    J H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    J Biomech 45:1299-304. 2012
    ..The aim of the present study was to evaluate the systemic biological effect of increased exercise on bone repair after stable fracture fixation...
  4. doi Erythropoietin stimulates bone formation, cell proliferation, and angiogenesis in a femoral segmental defect model in mice
    J H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrberger Strasse 1, 66421 Homburg Saar, Germany
    Bone 49:1037-45. 2011
    ..We conclude that EPO is capable of stimulating bone formation, cell proliferation and VEGF-mediated angiogenesis in a femoral segmental defect model...
  5. pmc Inhibition of angiotensin-converting enzyme stimulates fracture healing and periosteal callus formation - role of a local renin-angiotensin system
    P Garcia
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Br J Pharmacol 159:1672-80. 2010
    ..Therefore, we studied the expression and function of the key RAS component, angiotensin-converting enzyme (ACE), during fracture healing...
  6. doi A new technique for internal fixation of femoral fractures in mice: impact of stability on fracture healing
    P Garcia
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Kirrbergerstr 1, D 66421 Homburg, Saar, Germany
    J Biomech 41:1689-96. 2008
    ..We further show that a more stable osteosynthesis significantly improves the process of fracture healing also in mice...
  7. doi Intravital microscopic studies of angiogenesis during bone defect healing in mice calvaria
    J H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Injury 42:765-71. 2011
    ..Herein, we introduce a calvarian defect model in mice that allows the repetitive analysis of blood vessel formation during bone repair by intravital microscopy...
  8. doi Deficiencies of folate and vitamin B12 do not affect fracture healing in mice
    J H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Bone 47:151-5. 2010
    ..The main causes for hyperhomocysteinemia are deficiencies of folate and vitamin B12. However, there is no information on whether deficiencies of these B vitamins are affecting bone repair, too...
  9. doi Advances in the establishment of defined mouse models for the study of fracture healing and bone regeneration
    J H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, Institute for Clinical and Experimental Surgery, University of Saarland, Homburg Saar, Germany
    J Orthop Trauma 23:S31-8. 2009
    ..The use of these mouse models may now allow studying the influence of fracture stabilization techniques on molecular mechanisms of bone healing...
  10. ncbi In vivo gait analysis in a mouse femur fracture model
    T Histing
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    J Biomech 43:3240-3. 2010
    ..Thus, our study demonstrates distinct alterations of the gait of mice at 2 weeks after femur fracture and stabilization. Our results support the need of gait analysis in fracture healing studies to assess the animals' well-being...
  11. ncbi Rodent animal models of delayed bone healing and non-union formation: a comprehensive review
    P Garcia
    Department of Trauma, Hand and Reconstructive Surgery, University Hospital Muenster, D 48308 Muenster, Germany
    Eur Cell Mater 26:1-12; discussion 12-4. 2013
    ..We further summarise the value of different approaches to study normal and delayed fracture healing as well as non-union formation, and discuss different methods of data evaluation. ..
  12. doi Pantoprazole, a proton pump inhibitor, delays fracture healing in mice
    T Histing
    Department of Trauma, Hand, and Reconstructive Surgery, University of Saarland, 66421, Homburg Saar, Germany
    Calcif Tissue Int 90:507-14. 2012
    ..Pantoprazole delays fracture healing by affecting both bone formation and bone remodeling...
  13. pmc Rapamycin affects early fracture healing in mice
    J H Holstein
    Department of Trauma, Hand and Reconstructive Surgery, Homburg Saar, Germany
    Br J Pharmacol 154:1055-62. 2008
    ....
  14. doi Small animal bone healing models: standards, tips, and pitfalls results of a consensus meeting
    T Histing
    Department of Trauma, Hand and Reconstructive Surgery, University of Saarland, Homburg Saar, Germany
    Bone 49:591-9. 2011
    ..This review discusses distinct requirements for the experimental setups as well as the advantages and pitfalls of the different fixation techniques in rats and mice...
  15. ncbi The effect of estrogen on hepatic microcirculation after ischemia/reperfusion
    M Burkhardt
    Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Kirrberger Strasse, 66421 Homburg Saar, Germany
    Int J Colorectal Dis 23:113-9. 2008
    ..In the present study, we investigated whether hepatic ischemia/reperfusion (I/R) injury is gender-dependent and if hepatic microvascular reperfusion injury can be prevented by estrogen...
  16. doi [Post-traumatic torticollis in a schoolchild: fracture, congenital anomaly or age-appropriate radiological findings of the atlas?]
    M Burkhardt
    Klinik für Unfall, Hand und Wiederherstellungschirurgie, Universitatsklinikum des Saarlandes, 66421, Homburg Saar, Deutschland
    Unfallchirurg 113:230-4. 2010
    ..In addition to discoligamental injuries and fractures, congenital anomalies and normal variants of the immature anatomy of the cervical spine should also be considered in the diagnosis of the pediatric cervical spine after trauma...
  17. ncbi Vascularisation of porous scaffolds is improved by incorporation of adipose tissue-derived microvascular fragments
    M W Laschke
    Institute for Clinical and Experimental Surgery, University of Saarland, D 66421 Homburg Saar, Germany
    Eur Cell Mater 24:266-77. 2012
    ..Accordingly, this approach may markedly contribute to the success of future tissue engineering applications in clinical practice...
  18. ncbi [Complex pelvic trauma in elderly patients]
    G Tosounidis
    Klinik für Unfall, Hand und Wiederherstellungschirurgie, Universitatsklinikum des Saarlandes, Homburg Saar, Kirrberger Str 1, 66424, Homburg Saar, Deutschland
    Unfallchirurg 113:281-6. 2010
    ..6%, pelvic study group 2: 33% versus 22.6%, pelvic study group 3: 41% versus 10.4%, p <0.05, respectively)...