Research Topics
Genomes and Genes | Jan GalleSummaryCountry: Germany Publications
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Publications
[Therapy of inflammatory kidney diseases. More than steroids?]J Galle
Abteilung für Nephrologie, Medizinische Klinik, Universitatsklinikum Wurzburg
Internist (Berl) 45:1388-94. 2004..The clinical course and pathology of inflammatory kidney diseases have been reviewed extensively in this journal in 1997 and 2002...- Impact of oxidized low density lipoprotein on vascular cellsJan Galle
Department of Medicine, Division of Nephrology, Julius Maximilians University, Wurzburg, Germany
Atherosclerosis 185:219-26. 2006..Thus, through a variety of mechanisms, OxLDL importantly contributes to vascular dysfunction and remodeling... - Inflammation in uremic patients: what is the link?Jan Galle
Department of Medicine, Division of Nephrology, University of Wurzburg, Wurzburg, Germany
Kidney Blood Press Res 26:65-75. 2003..Based on pathophysiological considerations valid for uremic patients, we discuss therapeutical options that might help to reduce cardiovascular disease in uremic patients... - Has the time come to use antioxidant therapy in uraemic patients?Jan Galle
Medizinische Klinik, Schwerpunkt Nephrologie, , Germany
Nephrol Dial Transplant 18:1452-5. 2003 - [Atherosclerosis and arteriitis: implications for therapy of cardiovascular disease]Jan Galle
Medizinische Klinik der Universität Würzburg, Wurzburg, Germany
Herz 29:4-11. 2004.... - Dual effect of oxidized LDL on cell cycle in human endothelial cells through oxidative stressJ Galle
Division of Nephrology, Department of Medicine, University Hospital of Wurzburg, Wurzburg, Germany
Kidney Int Suppl 78:S120-3. 2001..Both effects are mediated by O2- formation, with NADPH oxidase being a major source for O2-. Thus, OxLDL contributes importantly to vascular cellular turnover through the induction of oxidative stress... - Modification of lipoproteins in uremia: oxidation, glycation and carbamoylationJ Galle
Department of Medicine, Division of Nephrology, University Hospital of Wurzburg, Germany
Miner Electrolyte Metab 25:263-8. 1999..Methods to analyze lipoprotein modification are introduced, and functional consequences related to vascular and renal function are presented... - Atherogenic lipoproteins, oxidative stress, and cell deathJ Galle
Department of Medicine, University Hospital of Wurzburg, Germany
Kidney Int Suppl 71:S62-5. 1999..We therefore determined the impact of oxLDL and oxLp(a) on O2- formation and on necrotic and apoptotic cell death in vascular and glomerular cells... - Lp(a) and LDL induce apoptosis in human endothelial cells and in rabbit aorta: role of oxidative stressJ Galle
Department of Medicine, University Hospital of Wurzburg, Germany
Kidney Int 55:1450-61. 1999..We assessed the effects of native (nLDL) and oxidized (oxLDL) low-density lipoprotein (LDL) and lipoprotein (a) [Lp(a)] on O2- formation and cell death in cultured human umbilical vein endothelial cells (HUVECs) and rabbit aorta (RA)... - Oxidized LDL and its compound lysophosphatidylcholine potentiate AngII-induced vasoconstriction by stimulation of RhoAJan Galle
Department of Medicine, Julius Maximilians Universitat, Wurzburg, Germany
J Am Soc Nephrol 14:1471-9. 2003..Lysophosphatidylcholine mimics the OxLDL effect, consistent with a causal role of this OxLDL compound. Stimulation of RhoA by OxLDL may contribute to vasospasm in atherosclerotic arteries... - L-Arginine does not affect renal morphology and cell survival in ischemic acute renal failure in ratsUlrike Raff
Division of Nephrology, Department of Medicine, Julius Maximilian University, , Germany
Nephron Physiol 101:p39-50. 2005..Thus, different mechanisms have to be considered, in particular improved intrarenal hemodynamics... - Monomeric C-reactive protein decreases acetylated LDL uptake in human endothelial cellsSusanne B Schwedler
Department of Medicine I, University of Wurzburg, Wurzburg, Germany
Clin Chem 55:1728-31. 2009..Here, we tested the impact of mCRP and nCRP on the uptake of acetylated LDL (acLDL), which is internalized by receptors similar to those of oxLDL in human endothelial cells... - Oxidized LDL induces proliferation and hypertrophy in human umbilical vein endothelial cells via regulation of p27Kip1 expression: role of RhoAStefan Seibold
Department of Medicine, University Hospital Wurzburg, Joseph Schneider Strasse 2, D 97080 Wurzburg, Germany
J Am Soc Nephrol 15:3026-34. 2004..OxLDL may importantly contribute to vascular hyperplasia in atherosclerosis and other diseases associated with increased levels of OxLDL... - L-Arginine counteracts nitric oxide deficiency and improves the recovery phase of ischemic acute renal failure in ratsReinhard Schneider
Division of Nephrology, Department of Medicine, Julius-Maximilians-University, , Germany
Kidney Int 64:216-25. 2003..l-Arg supplementation reduces O2- generation and significantly improves the expression of nitric oxide signaling proteins as well as the recovery phase of ischemic ARF... - Transmission of oxLDL-derived lipid peroxide radicals into membranes of vascular cells is the main inducer of oxLDL-mediated oxidative stressThomas E Hansen-Hagge
Department of Medicine, Division of Nephrology, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
Atherosclerosis 197:602-11. 2008..The novel data may help to design adequate therapeutic strategies against oxLDL-induced cardiovascular diseases... - Antiproteinuric effects of angiotensin receptor blockers: telmisartan versus valsartan in hypertensive patients with type 2 diabetes mellitus and overt nephropathyJan Galle
Department of Internal Medicine, University Hospital, Wurzburg, Germany
Nephrol Dial Transplant 23:3174-83. 2008..Experimental evidence demonstrates that angiotensin receptor blockers (ARBs) possess anti-inflammatory potential, which might contribute to reducing proteinuria and providing renoprotection... - C-reactive protein: a family of proteins to regulate cardiovascular functionSusanne B Schwedler
Division of Nephrology, Department of Medicine, University of Wurzburg, Germany
Am J Kidney Dis 47:212-22. 2006.... - Down-regulation of MTUS1 in human colon tumorsChristina Zuern
Department of Medicine, Division of Nephrology, University Clinic of Wuerzburg, Wuerzburg, Germany
Oncol Rep 23:183-9. 2010..Since reduced expression of MTUS1 results in increased cellular proliferation, these data suggest that MTUS1 could be involved in the loss of proliferative control in human colon cancer... - Identification of a new tumor suppressor gene located at chromosome 8p21.3-22Stefan Seibold
Department of Internal Medicine I, Cologne General Hospital, Merheim Medical Center, Medical Faculty University of Cologne, Cologne, Germany
FASEB J 17:1180-2. 2003..In conclusion, we identified a tumor suppressor gene at chromosome 8p21.3-22, encoding a mitochondrial protein, controlling cellular proliferation... - Glyc-oxidized LDL impair endothelial function more potently than oxidized LDL: role of enhanced oxidative stressJ Galle
Department of Medicine, University Hospital of Wurzburg, Germany
Atherosclerosis 138:65-77. 1998..This mechanism may play an important role in diabetic patients and may contribute to disturbed organ perfusion... - Native C-reactive protein increases whereas modified C-reactive protein reduces atherosclerosis in apolipoprotein E-knockout miceSusanne B Schwedler
Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
Circulation 112:1016-23. 2005..We tested the hypothesis that the configuration of CRP (pentameric, or native [nCRP], versus monomeric, or modified [mCRP]) determines these different characteristics in an in vivo model... - Oxidized LDL increases the sensitivity of the contractile apparatus in isolated resistance arteries for Ca(2+) via a rho- and rho kinase-dependent mechanismS S Bolz
Physiologisches Institut, Ludwig Maximilians Universitat, Munchen, Department of Medicine, Division of Nephrology, University Hospital of Wurzburg, Wurzburg, Germany
Circulation 102:2402-10. 2000..CONCLUSIONS: OxLDL reduces VSM responsiveness to vasodilators by increasing VSM Ca(2+) but preferentially by sensitizing VSM to Ca(2+) via a Rho- and Rho kinase-dependent pathway... - Increase in nitric oxide bioavailability improves endothelial function in endothelin-1 transgenic miceThomas Quaschning
Department of Medicine, Division of Nephrology, , , Germany
Nephrol Dial Transplant 18:479-83. 2003..Thus, in the presence of an activated ET system, up-regulation of NO production may be capable of maintaining vascular tone in a normal range and therefore may prevent the development of hypertension... - Nitric oxide prevents oxidised LDL-induced p53 accumulation, cytochrome c translocation, and apoptosis in macrophages via guanylate cyclase stimulationAlexandra Heinloth
Department of Medicine, Division of Nephrology, , Joseph-Schneider-Strasse 2, , Germany
Atherosclerosis 162:93-101. 2002..NO attenuates OxLDL-induced cytochrome c release and p53 accumulation via activation of sGC and cGMP formation. These effects may be of particular importance in arterial tissue with reduced NO activity... - Native C-reactive protein induces endothelial dysfunction in ApoE-/- mice: implications for iNOS and reactive oxygen speciesSusanne B Schwedler
Department of Medicine I, University Hospital Wurzburg, Josef Schneider Str 2, D 97080 Wurzburg, Germany
Atherosclerosis 195:e76-84. 2007..We evaluated the effects of two conformers of CRP (pentameric, or native [nCRP], versus monomeric, or modified [mCRP]) on vessel function and production of reactive oxygen species (ROS) in an in-vivo model of atherosclerosis... - Augmented endothelial uptake of oxidized low-density lipoprotein in response to endothelin-1Henning Morawietz
Institute of Pathophysiology, Faculty of Medicine, Martin Luther University Halle Wittenberg, D 06097 Halle, Germany
Clin Sci (Lond) 103:9S-12S. 2002..This mechanism could promote the development and progression of endothelial dysfunction and atherosclerosis. In addition, endothelin receptor blockade could be considered as a new anti-atherosclerotic therapeutic principle... - Oxidized low-density lipoprotein increases superoxide production by endothelial nitric oxide synthase by inhibiting PKCalphaIngrid Fleming
Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
Cardiovasc Res 65:897-906. 2005..We assessed whether the uncoupling of eNOS was associated with alterations in eNOS phosphorylation and/or the assembly of the eNOS signaling complex... - Reduction of proteinuria with angiotensin receptor blockersJan Galle
Department of Nephrology and Dialysis at Klinikum Lüdenscheid, Ludenscheid, Germany
Nat Clin Pract Cardiovasc Med 5:S36-43. 2008..These data support the proposition that blockade of the renin-angiotensin system beyond that required for maximum blood pressure reduction provides optimum renal protection... - Phosphorylation of blood vessel vasodilator-stimulated phosphoprotein at serine 239 as a functional biochemical marker of endothelial nitric oxide/cyclic GMP signalingCésar Ibarra-Alvarado
Rudolf Buchheim Institute for Pharmacology, Justus Liebig University, Giessen, Germany
Mol Pharmacol 61:312-9. 2002..These data suggest that vascular P(Ser239)-VASP is primarily regulated by the NO/cGMP pathway and may thus serve as a biochemical marker for the activity state of this essential pathway in endothelial function... - Lack of iNOS impairs endothelial function in endothelin-1 transgenic miceThomas Quaschning
Department of Nephrology, University Hospital of Freiburg, Freiburg, Germany
Kidney Blood Press Res 31:127-34. 2008.... - Endothelin B receptor-deficient mice develop endothelial dysfunction independently of salt loadingThomas Quaschning
Department of Nephrology, , Germany
J Hypertens 23:979-85. 2005..This indicates that, in this model, salt-induced hypertension is not mediated by endothelial dysfunction... - Vasopeptidase inhibition normalizes blood pressure and restores endothelial function in renovascular hypertensionThomas Quaschning
Department of Nephrology, University Hospital of Freiburg, Freiburg, Germany
Kidney Blood Press Res 29:351-9. 2006..The present study investigated the effect of the vasopeptidase inhibitor AVE7688 in comparison to the ACE inhibitor ramipril on systolic blood pressure (SBP) and endothelial function in renovascular hypertension... - Lack of endothelial nitric oxide synthase promotes endothelin-induced hypertension: lessons from endothelin-1 transgenic/endothelial nitric oxide synthase knockout miceThomas Quaschning
Department of Nephrology, University Hospital of Freiburg, Freiburg, Germany
J Am Soc Nephrol 18:730-40. 2007..The human ET+/+ eNOS-/- mice therefore represent a novel model of hypertension as a result of an imbalance between the vascular ET-1 and NO systems...