Jan Galle

Summary

Country: Germany

Publications

  1. ncbi request reprint Impact of oxidized low density lipoprotein on vascular cells
    Jan Galle
    Department of Medicine, Division of Nephrology, Julius Maximilians University, Wurzburg, Germany
    Atherosclerosis 185:219-26. 2006
  2. ncbi request reprint Inflammation in uremic patients: what is the link?
    Jan Galle
    Department of Medicine, Division of Nephrology, University of Wurzburg, Wurzburg, Germany
    Kidney Blood Press Res 26:65-75. 2003
  3. ncbi request reprint Has the time come to use antioxidant therapy in uraemic patients?
    Jan Galle
    Medizinische Klinik, Schwerpunkt Nephrologie, Universitat Wurzburg, Germany
    Nephrol Dial Transplant 18:1452-5. 2003
  4. ncbi request reprint [Atherosclerosis and arteriitis: implications for therapy of cardiovascular disease]
    Jan Galle
    Medizinische Klinik der Universität Würzburg, Wurzburg, Germany
    Herz 29:4-11. 2004
  5. ncbi request reprint [Therapy of inflammatory kidney diseases. More than steroids?]
    J Galle
    Abteilung für Nephrologie, Medizinische Klinik, Universitatsklinikum Wurzburg
    Internist (Berl) 45:1388-94. 2004
  6. ncbi request reprint Dual effect of oxidized LDL on cell cycle in human endothelial cells through oxidative stress
    J Galle
    Division of Nephrology, Department of Medicine, University Hospital of Wurzburg, Wurzburg, Germany
    Kidney Int Suppl 78:S120-3. 2001
  7. ncbi request reprint Modification of lipoproteins in uremia: oxidation, glycation and carbamoylation
    J Galle
    Department of Medicine, Division of Nephrology, University Hospital of Wurzburg, Germany
    Miner Electrolyte Metab 25:263-8. 1999
  8. ncbi request reprint Atherogenic lipoproteins, oxidative stress, and cell death
    J Galle
    Department of Medicine, University Hospital of Wurzburg, Germany
    Kidney Int Suppl 71:S62-5. 1999
  9. ncbi request reprint Lp(a) and LDL induce apoptosis in human endothelial cells and in rabbit aorta: role of oxidative stress
    J Galle
    Department of Medicine, University Hospital of Wurzburg, Germany
    Kidney Int 55:1450-61. 1999
  10. ncbi request reprint Oxidized LDL and its compound lysophosphatidylcholine potentiate AngII-induced vasoconstriction by stimulation of RhoA
    Jan Galle
    Department of Medicine, Julius Maximilians Universitat, Wurzburg, Germany
    J Am Soc Nephrol 14:1471-9. 2003

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Impact of oxidized low density lipoprotein on vascular cells
    Jan Galle
    Department of Medicine, Division of Nephrology, Julius Maximilians University, Wurzburg, Germany
    Atherosclerosis 185:219-26. 2006
    ..Thus, through a variety of mechanisms, OxLDL importantly contributes to vascular dysfunction and remodeling...
  2. ncbi request reprint Inflammation in uremic patients: what is the link?
    Jan Galle
    Department of Medicine, Division of Nephrology, University of Wurzburg, Wurzburg, Germany
    Kidney Blood Press Res 26:65-75. 2003
    ..Based on pathophysiological considerations valid for uremic patients, we discuss therapeutical options that might help to reduce cardiovascular disease in uremic patients...
  3. ncbi request reprint Has the time come to use antioxidant therapy in uraemic patients?
    Jan Galle
    Medizinische Klinik, Schwerpunkt Nephrologie, Universitat Wurzburg, Germany
    Nephrol Dial Transplant 18:1452-5. 2003
  4. ncbi request reprint [Atherosclerosis and arteriitis: implications for therapy of cardiovascular disease]
    Jan Galle
    Medizinische Klinik der Universität Würzburg, Wurzburg, Germany
    Herz 29:4-11. 2004
    ....
  5. ncbi request reprint [Therapy of inflammatory kidney diseases. More than steroids?]
    J Galle
    Abteilung für Nephrologie, Medizinische Klinik, Universitatsklinikum Wurzburg
    Internist (Berl) 45:1388-94. 2004
    ..The clinical course and pathology of inflammatory kidney diseases have been reviewed extensively in this journal in 1997 and 2002...
  6. ncbi request reprint Dual effect of oxidized LDL on cell cycle in human endothelial cells through oxidative stress
    J Galle
    Division of Nephrology, Department of Medicine, University Hospital of Wurzburg, Wurzburg, Germany
    Kidney Int Suppl 78:S120-3. 2001
    ..OxLDL suppressed the expression of A20 in a dose-dependent manner...
  7. ncbi request reprint Modification of lipoproteins in uremia: oxidation, glycation and carbamoylation
    J Galle
    Department of Medicine, Division of Nephrology, University Hospital of Wurzburg, Germany
    Miner Electrolyte Metab 25:263-8. 1999
    ..Methods to analyze lipoprotein modification are introduced, and functional consequences related to vascular and renal function are presented...
  8. ncbi request reprint Atherogenic lipoproteins, oxidative stress, and cell death
    J Galle
    Department of Medicine, University Hospital of Wurzburg, Germany
    Kidney Int Suppl 71:S62-5. 1999
    ..We therefore determined the impact of oxLDL and oxLp(a) on O2- formation and on necrotic and apoptotic cell death in vascular and glomerular cells...
  9. ncbi request reprint Lp(a) and LDL induce apoptosis in human endothelial cells and in rabbit aorta: role of oxidative stress
    J Galle
    Department of Medicine, University Hospital of Wurzburg, Germany
    Kidney Int 55:1450-61. 1999
    ..We assessed the effects of native (nLDL) and oxidized (oxLDL) low-density lipoprotein (LDL) and lipoprotein (a) [Lp(a)] on O2- formation and cell death in cultured human umbilical vein endothelial cells (HUVECs) and rabbit aorta (RA)...
  10. ncbi request reprint Oxidized LDL and its compound lysophosphatidylcholine potentiate AngII-induced vasoconstriction by stimulation of RhoA
    Jan Galle
    Department of Medicine, Julius Maximilians Universitat, Wurzburg, Germany
    J Am Soc Nephrol 14:1471-9. 2003
    ..Lysophosphatidylcholine mimics the OxLDL effect, consistent with a causal role of this OxLDL compound. Stimulation of RhoA by OxLDL may contribute to vasospasm in atherosclerotic arteries...
  11. ncbi request reprint L-Arginine does not affect renal morphology and cell survival in ischemic acute renal failure in rats
    Ulrike Raff
    Division of Nephrology, Department of Medicine, Julius Maximilian University, Wurzburg, Germany
    Nephron Physiol 101:p39-50. 2005
    ..L-Arginine (L-Arg), a substrate of nitric oxide synthases, improves renal function in ischemic acute renal failure (iARF). We evaluated whether L-Arg improves renal morphology and cell survival in the course of iARF...
  12. doi request reprint Monomeric C-reactive protein decreases acetylated LDL uptake in human endothelial cells
    Susanne B Schwedler
    Department of Medicine I, University of Wurzburg, Wurzburg, Germany
    Clin Chem 55:1728-31. 2009
    ..Here, we tested the impact of mCRP and nCRP on the uptake of acetylated LDL (acLDL), which is internalized by receptors similar to those of oxLDL in human endothelial cells...
  13. ncbi request reprint Oxidized LDL induces proliferation and hypertrophy in human umbilical vein endothelial cells via regulation of p27Kip1 expression: role of RhoA
    Stefan Seibold
    Department of Medicine, University Hospital Wurzburg, Joseph Schneider Strasse 2, D 97080 Wurzburg, Germany
    J Am Soc Nephrol 15:3026-34. 2004
    ..OxLDL may importantly contribute to vascular hyperplasia in atherosclerosis and other diseases associated with increased levels of OxLDL...
  14. ncbi request reprint Endothelin B receptor-deficient mice develop endothelial dysfunction independently of salt loading
    Thomas Quaschning
    Department of Nephrology, University Hospital of Wurzburg, Germany
    J Hypertens 23:979-85. 2005
    ..We used mice with a rescue of the lethal phenotype of an ETB knockout. These mice were generated by crossbreeding ETB mice with dopamine-hydroxylase ETB transgenic mice...
  15. ncbi request reprint Transmission of oxLDL-derived lipid peroxide radicals into membranes of vascular cells is the main inducer of oxLDL-mediated oxidative stress
    Thomas E Hansen-Hagge
    Department of Medicine, Division of Nephrology, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Atherosclerosis 197:602-11. 2008
    ..The novel data may help to design adequate therapeutic strategies against oxLDL-induced cardiovascular diseases...
  16. ncbi request reprint L-Arginine counteracts nitric oxide deficiency and improves the recovery phase of ischemic acute renal failure in rats
    Reinhard Schneider
    Division of Nephrology, Department of Medicine, Julius Maximilians University, Wurzburg, Germany
    Kidney Int 64:216-25. 2003
    ..Here we further analyzed the impact of l-Arg on functional and biochemical parameters of nitric oxide signaling during the course of ischemic ARF...
  17. ncbi request reprint C-reactive protein: a family of proteins to regulate cardiovascular function
    Susanne B Schwedler
    Division of Nephrology, Department of Medicine, University of Wurzburg, Germany
    Am J Kidney Dis 47:212-22. 2006
    ....
  18. doi request reprint Antiproteinuric effects of angiotensin receptor blockers: telmisartan versus valsartan in hypertensive patients with type 2 diabetes mellitus and overt nephropathy
    Jan Galle
    Department of Internal Medicine, University Hospital, Wurzburg, Germany
    Nephrol Dial Transplant 23:3174-83. 2008
    ..Experimental evidence demonstrates that angiotensin receptor blockers (ARBs) possess anti-inflammatory potential, which might contribute to reducing proteinuria and providing renoprotection...
  19. ncbi request reprint Down-regulation of MTUS1 in human colon tumors
    Christina Zuern
    Department of Medicine, Division of Nephrology, University Clinic of Wuerzburg, Wuerzburg, Germany
    Oncol Rep 23:183-9. 2010
    ..Since reduced expression of MTUS1 results in increased cellular proliferation, these data suggest that MTUS1 could be involved in the loss of proliferative control in human colon cancer...
  20. ncbi request reprint Identification of a new tumor suppressor gene located at chromosome 8p21.3-22
    Stefan Seibold
    Department of Internal Medicine I, Cologne General Hospital, Merheim Medical Center, Medical Faculty University of Cologne, Cologne, Germany
    FASEB J 17:1180-2. 2003
    ..In conclusion, we identified a tumor suppressor gene at chromosome 8p21.3-22, encoding a mitochondrial protein, controlling cellular proliferation...
  21. ncbi request reprint Glyc-oxidized LDL impair endothelial function more potently than oxidized LDL: role of enhanced oxidative stress
    J Galle
    Department of Medicine, University Hospital of Wurzburg, Germany
    Atherosclerosis 138:65-77. 1998
    ..This mechanism may play an important role in diabetic patients and may contribute to disturbed organ perfusion...
  22. ncbi request reprint Native C-reactive protein increases whereas modified C-reactive protein reduces atherosclerosis in apolipoprotein E-knockout mice
    Susanne B Schwedler
    Division of Nephrology, Department of Medicine, University of Wurzburg, Wurzburg, Germany
    Circulation 112:1016-23. 2005
    ..We tested the hypothesis that the configuration of CRP (pentameric, or native [nCRP], versus monomeric, or modified [mCRP]) determines these different characteristics in an in vivo model...
  23. ncbi request reprint Oxidized LDL increases the sensitivity of the contractile apparatus in isolated resistance arteries for Ca(2+) via a rho- and rho kinase-dependent mechanism
    S S Bolz
    Physiologisches Institut, Ludwig Maximilians Universitat, Munchen, Department of Medicine, Division of Nephrology, University Hospital of Wurzburg, Wurzburg, Germany
    Circulation 102:2402-10. 2000
    ..This sensitization to Ca(2+) by oxLDL was abolished after inhibition of Rho (C3 transferase) or Rho kinase (Y27632)...
  24. ncbi request reprint Medroxyprogesterone acetate but not drospirenone ablates the protective function of 17 beta-estradiol in aldosterone salt-treated rats
    Paula Anahi Arias-Loza
    Medizinische Klinik I, University of Wurzburg, Josef Schneider Str 2, D 97080 Wurzburg, Germany
    Hypertension 48:994-1001. 2006
    ..Novel progestins, such as drospirenone, confer superior effects compared with medroxyprogesterone acetate in a model of aldosterone-induced heart disease because of its antimineralocorticoid properties...
  25. ncbi request reprint Increase in nitric oxide bioavailability improves endothelial function in endothelin-1 transgenic mice
    Thomas Quaschning
    Department of Medicine, Division of Nephrology, University Hospital of Wurzburg, Wurzburg, Germany
    Nephrol Dial Transplant 18:479-83. 2003
    ..We thus hypothesized that vascular ET-1 effects may be antagonized by increased activity of other regulatory systems, such as the increase in bioavailability of the endothelial counterpart of ET-1, nitric oxide (NO)...
  26. ncbi request reprint Nitric oxide prevents oxidised LDL-induced p53 accumulation, cytochrome c translocation, and apoptosis in macrophages via guanylate cyclase stimulation
    Alexandra Heinloth
    Department of Medicine, Division of Nephrology, University Hospital of Wurzburg, Joseph Schneider Strasse 2, 97080 Wurzburg, Germany
    Atherosclerosis 162:93-101. 2002
    ..Here we studied the impact of nitric oxide (NO) on OxLDL-induced cytochrome c release, apoptosis, and expression of the proapoptotic p53 in macrophages...
  27. doi request reprint Reduction of proteinuria with angiotensin receptor blockers
    Jan Galle
    Department of Nephrology and Dialysis at Klinikum Lüdenscheid, Ludenscheid, Germany
    Nat Clin Pract Cardiovasc Med 5:S36-43. 2008
    ..These data support the proposition that blockade of the renin-angiotensin system beyond that required for maximum blood pressure reduction provides optimum renal protection...
  28. ncbi request reprint Phosphorylation of blood vessel vasodilator-stimulated phosphoprotein at serine 239 as a functional biochemical marker of endothelial nitric oxide/cyclic GMP signaling
    César Ibarra-Alvarado
    Rudolf Buchheim Institute for Pharmacology, Justus Liebig University, Giessen, Germany
    Mol Pharmacol 61:312-9. 2002
    ..These data suggest that vascular P(Ser239)-VASP is primarily regulated by the NO/cGMP pathway and may thus serve as a biochemical marker for the activity state of this essential pathway in endothelial function...
  29. ncbi request reprint Native C-reactive protein induces endothelial dysfunction in ApoE-/- mice: implications for iNOS and reactive oxygen species
    Susanne B Schwedler
    Department of Medicine I, University Hospital Wurzburg, Josef Schneider Str 2, D 97080 Wurzburg, Germany
    Atherosclerosis 195:e76-84. 2007
    ..We evaluated the effects of two conformers of CRP (pentameric, or native [nCRP], versus monomeric, or modified [mCRP]) on vessel function and production of reactive oxygen species (ROS) in an in-vivo model of atherosclerosis...
  30. ncbi request reprint Oxidized low-density lipoprotein increases superoxide production by endothelial nitric oxide synthase by inhibiting PKCalpha
    Ingrid Fleming
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Cardiovasc Res 65:897-906. 2005
    ..We assessed whether the uncoupling of eNOS was associated with alterations in eNOS phosphorylation and/or the assembly of the eNOS signaling complex...
  31. ncbi request reprint Augmented endothelial uptake of oxidized low-density lipoprotein in response to endothelin-1
    Henning Morawietz
    Institute of Pathophysiology, Faculty of Medicine, Martin Luther University Halle Wittenberg, D 06097 Halle, Germany
    Clin Sci (Lond) 103:9S-12S. 2002
    ..This mechanism could promote the development and progression of endothelial dysfunction and atherosclerosis. In addition, endothelin receptor blockade could be considered as a new anti-atherosclerotic therapeutic principle...
  32. doi request reprint Lack of iNOS impairs endothelial function in endothelin-1 transgenic mice
    Thomas Quaschning
    Department of Nephrology, University Hospital of Freiburg, Freiburg, Germany
    Kidney Blood Press Res 31:127-34. 2008
    ....
  33. ncbi request reprint Vasopeptidase inhibition normalizes blood pressure and restores endothelial function in renovascular hypertension
    Thomas Quaschning
    Department of Nephrology, University Hospital of Freiburg, Freiburg, Germany
    Kidney Blood Press Res 29:351-9. 2006
    ..The present study investigated the effect of the vasopeptidase inhibitor AVE7688 in comparison to the ACE inhibitor ramipril on systolic blood pressure (SBP) and endothelial function in renovascular hypertension...
  34. ncbi request reprint Lack of endothelial nitric oxide synthase promotes endothelin-induced hypertension: lessons from endothelin-1 transgenic/endothelial nitric oxide synthase knockout mice
    Thomas Quaschning
    Department of Nephrology, University Hospital of Freiburg, Freiburg, Germany
    J Am Soc Nephrol 18:730-40. 2007
    ..The human ET+/+ eNOS-/- mice therefore represent a novel model of hypertension as a result of an imbalance between the vascular ET-1 and NO systems...