Georgios Gakis

Summary

Country: Germany

Publications

  1. ncbi request reprint Evolution of the concept of androgen-sensitive bladder cancer
    Georgios Gakis
    Department of Urology, Eberhard Karls University, Tubingen, Germany
    Scand J Urol 47:173-8. 2013
  2. ncbi request reprint ICUD-EAU International Consultation on Bladder Cancer 2012: Radical cystectomy and bladder preservation for muscle-invasive urothelial carcinoma of the bladder
    Georgios Gakis
    Department of Urology, University Hospital Tuebingen, Germany
    Eur Urol 63:45-57. 2013
  3. ncbi request reprint Development of a new outcome prediction model in carcinoma invading the bladder based on preoperative serum C-reactive protein and standard pathological risk factors: the TNR-C score
    Georgios Gakis
    Department of Urology, Eberhard Karls University, Tuebingen, Germany
    BJU Int 108:1800-5. 2011
  4. ncbi request reprint Current status of molecular markers for prognostication and outcome in invasive bladder cancer
    Georgios Gakis
    Department of Urology, Eberhard Karls University, Tuebingen, Germany
    BJU Int 110:233-7. 2012
  5. ncbi request reprint Metastasis of malignant melanoma in the ureter: possible algorithms for a therapeutic approach
    Georgios Gakis
    Department of Urology, University Hospital Tuebingen, Eberhard Karls University, Tuebingen, Germany
    Int J Urol 16:407-9. 2009
  6. ncbi request reprint Comparison of the new American Joint Committee on Cancer substratification in node-negative pT2 urothelial carcinoma of the bladder: analysis of patient outcomes in a contemporary series
    Georgios Gakis
    Department of Urology, Eberhard Karls University, Tubingen, Germany
    BJU Int 107:919-23. 2011
  7. ncbi request reprint Sequential resection of malignant ureteral margins at radical cystectomy: a critical assessment of the value of frozen section analysis
    Georgios Gakis
    Department of Urology, University Hospital Tuebingen, Eberhard Karls University, Hoppe Seyler Strasse 3, 72076, Tubingen, Germany
    World J Urol 29:451-6. 2011
  8. ncbi request reprint The prognostic value of hematological and systemic inflammatory disorders in invasive bladder cancer
    Georgios Gakis
    Department of Urology, Eberhard Karls University, Tuebingen, Germany
    Curr Opin Urol 21:428-33. 2011
  9. ncbi request reprint Individual risk assessment in bladder cancer patients based on a multi-marker panel
    Tilman Todenhöfer
    Department of Urology, University Hospital Tuebingen, Tuebingen, Germany
    J Cancer Res Clin Oncol 139:49-56. 2013
  10. ncbi request reprint Altered expression of farnesyl pyrophosphate synthase in prostate cancer: evidence for a role of the mevalonate pathway in disease progression?
    Tilman Todenhöfer
    Department of Urology, University Hospital Tubingen, Tubingen, Germany
    World J Urol 31:345-50. 2013

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Evolution of the concept of androgen-sensitive bladder cancer
    Georgios Gakis
    Department of Urology, Eberhard Karls University, Tubingen, Germany
    Scand J Urol 47:173-8. 2013
    ..Determination of the AR status in cystectomy specimens offers new therapeutic approaches in locally advanced bladder cancer...
  2. ncbi request reprint ICUD-EAU International Consultation on Bladder Cancer 2012: Radical cystectomy and bladder preservation for muscle-invasive urothelial carcinoma of the bladder
    Georgios Gakis
    Department of Urology, University Hospital Tuebingen, Germany
    Eur Urol 63:45-57. 2013
    ..New guidelines of the International Consultation on Urological Diseases for the treatment of muscle-invasive bladder cancer (MIBC) have recently been published...
  3. ncbi request reprint Development of a new outcome prediction model in carcinoma invading the bladder based on preoperative serum C-reactive protein and standard pathological risk factors: the TNR-C score
    Georgios Gakis
    Department of Urology, Eberhard Karls University, Tuebingen, Germany
    BJU Int 108:1800-5. 2011
    ....
  4. ncbi request reprint Current status of molecular markers for prognostication and outcome in invasive bladder cancer
    Georgios Gakis
    Department of Urology, Eberhard Karls University, Tuebingen, Germany
    BJU Int 110:233-7. 2012
    ..It focuses on biostatistical considerations in the interpretation of study results which are essential to provide meaningful clinical conclusions for an individual patient...
  5. ncbi request reprint Metastasis of malignant melanoma in the ureter: possible algorithms for a therapeutic approach
    Georgios Gakis
    Department of Urology, University Hospital Tuebingen, Eberhard Karls University, Tuebingen, Germany
    Int J Urol 16:407-9. 2009
    ..Based on this case as well as on recent published reports, we propose a possible algorithm for the treatment of metastatic melanoma of the upper urinary tract...
  6. ncbi request reprint Comparison of the new American Joint Committee on Cancer substratification in node-negative pT2 urothelial carcinoma of the bladder: analysis of patient outcomes in a contemporary series
    Georgios Gakis
    Department of Urology, Eberhard Karls University, Tubingen, Germany
    BJU Int 107:919-23. 2011
    ....
  7. ncbi request reprint Sequential resection of malignant ureteral margins at radical cystectomy: a critical assessment of the value of frozen section analysis
    Georgios Gakis
    Department of Urology, University Hospital Tuebingen, Eberhard Karls University, Hoppe Seyler Strasse 3, 72076, Tubingen, Germany
    World J Urol 29:451-6. 2011
    ....
  8. ncbi request reprint The prognostic value of hematological and systemic inflammatory disorders in invasive bladder cancer
    Georgios Gakis
    Department of Urology, Eberhard Karls University, Tuebingen, Germany
    Curr Opin Urol 21:428-33. 2011
    ....
  9. ncbi request reprint Individual risk assessment in bladder cancer patients based on a multi-marker panel
    Tilman Todenhöfer
    Department of Urology, University Hospital Tuebingen, Tuebingen, Germany
    J Cancer Res Clin Oncol 139:49-56. 2013
    ..To investigate whether a combined application of urine cytology (CYT) and molecular markers for bladder cancer (BC) can predict tumor aggressiveness...
  10. ncbi request reprint Altered expression of farnesyl pyrophosphate synthase in prostate cancer: evidence for a role of the mevalonate pathway in disease progression?
    Tilman Todenhöfer
    Department of Urology, University Hospital Tubingen, Tubingen, Germany
    World J Urol 31:345-50. 2013
    ..The exact role of this pathway in prostate cancer (PC) has not been identified yet. Herein, we evaluate the expression of farnesyl pyrophosphate synthase (FPPS), the key enzyme of the mevalonate pathway, in PC...
  11. ncbi request reprint An update on the medical therapy of advanced metastatic renal cell carcinoma
    Stephan Kruck
    Department of Urology, Eberhard Karls University, Tuebingen, Germany
    Scand J Urol Nephrol 42:501-6. 2008
    ..This review discusses the effectiveness of the most frequently used substances for systemically progressive RCC in consideration of the currently available clinical data...
  12. ncbi request reprint Impact of different grades of microscopic hematuria on the performance of urine-based markers for the detection of urothelial carcinoma
    Tilman Todenhöfer
    Department of Urology, Eberhard Karls University, Tuebingen, Germany
    Urol Oncol 31:1148-54. 2013
    ....
  13. ncbi request reprint Bilateral laparoscopic postchemotherapy retroperitoneal lymph-node dissection in nonseminomatous germ cell tumors--a comparison to template dissection
    Stefan Aufderklamm
    Department of Urology, Eberhard Karls University, Tuebingen, Germany
    J Endourol 27:856-61. 2013
    ..Ipsilateral template dissection is a compromise between morbidity and oncological efficacy. Here, we compare ipsilateral with primary bilateral laparoscopic (L)-RPLND after chemotherapy in terms of morbidity and oncological safety...
  14. ncbi request reprint Exposed proliferation antigen 210 (XPA-210) in renal cell carcinoma (RCC) and oncocytoma: clinical utility and biological implications
    Stephan Kruck
    Departments of Urology Pathology, Eberhard Karls University, Tuebingen, Germany
    BJU Int 109:634-8. 2012
    ....
  15. ncbi request reprint XPA-210: a new proliferation marker determines locally advanced prostate cancer and is a predictor of biochemical recurrence
    Stefan Aufderklamm
    Department of Urology, Eberhard Karls University Tubingen, Hoppe Seyler Strasse 3, Tubingen, Germany
    World J Urol 30:547-52. 2012
    ..It is of clinical significance in kidney, breast, and bladder cancer. There are no data available for XPA-210 in prostate cancer (PC). Herein, we aim to determine the clinical usefulness of XPA-210 in PC...
  16. ncbi request reprint Urethral ultrasound as a screening tool for stricture recurrence after oral mucosa graft urethroplasty
    Joerg Seibold
    Department of Urology, Eberhard Karls University, Tuebingen, Germany
    Urology 78:696-700. 2011
    ..OMG urethroplasty is a standard treatment for men with recurrent urethral stricture. Because of its performance, the optimum follow-up algorithm remains controversial...
  17. ncbi request reprint Serum receptor activator of nuclear factor κB ligand (RANKL) levels predict biochemical recurrence in patients undergoing radical prostatectomy
    Tilman Todenhöfer
    Department of Urology, University Hospital Tubingen, Tubingen, Germany
    BJU Int 113:152-9. 2014
    ..Both high levels of RANKL and a higher RANKL/OPG ratio are independent predictors of early biochemical recurrence in these patients...
  18. ncbi request reprint Upper urinary tract laparoendoscopic single-site surgery based on a novel cost-effective reusable platform
    Christian Schwentner
    Department of Urology, Eberhard Karls University Tuebingen, Germany
    J Endourol 27:202-7. 2013
    ..Besides technical issues, cost is one of the main limiting factors for their widespread use. We present our experience with LESS surgery for kidney pathologies using the first completely reusable LESS platform...
  19. ncbi request reprint Prospective assessment of histological serial sectioning of pelvic lymph nodes in prostate cancer: a cost-benefit analysis
    David Schilling
    Department of Urology, Eberhard Karls University, Tuebingen, Germany
    BJU Int 110:E166-71. 2012
    ..However, the work-load and the expenses were significantly higher compared with routine evaluation...
  20. ncbi request reprint Anterior urethral reconstruction using the circular fasciocutaneous flap technique: long-term follow-up
    Christian Schwentner
    Department of Urology, Eberhard Karls University Tuebingen, University Hospital Tuebingen, Tuebingen, Germany
    World J Urol 29:115-20. 2011
    ..The circular fasciocutaneous skin flap technique (FCF) yields excellent short-term results for complex anterior urethral reconstruction. We performed an observational retrospective and descriptive study to report our long-term experience...
  21. ncbi request reprint Endoscopic inguinofemoral lymphadenectomy--extended follow-up
    Christian Schwentner
    Department of Urology, Eberhard Karls University, Tuebingen, Germany
    J Endourol 27:497-503. 2013
    ..Open lymphadenectomy (O-IFLA) exhibits complication rates of more than 50%. We are demonstrating our extended experience with a modified endoscopic approach (E-IFLA) for groin lymphadenectomy...
  22. ncbi request reprint Combined application of cytology and molecular urine markers to improve the detection of urothelial carcinoma
    Tilman Todenhöfer
    Department of Urology, University Hospital Tubingen, Tubingen, Germany
    Cancer Cytopathol 121:252-60. 2013
    ....
  23. ncbi request reprint Modified concept for radioisotope-guided sentinel lymph node dissection in prostate cancer
    David Schilling
    Department of Urology, Eberhard Karls University Tuebingen, Hoppe Seyler Str 3, 72076, Tuebingen, Germany
    World J Urol 28:715-20. 2010
    ..To present a modified concept for sentinel lymph node (SLN)-guided pelvic lymph node dissection in prostate cancer...
  24. ncbi request reprint Comparative analysis of comorbidity and performance indices for prediction of oncological outcomes in patients with upper tract urothelial carcinoma who were treated with radical nephroureterectomy
    Atiqullah Aziz
    Department of Urology, Caritas St Josef Medical Center, University of Regensburg, Regensburg, Germany Department of Urology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Urol Oncol 32:1141-50. 2014
    ....
  25. ncbi request reprint Impaired estimated glomerular filtration rate is a significant predictor for non-muscle-invasive bladder cancer recurrence and progression-Introducing a novel prognostic model for bladder cancer recurrence
    Steffen Rausch
    Department of Urology, Eberhard Karls University, Tubingen, Germany Electronic address
    Urol Oncol 32:1178-83. 2014
    ..To evaluate the influence of preoperative patient-associated parameters and comorbidities, with special focus on preoperative renal function on non-muscle-invasive bladder carcinoma (NMIBC) recurrence and progression...
  26. ncbi request reprint A new prognostic model for cancer-specific survival after radical cystectomy including pretreatment thrombocytosis and standard pathological risk factors
    Tilman Todenhöfer
    Department of Urology, Eberhard Karls University, Tubingen, Germany
    BJU Int 110:E533-40. 2012
    ..Consideration of platelet count in the final model increased its predictive accuracy significantly. Thrombocytosis may be a useful parameter to include within established international bladder cancer nomograms...
  27. ncbi request reprint Thymidine kinase and cancer monitoring
    Stefan Aufderklamm
    Department of Urology, Eberhard Karls University, Tubingen, Germany
    Cancer Lett 316:6-10. 2012
    ..Herein, we summarize the status of TK1 for cancer monitoring and point out its use as a proliferation marker. A comprehensive overview about the association of TK-1 with various entities is given...
  28. pmc Point-of-Care Tests for Bladder Cancer: The Influencing Role of Hematuria
    Joerg Hennenlotter
    Department of Urology, Eberhard Karls University Tuebingen, Hoppe Seyler Stra β e 3, 72076 Tuebingen, Germany
    Adv Urol 2011:937561. 2011
    ..0002). Conclusions. NMP22-BladderCheck was most resistant to blood. The diagnostic yield of all others was significantly influenced by HU. A well-defined HU grading helps to define limits of HU for a reliable interpretation of BC-POCTs...
  29. ncbi request reprint EAU guidelines on primary urethral carcinoma
    Georgios Gakis
    Department of Urology, Eberhard Karls University, Tubingen, Germany Electronic address
    Eur Urol 64:823-30. 2013
    ....
  30. ncbi request reprint Totally intracorporeal replacement of the ureter using whole-mount ileum
    Allen Sim
    Department of Urology, Eberhard Karls University Tuebingen, Germany
    J Endourol 28:1165-7. 2014
    ..We have demonstrated the safety and feasibility of laparoscopic intracorporeal ileal ureter with possible advantage of shorter operative time compared with the robotic-assisted technique reported recently...
  31. ncbi request reprint Postchemotherapy laparoscopic retroperitoneal lymph node dissection for nonseminomatous germ cell tumors infiltrating the great vessels
    Stefan Aufderklamm
    Department of Urology, Eberhard Karls University, Tubingen, Germany
    J Endourol 28:668-74. 2014
    ..We present our experience with L-RPLND in NSGCT residuals with significant vascular involvement necessitating intracorporeal reconstruction...
  32. ncbi request reprint Influence of urinary tract instrumentation and inflammation on the performance of urine markers for the detection of bladder cancer
    Tilman Todenhöfer
    Department of Urology, University Hospital, Tuebingen, Germany
    Urology 79:620-4. 2012
    ..The specificity of urine markers for urothelial cancer is subject to exogenous factors. There is evidence that nuclear matrix protein 22 (NMP22) is influenced by urinary tract infection and instrumented urinary sampling (IUS)...
  33. ncbi request reprint XPA-210: a new proliferation marker to characterize tumor biology and progression of renal cell carcinoma
    Georgios Gakis
    Department of Urology, Eberhard Karls University, Hoppe Seyler Strasse 3, 72076, Tubingen, Germany
    World J Urol 29:801-6. 2011
    ..Recent lung cancer data have shown an association of XPA-210, a key peptide of thymidine kinase, with advanced disease. We thus assessed its proliferation status in primary (M0) and metastatic (M1) renal cell carcinoma (RCC)...
  34. ncbi request reprint Preoperative C-reactive protein in the serum: a prognostic biomarker for upper urinary tract urothelial carcinoma treated with radical nephroureterectomy
    Atiqullah Aziz
    Department of Urology, Caritas St Josef Medical Center, University of Regensburg, Regensburg, Germany
    Urol Int 93:352-60. 2014
    ..To investigate the impact of preoperative serum C-reactive protein (CRP) on clinicopathological features and prognosis in patients with upper tract urothelial cancer (UTUC) after radical nephroureterectomy (RNU)...
  35. ncbi request reprint Evaluation of a new quantitative point-of-care test platform for urine-based detection of bladder cancer
    Rene Ritter
    Department of Urology, Eberhard Karls University of Tuebingen, Tuebingen, Germany
    Urol Oncol 32:337-44. 2014
    ..Recently, the first quantitative POC system based on the detection of cytokeratin fragments became available. The aim of the study was to evaluate the diagnostic accuracy of this quantitative POC test...
  36. ncbi request reprint Can the burden of follow-up in low-grade noninvasive bladder cancer be reduced by photodynamic diagnosis, perioperative instillations, imaging, and urine markers?
    Georgios Gakis
    Department of Urology, Eberhard Karls University, Tuebingen, Germany
    Curr Opin Urol 20:388-92. 2010
    ....
  37. ncbi request reprint Functional detrusor myoplasty for bladder acontractility: long-term results
    Georgios Gakis
    Department of Urology, Eberhard Karls University, Tuebingen, Germany
    J Urol 185:593-9. 2011
    ....
  38. ncbi request reprint The learning curve in minimally invasive percutaneous nephrolitholapaxy: a 1-year retrospective evaluation of a novice and an expert
    David Schilling
    Department of Urology, University Hospital Tuebingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    World J Urol 29:749-53. 2011
    ..The aim of this study was to compare a novice surgeon with an expert surgeon independently performing minimally invasive percutaneous neprolitholapaxy (PCNL) excluding the influence of the expert in the learning curve...
  39. ncbi request reprint Influence of renal excretory function on the performance of urine based markers to detect bladder cancer
    Tilman Todenhöfer
    Department of Urology, University Hospital Tubingen, Tubingen, Germany
    J Urol 187:68-73. 2012
    ..Many patients are elderly with renal insufficiency and have proteinuria as an additional influencing factor. To our knowledge no data are available on the accuracy of urine based bladder cancer tests in conjunction with renal function...
  40. ncbi request reprint Incidental prostate cancer at radical cystoprostatectomy: implications for apex-sparing surgery
    Georgios Gakis
    Department of Urology, Eberhard Karls University, Tubingen, Germany
    BJU Int 105:468-71. 2010
    ....
  41. ncbi request reprint Alterations of the RANKL pathway in blood and bone marrow samples of prostate cancer patients without bone metastases
    Tilman Todenhöfer
    Department of Urology, University Hospital Tuebingen, Tuebingen, Germany
    Prostate 73:162-8. 2013
    ..We aimed to investigate whether changes of RANKL, its inhibitor osteoprotegerin (OPG) and bone marrow-mesenchymal stromal cells (BM-MSCs) occur in PC patients without manifest bone metastases...
  42. ncbi request reprint Monitoring high-risk bladder cancer
    Christian Schwentner
    Department of Urology, Eberhard Karls University, Tuebingen, Germany
    Curr Opin Urol 22:421-6. 2012
    ....
  43. ncbi request reprint Small renal oncocytomas: differentiation with multiphase CT
    Georgios Gakis
    Department of Urology, University Hospital Tubingen, Eberhard Karls University, Hoppe Seyler Strasse 3, Tubingen, Germany
    Eur J Radiol 80:274-8. 2011
    ..To evaluate characteristic imaging findings of tumor attenuation in multiphase computed tomography (CT) between renal oncocytomas and clear-cell renal cell carcinoma (ccRCC) of small tumor size (≤5 cm)...
  44. ncbi request reprint Objective long-term evaluation after distal hypospadias repair using the meatal mobilization technique
    Joerg Seibold
    Department of Urology, Eberhard Karls University, Tuebingen, Germany
    Scand J Urol Nephrol 44:298-303. 2010
    ..This study objectively evaluates individual patient satisfaction using a validated score in the long term...
  45. ncbi request reprint Prospective evaluation of fluorescence-in situ-hybridization to detect bladder cancer: results from the UroScreen-Study
    Séverine Banek
    Department of Urology, Eberhard Karls University, Tubingen, Germany
    Urol Oncol 31:1656-62. 2013
    ..Here we evaluate the cancer-predictive values and potential effect modifiers of fluorescence-in-situ-hybridization (FISH)...
  46. ncbi request reprint Prognostic relevance of postoperative platelet count in upper tract urothelial carcinoma after radical nephroureterectomy
    Georgios Gakis
    Department of Urology, University Hospital Tubingen, Tubingen, Germany Electronic address
    Eur J Cancer 50:2583-91. 2014
    ..To assess the impact of perioperative platelet count (PLT) kinetics on recurrence-free survival (RFS) after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC)...
  47. ncbi request reprint Predictors of survival in patients with disease recurrence after radical nephroureterectomy
    Luis A Kluth
    Department of Urology, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY, USA Department of Urology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    BJU Int 113:911-7. 2014
    ..To investigate whether clinical, pathological and/or biological factors at time of disease recurrence are also associated with cancer-specific outcomes in these patients...
  48. ncbi request reprint Gender-specific differences in muscle-invasive bladder cancer: the concept of sex steroid sensitivity
    Georgios Gakis
    Department of Urology, Eberhard Karls University, Hoppe Seyler Strasse 3, 72076, Tubingen, Germany
    World J Urol 31:1059-64. 2013
    ....
  49. ncbi request reprint Chemoprevention of prostate cancer by isoflavonoids
    Stefan Aufderklamm
    Department of Urology, Eberhard Karls University, Tubingen, Germany
    Recent Results Cancer Res 202:101-8. 2014
    ..Therefore, randomized clinical trials are urgently needed to evaluate in depth its oncologic effects in PC. ..
  50. ncbi request reprint Flow matters: irrigation flow differs in flexible ureteroscopes of the newest generation
    Stephan Kruck
    Department of Urology, University of Tuebingen, Germany
    Urol Res 39:483-6. 2011
    ..This study showed inter-manufactural differences in terms of irrigation flow rates with either empty or occupied working channels resulting in significant alterations in endoscopic view...
  51. ncbi request reprint Do we use the right criteria for determining the clinical significance of incidental prostate cancer at radical cystoprostatectomy?
    Georgios Gakis
    Department of Urology, Eberhard Karls University, Tubingen, Germany
    Scand J Urol 47:358-62. 2013
    ..g. patient age and comorbidities). Assessment of PSCA expression in RCP specimens may enable improved risk assessment for PCa recurrence after RCP...
  52. ncbi request reprint Disseminated and circulating tumor cells for monitoring chemotherapy in urological tumors
    Stephan Kruck
    Department of Urology, Eberhard Karls University Tuebingen, Hoppe Seyler Str 3, D 72076 Tuebingen, Germany
    Anticancer Res 31:2053-7. 2011
    ..Advanced technologies offer new options for estimating the risk of progression after curative-intended surgery and may allow a more effective monitoring of disease progression or response to therapy...
  53. pmc Circulating and disseminated tumor cells in the management of advanced prostate cancer
    Stephan Kruck
    Department of Urology, Eberhard Karls University, Hoppe Seyler Straße 3, 72076 Tubingen, Germany
    Adv Urol 2012:135281. 2012
    ..Careful randomized prospective trials will be required to justify the routine use of CTCs/DTCs for therapy decision making...
  54. ncbi request reprint Novel therapeutic options in metastatic renal cancer - review and post ASCO 2007 update
    Stephan Kruck
    Department of Urology, Eberhard Karls University, Tuebingen, Germany
    Rev Recent Clin Trials 3:212-6. 2008
    ..This review presents and discusses the effectiveness of the most frequently used substances in mono- or combination regimes based on current data of the ASCO 2007...