Genomes and Genes
- Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complexYasuyuki Fujita
Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, 13125 Berlin, Germany
Nat Cell Biol 4:222-31. 2002..Through dynamic recycling of E-cadherin, Hakai can thus modulate cell adhesion, and could participate in the regulation of epithelial--mesenchymal transitions in development or metastasis...
- Rap1 regulates the formation of E-cadherin-based cell-cell contactsCatherine Hogan
MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, University College London, Gower Street, London WC1E 6BT, United Kingdom
Mol Cell Biol 24:6690-700. 2004..Furthermore, our data suggest that Cdc42 functions downstream of Rap1 in this process. We conclude that Rap1 plays a vital role in the establishment of E-cadherin-based cell-cell adhesion...
- The transcriptional repressor Glis2 is a novel binding partner for p120 cateninCatherine Rose Hosking
Medical Research Council Laboratory for Molecular Cell Biology and Cell Biology Unit, Department of Biology, University College London, London WC1E 6BT, UK
Mol Biol Cell 18:1918-27. 2007..These data indicate that p120 has additional novel functions in the nucleus together with Glis2...
- Casein kinase 1 is a novel negative regulator of E-cadherin-based cell-cell contactsSophie Dupre-Crochet
MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, and Department of Biology, University College London, Gower Street, London, United Kingdom
Mol Cell Biol 27:3804-16. 2007..These data indicate that CK1 is a novel negative regulator of cadherin-based cell-cell contacts...
- beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous systemDietmar Zechner
Max Delbrück Center of Molecular Medicine, Robert Rossle Str 10, 13125, Berlin, Germany
Dev Biol 258:406-18. 2003..beta-Catenin signals are thus essential for the maintenance of proliferation of neuronal progenitors, controlling the size of the progenitor pool, and impinging on the decision of neuronal progenitors to proliferate or to differentiate...
- A role for the cleaved cytoplasmic domain of E-cadherin in the nucleusEmma C Ferber
University College London, London, WC1E 6BT, UK
J Biol Chem 283:12691-700. 2008..Finally, we show that E-cad/CTF2 can regulate the p120-Kaiso-mediated signaling pathway in the nucleus. These data indicate a novel role for cleaved E-cadherin in the nucleus...
- Lysosomal targeting of E-cadherin: a unique mechanism for the down-regulation of cell-cell adhesion during epithelial to mesenchymal transitionsFelipe Palacios
Department of Biological Sciences, University of Notre Dame, Box 369, Galvin Life Sciences Bldg, Notre Dame, IN 46556 0369, USA
Mol Cell Biol 25:389-402. 2005..Our studies reveal that the lysosomal targeting of E-cadherin is an important posttranscriptional mechanism to deplete cellular E-cadherin during Src-induced epithelial to mesenchymal transitions...
- Epithelial cell shape and Rho small GTPasesYasuyuki Fujita
MRC Laboratory for Cell and Molecular Biology, Cell Biology Unit and Department of Biology, University College London, UK
Novartis Found Symp 269:144-55; discussion 155-8, 223-30. 2005....
- CTACK/CCL27 accelerates skin regeneration via accumulation of bone marrow-derived keratinocytesDaisuke Inokuma
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Stem Cells 24:2810-6. 2006....
- A novel interaction between kinesin and p120 modulates p120 localization and functionMasahiro Yanagisawa
Mayo Clinic Cancer Center, Jacksonville, Florida 32224, USA
J Biol Chem 279:9512-21. 2004..Taken together, the data suggest that kinesin affects both the targeting and activity of p120 at several cellular locations...
- p32 is a novel mammalian Lgl binding protein that enhances the activity of protein kinase Czeta and regulates cell polarityCarl U Bialucha
Medical Research Council Laboratory for Molecular Cell Biology and Cell Biology Unit, Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, England, UK
J Cell Biol 178:575-81. 2007..p32 knockdown by short hairpin RNA also induces cell polarity defects. Collectively, our data indicate that p32 is a novel regulator of cell polarity that forms a complex with mLgl2 and aPKC and enhances aPKC activity...
- Regulation of cell-cell adhesion by Rap1Yasuyuki Fujita
MRC Laboratory for Molecular and Cell Biology, Cell Biology Unit and Department of Biology, University College, London, United Kingdom
Methods Enzymol 407:359-72. 2006..This is important, because different receptors that accumulate at sites of cell-cell contacts are also able to activate Rap1 (Fukuyama et al., 2005; Mandell et al., 2005)...