Susanne Fuessel

Summary

Country: Germany

Publications

  1. pmc Combined mRNA expression levels of members of the urokinase plasminogen activator (uPA) system correlate with disease-associated survival of soft-tissue sarcoma patients
    Matthias Kotzsch
    Institute of Pathology, Dresden University of Technology, Dresden, Germany
    BMC Cancer 11:273. 2011
  2. ncbi request reprint Chemosensitization of bladder cancer cells by survivin-directed antisense oligodeoxynucleotides and siRNA
    Susanne Fuessel
    Department of Urology, Technical University Dresden, Fetscherstr 74, D 01307 Dresden, Germany
    Cancer Lett 232:243-54. 2006
  3. ncbi request reprint Transcript quantification of Dresden G protein-coupled receptor (D-GPCR) in primary prostate cancer tissue pairs
    Susanne Fuessel
    Department of Urology, Technical University Dresden, Fetscherstr 74, D 01307 Dresden, Germany
    Cancer Lett 236:95-104. 2006
  4. ncbi request reprint Synthetic nucleic acids as potential therapeutic tools for treatment of bladder carcinoma
    Susanne Fuessel
    Department of Urology, Technical University of Dresden, Dresden, Germany
    Eur Urol 51:315-26; discussion 326-7. 2007
  5. ncbi request reprint [Comparative evaluation of expression patterns of established and new prostate carcinoma associated genes with reference to suitability for molecular biologic diagnostic and prognostic factors]
    S Fussel
    Klinik für Urologie, Medizinische Fakultät der TU Dresden, Dresden
    Urologe A 46:1088-9. 2007
  6. ncbi request reprint Quantitative multi-gene expression profiling of primary prostate cancer
    Uta Schmidt
    Department of Urology, Technical University of Dresden, Germany
    Prostate 66:1521-34. 2006
  7. ncbi request reprint Antisense-mediated inhibition of survivin, hTERT and VEGF in bladder cancer cells in vitro and in vivo
    Doreen Kunze
    Department of Urology, Faculty of Medicine, Technical University of Dresden, 01307 Dresden, Germany
    Int J Oncol 32:1049-56. 2008
  8. ncbi request reprint D-GPCR: a novel putative G protein-coupled receptor overexpressed in prostate cancer and prostate
    Bernd Weigle
    Institute of Immunology, Medical Faculty, Technical University of Dresden, Germany
    Biochem Biophys Res Commun 322:239-49. 2004
  9. ncbi request reprint siRNA-mediated down-regulation of survivin inhibits bladder cancer cell growth
    Shuangli Ning
    Department of Urology, Technical University Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
    Int J Oncol 25:1065-71. 2004
  10. ncbi request reprint Multitarget siRNA inhibition of antiapoptotic genes (XIAP, BCL2, BCL-X(L)) in bladder cancer cells
    Doreen Kunze
    Department of Urology, Technical University of Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
    Anticancer Res 28:2259-63. 2008

Collaborators

Detail Information

Publications41

  1. pmc Combined mRNA expression levels of members of the urokinase plasminogen activator (uPA) system correlate with disease-associated survival of soft-tissue sarcoma patients
    Matthias Kotzsch
    Institute of Pathology, Dresden University of Technology, Dresden, Germany
    BMC Cancer 11:273. 2011
    ..However, the mRNA expression of uPA system components has not yet been comprehensively investigated in STS patients...
  2. ncbi request reprint Chemosensitization of bladder cancer cells by survivin-directed antisense oligodeoxynucleotides and siRNA
    Susanne Fuessel
    Department of Urology, Technical University Dresden, Fetscherstr 74, D 01307 Dresden, Germany
    Cancer Lett 232:243-54. 2006
    ..Nevertheless, both therapy approaches in combination with all tested chemotherapeutics provoked a remarkable inhibition of viability and may serve as suitable additive tools for chemosensitization of bladder cancer cells...
  3. ncbi request reprint Transcript quantification of Dresden G protein-coupled receptor (D-GPCR) in primary prostate cancer tissue pairs
    Susanne Fuessel
    Department of Urology, Technical University Dresden, Fetscherstr 74, D 01307 Dresden, Germany
    Cancer Lett 236:95-104. 2006
    ..6452. Hence, the evaluation of D-GPCR as possible additive diagnostic tool and putative therapy target appears promising...
  4. ncbi request reprint Synthetic nucleic acids as potential therapeutic tools for treatment of bladder carcinoma
    Susanne Fuessel
    Department of Urology, Technical University of Dresden, Dresden, Germany
    Eur Urol 51:315-26; discussion 326-7. 2007
    ..Therefore, silencing of abnormally activated genes appears to be a rational approach for specific target-directed and sensitising therapies...
  5. ncbi request reprint [Comparative evaluation of expression patterns of established and new prostate carcinoma associated genes with reference to suitability for molecular biologic diagnostic and prognostic factors]
    S Fussel
    Klinik für Urologie, Medizinische Fakultät der TU Dresden, Dresden
    Urologe A 46:1088-9. 2007
  6. ncbi request reprint Quantitative multi-gene expression profiling of primary prostate cancer
    Uta Schmidt
    Department of Urology, Technical University of Dresden, Germany
    Prostate 66:1521-34. 2006
    ..This study describes the evaluation of the expression patterns of prostate-related transcripts in 106 matched prostate tissues from prostatectomies as predictors for prostate cancer (PCa)...
  7. ncbi request reprint Antisense-mediated inhibition of survivin, hTERT and VEGF in bladder cancer cells in vitro and in vivo
    Doreen Kunze
    Department of Urology, Faculty of Medicine, Technical University of Dresden, 01307 Dresden, Germany
    Int J Oncol 32:1049-56. 2008
    ..In vivo studies with 9 consecutive intraperitoneal injections with 20 mg/kg AS-ODNs or 4.6 mg/kg siRNAs revealed the biocompatibility of both antisense inhibitor types and showed anti-tumoural activity of the AS-ODNs used...
  8. ncbi request reprint D-GPCR: a novel putative G protein-coupled receptor overexpressed in prostate cancer and prostate
    Bernd Weigle
    Institute of Immunology, Medical Faculty, Technical University of Dresden, Germany
    Biochem Biophys Res Commun 322:239-49. 2004
    ..These data provide the basis for future studies evaluating the diagnostic potential of D-GPCR and its utility as a novel target in immunotherapy of prostate cancer...
  9. ncbi request reprint siRNA-mediated down-regulation of survivin inhibits bladder cancer cell growth
    Shuangli Ning
    Department of Urology, Technical University Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
    Int J Oncol 25:1065-71. 2004
    ..In summary, the results suggest that the anti-survivin siRNA treatment might represent a suitable therapeutic approach to selectively inhibit growth of BCa cells in addition to commonly applied therapy schemes...
  10. ncbi request reprint Multitarget siRNA inhibition of antiapoptotic genes (XIAP, BCL2, BCL-X(L)) in bladder cancer cells
    Doreen Kunze
    Department of Urology, Technical University of Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
    Anticancer Res 28:2259-63. 2008
    ..The knockdown of XIAP, BCL2 and BCL-X(L) by siRNAs represents a promising treatment option for bladder cancer (BCa) since the overexpression of antiapoptotic genes is often associated with tumor progression and treatment resistance...
  11. ncbi request reprint D-TMPP: a novel androgen-regulated gene preferentially expressed in prostate and prostate cancer that is the first characterized member of an eukaryotic gene family
    Andrea Kiessling
    Institute of Immunology, Medical Faculty Carl Gustav Carus, Technical University of Dresden, Dresden, Germany
    Prostate 64:387-400. 2005
    ..Here, we identify the novel gene Dresden-transmembrane protein of the prostate (D-TMPP) that is overexpressed in human prostate and prostate cancer...
  12. doi request reprint Gene signatures of pulmonary metastases of renal cell carcinoma reflect the disease-free interval and the number of metastases per patient
    Daniela Wuttig
    Department of Urology, Dresden University of Technology, Dresden, Germany
    Int J Cancer 125:474-82. 2009
    ..To what extent the identified molecular factors contribute to the development of these characteristics of metastatic spread needs to be analyzed in further studies...
  13. ncbi request reprint Vaccination of hormone-refractory prostate cancer patients with peptide cocktail-loaded dendritic cells: results of a phase I clinical trial
    Susanne Fuessel
    Department of Urology, Medical Faculty, Technical University Dresden, Dresden, Germany
    Prostate 66:811-21. 2006
    ....
  14. ncbi request reprint D-PCa-2: a novel transcript highly overexpressed in human prostate and prostate cancer
    Bernd Weigle
    Institute of Immunology, Medical Faculty, Technical University Dresden, Dresden, Germany
    Int J Cancer 109:882-92. 2004
    ..These results validate D-PCa-2 as a transcript with high tissue specificity and with a potential application in the diagnosis of PCa...
  15. ncbi request reprint Functional analyses of C13orf19/P38IP in prostate cell lines
    Doreen Kunze
    Department of Urology, Technical University Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
    Oncol Rep 15:1599-604. 2006
    ..No interaction between C13orf19 and p38MAPK was identified. Therefore, the gene should forthwith be named C13orf19 or Fam48A and not P38IP...
  16. pmc Loss of heterozygosity and copy number abnormality in clear cell renal cell carcinoma discovered by high-density affymetrix 10K single nucleotide polymorphism mapping array
    Marieta I Toma
    Institute for Pathology, University of Technology Dresden, D 01307 Dresden, Germany
    Neoplasia 10:634-42. 2008
    ..Genome-wide SNP array analysis not only confirmed previously described large chromosomal aberrations but also detected novel microdeletions in genes potentially involved in tumor genesis of cc-RCC...
  17. ncbi request reprint Telomerase inhibition by synthetic nucleic acids and chemosensitization in human bladder cancer cell lines
    Kai Kraemer
    Department of Urology, Technical University Dresden, Dresdan, Gernany
    Methods Mol Biol 405:9-22. 2007
    ..Methods for a successful down-regulation of hTERT and for the quantitative determination of resulting effects on cellular growth were described herein...
  18. ncbi request reprint Chemosensitization of bladder cancer cell lines by human telomerase reverse transcriptase antisense treatment
    Kai Kraemer
    Department of Urology, Technical University Dresden, Dresden, Germany
    J Urol 172:2023-8. 2004
    ..We investigated whether combinations of hTERT antisense (AS)-oligonucleotides (ODNs) with common chemotherapy (CT) schedules may improve drug mediated antitumor effects...
  19. ncbi request reprint Microarray analyses in bladder cancer cells: inhibition of hTERT expression down-regulates EGFR
    Kai Kraemer
    Department of Urology, Technical University of Dresden, Dresden, Germany
    Int J Cancer 119:1276-84. 2006
    ..The detailed clarification of these processes will shed light on the question, whether telomerase inhibitors might constitute suitable anticancer tools...
  20. ncbi request reprint Vascular endothelial growth factor antisense pretreatment of bladder cancer cells significantly enhances the cytotoxicity of mitomycin C, gemcitabine and Cisplatin
    Sabine Krause
    Institutes of Biochemistry, Technical University Dresden, Dresden, Germany
    J Urol 174:328-31. 2005
    ..We investigated the possibility of sensitizing transitional bladder cancer cell lines to CT by pretreatment with VEGF antisense (AS) oligodeoxynucleotides (AS-ODNs)...
  21. ncbi request reprint Systematic in vitro evaluation of survivin directed antisense oligodeoxynucleotides in bladder cancer cells
    Susanne Fuessel
    Department of Urology and Institute of Pathology, Technical University Dresden, Dresden, Germany
    J Urol 171:2471-6. 2004
    ..Survivin, an apoptosis inhibitor that is up-regulated in the majority of malignancies, including BCa, provides an attractive target for molecular therapies, such as treatment with specific antisense oligode-oxynucleotides (AS-ODNs)...
  22. ncbi request reprint Urokinase receptor splice variant uPAR-del4/5-associated gene expression in breast cancer: identification of rab31 as an independent prognostic factor
    Matthias Kotzsch
    Institute of Pathology, Dresden University of Technology, Fetscherstr 74, 01307, Dresden, Germany
    Breast Cancer Res Treat 111:229-40. 2008
    ..To evaluate the pure prognostic impact of the uPA-receptor splice variant uPAR-del4/5 for lymph node-negative breast cancer patients, and to identify differentially expressed genes associated with high or low uPAR-del4/5 mRNA levels...
  23. ncbi request reprint Quantification of C13orf19/P38IP mRNA expression by quantitative real-time PCR in patients with urological malignancies
    Uta Schmidt
    Department of Urology, Technical University of Dresden, Fetscherstr 74, D 01307 Dresden, Germany
    Cancer Lett 225:253-60. 2005
    ..5-fold upregulation was observed in samples from 17 patients (28%). In contrast, C13orf19 mRNA alterations in expression seemed to be random events in kidney cancers...
  24. doi request reprint Deregulated expression of urokinase and its inhibitor type 1 in prostate cancer cells: role of epigenetic mechanisms
    Albert Hagelgans
    Institute of Clinical Chemistry and Laboratory Medicine of Technical University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, Germany
    Exp Mol Pathol 94:458-65. 2013
    ..Methylation of the PAI-1 gene is suggested as one of the molecular mechanisms involved in the cancer-associated down-regulation of the PAI-1 expression...
  25. doi request reprint Importance of erythrocyte band III anion transporter (SLC4A1) on oxalate clearance of calcium oxalate monohydrate stone-formering patients vs. normal controls
    Sven Oehlschläger
    Department of Urology, Technical University, Dresden, Germany
    Urology 77:250.e1-5. 2011
    ....
  26. ncbi request reprint Multiple tumor marker analyses (PSA, hK2, PSCA, trp-p8) in primary prostate cancers using quantitative RT-PCR
    Susanne Fuessel
    Department of Urology, Technical University Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
    Int J Oncol 23:221-8. 2003
    ..According to our data, the novel marker trp-p8 seems to represent a highly prostate-specific and PCa-associated gene qualifying it as a potential target for specific therapies...
  27. ncbi request reprint siRNA-mediated inhibition of antiapoptotic genes enhances chemotherapy efficacy in bladder cancer cells
    Doreen Kunze
    Department of Urology, University Hospital Carl Gustav Carus, Technical University of Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
    Anticancer Res 32:4313-8. 2012
    ..Therefore, the knockdown of these four genes could sensitise bladder cancer (BCa) cells towards chemotherapy...
  28. ncbi request reprint Antisense-mediated hTERT inhibition specifically reduces the growth of human bladder cancer cells
    Kai Kraemer
    Department of Urology, Technical University Dresden, D 01307, Dresden, Germany
    Clin Cancer Res 9:3794-800. 2003
    ..The aim of this study was to investigate whether hTERT inhibition by antisense oligodeoxynucleotides (AS-ODN) can act as an efficient strategy to specifically impair the growth of bladder cancer (BCa) cells in vitro...
  29. ncbi request reprint Quantification of disseminated tumor cells in the bloodstream of patients with hormone-refractory prostate carcinoma undergoing cytotoxic chemotherapy
    Uta Schmidt
    Technical University of Dresden, Department of Urology, D 01307 Dresden, Germany
    Int J Oncol 24:1393-9. 2004
    ..This study demonstrates that circulating tumor cells are detectable during chemotherapy for hormone-refractory prostate cancer regardless of the degree of PSA response...
  30. pmc Simultaneous siRNA-mediated knockdown of antiapoptotic BCL2, Bcl-xL, XIAP and survivin in bladder cancer cells
    Doreen Kunze
    Department of Urology, University Hospital Carl Gustav Carus, Technical University of Dresden, D 01307 Dresden, Germany
    Int J Oncol 41:1271-7. 2012
    ..5-fold enhancement in apoptosis rate and reduced cellular viability by 40%. Therefore, simultaneous knockdown of antiapoptotic BCL2, Bcl‑xL, XIAP and survivin may represent a promising treatment option for bladder cancer...
  31. ncbi request reprint Prognostic relevance of uPAR-del4/5 and TIMP-3 mRNA expression levels in breast cancer
    Matthias Kotzsch
    Institute of Pathology, Technical University Dresden, Fetscherstr 74, D 01307 Dresden, Germany
    Eur J Cancer 41:2760-8. 2005
    ..Therefore, considering the prognostic impact of two proteolytic factors stemming from complementary protease systems may improve the prediction of disease recurrence in breast cancer...
  32. ncbi request reprint Qualitative and quantitative assessment of urinary cytokeratin 8 and 18 fragments compared with voided urine cytology in diagnosis of bladder carcinoma
    Oliver W Hakenberg
    Department of Urology, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Urology 64:1121-6. 2004
    ..To evaluate the value of urine tests based on the detection of cytokeratins 8 and 18 for the diagnosis of bladder cancer compared with urine cytology...
  33. pmc Analyses of potential predictive markers and survival data for a response to sunitinib in patients with metastatic renal cell carcinoma
    Juana Dornbusch
    Department of Urology, Dresden University of Technology, Dresden, Germany
    PLoS ONE 8:e76386. 2013
    ..Furthermore, the angiogenic phenotype of ccRCC is also reflected by endothelial markers (CD31, CD34) or other tumor-promoting factors like Ki67 or survivin...
  34. doi request reprint Serum amyloid A, phospholipase A₂-IIA and C-reactive protein as inflammatory biomarkers for prostate diseases
    Mario Menschikowski
    Medical Faculty Carl Gustav Carus, Institute of Clinical Chemistry and Laboratory Medicine, Technical University of Dresden, Fetscherstrasse 74, 01307, Dresden, Germany
    Inflamm Res 62:1063-72. 2013
    ....
  35. doi request reprint Expression profile of WNT molecules in prostate cancer and its regulation by aminobisphosphonates
    Sylvia Thiele
    Division of Endocrinology, Diabetes, and Metabolic Bone Diseases, Department of Medicine III, Technical University, Dresden, Germany
    J Cell Biochem 112:1593-600. 2011
    ..The WNT signaling pathway is up-regulated in advanced PCa, differentially expressed in osteotropic versus non-osteotropic cells, and is regulated by zoledronic acid...
  36. pmc Enhanced Inhibition of Bladder Cancer Cell Growth by Simultaneous Knockdown of Antiapoptotic Bcl-xL and Survivin in Combination with Chemotherapy
    Doreen Kunze
    Department of Urology, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Int J Mol Sci 14:12297-312. 2013
    ....
  37. doi request reprint Immunohistochemical analysis of prognostic protein markers for primary localized clear cell renal cell carcinoma
    Thomas Weber
    Department of Urology, Technical University of Dresden, Dresden, Germany
    Cancer Invest 31:51-9. 2013
    ..A score-variable, combining Ki67-, p21-, and nS-staining identified a subset of patients with high risk of disease recurrence and increased predictive ability in the multivariate model to 84%...
  38. doi request reprint Role of cellular oxalate in oxalate clearance of patients with calcium oxalate monohydrate stone formation and normal controls
    Sven Oehlschläger
    Department of Urology, University Hospital Carl Gustav Carus Technical University, Dresden, Germany
    Urology 73:480-3. 2009
    ..An underlying cause of deficient oxalate clearance could be defective transmembrane oxalate transport, which, in many tissues, is regulated by an anion exchanger (SLC26)...
  39. ncbi request reprint [Multifunctional carbon nano-tubes for biomedical applications (CARBIO). A project of the European Marie Curie Network]
    K Kramer
    Klinik für Urologie, Medizinische Fafultät, Technische Universitat Dresden, Fetscherstrasse 74, 01307 Dresden
    Urologe A 46:1248. 2007
  40. ncbi request reprint Comparative evaluation of microsatellite marker, AP-PCR and CGH studies in primary renal cell carcinoma
    Christian Hoefling
    Department of Urology, Technical University Dresden, D 01307 Dresden, Germany
    Int J Mol Med 13:835-42. 2004
    ..Based on this study of RCC and in contrast to other reports for solid tumors, we conclude that AP-PCR is far less informative in investigation of renal cancers...
  41. doi request reprint Serum levels of secreted group IIA phospholipase A(2) in benign prostatic hyperplasia and prostate cancer: a biomarker for inflammation or neoplasia?
    Mario Menschikowski
    Institute of Clinical Chemistry and Laboratory Medicine, Medical Faculty Carl Gustav Carus, Technical University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Inflammation 35:1113-8. 2012
    ....