Research Topics
| Dmitrij FrishmanSummaryCountry: Germany Publications
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Detail Information
Publications
Assignment of isochores for all completely sequenced vertebrate genomes using a consensusThorsten Schmidt
Department of Genome Oriented Bioinformatics, Wissenschaftszentrum Weihenstephan, Technische Universitat Munchen, D 85350 Freising, Germany
Genome Biol 9:R104. 2008..We present a new consensus isochore assignment method based on majority voting and provide IsoBase, a comprehensive on-line database of isochore maps for all completely sequenced vertebrate genomes...
Protein abundance profiling of the Escherichia coli cytosolYasushi Ishihama
Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997 0017, Japan
BMC Genomics 9:102. 2008..Thus far, protein concentrations have been difficult to measure on a large scale, but proteomic technologies have now advanced to a stage where this information becomes readily accessible...
Testis-specific glyceraldehyde-3-phosphate dehydrogenase: origin and evolutionMikhail L Kuravsky
Faculty of Bioengineering and Bioinformatics, MV Lomonosov Moscow State University, Moscow, Russian Federation
BMC Evol Biol 11:160. 2011..In this study we investigate the evolutionary history of GAPD and gain some insights into specialization of GAPD-2 as a testis-specific protein...
Alternative splicing and protein functionA D Neverov
State Scientific Center GosNIIGenetika, 1st Dorozhny Proezd 1, Moscow, 117545, Russia
BMC Bioinformatics 6:266. 2005..The problem is obscured by uneven coverage of genes by ESTs and a large number of artifacts in the EST data...
TargetSpy: a supervised machine learning approach for microRNA target predictionMartin Sturm
Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, Neuherberg, Germany
BMC Bioinformatics 11:292. 2010..Recently however, it has been shown that this requirement might be too stringent, leading to a substantial number of missed target sites...
No statistical support for correlation between the positions of protein interaction sites and alternatively spliced regionsMarc N Offman
Department of Genome Oriented Bioinformatics, Technical University of Munich, Wissenschaftszentrum Weihenstephan, 85350 Freising, Germany
BMC Bioinformatics 5:41. 2004..The objective of this work was to test the hypothesis that alternative splicing is correlated with contact regions of protein-protein interactions...
Applying negative rule mining to improve genome annotationIrena I Artamonova
Institute for Bioinformatics, GSF National Research Center for Environment and Health, Neuherberg, Germany
BMC Bioinformatics 8:261. 2007..Here we investigate the applicability of negative association rule mining to revealing erroneously assigned annotation items...
An evolutionary and structural characterization of mammalian protein complex organizationPhilip Wong
Helmholtz Center Munich German Research Center for Environmental Health GmbH, Institute of Bioinformatics and Systems Biology, Ingolstadter Landstrasse 1, Neuherberg, Germany
BMC Genomics 9:629. 2008..Combining CORUM with other resources, we assembled a dataset of over 2700 mammalian complexes. The availability of a rich information resource allows us to search for organizational properties concerning these complexes...
Ionic interactions promote transmembrane helix-helix association depending on sequence contextJana R Herrmann
Lehrstuhl für Chemie der Biopolymere, Department für biowissenschaftliche Grundlagen, Technische Universitat Munchen, Freising, Germany
J Mol Biol 396:452-61. 2010..We conclude that intramembrane charge-charge interactions depend on sequence context. Moreover, they appear important for homotypic and heterotypic interactions of numerous natural TMDs...
DIMA 2.0--predicted and known domain interactionsPhilipp Pagel
Lehrstuhl für Genomorientierte Bioinformatik, Wissenschaftszentrum Weihenstephan, Technische Universitat Munchen, Am Forum 1, D 85350 Freising, Germany
Nucleic Acids Res 36:D651-5. 2008..Taken together, these two resources yielded 3653 distinct interacting domain pairs. DIMA is available at http://mips.gsf.de/genre/proj/dima...
Complex patterns of histidine, hydroxylated amino acids and the GxxxG motif mediate high-affinity transmembrane domain interactionsJana R Herrmann
Lehrstuhl für Chemie der Biopolymere, Department für biowissenschaftliche Grundlagen, Technische Universitat Munchen, Weihenstephaner Berg 3, 85354 Freising, Germany
J Mol Biol 385:912-23. 2009..Notably, a similar motif contributes to self-interaction of the BNIP3 transmembrane domain...
Co-evolving residues in membrane proteinsAngelika Fuchs
Department of Genome Oriented Bioinformatics, Technische Universitat Munchen, Wissenschaftszentrum Weihenstephan, 85350 Freising, Germany
Bioinformatics 23:3312-9. 2007..Membrane proteins, which constitute between one-fourth and one-third of all proteins in an organism, were only considered in few individual case studies...
PROMPT: a protein mapping and comparison toolThorsten Schmidt
Department of Genome Oriented Bioinformatics, Technische Universitat Munchen, Wissenschaftszentrum Weihenstephan, 85350 Freising, Germany
BMC Bioinformatics 7:331. 2006....
Current status of membrane protein structure classificationSindy Neumann
Department of Genome Oriented Bioinformatics, Technische Universitat Munchen, Wissenschaftszentrum Weihenstephan, D 85354 Freising, Germany
Proteins 78:1760-73. 2010....
Protein solubility: sequence based prediction and experimental verificationPawel Smialowski
Department of Genome Oriented Bioinformatics, Technische Universitat Munchen, Wissenschaftszentrum Weihenstephan, 85350 Freising, Germany
Bioinformatics 23:2536-42. 2007..We also provide experimental verification of our predictions using solubility measurements for 31 mutational variants of two different proteins...
Structural comparison and classification of alpha-helical transmembrane domains based on helix interaction patternsAngelika Fuchs
Department of Genome Oriented Bioinformatics, Technische Universitat Munchen, Wissenschaftszentrum Weihenstephan, Freising 85354, Germany
Proteins 78:2587-99. 2010....
The DIMA web resource--exploring the protein domain networkPhilipp Pagel
Department of Genome Oriented Bioinformatics, Technical University of Munich, Wissenschaftszentrum Weihenstephan, 85350 Freising, Germany
Bioinformatics 22:997-8. 2006..A powerful yet simple user interface enables the user to compute, visualize, navigate and download domain networks based on specific search criteria. Availability: http://mips.gsf.de/genre/proj/dima..
Prediction of helix-helix contacts and interacting helices in polytopic membrane proteins using neural networksAngelika Fuchs
Department of Genome Oriented Bioinformatics, Technische Universitat Munchen, Wissenschaftszentrum Weihenstephan, 85354 Freising, Germany
Proteins 74:857-71. 2009..Because the reliable prediction of helix interaction patterns is an important step in the classification and prediction of membrane protein folds, our method will be a helpful tool in compiling a structural census of membrane proteins...
Prediction of beta-turns and beta-turn types by a novel bidirectional Elman-type recurrent neural network with multiple output layers (MOLEBRNN)Andreas Kirschner
Department of Genome Oriented Bioinformatics, Technische Universitat Munchen, Weihenstephan, Germany
Gene 422:22-9. 2008..The MOLEBRNN presented here is a generic method applicable in a variety of research fields where multiple mutually depending target classes need to be predicted. Availability: http://webclu.bio.wzw.tum.de/predator-web/...
Designability and diseasePhilip Wong
Institute for Bioinformatics, GSF National Research Center for Environment and Health, Neuherberg, Germany
Methods Mol Biol 484:491-504. 2008..Here, we describe definitions and principles underlying the concept of designability and discuss its relation to disease...
Predicting experimental properties of proteins from sequence by machine learning techniquesPawel Smialowski
Department of Genome Oriented Bioinformatics, Technische Universitat Munchen, Wissenschaftszentrum Weihenstephan, 85350 Freising, Germany
Curr Protein Pept Sci 8:121-33. 2007..We also describe experimental data repositories and machine learning techniques used for classification and feature selection...
Predicting experimental properties of integral membrane proteins by a naive Bayes approachAntonio J Martin-Galiano
Department of Genome Oriented Bioinformatics, Technische Universitat Munchen, Wissenchaftszentrum Weihenstephan, 85350 Freising, Germany
Proteins 70:1243-56. 2008..In most cases, sets of 10-20 protein features were found actually relevant, most notably, the content of isoleucine, valine, and positively-charged residues...
PEDANT covers all complete RefSeq genomesMathias C Walter
Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health GmbH, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
Nucleic Acids Res 37:D408-11. 2009..PEDANT is freely accessible to academic users at http://pedant.gsf.de. For programmatic access Web Services are available at http://pedant.gsf.de/webservices.jsp...
Defining the fold space of membrane proteins: the CAMPS databaseAntonio J Martin-Galiano
Department of Genome Oriented Bioinformatics, Technische Universitat Munchen, Freising, Germany
Proteins 64:906-22. 2006....
Mining sequence annotation databanks for association patternsIrena I Artamonova
Institute for Bioinformatics, GSF-National Research Center for Environment and Health, Neuherberg, Germany
Bioinformatics 21:iii49-57. 2005..AVAILABILITY: All data generated in this study are available for download and browsing at http://pedant.gsf.de/ARIA/index.htm...
Protein annotation at genomic scale: the current statusDmitrij Frishman
Department of Genome Oriented Bioinformatics, , Wissenchaftszentrum Weihenstephan, 85350 Freising, Germany
Chem Rev 107:3448-66. 2007
Will my protein crystallize? A sequence-based predictorPawel Smialowski
Department of Genome Oriented Bioinformatics, Technische Universitat Munchen, Wissenschaftszentrum Weihenstephan, Freising, Germany
Proteins 62:343-55. 2006..A Web server for protein crystallizability prediction called SECRET is available at http://webclu.bio.wzw.tum.de:8080/secret...
Phenylalanine promotes interaction of transmembrane domains via GxxxG motifsStephanie Unterreitmeier
Technische Universitat Munchen, Lehrstuhl für Chemie der Biopolymere, Weihenstephaner Berg 3, D 85354 Freising Weihenstephan, and Munich Center For Integrated Protein Science CIPS M, Germany
J Mol Biol 374:705-18. 2007..We conclude that Phe stabilises membrane-spanning GxxxG motifs. This is one example of how the role of certain side-chains in helix-helix interfaces is modulated by sequence context...
DIMA 3.0: Domain Interaction MapQibin Luo
Department of Genome Oriented Bioinformatics, Technische Universitat Munchen, Wissenschaftszentrum Weihenstephan, 85350 Freising, Germany
Nucleic Acids Res 39:D724-9. 2011..The DIMA Web site allows to calculate domain interaction networks either for a domain of interest or for entire organisms, and to explore them interactively using the Flash-based Cytoscape Web software...
STRIDE: a web server for secondary structure assignment from known atomic coordinates of proteinsMatthias Heinig
Department of Genome Oriented Bioinformatics, Technical University of Munich, Wissenschaftszentrum Weihenstephan, 85354 Freising, Germany
Nucleic Acids Res 32:W500-2. 2004..A searchable database of STRIDE assignments for the latest PDB release is also provided. The STRIDE server is accessible from http://webclu.bio.wzw.tum.de/stride/...
Complex principal component and correlation structure of 16 yeast genomic variablesFabian J Theis
Helmholtz Center Munich German Research Center for Environmental Health, Institute of Bioinformatics and Systems Biology, Ingolstädter Landstraße 1, Neuherberg, Germany
Mol Biol Evol 28:2501-12. 2011..cerevisiae, and Homo sapiens (http://webclu.bio.wzw.tum.de:18080/quagmire)...
Fold designability, distribution, and diseasePhilip Wong
Institute for Bioinformatics, GSF--National Research Center for Environment and Health, Neuherberg, Germany
PLoS Comput Biol 2:e40. 2006..These results suggest that family counts reflect how certain structures are distributed in nature and is an important characteristic associated with many human diseases...
