R Zell

Summary

Affiliation: Friedrich Schiller University
Country: Germany

Publications

  1. ncbi request reprint Application of genome sequence information to the classification of bovine enteroviruses: the importance of 5'- and 3'-nontranslated regions
    R Zell
    Institut fur Virologie, Klinikum der Friedrich Schiller Universität, Jena, Germany
    Virus Res 51:213-29. 1997
  2. ncbi request reprint Global climate change and the emergence/re-emergence of infectious diseases
    Roland Zell
    Institute for Virology and Antiviral Therapy, Medical Center at the Friedrich Schiller University, Jena, Germany
    Int J Med Microbiol 293:16-26. 2004
  3. ncbi request reprint Nitric oxide donors inhibit the coxsackievirus B3 proteinases 2A and 3C in vitro, virus production in cells, and signs of myocarditis in virus-infected mice
    Roland Zell
    Institute for Virology, Medical Center at the Friedrich Schiller University, Winzerlaer Strasse 10, 07745 Jena, Germany
    Med Microbiol Immunol 193:91-100. 2004
  4. ncbi request reprint Linkage map of protein-protein interactions of Porcine teschovirus
    Roland Zell
    Institute for Virology and Antiviral Therapy, Hans Knöll Str 2, D 07745 Jena, Germany
    J Gen Virol 86:2763-8. 2005
  5. pmc Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C
    Roland Zell
    Institut fur Virologie, Klinikum der Friedrich Schiller Universität, Jena, Germany
    RNA 8:188-201. 2002
  6. pmc Porcine teschoviruses comprise at least eleven distinct serotypes: molecular and evolutionary aspects
    R Zell
    Institut fur Virologie, Klinikum der Friedrich Schiller Universität, 07745 Jena, Germany
    J Virol 75:1620-31. 2001
  7. ncbi request reprint Functional features of the bovine enterovirus 5'-non-translated region
    R Zell
    Institut fur Virologie, Klinikum der Friedrich Schiller Universität, Jena, Germany
    J Gen Virol 80:2299-309. 1999
  8. ncbi request reprint Detection of porcine enteroviruses by nRT-PCR: differentiation of CPE groups I-III with specific primer sets
    R Zell
    Institut fur Virologie, Klinikum der Friedrich Schiller Universität, Winzerlaer Str 10, 07745 Jena, Germany
    J Virol Methods 88:205-18. 2000
  9. doi request reprint Monitoring prevalence of varicella-zoster virus clades in Germany
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Jena University Hospital, Hans Knoell Strasse 2, 07745, Jena, Germany
    Med Microbiol Immunol 200:99-107. 2011
  10. ncbi request reprint DNA vaccine-mediated immune responses in Coxsackie virus B3-infected mice
    A Henke
    Institute of Virology, Medical Center, Friedrich Schiller University, Winzerlaer Str 10, D 07745 Jena, Germany
    Antiviral Res 49:49-54. 2001

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Application of genome sequence information to the classification of bovine enteroviruses: the importance of 5'- and 3'-nontranslated regions
    R Zell
    Institut fur Virologie, Klinikum der Friedrich Schiller Universität, Jena, Germany
    Virus Res 51:213-29. 1997
    ..For rhinoviruses, the existence of two virus clusters was confirmed...
  2. ncbi request reprint Global climate change and the emergence/re-emergence of infectious diseases
    Roland Zell
    Institute for Virology and Antiviral Therapy, Medical Center at the Friedrich Schiller University, Jena, Germany
    Int J Med Microbiol 293:16-26. 2004
    ..The complexity of not yet fully understood pathogen transmission dynamics with numerous variables might be an explanation of the problems in assessing the risk factors...
  3. ncbi request reprint Nitric oxide donors inhibit the coxsackievirus B3 proteinases 2A and 3C in vitro, virus production in cells, and signs of myocarditis in virus-infected mice
    Roland Zell
    Institute for Virology, Medical Center at the Friedrich Schiller University, Winzerlaer Strasse 10, 07745 Jena, Germany
    Med Microbiol Immunol 193:91-100. 2004
    ....
  4. ncbi request reprint Linkage map of protein-protein interactions of Porcine teschovirus
    Roland Zell
    Institute for Virology and Antiviral Therapy, Hans Knöll Str 2, D 07745 Jena, Germany
    J Gen Virol 86:2763-8. 2005
    ..Unlike the poliovirus 3C, the teschovirus 3C proteinase dimerizes and interacts with 2BC, 3CD and 3D. The strongest interactions were observed for L-3C, L-3CD and 3C-3CD...
  5. pmc Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C
    Roland Zell
    Institut fur Virologie, Klinikum der Friedrich Schiller Universität, Jena, Germany
    RNA 8:188-201. 2002
    ..Binding assays using mutated versions of CVB3 and HRV14 cloverleaf RNAs suggest that the presence of structural features rather than a defined sequence motif of loop D are important for 3C proteinase-RNA interaction...
  6. pmc Porcine teschoviruses comprise at least eleven distinct serotypes: molecular and evolutionary aspects
    R Zell
    Institut fur Virologie, Klinikum der Friedrich Schiller Universität, 07745 Jena, Germany
    J Virol 75:1620-31. 2001
    ..Sequencing of field isolates collected from animals presenting with neurological disorders prove that other serotypes than PTV-1 may also cause polioencephalomyelitis of swine...
  7. ncbi request reprint Functional features of the bovine enterovirus 5'-non-translated region
    R Zell
    Institut fur Virologie, Klinikum der Friedrich Schiller Universität, Jena, Germany
    J Gen Virol 80:2299-309. 1999
    ....
  8. ncbi request reprint Detection of porcine enteroviruses by nRT-PCR: differentiation of CPE groups I-III with specific primer sets
    R Zell
    Institut fur Virologie, Klinikum der Friedrich Schiller Universität, Winzerlaer Str 10, 07745 Jena, Germany
    J Virol Methods 88:205-18. 2000
    ....
  9. doi request reprint Monitoring prevalence of varicella-zoster virus clades in Germany
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Jena University Hospital, Hans Knoell Strasse 2, 07745, Jena, Germany
    Med Microbiol Immunol 200:99-107. 2011
    ..In primary VZV infection, nearly 20% of clade 1 has been replaced by clade 5 that might spread more effectively in the population than the European VZV clades...
  10. ncbi request reprint DNA vaccine-mediated immune responses in Coxsackie virus B3-infected mice
    A Henke
    Institute of Virology, Medical Center, Friedrich Schiller University, Winzerlaer Str 10, D 07745 Jena, Germany
    Antiviral Res 49:49-54. 2001
    ..In summary, our results indicate that the induction of B cell and/or T cell memory in vaccinated mice prior to challenge is responsible for the protection observed...
  11. doi request reprint High prevalence of amantadine resistance among circulating European porcine influenza A viruses
    Andi Krumbholz
    Institut für Virologie und Antivirale Therapie, Universitatsklinikum Jena, Hans Knöll Str 2, D 07745 Jena, Germany
    J Gen Virol 90:900-8. 2009
    ..Transfer of amantadine resistance by exchange of the M segment and viability of recombinant A/WSN/33 viruses with avian-like M segments raises concerns about the emergence of natural human reassortants...
  12. doi request reprint Genotypes of varicella-zoster virus wild-type strains in Germany
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Jena, Germany
    J Med Virol 80:1123-30. 2008
    ..The possible recombinant could not be classified definitely by the scattered SNP method used and, therefore, has to be confirmed by full-genome sequencing studies...
  13. ncbi request reprint Attachment of coxsackievirus B3 variants to various cell lines: mapping of phenotypic differences to capsid protein VP1
    M Schmidtke
    Institute for Virology, Medical Center at the Friedrich Schiller University, Winzerlaer Str 10, Jena D 07745, Germany
    Virology 275:77-88. 2000
    ..Moreover, the lytic replication of CVB3 PD and the hybrid virus in various nonpermissive rodent cell lines indicates that cell surface molecules other than CAR and DAF may be involved in attachment of this variant to cell surfaces...
  14. pmc Expression of immunoregulatory cytokines by recombinant coxsackievirus B3 variants confers protection against virus-caused myocarditis
    A Henke
    Institute of Virology, Medical Center, Friedrich Schiller University, D 07745 Jena, Germany
    J Virol 75:8187-94. 2001
    ..This study demonstrates that expression of immunoregulatory cytokines during CVB3 replication simultaneously protects mice against a lethal disease and prevents virus-caused tissue destruction...
  15. pmc Variability of immediate-early gene 62 in german varicella-zoster virus wild-type strains
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
    J Clin Microbiol 47:3717-20. 2009
    ..M1 strains in Germany display a uniform ORF 62 pattern, suggesting that these strains were introduced from Africa and/or Asia via few sources during the last years...
  16. ncbi request reprint The apoptotic capability of coxsackievirus B3 is influenced by the efficient interaction between the capsid protein VP2 and the proapoptotic host protein Siva
    A Henke
    Institute of Virology, Medical Center, Friedrich Schiller University Jena, Winzerlaer Strasse 10, D 07745 Jena, Germany
    Virology 289:15-22. 2001
    ..Together, these results show that the interaction between VP2 of CVB3H3 and Siva is a highly specific process involving distinct amino acids on both proteins that most likely influence the outcome of CVB3-caused disease...
  17. ncbi request reprint Detection of porcine teschoviruses and enteroviruses by LightCycler real-time PCR
    Andi Krumbholz
    Institut für Virologie und Antivirale Therapie, Klinikum der Friedrich Schiller Universität, Winzerlaer Str 10, Jena 07745, Germany
    J Virol Methods 113:51-63. 2003
    ..Viruses of the PEV CPE group III can be distinguished from the closely related swine vesicular disease virus (SVDV)...
  18. doi request reprint Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
    Antiviral Res 86:246-52. 2010
    ..g. site-directed mutagenesis experiments are required to characterize mutations of the TK and DNA pol genes in ACV-resistant viral strains as part of viral gene polymorphism or as cause of drug resistance...
  19. ncbi request reprint Analysis of repeat units in the R2 region among different Oka varicella-zoster virus vaccine strains and wild-type strains in Germany
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Jena, Germany
    Intervirology 50:40-4. 2007
    ..The present study compared the number of R2 repeat units in six different Oka strains and in 54 varicella-zoster virus (VZV) wild-type strains isolated from patients with varicella or zoster in Germany...
  20. doi request reprint Interaction of poly(rC)-binding protein 2 domains KH1 and KH3 with coxsackievirus RNA
    Roland Zell
    Institute for Virology and Antiviral Therapy, Friedrich Schiller University, Hans Knöll Str 2, D 07745 Jena, Germany
    Biochem Biophys Res Commun 377:500-3. 2008
    ..The data demonstrate interaction of isolated PCBP2 KH1 and KH3 domains to four distinct target sites within the 5'-nontranslated region of the CVB3 genomic RNA...
  21. ncbi request reprint Chemotactic activity of serum obtained from patients with idiopathic dilated cardiomyopathy
    H H Sigusch
    University of Jena, Department of Internal Medicine, Division of Cardiology, 07740 Jena, Germany
    Pharmazie 61:706-9. 2006
    ..05) associated with significantly higher circulating MCP-1 levels. Sera obtained from IDCM patients show a high chemotactic activity associated with significantly elevated circulating MCP-1...
  22. pmc Apoptosis in coxsackievirus B3-caused diseases: interaction between the capsid protein VP2 and the proapoptotic protein siva
    A Henke
    Institute of Virology, Medical Center, Friedrich Schiller University Jena, Germany
    J Virol 74:4284-90. 2000
    ..It has been proposed that Siva is involved in the CD27/CD70-transduced apoptosis. Therefore, we suggest a molecular mechanism through which apoptotic events contributes to CVB3-caused pathogenesis...
  23. ncbi request reprint The non-coding region of BK subtype II viruses
    Andi Krumbholz
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Hans Knoell Str 2, 07745 Jena, Germany
    Virus Genes 36:27-9. 2008
    ..Sequence comparisons revealed that the archetypal configuration of subtype I strain WW seems to be predominant among BKV subtypes...
  24. ncbi request reprint Poly(rC)-binding protein 2 interacts with the oligo(rC) tract of coxsackievirus B3
    Roland Zell
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University, Hans Knoell Strasse 2, D 07745 Jena, Germany
    Biochem Biophys Res Commun 366:917-21. 2008
    ..In the presence of 3C proteinase, cloverleaf RNA (1-87) interacts with PCBP2...
  25. ncbi request reprint Novel reassortant of swine influenza H1N2 virus in Germany
    Roland Zell
    Institut für Virologie und Antivirale Therapie, Universitatsklinikum, Friedrich Schiller Universitat, Hans Knöll Str 2, D 07745 Jena, Germany
    J Gen Virol 89:271-6. 2008
    ..Genome sequencing revealed the novel combination of the human-like HAH1 gene of European porcine H1N2 influenza viruses and the NAN2 gene of European porcine H3N2 viruses...
  26. doi request reprint Characterization of the protective capability of a recombinant coxsackievirus B3 variant expressing interferon-gamma
    Andreas Henke
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Jena, Germany
    Viral Immunol 21:38-48. 2008
    ..Using a murine model of CVB3-induced myocarditis, other aspects of the CVB3/IFN-gamma application as a vaccine were studied concerning route of administration, age, and presence of a pre-existing immune response...
  27. doi request reprint Impact of global warming on viral diseases: what is the evidence?
    Roland Zell
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University Jena, Hans Knoell Street 2, D 07745 Jena, Germany
    Curr Opin Biotechnol 19:652-60. 2008
    ..Coupled ocean/atmosphere circulations and 'global change' that also includes shifting of demographic, social, and economical conditions are important drivers of viral disease variability whereas global warming at best contributes...
  28. doi request reprint Ongoing evolution of swine influenza viruses: a novel reassortant
    Roland Zell
    Institut für Virologie und Antivirale Therapie, Universitatsklinikum, Friedrich Schiller Universitat, Hans Knöll Str 2, 07745, Jena, Germany
    Arch Virol 153:2085-92. 2008
    ..Analysis of GenBank sequence data reveals numerous reassortment events in recent years, demonstrating ongoing evolution of swine influenza viruses...
  29. doi request reprint Phylogenetics, evolution, and medical importance of polyomaviruses
    Andi Krumbholz
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
    Infect Genet Evol 9:784-99. 2009
    ..Finally, we reveal that the hypothesis of a strict codivergence of polyomaviruses with their respective hosts does not represent a realistic assumption in light of phylogenetic findings presented here...
  30. doi request reprint Polymorphism of interleukin-23 receptor gene but not of NOD2/CARD15 is associated with graft-versus-host disease after hematopoietic stem cell transplantation in children
    Bernd Gruhn
    Department of Pediatrics, University of Jena, Jena, Germany
    Biol Blood Marrow Transplant 15:1571-7. 2009
    ....
  31. ncbi request reprint Prevalence of BK virus subtype I in Germany
    Andi Krumbholz
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University Jena, Jena, Germany
    J Med Virol 78:1588-98. 2006
    ..For the genotyping region, a relationship of BKV subgroups to disease patterns like hemorrhagic cystitis or tubulointerstitial nephritis could not be demonstrated...
  32. doi request reprint Epstein-Barr virus-associated pneumonia and bronchiolitis obliterans syndrome in a lung transplant recipient
    Andi Krumbholz
    Institute of Virology and Antiviral Therapy, Jena University Hospital Friedrich Schiller University Jena, Jena, Germany
    Med Microbiol Immunol 199:317-22. 2010
    ..The clinical situation improved soon after re-transplantation, and the EBV load detected in the lower respiratory tract decreased significantly...
  33. doi request reprint Prevalence of antibodies to swine influenza viruses in humans with occupational exposure to pigs, Thuringia, Germany, 2008-2009
    Andi Krumbholz
    Department of Virology and Antiviral Therapy, Jena University Hospital, Jena, Germany
    J Med Virol 82:1617-25. 2010
    ..All increased hemagglutination-inhibition titers of the control group may be explained by cross-reactivity with seasonal influenza virus strains, as all these sera also reacted with human strains...
  34. doi request reprint Current knowledge on PB1-F2 of influenza A viruses
    Andi Krumbholz
    Department of Virology and Antiviral Therapy, Jena University Hospital, Friedrich Schiller University Jena, Hans Knoell Strasse 2, 07745, Jena, Germany
    Med Microbiol Immunol 200:69-75. 2011
    ..These properties could contribute to an enhanced pathogenicity. However, the underlying mechanism is not fully understood yet. New data suggest that some effects of PB1-F2 are strain-specific and host-specific...
  35. doi request reprint Cardioprotective effect of NO-metoprolol in murine coxsackievirus B3-induced myocarditis
    Brigitte Glück
    Department of Virology and Antiviral Therapy, Jena University Hospital, Jena, Germany
    J Med Virol 82:2043-52. 2010
    ..The results indicate that NO-metoprolol treatment has a greater therapeutic benefit than metoprolol...
  36. doi request reprint Sequence analysis of the glycoprotein E gene of varicella-zoster virus strains of clades 1, 3 and 5
    Andreas Sauerbrei
    Reference Laboratory for HSV and VZV, Institute of Virology and Antiviral Therapy, Jena University Hospital, Hans Knoell Strasse 2, 07745 Jena, Germany
    Arch Virol 156:505-9. 2011
    ..The profile of single-nucleotide polymorphisms was found to be significantly associated with the VZV clades 1, 3 and 5...
  37. ncbi request reprint Testing of herpes simplex virus for resistance to antiviral drugs
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Hospital, Jena, Germany
    Virulence 1:555-7. 2010
    ..In conclusion, for reliable interpretation of genotypic resistance, a database of non-synonymous mutations has to be established...
  38. ncbi request reprint Recombinant coxsackievirus vectors for prevention and therapy of virus-induced heart disease
    Andreas Henke
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Hans Knöll Strasse 2, D 07745 Jena, Germany
    Int J Med Microbiol 298:127-34. 2008
    ..The local and simultaneous expression of an immuno-relevant cytokine by the virus itself induces a strong and long-lasting immune response which protects laboratory animals against lethal infections...
  39. ncbi request reprint Genotyping of varicella-zoster virus strains after serial passages in cell culture
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, D 07745 Jena, Germany
    J Virol Methods 145:80-3. 2007
    ..For rapid diagnostic identification of vaccine versus wild-type strains, the RFLP profile that is stable within several cell culture passages can be determined using DNA prepared from clinical specimens...
  40. ncbi request reprint Co-expression of interleukin-2 by a bicistronic plasmid increases the efficacy of DNA immunization to prevent influenza virus infections
    Andreas Henke
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Jena, Germany
    Intervirology 49:249-52. 2006
    ....
  41. ncbi request reprint Amantadine resistance among porcine H1N1, H1N2, and H3N2 influenza A viruses isolated in Germany between 1981 and 2001
    Michaela Schmidtke
    Institute of Virology and Antiviral Therapy, Medical Centre of the Friedrich Schiller University Jena, Jena, Germany
    Intervirology 49:286-93. 2006
    ..Therefore, drug susceptibility monitoring appears to be warranted for effective application of those drugs...
  42. pmc A novel cGUUAg tetraloop structure with a conserved yYNMGg-type backbone conformation from cloverleaf 1 of bovine enterovirus 1 RNA
    Yvonne Ihle
    Molekulare Biophysik NMR Spektroskopie, , D 07745 Jena, Germany
    Nucleic Acids Res 33:2003-11. 2005
    ..Ohlenschlager, J. Wohnert, E. Bucci, S. Seitz, S. Hafner, R. Ramachandran, R. Zell and M. Gorlach (2004) Structure, 12, 237-248] that the proteinase 3C(pro) recognizes structure rather than sequence...
  43. ncbi request reprint Molecular-based reclassification of the bovine enteroviruses
    Roland Zell
    Institute for Virology and Antiviral Therapy, Hans Knöll Str 2, 07745 Jena, Germany
    J Gen Virol 87:375-85. 2006
    ..Incongruent phylogenies of the 5'-non-translated region, the capsid proteins and the 3D polymerase indicate frequent intraserotypic and interserotypic recombination within the non-capsid and the capsid region of the BEV genome...
  44. ncbi request reprint Co-expression of interleukin-2 to increase the efficacy of DNA vaccine-mediated protection in coxsackievirus B3-infected mice
    Andreas Henke
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, D 07740 Jena, Germany
    Antiviral Res 64:131-6. 2004
    ..Here, we report that the co-expression of the immune-stimulatory interleukin-2 (IL-2) can increase the efficacy of the inoculated DNA vaccine depending on the route of administration and the mouse strain used...
  45. ncbi request reprint Direct interferon-gamma-mediated protection caused by a recombinant coxsackievirus B3
    Andreas Henke
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Winzerlaer Strasse 10, D 07745 Jena, Germany
    Virology 315:335-44. 2003
    ..This direct effect was not restricted to the homologous virus. In vitro, cocultivation of CVB3(IFN-gamma)-infected cells induced a reduction of CVB3H3 replication and virus-induced cytopathogenicity...
  46. ncbi request reprint Comparison of a LightCycler-based real-time PCR for quantitation of Epstein-Barr viral load in different clinical specimens with semiquantitative PCR
    Andi Krumbholz
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University Jena, Jena, Germany
    J Med Virol 78:598-607. 2006
    ..Positive specimens containing more than 500 copies/10(5) cells are measured for exact values by real-time PCR. To circumvent inhibitory effects of cellular DNA, measurements should be carried out generally with 50-10 ng DNA...
  47. ncbi request reprint Prevalence of PB1-F2 of influenza A viruses
    Roland Zell
    Institute of Virology and Antiviral Therapy, Medical Center at Friedrich Schiller University, Hans Knoell Str 2, D 07745 Jena, Germany
    J Gen Virol 88:536-46. 2007
    ..This indicates similar properties and function of porcine and human FLUAV PB1-F2...
  48. doi request reprint Evolution of four BK virus subtypes
    Andi Krumbholz
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University Jena, Hans Knoell Strasse 2, D 07745 Jena, Germany
    Infect Genet Evol 8:632-43. 2008
    ..Another approach, external calibration by linking BKV divergence to the evolution of mammals, was rejected as it advances BKV divergence prior to the emergence of modern humans...
  49. ncbi request reprint Susceptibility of coxsackievirus B3 laboratory strains and clinical isolates to the capsid function inhibitor pleconaril: antiviral studies with virus chimeras demonstrate the crucial role of amino acid 1092 in treatment
    Michaela Schmidtke
    Institute of Virology and Antiviral Therapy, Medical Centre of the Friedrich Schiller University Jena, Hans Knoell Str 2, D 07740 Jena, Germany
    J Antimicrob Chemother 56:648-56. 2005
    ..This study was designed to better understand the polymorphism of the hydrophobic pocket in CVB3 laboratory strains and clinical isolates and its implications for treatment with the capsid function inhibitor pleconaril...
  50. pmc Sequencing of porcine enterovirus groups II and III reveals unique features of both virus groups
    Andi Krumbholz
    Institut fur Virologie, Klinikum der Friedrich Schiller Universität, 07745 Jena, Germany
    J Virol 76:5813-21. 2002
    ..A reclassification of this group into a new picornavirus genus is suggested. PEV group III viruses are typical enteroviruses. They differ from other enteroviruses by a prolonged stem-loop D of the 5'-cloverleaf structure...
  51. ncbi request reprint Antiviral effects of pan-caspase inhibitors on the replication of coxsackievirus B3
    Ulrike Martin
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Jena, Germany
    Apoptosis 12:525-33. 2007
    ..A delayed release of cytochrome c into the cytoplasm was detected in Q-VD-OPH-treated CVB3-infected cells pointing to an involvement of caspases in the initial steps of mitochondrial membrane-permeabilization...
  52. ncbi request reprint Influence of pan-caspase inhibitors on coxsackievirus B3-infected CD19+ B lymphocytes
    Nadine Jarasch
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Hans Knöll Str 2, 07745 Jena, Germany
    Apoptosis 12:1633-43. 2007
    ..This proportion could be decreased up to 45%, if 3 days p. i. mice were intravenously treated with the pan-caspase inhibitors Z-VAD-FMK or Q-VD-OPH. These data were compared with results obtained from CVB3-infected human Raji cells...
  53. ncbi request reprint Genotyping of different varicella vaccine strains
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, D 07745 Jena, Germany
    J Clin Virol 37:109-17. 2006
    ..These findings need attention since mutations in the vaccine strain could result in changes of virulence and efficacy of the vaccine...
  54. doi request reprint Prenatal origin of childhood acute lymphoblastic leukemia, association with birth weight and hyperdiploidy
    B Gruhn
    Department of Pediatrics, University Children s Hospital Jena, University of Jena, Jena, Germany
    Leukemia 22:1692-7. 2008
    ..Pending the development of suitable methods, childhood leukemia is a potentially screenable disease...
  55. ncbi request reprint Pre-emptive therapy with rituximab for prevention of Epstein-Barr virus-associated lymphoproliferative disease after hematopoietic stem cell transplantation
    B Gruhn
    Department of Pediatrics, University of Jena, Jena, Germany
    Bone Marrow Transplant 31:1023-5. 2003
    ..In all three patients, no EBV-associated LPD occurred. We conclude that pre-emptive therapy with rituximab appears to be effective for prevention of EBV-associated LPD after HSCT...
  56. ncbi request reprint Characterization of coxsackievirus B3-caused apoptosis under in vitro conditions
    Ulrike Martin
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University Jena, Winzerlaer Str 10, 07745 Jena, Germany
    Med Microbiol Immunol 193:133-9. 2004
    ..These in vitro results indicate that the induction of apoptosis during CVB3H3 infection is based on the interaction between the capsid protein VP2 and the proapoptotic protein Siva, independently from the complex situation in vivo...
  57. ncbi request reprint A short PNA targeting coxsackievirus B3 5'-nontranslated region prevents virus-induced cytolysis
    Domenica Musumeci
    Istituto di Biostrutture e Bioimmagini, CNR, I 80134 Naples, Italy
    J Pept Sci 12:161-70. 2006
    ..The results obtained by studying the interaction of such PNA with their RNA target, the entrance into the cell and the viral inhibition are herein presented...
  58. pmc Biological significance of a human enterovirus B-specific RNA element in the 3' nontranslated region
    Ingrid Merkle
    Institute of Virology, Friedrich Schiller University, D 07745 Jena, Germany
    J Virol 76:9900-9. 2002
    ..However, the heart tissue from mice infected with the recombinant virus showed only slight signs of myocarditis. These results suggest that the enterovirus B-like-specific Z domain plays a role in coxsackievirus-induced pathogenesis...
  59. ncbi request reprint The structure of the stemloop D subdomain of coxsackievirus B3 cloverleaf RNA and its interaction with the proteinase 3C
    Oliver Ohlenschläger
    Institut für Molekulare Biotechnologie eV, Bentenbergstr 100813, D 07745 Jena, Germany
    Structure 12:237-48. 2004
    ..The binding of 3Cpro to SLD requires the integrity of those structural elements, strongly suggesting that 3Cpro recognizes a structural motif instead of a specific sequence...
  60. ncbi request reprint Interferon-gamma-induced activation of nitric oxide-mediated antiviral activity of macrophages caused by a recombinant coxsackievirus B3
    Nadine Jarasch
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Hans Knöll Str 2, D 07745 Jena, Germany
    Viral Immunol 18:355-64. 2005
    ..In addition, the expression of IFN-gamma by CVB3/IFN-gamma contributes to protect mice from lethal infections by iNOS induction in murine peritoneal macrophages, viral load reduction, and pancreatic tissue protection...
  61. pmc Influenza A virus PB1-F2 gene
    Roland Zell
    Emerg Infect Dis 12:1607-8; author reply 1608-9. 2006
  62. ncbi request reprint RNA interaction and cleavage of poly(C)-binding protein 2 by hepatitis A virus protease
    Bo Zhang
    Institute of Medical Molecular Biology, University of Lubeck, Germany
    Biochem Biophys Res Commun 364:725-30. 2007
    ..The results suggest that during HAV infection PCBP2 cleavage might specifically down-regulate viral protein synthesis, thereby giving way to viral RNA synthesis...