Research Topics
| R ZellSummaryAffiliation: Friedrich Schiller University Country: Germany Publications
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Publications
Application of genome sequence information to the classification of bovine enteroviruses: the importance of 5'- and 3'-nontranslated regionsR Zell
Institut fur Virologie, Klinikum der Friedrich Schiller Universität, Jena, Germany
Virus Res 51:213-29. 1997..For rhinoviruses, the existence of two virus clusters was confirmed...- Global climate change and the emergence/re-emergence of infectious diseasesRoland Zell
Institute for Virology and Antiviral Therapy, Medical Center at the Friedrich Schiller University, Jena, Germany
Int J Med Microbiol 293:16-26. 2004..The complexity of not yet fully understood pathogen transmission dynamics with numerous variables might be an explanation of the problems in assessing the risk factors... - Nitric oxide donors inhibit the coxsackievirus B3 proteinases 2A and 3C in vitro, virus production in cells, and signs of myocarditis in virus-infected miceRoland Zell
Institute for Virology, Medical Center at the Friedrich Schiller University, Winzerlaer Strasse 10, 07745 Jena, Germany
Med Microbiol Immunol 193:91-100. 2004.... - Linkage map of protein-protein interactions of Porcine teschovirusRoland Zell
Institute for Virology and Antiviral Therapy, Hans Knöll Str 2, D 07745 Jena, Germany
J Gen Virol 86:2763-8. 2005..Unlike the poliovirus 3C, the teschovirus 3C proteinase dimerizes and interacts with 2BC, 3CD and 3D. The strongest interactions were observed for L-3C, L-3CD and 3C-3CD... 
Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3CRoland Zell
Institut fur Virologie, Klinikum der Friedrich Schiller Universität, Jena, Germany
RNA 8:188-201. 2002..Binding assays using mutated versions of CVB3 and HRV14 cloverleaf RNAs suggest that the presence of structural features rather than a defined sequence motif of loop D are important for 3C proteinase-RNA interaction...- Porcine teschoviruses comprise at least eleven distinct serotypes: molecular and evolutionary aspectsR Zell
Institut fur Virologie, Klinikum der Friedrich Schiller Universität, 07745 Jena, Germany
J Virol 75:1620-31. 2001..Sequencing of field isolates collected from animals presenting with neurological disorders prove that other serotypes than PTV-1 may also cause polioencephalomyelitis of swine... - Functional features of the bovine enterovirus 5'-non-translated regionR Zell
Institut fur Virologie, Klinikum der Friedrich Schiller Universität, Jena, Germany
J Gen Virol 80:2299-309. 1999.... - Detection of porcine enteroviruses by nRT-PCR: differentiation of CPE groups I-III with specific primer setsR Zell
Institut fur Virologie, Klinikum der Friedrich Schiller Universität, Winzerlaer Str 10, 07745 Jena, Germany
J Virol Methods 88:205-18. 2000.... 
Monitoring prevalence of varicella-zoster virus clades in GermanyA Sauerbrei
Institute of Virology and Antiviral Therapy, Jena University Hospital, Hans Knoell Strasse 2, 07745, Jena, Germany
Med Microbiol Immunol 200:99-107. 2011..In primary VZV infection, nearly 20% of clade 1 has been replaced by clade 5 that might spread more effectively in the population than the European VZV clades...- DNA vaccine-mediated immune responses in Coxsackie virus B3-infected miceA Henke
Institute of Virology, Medical Center, Friedrich Schiller University, Winzerlaer Str 10, D 07745 Jena, Germany
Antiviral Res 49:49-54. 2001..In summary, our results indicate that the induction of B cell and/or T cell memory in vaccinated mice prior to challenge is responsible for the protection observed... - High prevalence of amantadine resistance among circulating European porcine influenza A virusesAndi Krumbholz
Institut für Virologie und Antivirale Therapie, Universitatsklinikum Jena, Hans Knöll Str 2, D 07745 Jena, Germany
J Gen Virol 90:900-8. 2009..Transfer of amantadine resistance by exchange of the M segment and viability of recombinant A/WSN/33 viruses with avian-like M segments raises concerns about the emergence of natural human reassortants... - Genotypes of varicella-zoster virus wild-type strains in GermanyA Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Jena, Germany
J Med Virol 80:1123-30. 2008..The possible recombinant could not be classified definitely by the scattered SNP method used and, therefore, has to be confirmed by full-genome sequencing studies... - Attachment of coxsackievirus B3 variants to various cell lines: mapping of phenotypic differences to capsid protein VP1M Schmidtke
Institute for Virology, Medical Center at the Friedrich Schiller University, Winzerlaer Str 10, Jena D 07745, Germany
Virology 275:77-88. 2000..Moreover, the lytic replication of CVB3 PD and the hybrid virus in various nonpermissive rodent cell lines indicates that cell surface molecules other than CAR and DAF may be involved in attachment of this variant to cell surfaces... - Expression of immunoregulatory cytokines by recombinant coxsackievirus B3 variants confers protection against virus-caused myocarditisA Henke
Institute of Virology, Medical Center, Friedrich Schiller University, D 07745 Jena, Germany
J Virol 75:8187-94. 2001..This study demonstrates that expression of immunoregulatory cytokines during CVB3 replication simultaneously protects mice against a lethal disease and prevents virus-caused tissue destruction... - Variability of immediate-early gene 62 in german varicella-zoster virus wild-type strainsA Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
J Clin Microbiol 47:3717-20. 2009..M1 strains in Germany display a uniform ORF 62 pattern, suggesting that these strains were introduced from Africa and/or Asia via few sources during the last years... - The apoptotic capability of coxsackievirus B3 is influenced by the efficient interaction between the capsid protein VP2 and the proapoptotic host protein SivaA Henke
Institute of Virology, Medical Center, Friedrich Schiller University Jena, Winzerlaer Strasse 10, D 07745 Jena, Germany
Virology 289:15-22. 2001..Together, these results show that the interaction between VP2 of CVB3H3 and Siva is a highly specific process involving distinct amino acids on both proteins that most likely influence the outcome of CVB3-caused disease... - Detection of porcine teschoviruses and enteroviruses by LightCycler real-time PCRAndi Krumbholz
, , Winzerlaer Str 10, Jena 07745, Germany
J Virol Methods 113:51-63. 2003..Viruses of the PEV CPE group III can be distinguished from the closely related swine vesicular disease virus (SVDV)... - Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virusA Sauerbrei
Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
Antiviral Res 86:246-52. 2010..g. site-directed mutagenesis experiments are required to characterize mutations of the TK and DNA pol genes in ACV-resistant viral strains as part of viral gene polymorphism or as cause of drug resistance... - Analysis of repeat units in the R2 region among different Oka varicella-zoster virus vaccine strains and wild-type strains in GermanyA Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Jena, Germany
Intervirology 50:40-4. 2007..The present study compared the number of R2 repeat units in six different Oka strains and in 54 varicella-zoster virus (VZV) wild-type strains isolated from patients with varicella or zoster in Germany... - Interaction of poly(rC)-binding protein 2 domains KH1 and KH3 with coxsackievirus RNARoland Zell
Institute for Virology and Antiviral Therapy, Friedrich Schiller University, Hans Knöll Str 2, D 07745 Jena, Germany
Biochem Biophys Res Commun 377:500-3. 2008..The data demonstrate interaction of isolated PCBP2 KH1 and KH3 domains to four distinct target sites within the 5'-nontranslated region of the CVB3 genomic RNA... - Chemotactic activity of serum obtained from patients with idiopathic dilated cardiomyopathyH H Sigusch
University of Jena, Department of Internal Medicine, Division of Cardiology, 07740 Jena, Germany
Pharmazie 61:706-9. 2006..05) associated with significantly higher circulating MCP-1 levels. Sera obtained from IDCM patients show a high chemotactic activity associated with significantly elevated circulating MCP-1... - Apoptosis in coxsackievirus B3-caused diseases: interaction between the capsid protein VP2 and the proapoptotic protein sivaA Henke
Institute of Virology, Medical Center, Friedrich Schiller University Jena, Germany
J Virol 74:4284-90. 2000..It has been proposed that Siva is involved in the CD27/CD70-transduced apoptosis. Therefore, we suggest a molecular mechanism through which apoptotic events contributes to CVB3-caused pathogenesis... - The non-coding region of BK subtype II virusesAndi Krumbholz
Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Hans Knoell Str 2, 07745 Jena, Germany
Virus Genes 36:27-9. 2008..Sequence comparisons revealed that the archetypal configuration of subtype I strain WW seems to be predominant among BKV subtypes... - Poly(rC)-binding protein 2 interacts with the oligo(rC) tract of coxsackievirus B3Roland Zell
Institute of Virology and Antiviral Therapy, Friedrich Schiller University, Hans Knoell Strasse 2, D 07745 Jena, Germany
Biochem Biophys Res Commun 366:917-21. 2008..In the presence of 3C proteinase, cloverleaf RNA (1-87) interacts with PCBP2... - Novel reassortant of swine influenza H1N2 virus in GermanyRoland Zell
Institut für Virologie und Antivirale Therapie, Universitatsklinikum, Friedrich Schiller Universitat, Hans Knöll Str 2, D 07745 Jena, Germany
J Gen Virol 89:271-6. 2008..Genome sequencing revealed the novel combination of the human-like HAH1 gene of European porcine H1N2 influenza viruses and the NAN2 gene of European porcine H3N2 viruses... - Characterization of the protective capability of a recombinant coxsackievirus B3 variant expressing interferon-gammaAndreas Henke
Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Jena, Germany
Viral Immunol 21:38-48. 2008..Using a murine model of CVB3-induced myocarditis, other aspects of the CVB3/IFN-gamma application as a vaccine were studied concerning route of administration, age, and presence of a pre-existing immune response... - Impact of global warming on viral diseases: what is the evidence?Roland Zell
Institute of Virology and Antiviral Therapy, Friedrich Schiller University Jena, Hans Knoell Street 2, D 07745 Jena, Germany
Curr Opin Biotechnol 19:652-60. 2008..Coupled ocean/atmosphere circulations and 'global change' that also includes shifting of demographic, social, and economical conditions are important drivers of viral disease variability whereas global warming at best contributes... - Ongoing evolution of swine influenza viruses: a novel reassortantRoland Zell
Institut für Virologie und Antivirale Therapie, Universitatsklinikum, Friedrich Schiller Universitat, Hans Knöll Str 2, 07745, Jena, Germany
Arch Virol 153:2085-92. 2008..Analysis of GenBank sequence data reveals numerous reassortment events in recent years, demonstrating ongoing evolution of swine influenza viruses... - Phylogenetics, evolution, and medical importance of polyomavirusesAndi Krumbholz
Institute of Virology and Antiviral Therapy, Friedrich Schiller University Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
Infect Genet Evol 9:784-99. 2009..Finally, we reveal that the hypothesis of a strict codivergence of polyomaviruses with their respective hosts does not represent a realistic assumption in light of phylogenetic findings presented here... - Polymorphism of interleukin-23 receptor gene but not of NOD2/CARD15 is associated with graft-versus-host disease after hematopoietic stem cell transplantation in childrenBernd Gruhn
Department of Pediatrics, University of Jena, Jena, Germany
Biol Blood Marrow Transplant 15:1571-7. 2009.... - Prevalence of BK virus subtype I in GermanyAndi Krumbholz
Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University Jena, Jena, Germany
J Med Virol 78:1588-98. 2006..For the genotyping region, a relationship of BKV subgroups to disease patterns like hemorrhagic cystitis or tubulointerstitial nephritis could not be demonstrated... - Epstein-Barr virus-associated pneumonia and bronchiolitis obliterans syndrome in a lung transplant recipientAndi Krumbholz
Institute of Virology and Antiviral Therapy, Jena University Hospital Friedrich Schiller University Jena, Jena, Germany
Med Microbiol Immunol 199:317-22. 2010..The clinical situation improved soon after re-transplantation, and the EBV load detected in the lower respiratory tract decreased significantly... - Prevalence of antibodies to swine influenza viruses in humans with occupational exposure to pigs, Thuringia, Germany, 2008-2009Andi Krumbholz
Department of Virology and Antiviral Therapy, Jena University Hospital, Jena, Germany
J Med Virol 82:1617-25. 2010..All increased hemagglutination-inhibition titers of the control group may be explained by cross-reactivity with seasonal influenza virus strains, as all these sera also reacted with human strains... - Current knowledge on PB1-F2 of influenza A virusesAndi Krumbholz
Department of Virology and Antiviral Therapy, Jena University Hospital, Friedrich Schiller University Jena, Hans Knoell Strasse 2, 07745, Jena, Germany
Med Microbiol Immunol 200:69-75. 2011..These properties could contribute to an enhanced pathogenicity. However, the underlying mechanism is not fully understood yet. New data suggest that some effects of PB1-F2 are strain-specific and host-specific... - Cardioprotective effect of NO-metoprolol in murine coxsackievirus B3-induced myocarditisBrigitte Glück
Department of Virology and Antiviral Therapy, Jena University Hospital, Jena, Germany
J Med Virol 82:2043-52. 2010..The results indicate that NO-metoprolol treatment has a greater therapeutic benefit than metoprolol... - Sequence analysis of the glycoprotein E gene of varicella-zoster virus strains of clades 1, 3 and 5Andreas Sauerbrei
Reference Laboratory for HSV and VZV, Institute of Virology and Antiviral Therapy, Jena University Hospital, Hans Knoell Strasse 2, 07745 Jena, Germany
Arch Virol 156:505-9. 2011..The profile of single-nucleotide polymorphisms was found to be significantly associated with the VZV clades 1, 3 and 5... - Testing of herpes simplex virus for resistance to antiviral drugsAndreas Sauerbrei
Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Hospital, Jena, Germany
Virulence 1:555-7. 2010..In conclusion, for reliable interpretation of genotypic resistance, a database of non-synonymous mutations has to be established... - Recombinant coxsackievirus vectors for prevention and therapy of virus-induced heart diseaseAndreas Henke
Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Hans Knöll Strasse 2, D 07745 Jena, Germany
Int J Med Microbiol 298:127-34. 2008..The local and simultaneous expression of an immuno-relevant cytokine by the virus itself induces a strong and long-lasting immune response which protects laboratory animals against lethal infections... - Genotyping of varicella-zoster virus strains after serial passages in cell cultureAndreas Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, D 07745 Jena, Germany
J Virol Methods 145:80-3. 2007..For rapid diagnostic identification of vaccine versus wild-type strains, the RFLP profile that is stable within several cell culture passages can be determined using DNA prepared from clinical specimens... - Co-expression of interleukin-2 by a bicistronic plasmid increases the efficacy of DNA immunization to prevent influenza virus infectionsAndreas Henke
Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Jena, Germany
Intervirology 49:249-52. 2006.... - Amantadine resistance among porcine H1N1, H1N2, and H3N2 influenza A viruses isolated in Germany between 1981 and 2001Michaela Schmidtke
Institute of Virology and Antiviral Therapy, Medical Centre of the Friedrich Schiller University Jena, Jena, Germany
Intervirology 49:286-93. 2006..Therefore, drug susceptibility monitoring appears to be warranted for effective application of those drugs... 
A novel cGUUAg tetraloop structure with a conserved yYNMGg-type backbone conformation from cloverleaf 1 of bovine enterovirus 1 RNAYvonne Ihle
Molekulare Biophysik NMR Spektroskopie, , D 07745 Jena, Germany
Nucleic Acids Res 33:2003-11. 2005..Ohlenschlager, J. Wohnert, E. Bucci, S. Seitz, S. Hafner, R. Ramachandran, R. Zell and M. Gorlach (2004) Structure, 12, 237-248] that the proteinase 3C(pro) recognizes structure rather than sequence...- Molecular-based reclassification of the bovine enterovirusesRoland Zell
Institute for Virology and Antiviral Therapy, Hans Knöll Str 2, 07745 Jena, Germany
J Gen Virol 87:375-85. 2006..Incongruent phylogenies of the 5'-non-translated region, the capsid proteins and the 3D polymerase indicate frequent intraserotypic and interserotypic recombination within the non-capsid and the capsid region of the BEV genome... - Co-expression of interleukin-2 to increase the efficacy of DNA vaccine-mediated protection in coxsackievirus B3-infected miceAndreas Henke
Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, D 07740 Jena, Germany
Antiviral Res 64:131-6. 2004..Here, we report that the co-expression of the immune-stimulatory interleukin-2 (IL-2) can increase the efficacy of the inoculated DNA vaccine depending on the route of administration and the mouse strain used... - Direct interferon-gamma-mediated protection caused by a recombinant coxsackievirus B3Andreas Henke
Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Winzerlaer Strasse 10, D 07745 Jena, Germany
Virology 315:335-44. 2003..This direct effect was not restricted to the homologous virus. In vitro, cocultivation of CVB3(IFN-gamma)-infected cells induced a reduction of CVB3H3 replication and virus-induced cytopathogenicity... - Comparison of a LightCycler-based real-time PCR for quantitation of Epstein-Barr viral load in different clinical specimens with semiquantitative PCRAndi Krumbholz
Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University Jena, Jena, Germany
J Med Virol 78:598-607. 2006..Positive specimens containing more than 500 copies/10(5) cells are measured for exact values by real-time PCR. To circumvent inhibitory effects of cellular DNA, measurements should be carried out generally with 50-10 ng DNA... - Prevalence of PB1-F2 of influenza A virusesRoland Zell
Institute of Virology and Antiviral Therapy, Medical Center at Friedrich Schiller University, Hans Knoell Str 2, D 07745 Jena, Germany
J Gen Virol 88:536-46. 2007..This indicates similar properties and function of porcine and human FLUAV PB1-F2... - Evolution of four BK virus subtypesAndi Krumbholz
Institute of Virology and Antiviral Therapy, Friedrich Schiller University Jena, Hans Knoell Strasse 2, D 07745 Jena, Germany
Infect Genet Evol 8:632-43. 2008..Another approach, external calibration by linking BKV divergence to the evolution of mammals, was rejected as it advances BKV divergence prior to the emergence of modern humans... - Susceptibility of coxsackievirus B3 laboratory strains and clinical isolates to the capsid function inhibitor pleconaril: antiviral studies with virus chimeras demonstrate the crucial role of amino acid 1092 in treatmentMichaela Schmidtke
Institute of Virology and Antiviral Therapy, Medical Centre of the Friedrich Schiller University Jena, Hans Knoell Str 2, D 07740 Jena, Germany
J Antimicrob Chemother 56:648-56. 2005..This study was designed to better understand the polymorphism of the hydrophobic pocket in CVB3 laboratory strains and clinical isolates and its implications for treatment with the capsid function inhibitor pleconaril... - Sequencing of porcine enterovirus groups II and III reveals unique features of both virus groupsAndi Krumbholz
Institut fur Virologie, Klinikum der Friedrich Schiller Universität, 07745 Jena, Germany
J Virol 76:5813-21. 2002..A reclassification of this group into a new picornavirus genus is suggested. PEV group III viruses are typical enteroviruses. They differ from other enteroviruses by a prolonged stem-loop D of the 5'-cloverleaf structure... - Antiviral effects of pan-caspase inhibitors on the replication of coxsackievirus B3Ulrike Martin
Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Jena, Germany
Apoptosis 12:525-33. 2007..A delayed release of cytochrome c into the cytoplasm was detected in Q-VD-OPH-treated CVB3-infected cells pointing to an involvement of caspases in the initial steps of mitochondrial membrane-permeabilization... - Influence of pan-caspase inhibitors on coxsackievirus B3-infected CD19+ B lymphocytesNadine Jarasch
Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Hans Knöll Str 2, 07745 Jena, Germany
Apoptosis 12:1633-43. 2007..This proportion could be decreased up to 45%, if 3 days p. i. mice were intravenously treated with the pan-caspase inhibitors Z-VAD-FMK or Q-VD-OPH. These data were compared with results obtained from CVB3-infected human Raji cells... - Genotyping of different varicella vaccine strainsA Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, D 07745 Jena, Germany
J Clin Virol 37:109-17. 2006..These findings need attention since mutations in the vaccine strain could result in changes of virulence and efficacy of the vaccine... - Prenatal origin of childhood acute lymphoblastic leukemia, association with birth weight and hyperdiploidyB Gruhn
Department of Pediatrics, University Children s Hospital Jena, University of Jena, Jena, Germany
Leukemia 22:1692-7. 2008..Pending the development of suitable methods, childhood leukemia is a potentially screenable disease... - Pre-emptive therapy with rituximab for prevention of Epstein-Barr virus-associated lymphoproliferative disease after hematopoietic stem cell transplantationB Gruhn
Department of Pediatrics, University of Jena, Jena, Germany
Bone Marrow Transplant 31:1023-5. 2003..In all three patients, no EBV-associated LPD occurred. We conclude that pre-emptive therapy with rituximab appears to be effective for prevention of EBV-associated LPD after HSCT... - Characterization of coxsackievirus B3-caused apoptosis under in vitro conditionsUlrike Martin
Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University Jena, Winzerlaer Str. 10, 07745 Jena, Germany
Med Microbiol Immunol 193:133-9. 2004..These in vitro results indicate that the induction of apoptosis during CVB3H3 infection is based on the interaction between the capsid protein VP2 and the proapoptotic protein Siva, independently from the complex situation in vivo... - A short PNA targeting coxsackievirus B3 5'-nontranslated region prevents virus-induced cytolysisDomenica Musumeci
Istituto di Biostrutture e Bioimmagini, CNR, I-80134 Naples, Italy
J Pept Sci 12:161-70. 2006..The results obtained by studying the interaction of such PNA with their RNA target, the entrance into the cell and the viral inhibition are herein presented... - Biological significance of a human enterovirus B-specific RNA element in the 3' nontranslated regionIngrid Merkle
Institute of Virology, Friedrich Schiller University, D-07745 Jena, Germany
J Virol 76:9900-9. 2002..However, the heart tissue from mice infected with the recombinant virus showed only slight signs of myocarditis. These results suggest that the enterovirus B-like-specific Z domain plays a role in coxsackievirus-induced pathogenesis... - The structure of the stemloop D subdomain of coxsackievirus B3 cloverleaf RNA and its interaction with the proteinase 3COliver Ohlenschläger
Institut für Molekulare Biotechnologie eV, Bentenbergstr 100813, D 07745 Jena, Germany
Structure 12:237-48. 2004..The binding of 3Cpro to SLD requires the integrity of those structural elements, strongly suggesting that 3Cpro recognizes a structural motif instead of a specific sequence... - Interferon-gamma-induced activation of nitric oxide-mediated antiviral activity of macrophages caused by a recombinant coxsackievirus B3Nadine Jarasch
Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, , D-07745 Jena, Germany
Viral Immunol 18:355-64. 2005..In addition, the expression of IFN-gamma by CVB3/IFN-gamma contributes to protect mice from lethal infections by iNOS induction in murine peritoneal macrophages, viral load reduction, and pancreatic tissue protection... - Influenza A virus PB1-F2 geneRoland Zell
Emerg Infect Dis 12:1607-8; author reply 1608-9. 2006 - RNA interaction and cleavage of poly(C)-binding protein 2 by hepatitis A virus proteaseBo Zhang
Institute of Medical Molecular Biology, University of Lubeck, Germany
Biochem Biophys Res Commun 364:725-30. 2007..The results suggest that during HAV infection PCBP2 cleavage might specifically down-regulate viral protein synthesis, thereby giving way to viral RNA synthesis...