Gunter Wolf


Affiliation: Friedrich Schiller University
Country: Germany


  1. Wolf G. Novel aspects of the renin-angiotensin-aldosterone-system. Front Biosci. 2008;13:4993-5005 pubmed
    ..This review will highlight some of these novel insights into the RAAS in regards to renal injury. ..
  2. Pfeil A, Oelzner P, Renz D, Hansch A, Wolf G, Böttcher J. Is there a role for Digital X-ray Radiogrammetry as surrogate marker for radiological progression and imaging of structural integrity in rheumatoid arthritis?. BMC Musculoskelet Disord. 2015;16:155 pubmed publisher
    ..Quantitative data of hand bone mass estimated by the presented DXR-technique may be a complementary precise tool in the identification of RA-related radiographic changes and in the assessment of structural integrity. ..
  3. Loeffler I, Wolf G. Epithelial-to-Mesenchymal Transition in Diabetic Nephropathy: Fact or Fiction?. Cells. 2015;4:631-52 pubmed publisher
    ..While the precise extent of the contribution to nephrotic fibrosis is certainly arduous to quantify, the picture that emerges from this extensive body of literature suggests EMT as a major source of myofibroblasts in DN. ..
  4. Fischer C, Deininger N, Wolf G, Loeffler I. CERA Attenuates Kidney Fibrogenesis in the db/db Mouse by Influencing the Renal Myofibroblast Generation. J Clin Med. 2018;7: pubmed publisher
    ..Many of these CERA effects can be explained by the finding that CERA inhibits the renal expression of the cytokine TGF-β1. ..
  5. Wolf G. Role of reactive oxygen species in angiotensin II-mediated renal growth, differentiation, and apoptosis. Antioxid Redox Signal. 2005;7:1337-45 pubmed
    ..Thus, ANG II-induced ROS generation plays a pivotal role in several pathophysiological situations, leading to renal growth regulation and remodeling after injury. ..
  6. Wolf G, Schanze A, Stahl R, Shankland S, Amann K. p27(Kip1) Knockout mice are protected from diabetic nephropathy: evidence for p27(Kip1) haplotype insufficiency. Kidney Int. 2005;68:1583-9 pubmed
    ..The p27(Kip1) gene is haplo-insufficient because diabetic p27(Kip1)+/- mice exhibited an intermediate degree of functional and structural renal injury. Our data shows that p27(Kip1) plays an important role in diabetic nephropathy. ..
  7. Wolf G. Portrayal of negative qualities in a doctor as a potential teaching tool in medical ethics and humanism: Journey to the End of Night by Louis-Ferdinand Celine. Postgrad Med J. 2006;82:154-6 pubmed
    ..Unfortunately, Dr Bardamu develops an unprofessional, even criminal behaviour, and may serve as a negative role model for the virtues of physicians. This article will familiarise the reader with the novel and its physician author. ..
  8. Wolf G, Bohlender J, Bondeva T, Roger T, Thaiss F, Wenzel U. Angiotensin II upregulates toll-like receptor 4 on mesangial cells. J Am Soc Nephrol. 2006;17:1585-93 pubmed
    ..g., extracellular matrix components) in addition to microbial products, AngII-mediated upregulation of TLR4 also could be relevant for the development of inflammation in many noninfectious renal diseases. ..
  9. Wolf G. A kidney from hell? A nephrological view of the Whitechapel murders in 1888. Nephrol Dial Transplant. 2008;23:3343-9 pubmed publisher
    ..We will never know who this mentally disturbed 'nephrophilic' was. Today, the story of Jack the Ripper is part of contemporary culture. ..

More Information


  1. Ruster C, Franke S, Wenzel U, Schmidthaupt R, Fraune C, Krebs C, et al. Podocytes of AT2 receptor knockout mice are protected from angiotensin II-mediated RAGE induction. Am J Nephrol. 2011;34:309-17 pubmed publisher
    ..The present findings may suggest that not all ANG II-mediated changes in diabetic nephropathy can be treated with AT1 receptor blockers. ..
  2. Loeffler I, Ruster C, Franke S, Liebisch M, Wolf G. Erythropoietin ameliorates podocyte injury in advanced diabetic nephropathy in the db/db mouse. Am J Physiol Renal Physiol. 2013;305:F911-8 pubmed publisher
    ..Our data show, for the first time, that medication of overt DN with erythropoietin for a short time can ameliorate albuminuria and podocyte loss. ..
  3. Bondeva T, Heinzig J, Ruhe C, Wolf G. Advanced glycated end-products affect HIF-transcriptional activity in renal cells. Mol Endocrinol. 2013;27:1918-33 pubmed publisher
    ..These findings are important for a better understanding of the molecular mechanisms of diabetic nephropathy. ..
  4. Loeffler I, Wolf G. Morg1 heterozygous deficiency ameliorates hypoxia-induced acute renal injury. Am J Physiol Renal Physiol. 2015;308:F511-21 pubmed publisher
    ..Our findings suggest that therapeutical manipulation of Morg1 may be an interesting novel target to prevent hypoxia-associated renal damage. ..