Gunter Wolf

Summary

Affiliation: Friedrich Schiller University
Country: Germany

Publications

  1. ncbi request reprint Combination therapy with ACE inhibitors and angiotensin II receptor blockers to halt progression of chronic renal disease: pathophysiology and indications
    Gunter Wolf
    Department of Medicine, Division of Nephrology, Osteology, and Rheumatology, University of Hamburg, Hamburg, Germany
    Kidney Int 67:799-812. 2005
  2. ncbi request reprint Angiotensin II down-regulates the SR-BI HDL receptor in proximal tubular cells
    Gunter Wolf
    Department of Medicine, University of Jena, Germany
    Nephrol Dial Transplant 20:1222-7. 2005
  3. doi request reprint Resolution of renal inflammation: a new role for NF-kappaB1 (p50) in inflammatory kidney diseases
    Ulf Panzer
    III Medizinische Klinik, Zentrum fur Innere Medizin, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Am J Physiol Renal Physiol 297:F429-39. 2009
  4. doi request reprint 15-deoxy-Delta12,14-prostaglandin J2 inhibits INF-gamma-induced JAK/STAT1 signalling pathway activation and IP-10/CXCL10 expression in mesangial cells
    Ulf Panzer
    Medizinische Klinik III, University of Hamburg, Hamburg, Germany
    Nephrol Dial Transplant 23:3776-85. 2008
  5. ncbi request reprint Angiotensin II's antiproliferative effects mediated through AT2-receptors depend on down-regulation of SM-20
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Hamburg, Germany
    Lab Invest 82:1305-17. 2002
  6. ncbi request reprint Compartment-specific expression and function of the chemokine IP-10/CXCL10 in a model of renal endothelial microvascular injury
    Ulf Panzer
    Medizinische Klinik IV, Zentrum fur Innere Medizin, University of Hamburg, Martinistrasse 52, Hamburg 20246, Germany
    J Am Soc Nephrol 17:454-64. 2006
  7. ncbi request reprint Angiotensin II-induced hypertrophy of proximal tubular cells requires p27Kip1
    Gunter Wolf
    Division of Nephrology and Osteology, Department of Medicine, University of Hamburg, Hamburg, Germany
    Kidney Int 64:71-81. 2003
  8. pmc Lack of type VIII collagen in mice ameliorates diabetic nephropathy
    Ulrike Hopfer
    Department of Medicine, University of Hamburg, Hamburg, Germany
    Diabetes 58:1672-81. 2009
  9. ncbi request reprint Existence of a regulatory loop between MCP-1 and TGF-beta in glomerular immune injury
    Gunter Wolf
    Division of Nephrology, Department of Medicine, University of Hamburg, 20246 Hamburg, Germany
    Am J Physiol Renal Physiol 283:F1075-84. 2002
  10. ncbi request reprint Angiotensin II induces hypoxia-inducible factor-1 alpha in PC 12 cells through a posttranscriptional mechanism: role of AT2 receptors
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, DE 20246 Hamburg, Germany
    Am J Nephrol 24:415-21. 2004

Detail Information

Publications106 found, 100 shown here

  1. ncbi request reprint Combination therapy with ACE inhibitors and angiotensin II receptor blockers to halt progression of chronic renal disease: pathophysiology and indications
    Gunter Wolf
    Department of Medicine, Division of Nephrology, Osteology, and Rheumatology, University of Hamburg, Hamburg, Germany
    Kidney Int 67:799-812. 2005
    ..In our opinion patients with proteinuria >1 g/day despite optimal blood pressure control under RAS-blocking monotherapy are a high-risk group which will presumably benefit from combination therapy...
  2. ncbi request reprint Angiotensin II down-regulates the SR-BI HDL receptor in proximal tubular cells
    Gunter Wolf
    Department of Medicine, University of Jena, Germany
    Nephrol Dial Transplant 20:1222-7. 2005
    ..Therefore, the present study sought to gain insight into the expression of the HDL receptor scavenger receptor class B type I (SR-BI) in cultured renal cells and a potential regulation by angiotensin II (ANG II)...
  3. doi request reprint Resolution of renal inflammation: a new role for NF-kappaB1 (p50) in inflammatory kidney diseases
    Ulf Panzer
    III Medizinische Klinik, Zentrum fur Innere Medizin, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Am J Physiol Renal Physiol 297:F429-39. 2009
    ..In conclusion, our studies indicate that NF-kappaB subunit p50 proteins have critical in vivo functions in immunologically mediated renal disease by downregulating inflammation during the resolution period...
  4. doi request reprint 15-deoxy-Delta12,14-prostaglandin J2 inhibits INF-gamma-induced JAK/STAT1 signalling pathway activation and IP-10/CXCL10 expression in mesangial cells
    Ulf Panzer
    Medizinische Klinik III, University of Hamburg, Hamburg, Germany
    Nephrol Dial Transplant 23:3776-85. 2008
    ....
  5. ncbi request reprint Angiotensin II's antiproliferative effects mediated through AT2-receptors depend on down-regulation of SM-20
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Hamburg, Germany
    Lab Invest 82:1305-17. 2002
    ..This gene apparently plays an important role in the regulatory processes determining whether a cell should undergo differentiation, apoptosis, or proliferation...
  6. ncbi request reprint Compartment-specific expression and function of the chemokine IP-10/CXCL10 in a model of renal endothelial microvascular injury
    Ulf Panzer
    Medizinische Klinik IV, Zentrum fur Innere Medizin, University of Hamburg, Martinistrasse 52, Hamburg 20246, Germany
    J Am Soc Nephrol 17:454-64. 2006
    ....
  7. ncbi request reprint Angiotensin II-induced hypertrophy of proximal tubular cells requires p27Kip1
    Gunter Wolf
    Division of Nephrology and Osteology, Department of Medicine, University of Hamburg, Hamburg, Germany
    Kidney Int 64:71-81. 2003
    ....
  8. pmc Lack of type VIII collagen in mice ameliorates diabetic nephropathy
    Ulrike Hopfer
    Department of Medicine, University of Hamburg, Hamburg, Germany
    Diabetes 58:1672-81. 2009
    ....
  9. ncbi request reprint Existence of a regulatory loop between MCP-1 and TGF-beta in glomerular immune injury
    Gunter Wolf
    Division of Nephrology, Department of Medicine, University of Hamburg, 20246 Hamburg, Germany
    Am J Physiol Renal Physiol 283:F1075-84. 2002
    ..Our data demonstrate an intrinsic regulatory loop in which increased MCP-1 levels stimulate TGF-beta formation in resident glomerular cells in the absence of infiltrating immune competent cells...
  10. ncbi request reprint Angiotensin II induces hypoxia-inducible factor-1 alpha in PC 12 cells through a posttranscriptional mechanism: role of AT2 receptors
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, DE 20246 Hamburg, Germany
    Am J Nephrol 24:415-21. 2004
    ..The present study was undertaken to investigate whether the ANG-II-mediated suppression of SM-20/PHD3/PHD3 may be associated with an increase in HIF-1 alpha...
  11. ncbi request reprint Chronic anti-Thy-1 nephritis is aggravated in the nonclipped but not in the clipped kidney of Goldblatt hypertensive rats
    Ulrich O Wenzel
    Division of Nephrology, Department of Medicine, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Kidney Int 61:2119-31. 2002
    ..To test whether a chronic model of the Thy-1 nephritis is more susceptible to high blood pressure, the repetitive hit model was evaluated in rats with 2-kidney, 1-clip Goldblatt hypertension...
  12. ncbi request reprint p27(Kip1) Knockout mice are protected from diabetic nephropathy: evidence for p27(Kip1) haplotype insufficiency
    Gunter Wolf
    Klinik fur Innere Medizin III, University of Jena, Jena, Germany
    Kidney Int 68:1583-9. 2005
    ..However, it is unclear whether deletion of p27(Kip1) protects the kidneys of diabetic nephropathy in vivo...
  13. doi request reprint Serum levels of the advanced glycation end products Nepsilon-carboxymethyllysine and pentosidine are not influenced by treatment with the angiotensin receptor II type 1 blocker irbesartan in patients with type 2 diabetic nephropathy and hypertension
    Martin Busch
    Department of Internal Medicine III, University of Jena, Jena, Germany
    Nephron Clin Pract 108:c291-7. 2008
    ....
  14. ncbi request reprint The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3)
    Ulrike Hopfer
    Department of Medicine, University of Hamburg, Martinistr 52, D 20246 Hamburg
    J Biol Chem 281:8645-55. 2006
    ..These results indicate that Morg1 specifically interacts with PHD3 most likely by acting as a molecular scaffold. This interaction may provide a molecular framework between HIF regulation and other signaling pathways...
  15. ncbi request reprint Oxidized LDL induces proliferation and hypertrophy in human umbilical vein endothelial cells via regulation of p27Kip1 expression: role of RhoA
    Stefan Seibold
    Department of Medicine, University Hospital Wurzburg, Joseph Schneider Strasse 2, D 97080 Wurzburg, Germany
    J Am Soc Nephrol 15:3026-34. 2004
    ..OxLDL may importantly contribute to vascular hyperplasia in atherosclerosis and other diseases associated with increased levels of OxLDL...
  16. ncbi request reprint Angiotensin II and cell cycle regulation
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, University Hospital, Germany
    Hypertension 43:693-8. 2004
    ..We review the various angiotensin II-mediated growth processes and their relationship to events governing cell cycle regulation...
  17. pmc Type VIII collagen modulates TGF-β1-induced proliferation of mesangial cells
    Ivonne Loeffler
    Department of Internal Medicine III, University of Jena, Erlanger Allee 101, D 07740 Jena, Germany
    J Am Soc Nephrol 22:649-63. 2011
    ..Taken together, these data suggest that type VIII collagen significantly modulates the effect of TGF-β1 on mesangial cells and may therefore play a role in the pathogenesis of diabetic nephropathy...
  18. ncbi request reprint Angiotensin II upregulates toll-like receptor 4 on mesangial cells
    Gunter Wolf
    Klinik fur Innere Medizin III, University of Jena, Germany, and Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Am Soc Nephrol 17:1585-93. 2006
    ..g., extracellular matrix components) in addition to microbial products, AngII-mediated upregulation of TLR4 also could be relevant for the development of inflammation in many noninfectious renal diseases...
  19. ncbi request reprint Kidney diseases and chemokines
    Ulf Panzer
    Medizinische Klinik IV, Universtätsklinikum Hamburg Eppendorf, Hamburg, Germany
    Curr Drug Targets 7:65-80. 2006
    ..This suggests that inhibition of chemokine expression and action must be time and compartment specific to provide therapeutic benefit for renal structure and function...
  20. ncbi request reprint Role of reactive oxygen species in angiotensin II-mediated renal growth, differentiation, and apoptosis
    Gunter Wolf
    Department of Medicine, Division of Nephrology, University of Jena, Jena, Germany
    Antioxid Redox Signal 7:1337-45. 2005
    ..Thus, ANG II-induced ROS generation plays a pivotal role in several pathophysiological situations, leading to renal growth regulation and remodeling after injury...
  21. ncbi request reprint Albumin up-regulates the type II transforming growth factor-beta receptor in cultured proximal tubular cells
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Hamburg, Germany
    Kidney Int 66:1849-58. 2004
    ..We studied in an in vitro system using a well-defined mouse proximal tubular cell line (MCT cells) whether fatty acid-free bovine albumin modulates expression of specific receptors for TGF-beta...
  22. ncbi request reprint Differential regulation of Toll-like receptor 4 gene expression in renal cells by angiotensin II: dependency on AP1 and PU.1 transcriptional sites
    Tzvetanka Bondeva
    Clinic of Internal Medicine III, University of Jena, Jena, Germany
    Am J Nephrol 27:308-14. 2007
    ..However, the factors controlling transcriptional activation of the Tlr4 gene in mesangial cells are not known, and the specificity of this response for other renal cells is unclear...
  23. doi request reprint Vitamin B6 metabolism in chronic kidney disease--relation to transsulfuration, advanced glycation and cardiovascular disease
    Martin Busch
    Department of Internal Medicine III, University of Jena, Jena, Germany
    Nephron Clin Pract 114:c38-46. 2010
    ..Pyridoxamine exerts inhibitory effects on the formation of advanced glycation endproducts (AGE) implicated in the pathogenesis of CKD and atherosclerosis...
  24. doi request reprint Collagen VIII influences epithelial phenotypic changes in experimental diabetic nephropathy
    Ivonne Loeffler
    Department of Internal Medicine III, University Hospital, University of Jena, Erlanger Allee 101, Jena, Germany
    Am J Physiol Renal Physiol 303:F733-45. 2012
    ....
  25. ncbi request reprint Extracellular actin impairs glomerular capillary repair in experimental mesangioproliferative glomerulonephritis
    Ulf Janssen
    Division of Nephrology, Universitie of Aachen, Germany
    Nephron Exp Nephrol 93:e158-67. 2003
    ..Our combined in vivo and in vitro observations suggest that the release of intracellular actin during mesangiolysis is an endogenous pathway by which glomerular capillary damage is augmented...
  26. ncbi request reprint Cell cycle control in glomerular disease
    Gunter Wolf
    Department of Medicine, Division of Nephrology, University of Hamburg, Hamburg, Germany
    Prog Cell Cycle Res 5:71-9. 2003
    ..Each leads to glomerular scarring, and a decline in renal function. Studies have shown that these events are critically controlled by cell cycle regulatory proteins, providing potential targets for the development of future therapeutics...
  27. ncbi request reprint Rosiglitazone increases PPARgamma in renal tubular epithelial cells and protects against damage by hydrogen peroxide
    Manfred Sommer
    Department of Internal Medicine III, University of Jena, Jena, Germany
    Am J Nephrol 27:425-34. 2007
    ....
  28. ncbi request reprint Inhibition of platelet-derived growth factor-induced mesangial cell proliferation by cyclooxygenase-2 overexpression is abolished through reactive oxygen species
    Gunther Zahner
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Martinistr 52, 20246 Hamburg, Germany
    FEBS Lett 580:2523-8. 2006
    ..The data suggest that COX-2 decreases ROS formation which consequently leads to the PDGF-induced inhibition of MC proliferation...
  29. doi request reprint Renal IL-17 expression in human ANCA-associated glomerulonephritis
    Joachim Velden
    Nierenregister, Institut fur Pathologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Am J Physiol Renal Physiol 302:F1663-73. 2012
    ..IL-17 may thus be a target for treating acute ANCA-associated glomerulonephritis...
  30. ncbi request reprint No association between a genetic variant of the p22(phox) component of NAD(P)H oxidase and the incidence and progression of IgA nephropathy
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Hamburg, Germany
    Nephrol Dial Transplant 17:1509-12. 2002
    ..Patients with lupus nephritis were also investigated. The distribution of the C242T gene variation of p22(phox) has not been previously studied in patients with renal disease...
  31. ncbi request reprint New aspects of the relationship among hypertension, obesity, and the kidneys
    Anja Sachse
    Klinik fur Innere Medizin III, University of Jena, Erlanger Allee 101, D 07347 Jena, Germany
    Curr Hypertens Rep 10:138-42. 2008
    ..The causal pathways linking excess weight to chronic kidney disease and hypertension are briefly reviewed in this article, and therapeutic approaches to combat this growing health problem are highlighted...
  32. ncbi request reprint Effects of different PPARgamma-agonists on MCP-1 expression and monocyte recruitment in experimental glomerulonephritis
    Ulf Panzer
    Zentrum fur Innere Medizin, Medizinische Klinik IV, University of Hamburg, Hamburg, Germany
    Kidney Int 62:455-64. 2002
    ..We evaluated the effects of different forms of PPARgamma activators in a model of experimental glomerulonephritis (GN) in rats...
  33. ncbi request reprint Angiotensin II-induced reactive oxygen species and the kidney
    Anja Sachse
    Department of Medicine, University of Jena, Jena, Germany
    J Am Soc Nephrol 18:2439-46. 2007
    ..Although the concept that AngII mediates oxidative stress in the kidney has been validated in experimental models, the exact role is still incompletely understood in human renal diseases...
  34. ncbi request reprint The renin-angiotensin system and progression of renal disease: from hemodynamics to cell biology
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Germany
    Nephron Physiol 93:P3-13. 2003
    ..Finally, clinical implications are suggested based on data from clinical studies. A thorough understanding of the RAS is important to recognize the potential of nephroprotective strategies through inhibition of its components...
  35. ncbi request reprint Beneficial and adverse renal and vascular effects of the vasopeptidase inhibitor omapatrilat in renovascular hypertensive rats
    Ulrich O Wenzel
    University Hospital of Hamburg Eppendorf, Department of Medicine, Division of Nephrology, Pav 61, Martinistrasse 52, D 20246 Hamburg, Germany
    Nephrol Dial Transplant 18:2005-13. 2003
    ....
  36. ncbi request reprint Angiotensin II activates nuclear transcription factor-kappaB through AT1 and AT2 receptors
    Gunter Wolf
    Division of Nephrology and Osteology, Department of Medicine, University of Hamburg, Hamburg, Germany
    Kidney Int 61:1986-95. 2002
    ..We focused particularly on the Ang II subtype 2 (AT2) receptor because we previously observed that Ang II-induction of the chemokine RANTES in vitro and in vivo is mediated through AT2 receptors...
  37. ncbi request reprint CD2-associated protein and glomerular disease
    Gunter Wolf
    Department of Medicine, Division of Nephrology, Rheumatology, and Osteology, University of Hamburg, D 20246, Hamburg, Germany
    Lancet 362:1746-8. 2003
    ..However, first studies looking at the most common form of glomerulonephritis, IgA nephropathy, have failed to show decreased renal CD2AP expression...
  38. ncbi request reprint Friedrich Theodor von Frerichs (1819-1885) and Bright's disease
    Gunter Wolf
    Division of Nephrology and Osteology, Department of Medicine, University of Hamburg, Germany
    Am J Nephrol 22:596-602. 2002
    ..Friedrich Theodor von Frerichs (1819-1885) performed microscopic studies on Bright's disease and wrote the first German textbook of nephrology. The present contribution analyzes Frerichs' work...
  39. doi request reprint Influence of direct thrombin inhibitor argatroban on coagulation assays in healthy individuals, patients under oral anticoagulation therapy and patients with liver dysfunction
    Robert Siegmund
    Institut für Klinische Chemie und Laboratoriumsdiagnostik, Universitatsklinikum Jena, Jena, Germany
    Blood Coagul Fibrinolysis 19:288-93. 2008
    ..Argatroban had no influence on chromogenic protein C measurement, batroxobin time and induced platelet aggregation. Knowledge of argatroban interference is a prerequisite for the reliable interpretation of coagulation assays...
  40. doi request reprint [Very severe thrombotic thrombocytopenic purpura (TTP) after H1N1 vaccination]
    Regina Hermann
    Klinik fur Innere Medizin III, Universitatsklinikum Jena, Jena, Germany
    Med Klin (Munich) 105:663-8. 2010
    ..Induction of autoantibodies mechanistically is incompletely understood, but certain drugs can induce anti-ADAMTS13 antibodies through hapten mechanisms...
  41. ncbi request reprint Computer-aided joint space analysis of the metacarpal-phalangeal and proximal-interphalangeal finger joint: normative age-related and gender-specific data
    Alexander Pfeil
    Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University Jena, Erlanger Allee 101, 07747 Jena, Germany
    Skeletal Radiol 36:853-64. 2007
    ....
  42. ncbi request reprint "As time goes by": angiotensin II-mediated transactivation of the EGF receptor comes of age
    Gunter Wolf
    Department of Internal Medicine III, University Hospital Jena, Erlanger Allee 101, D 07740 Jena, Germany
    Nephrol Dial Transplant 20:2050-3. 2005
  43. ncbi request reprint Influence of flickering light on the retinal vessels in diabetic patients
    Aleksandra Mandecka
    Department of Internal Medicine III, Friedrich Schiller University, Bachstrasse 18, 07743, Jena, Germany
    Diabetes Care 30:3048-52. 2007
    ..The reduction of vasodilation is considered an endothelial dysfunction. We investigated the response of retinal vessels to flickering light in diabetic patients in different stages of diabetic retinopathy...
  44. ncbi request reprint Advanced glycation endproducts influence the mRNA expression of RAGE, RANKL and various osteoblastic genes in human osteoblasts
    Sybille Franke
    Clinic of Internal Medicine III, Friedrich Schiller University Jena, Germany
    Arch Physiol Biochem 113:154-61. 2007
    ..Thus, AGEs may play a functional role in the development of bone diseases (e.g. osteoporosis)...
  45. doi request reprint Comparison of the ecarin chromogenic assay and different aPTT assays for the measurement of argatroban concentrations in plasma from healthy individuals and from coagulation factor deficient patients
    Robert Siegmund
    Institut für Klinische Chemie und Laboratoriumsdiagnostik, Universitatsklinikum Jena, Jena, Germany
    Thromb Res 123:159-65. 2008
    ....
  46. doi request reprint Significance of risk factors for osteoporosis is dependent on gender and menopause in rheumatoid arthritis
    Peter Oelzner
    Division of Rheumatology and Osteology, Department of Internal Medicine III, Friedrich Schiller University of Jena, Erlanger Allee 101, 07740 Jena, Germany
    Rheumatol Int 28:1143-50. 2008
    ..There is a very high prevalence of osteoporosis not only in postmenopausal women but also in men with RA. Osteoporosis risk factors are strongly dependent from gender and menopausal state...
  47. pmc Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells
    Sybille Franke
    Department Internal Medicine III, Jena University Hospital, Erlanger Allee 101, Jena, 07740, Germany
    Arthritis Res Ther 11:R136. 2009
    ..The present study investigates a potential influence of AGE-modified bovine serum albumin (AGE-BSA) on cell growth, and on the expression of proinflammatory and osteoclastogenic markers in cultured FLS...
  48. doi request reprint Parenchymal and pleural findings in pulmonary embolism visualized by multi-channel detector computed tomography
    Alexander Pfeil
    Department of Internal Medicine III, Friedrich Schiller University Jena, Germany
    Acta Radiol 51:775-81. 2010
    ..Multi-channel detector CT (MDCT) with thinner collimation may improve the detection of small peripheral PEs causing such abnormalities...
  49. doi request reprint Abnormal retinal autoregulation is detected by provoked stimulation with flicker light in well-controlled patients with type 1 diabetes without retinopathy
    Aleksandra Mandecka
    Department of Internal Medicine III, Friedrich Schiller University, Jena, Germany
    Diabetes Res Clin Pract 86:51-5. 2009
    ..We investigated whether dynamic analysis apart from the static one in type 1 diabetic patients without diabetic retinopathy with well-controlled diabetes could lead to additional information regarding retinal autoregulation...
  50. doi request reprint [Prevalence of polyglandular autoimmune syndrome in patients with diabetes mellitus type 1]
    Wilgard Hunger-Battefeld
    Klinik fur Innere Medizin III, Universitatsklinikum Jena, Jena
    Med Klin (Munich) 104:183-91. 2009
    ....
  51. doi request reprint Combined en-bloc liver-pancreas transplantation in patients with liver cirrhosis and insulin-dependent type 2 diabetes mellitus
    Arno Kornberg
    Department of General, Visceral and Vascular Surgery, Friedrich Schiller University, Jena, Germany
    Transplantation 87:542-5. 2009
    ....
  52. doi request reprint Transthoracic sonography in comparison to multislice computed tomography in detection of peripheral pulmonary embolism
    Alexander Pfeil
    Department of Internal Medicine III, Friedrich Schiller University of Jena, Erlanger Allee 101, 07747 Jena, Germany
    Lung 188:43-50. 2010
    ..In case of contraindication with MSCT, TS is a potential technique for diagnosing PE-related parenchymal findings and can serve as an alternative method in the diagnosis of PE. However, a negative result with TS does not rule out a PE...
  53. pmc Cognitive function is not associated with recurrent foot ulcers in patients with diabetes and neuropathy
    Christof Kloos
    Department of Medicine III, University Hospital, Jena, Germany
    Diabetes Care 32:894-6. 2009
    ..To study whether there is an association between cognitive impairment and the relapse rate of foot ulcers in diabetic patients and those with previous foot ulcers...
  54. doi request reprint Influence of Rituximab on markers of bone remodeling in patients with rheumatoid arthritis: a prospective open-label pilot study
    Gert Hein
    Department of Internal Medicine III, University Hospital Jena, Erlanger Allee 101, 07740, Jena, Germany
    Rheumatol Int 31:269-72. 2011
    ..In contrast, it appears that Rtx lowered osteoclast activity often found increased in active rheumatoid arthritis contributing to osteoporosis in this disease...
  55. doi request reprint Acute chest pain, heart failure, and eosinophilia in a woman without coronary disease
    Alexander Pfeil
    Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University Jena, Erlanger Allee 101, Jena, 07747, Germany
    Cardiovasc Intervent Radiol 32:1272-4. 2009
    ..CMRI is a potentially important diagnostic tool for the early detection of dangerous cardiac complications of CSS, allowing optimal and timely therapy and reducing the comorbidity of the disease...
  56. doi request reprint Diabetic foot syndrome and renal function in type 1 and 2 diabetes mellitus show close association
    Gunter Wolf
    Klinik fur Innere Medizin III, Klinikum der Friedrich Schiller Universitat Jena, Jena, Germany
    Nephrol Dial Transplant 24:1896-901. 2009
    ..Patients were grouped into the chronic kidney disease (CKD) stages according to the eGFR and presence of albuminuria. DFS was classified according to Wagner as well as Armstrong stages...
  57. doi request reprint Benefit of a 17-year long-term bisphosphonate therapy in a patient with Gorham-Stout syndrome
    Gabriele Lehmann
    Department of Internal Medicine III, Friedrich Schiller University Jena, Erlanger Allee 101, 07747, Jena, Germany
    Arch Orthop Trauma Surg 129:967-72. 2009
    ..However, physical disability is reduced, but without soaring handicaps suggesting that long-term bisphophonate therapy is a therapeutical option for this rare syndrome...
  58. doi request reprint Hemoglobin concentrations are closely linked to renal function in patients with type 1 or 2 diabetes mellitus
    Gunter Wolf
    Klinik fur Innere Medizin III, Klinikum der Friedrich Schiller Universität, Jena, Germany
    Kidney Blood Press Res 31:313-21. 2008
    ..It has been reported that anemia is more common in patients with diabetes mellitus, and that it occurs early in the disease process...
  59. doi request reprint [Treatment of idiopathic membranous nephropathy. Is the anti-CD20 antibody rituximab a reasonable option?]
    Martin Busch
    Klinik fur Innere Medizin III, Klinikum der Friedrich Schiller Universitat Jena, Jena
    Med Klin (Munich) 103:519-24. 2008
    ..In many cases, the etiology is unknown. Whether and how to treat MN is still a controversial question. Despite the use of corticosteroids and alkylating agents, up to 40% of patients still progress to end-stage renal failure...
  60. doi request reprint Combined magnetic resonance imaging of deep venous thrombosis and pulmonary arteries after a single injection of a blood pool contrast agent
    Andreas Hansch
    Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University Jena, Jena, Germany
    Eur Radiol 21:318-25. 2011
    ..The potential of this method to detect pulmonary embolism (PE) was also evaluated...
  61. ncbi request reprint Novel aspects of the renin-angiotensin-aldosterone-system
    Gunter Wolf
    Department of Internal Medicine III, Friedrich Schiller University, Jena, Germany
    Front Biosci 13:4993-5005. 2008
    ..This review will highlight some of these novel insights into the RAAS in regards to renal injury...
  62. ncbi request reprint [The renin-angiotensin-aldosterone system -- more complex as previously thought]
    Gunter Wolf
    Klinik fur Innere Medizin III, Klinikum der Friedrich Schiller Universitat Jena, Jena
    Med Klin (Munich) 100:471-7. 2005
    ..ANG II has many pleiotropic effects on the kidney such as pro-inflammatory and profibrotic actions besides the well-known blood pressure-increasing effect...
  63. ncbi request reprint [A rare cause of anemia in a kidney-transplant recipient]
    Jan von Ohsen
    Klinik für Innere Medizin III der Friedrich Schiller Universität Jena, Jena
    Med Klin (Munich) 101:577-82. 2006
    ..Anemia is a phenomenon frequently observed after kidney transplantation and differential diagnosis is broad...
  64. ncbi request reprint [Prevalence of renal insufficiency in the diabetes TUV of the Deutsche BKK]
    Gunter Wolf
    Klinik für Innere Medizin III der Friedrich Schiller Universität Jena, Jena
    Med Klin (Munich) 101:441-7. 2006
    ..The aim of this retrospective study was to screen the diabetes TUV registry data regarding nephropathy...
  65. ncbi request reprint Normative data for digital X-ray radiogrammetry from a female and male German cohort
    Joachim Böttcher
    Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University Jena, Jena, Germany
    J Clin Densitom 9:341-50. 2006
    ..Based on this reference data, a valid and reliable quantification of disease-related demineralization based on measurements of DXR BMD and MCI is now available for the Caucasian ethnic group...
  66. ncbi request reprint Images in cardiovascular medicine. A swelling of the right neck and sudden death
    Thomas Neumann
    Department of Medicine III, Friedrich Schiller University Jena, Germany
    Circulation 113:e768-9. 2006
  67. ncbi request reprint Are oral contraceptives associated with increased renin-angiotensin activity and risk of nephropathy in diabetic women?
    Gunter Wolf
    Department of Internal Medicine III, Friedrich Schiller University of Jena Jena, Germany
    Nat Clin Pract Nephrol 2:78-9. 2006
  68. pmc Computerized digital imaging techniques provided by digital X-ray radiogrammetry as new diagnostic tool in rheumatoid arthritis
    Joachim Böttcher
    Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University Jena, Erlanger Allee 101, 07747, Jena, Germany
    J Digit Imaging 19:279-88. 2006
    ....
  69. ncbi request reprint Advanced glycation end products and the kidney
    Jürgen M Bohlender
    Klinik fur Innere Medizin III, Universitätsklinik Jena, Erlanger Allee 101, Jena, Germany
    Am J Physiol Renal Physiol 289:F645-59. 2005
    ..Interference with AGE formation has therapeutic potential for preventing the progression of chronic renal diseases, as shown from data of animal experiments and, more recently, the first clinical trials...
  70. ncbi request reprint Hypercalcemia in rheumatoid arthritis: relationship with disease activity and bone metabolism
    Peter Oelzner
    Department of Internal Medicine III, Division of Rheumatology Osteology, Friedrich Schiller University, Erlanger Allee 101, 07740 Jena, Germany
    Rheumatol Int 26:908-15. 2006
    ..High levels of ionized calcium may be a reflection of disease-activity-related systemic bone loss, and could be a predictor of BMD at the lumbar spine in RA...
  71. ncbi request reprint Computerized quantification of joint space narrowing and periarticular demineralization in patients with rheumatoid arthritis based on digital x-ray radiogrammetry
    Joachim Böttcher
    Institute of Diagnostic and Interventional Radiology Friedrich Schiller University Jena, Germany
    Invest Radiol 41:36-44. 2006
    ....
  72. ncbi request reprint [Nephrology: renal transplantation]
    Undine Ott
    Klinik fur Innere Medizin III, Friedrich Schiller Universitat Jena, Jena, Deutschland
    Med Klin (Munich) 102:219-29. 2007
    ..New markers are necessary for monitoring. The aftercare in the transplant center in close collaboration with nephrologists and family doctors is essential for a successful transplantation...
  73. pmc Normative reference values of joint space width estimated by computer-aided joint space analysis (CAJSA): the distal interphalangeal joint
    Alexander Pfeil
    Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University Jena, Jena, Germany
    J Digit Imaging 21:104-12. 2008
    ..The semiautomated computer-aided diagnostic system provides the estimation of joint space width at the distal interphalangeal joints, considering gender-specific and age-related changes...
  74. ncbi request reprint Leptin and renal fibrosis
    Gunter Wolf
    Department of Internal Medicine III, Friedrich Schiller University, Jena, Germany
    Contrib Nephrol 151:175-83. 2006
    ..These findings collectively suggest that the kidney is a target organ for leptin and that this hormone might play an important role in renal pathophysiology...
  75. doi request reprint Association between socioeconomic status and renal function in a population of German patients with diabetic nephropathy treated at a tertiary centre
    Gunter Wolf
    Department of Internal Medicine III, University of Jena, Jena, Germany
    Nephrol Dial Transplant 26:4017-23. 2011
    ..No data are available whether the SES influences the development of diabetic nephropathy in patients with diabetes mellitus in Germany...
  76. doi request reprint Cardiac involvement in Churg-Strauss syndrome: impact of endomyocarditis
    Thomas Neumann
    Department of Internal Medicine, University of Jena, Jena, Germany
    Medicine (Baltimore) 88:236-43. 2009
    ..A structured clinical assessment incorporating cardiac imaging with echocardiography and MRI can identify impaired cardiac function and endomyocardial abnormalities...
  77. ncbi request reprint Cellular and molecular mechanisms of proteinuria in diabetic nephropathy
    Gunter Wolf
    Klinik fur Innere Medizin III, University of Jena, Jena, Germany
    Nephron Physiol 106:p26-31. 2007
    ..Good control of hyperglycemia and hypertension and maximal inhibition of ANG II are essential steps in preventing the development and progression of diabetic nephropathy...
  78. ncbi request reprint Angiotensin II and tubular development
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, University Hospital Eppendorf, Hamburg, Germany
    Nephrol Dial Transplant 17:48-51. 2002
    ..Therefore, alterations in AT2 receptor signalling may alter the delicate balance between growth stimulation and inhibition, leading to alterations in tubular formation...
  79. ncbi request reprint The advanced glycation end product N(epsilon)-carboxymethyllysine is not a predictor of cardiovascular events and renal outcomes in patients with type 2 diabetic kidney disease and hypertension
    Martin Busch
    Department of Internal Medicine III and Institute of Medical Statistics and Computer Sciences, University of Jena, Germany
    Am J Kidney Dis 48:571-9. 2006
    ..The oxidatively formed AGE N(epsilon)-carboxymethyllysine (CML) is thought to be a marker of oxidative stress...
  80. pmc Hydroxyethylstarch impairs renal function and induces interstitial proliferation, macrophage infiltration and tubular damage in an isolated renal perfusion model
    Lars Hüter
    Department of Anaesthesiology and Intensive Care Medicine, University of Jena, Erlanger Allee, Jena, Germany
    Crit Care 13:R23. 2009
    ..The aim of the study was to evaluate some of the underlying pathomechanisms of hydroxyethylstarch (HES) induced adverse effects on renal function using 24 porcine kidneys in an isolated perfusion model over six hours...
  81. ncbi request reprint Growth factors and the development of diabetic nephropathy
    Gunter Wolf
    University of Hamburg, University Hospital Eppendorf, Department of Medicine, Division of Nephrology, Rheumatology, and Osteology, Hamburg, Germany
    Curr Diab Rep 3:485-90. 2003
    ..However, the pleiotropic function of many of these factors and their physiologic role in normal renal homeostasis may make this approach difficult...
  82. ncbi request reprint A 63-year-old man with acute abdominal pain and laboratory signs of rapid progressive renal disease
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Hamburg, Germany
    Nephrol Dial Transplant 19:742-4. 2004
  83. ncbi request reprint After all those fat years: renal consequences of obesity
    Gunter Wolf
    Department of Medicine, Division of Nephrology, Rheumatology and Osteology, University of Hamburg, University Hospital Eppendorf, Pavilion N26, Martinistrasse 52, D 20246 Hamburg, Germany
    Nephrol Dial Transplant 18:2471-4. 2003
  84. ncbi request reprint Georg Büchner's Woyzeck. A tragic example of human experimentation without informed consent
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, University Hospital Eppendorf, Pavilion N26, Martinistrasse 52, D 20246 Hamburg, Germany
    Pharos Alpha Omega Alpha Honor Med Soc 67:23-8. 2004
  85. doi request reprint Cholesterol embolization in a renal graft
    Undine Ott
    Department of Internal Medicine III, University of Jena, Jena, Germany
    Clin Transplant 22:677-80. 2008
    ..The reason for this difference may be the more extensive embolization developing in an atherosclerotic cadaver donor occurring during the organ procurement or the severe trauma leading to death...
  86. doi request reprint A kidney from hell? A nephrological view of the Whitechapel murders in 1888
    Gunter Wolf
    Department of Medicine, University of Jena, Jena, Germany
    Nephrol Dial Transplant 23:3343-9. 2008
    ..We will never know who this mentally disturbed 'nephrophilic' was. Today, the story of Jack the Ripper is part of contemporary culture...
  87. ncbi request reprint The hypertrophic effect of transforming growth factor-beta is reduced in the absence of cyclin-dependent kinase-inhibitors p21 and p27
    Toshiaki Monkawa
    Department of Medicine, Division of Nephrology, University of Washington, Seattle, Washington 98195, USA
    J Am Soc Nephrol 13:1172-8. 2002
    ..However, the hypertrophic growth effects of TGF-beta are reduced in the absence of both p21 and p27. These data suggest that the regulation of the antiproliferative and hypertrophic effects of TGF-beta may be distinct processes...
  88. ncbi request reprint A woman with increasing weakness of the legs and irregular heartbeat who took her husband's medication
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Germany
    Nephrol Dial Transplant 17:1698-701. 2002
  89. ncbi request reprint Diabetic nephropathy in type 2 diabetes prevention and patient management
    Gunter Wolf
    Department of Medicine, Division of Nephrology, University of Hamburg, Hamburg, Germany
    J Am Soc Nephrol 14:1396-405. 2003
  90. ncbi request reprint Histiocytosis X and renal insufficiency
    Christine Materne
    Department of Internal Medicine III, University of Jena, Jena, Germany
    Nephrol Dial Transplant 22:3664-7. 2007
  91. ncbi request reprint Angiotensin II infusion ameliorates the early phase of a mesangioproliferative glomerulonephritis
    Ulrich O Wenzel
    Division of Nephrology, Department of Medicine, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Kidney Int 61:1020-9. 2002
    ..Inhibition of the renin-angiotensin system slows the progression of chronic renal disease...
  92. ncbi request reprint An expensive multifactorial renal failure
    Gunter Wolf
    Division of Nephrology and Osteology, Department of Medicine, University of Hamburg, Germany
    Nephrol Dial Transplant 19:2921-2. 2004
  93. ncbi request reprint Leptin and renal disease
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Germany
    Am J Kidney Dis 39:1-11. 2002
    ..These findings collectively suggest that the kidney is not only a site of leptin metabolism, but also a target organ for leptin action in pathophysiological states...
  94. ncbi request reprint Computer-aided joint space analysis (CAJSA) of the proximal-interphalangeal joint-normative age-related and gender specific data
    Alexander Pfeil
    Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University Jena, Erlanger Allee 101, 07747 Jena, Germany
    Acad Radiol 14:594-602. 2007
    ....
  95. ncbi request reprint Induction of p27KIP1 after unilateral ureteral obstruction is independent of angiotensin II
    Jens H Gerth
    Klinik für Innere Medizin IV der Universität Jena, Germany
    Kidney Int 61:68-79. 2002
    ..The current study tested the hypothesis that interference with the RAS may modulate renal expression of p27KIP1 after UUO...
  96. ncbi request reprint "The road not taken": role of angiotensin II type 2 receptor in pathophysiology
    Gunter Wolf
    Nephrol Dial Transplant 17:195-8. 2002
  97. ncbi request reprint Renin-angiotensin-aldosterone system and progression of renal disease
    Christiane Ruster
    Department of Internal Medicine III, Friedrich Schiller University, Jena, Germany
    J Am Soc Nephrol 17:2985-91. 2006
    ....
  98. ncbi request reprint New selective AT2 receptor ligands encompassing a gamma-turn mimetic replacing the amino acid residues 4-5 of angiotensin II act as agonists
    Ulrika Rosenström
    Department of Medicinal Chemistry, BMC, Uppsala University, Sweden
    J Med Chem 48:4009-24. 2005
    ..The pseudopeptides selected for agonist studies were shown to act as AT(2) receptor agonists being able to induce outgrowth of neurite cells, stimulate p42/p44(mapk), and suppress proliferation of PC12 cells...
  99. ncbi request reprint A Friday afternoon case of apparent anti-glomerular basement nephritis
    Michael Ruster
    Department of Internal Medicine III, University Hospital Jena, Erlanger Allee 101, D 07747 Jena, Germany
    Nephrol Dial Transplant 21:2328-30. 2006
  100. ncbi request reprint From the periphery of the glomerular capillary wall toward the center of disease: podocyte injury comes of age in diabetic nephropathy
    Gunter Wolf
    Renal Electrolyte and Hypertension Division, University of Pennsylvania, 700 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104 4218, USA
    Diabetes 54:1626-34. 2005
    ..The mainstays of therapy, glycemic control and inhibition of ANG II, are key measures to prevent early podocyte injury and the subsequent development of diabetic nephropathy...
  101. ncbi request reprint Angiotensin II stimulates alpha3(IV) collagen production in mouse podocytes via TGF-beta and VEGF signalling: implications for diabetic glomerulopathy
    Sheldon Chen
    Renal Electrolyte and Hypertension Division of the University of Pennsylvania, Philadelphia, PA, USA
    Nephrol Dial Transplant 20:1320-8. 2005
    ..Podocyte expression of alpha3(IV) collagen may involve the transforming growth factor-beta (TGF-beta) and vascular endothelial growth factor (VEGF) systems...