Gerd Wagner

Summary

Affiliation: Friedrich Schiller University
Country: Germany

Publications

  1. ncbi request reprint Influence of antipsychotic medication on pain perception in schizophrenia
    Thomas Jochum
    Department of Psychiatry, Friedrich Schiller University of Jena, Germany
    Psychiatry Res 142:151-6. 2006
  2. pmc Enhanced rostral anterior cingulate cortex activation during cognitive control is related to orbitofrontal volume reduction in unipolar depression
    Gerd Wagner
    Department of Psychiatry, University of Jena, Ersatztext Jena, Germany
    J Psychiatry Neurosci 33:199-208. 2008
  3. pmc Self-referential processing influences functional activation during cognitive control: an fMRI study
    Gerd Wagner
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Centre for Neuroimaging, Jahnstr 3, 07740 Jena, Germany
    Soc Cogn Affect Neurosci 8:828-37. 2013
  4. doi request reprint Prefrontal cortical thickness in depressed patients with high-risk for suicidal behavior
    Gerd Wagner
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Centre for Neuroimaging, Jahnstr 3, 07740 Jena, Germany
    J Psychiatr Res 46:1449-55. 2012
  5. ncbi request reprint Cortical inefficiency in patients with unipolar depression: an event-related FMRI study with the Stroop task
    Gerd Wagner
    Department of Psychiatry, University of Jena, Jena, Germany
    Biol Psychiatry 59:958-65. 2006
  6. doi request reprint Structural brain alterations in patients with major depressive disorder and high risk for suicide: evidence for a distinct neurobiological entity?
    Gerd Wagner
    Department of Psychiatry and Psychotherapy, University of Jena, Jena, Germany
    Neuroimage 54:1607-14. 2011
  7. pmc Differential effects of serotonergic and noradrenergic antidepressants on brain activity during a cognitive control task and neurofunctional prediction of treatment outcome in patients with depression
    Gerd Wagner
    Department of Psychiatry and Psychotherapy, University of Jena, Germany
    J Psychiatry Neurosci 35:247-57. 2010
  8. ncbi request reprint The special involvement of the rostrolateral prefrontal cortex in planning abilities: an event-related fMRI study with the Tower of London paradigm
    Gerd Wagner
    Department of Psychiatry, University of Jena, Germany
    Neuropsychologia 44:2337-47. 2006
  9. ncbi request reprint Inefficient executive cognitive control in schizophrenia is preceded by altered functional activation during information encoding: an fMRI study
    Ralf G M Schlösser
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Neuropsychologia 46:336-47. 2008
  10. doi request reprint Reduced anterior cingulate cognitive activation is associated with prefrontal-temporal cortical thinning in schizophrenia
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jena, Germany
    Biol Psychiatry 71:146-53. 2012

Detail Information

Publications49

  1. ncbi request reprint Influence of antipsychotic medication on pain perception in schizophrenia
    Thomas Jochum
    Department of Psychiatry, Friedrich Schiller University of Jena, Germany
    Psychiatry Res 142:151-6. 2006
    ..Future studies should evaluate attentional deficits in schizophrenia in relation to pain perception...
  2. pmc Enhanced rostral anterior cingulate cortex activation during cognitive control is related to orbitofrontal volume reduction in unipolar depression
    Gerd Wagner
    Department of Psychiatry, University of Jena, Ersatztext Jena, Germany
    J Psychiatry Neurosci 33:199-208. 2008
    ....
  3. pmc Self-referential processing influences functional activation during cognitive control: an fMRI study
    Gerd Wagner
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Centre for Neuroimaging, Jahnstr 3, 07740 Jena, Germany
    Soc Cogn Affect Neurosci 8:828-37. 2013
    ....
  4. doi request reprint Prefrontal cortical thickness in depressed patients with high-risk for suicidal behavior
    Gerd Wagner
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Centre for Neuroimaging, Jahnstr 3, 07740 Jena, Germany
    J Psychiatr Res 46:1449-55. 2012
    ..This alteration may constitute the neurobiological basis for an increased predisposition to suicidal behavior...
  5. ncbi request reprint Cortical inefficiency in patients with unipolar depression: an event-related FMRI study with the Stroop task
    Gerd Wagner
    Department of Psychiatry, University of Jena, Jena, Germany
    Biol Psychiatry 59:958-65. 2006
    ..The present study is aimed to examine the neuronal correlates of Stroop interference in medication-free patients with major depressive disorder...
  6. doi request reprint Structural brain alterations in patients with major depressive disorder and high risk for suicide: evidence for a distinct neurobiological entity?
    Gerd Wagner
    Department of Psychiatry and Psychotherapy, University of Jena, Jena, Germany
    Neuroimage 54:1607-14. 2011
    ....
  7. pmc Differential effects of serotonergic and noradrenergic antidepressants on brain activity during a cognitive control task and neurofunctional prediction of treatment outcome in patients with depression
    Gerd Wagner
    Department of Psychiatry and Psychotherapy, University of Jena, Germany
    J Psychiatry Neurosci 35:247-57. 2010
    ..We predicted that pretreatment hyperactivity in the rostral anterior cingulate cortex would predict better treatment outcomes...
  8. ncbi request reprint The special involvement of the rostrolateral prefrontal cortex in planning abilities: an event-related fMRI study with the Tower of London paradigm
    Gerd Wagner
    Department of Psychiatry, University of Jena, Germany
    Neuropsychologia 44:2337-47. 2006
    ....
  9. ncbi request reprint Inefficient executive cognitive control in schizophrenia is preceded by altered functional activation during information encoding: an fMRI study
    Ralf G M Schlösser
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Neuropsychologia 46:336-47. 2008
    ..These results could be explained by increased top-down control processing from prefrontal cortex as a compensation for functional deficits occurring during encoding...
  10. doi request reprint Reduced anterior cingulate cognitive activation is associated with prefrontal-temporal cortical thinning in schizophrenia
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jena, Germany
    Biol Psychiatry 71:146-53. 2012
    ..Therefore, this study investigated the association of anterior cingulate cognitive activation and cortical thickness in schizophrenia combining functional magnetic resonance imaging (fMRI) and surface-based morphometry...
  11. pmc Association between learning capabilities and practice-related activation changes in schizophrenia
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Schizophr Bull 36:486-95. 2010
    ..The findings also suggest that successful learners can better compensate potentially interfering effects exerted by disorder-related psychopathology...
  12. ncbi request reprint Disrupted white matter integrity of corticopontine-cerebellar circuitry in schizophrenia
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jahnstr 3, Philosophenweg 3, 07740, Jena, Germany
    Eur Arch Psychiatry Clin Neurosci 260:419-26. 2010
    ..They corroborate preceding findings of white matter structural deficits in mainly long-ranging association fibers and provide first evidence for neuroplastic changes in terms of an increased directionality in more inferior fiber tracts...
  13. ncbi request reprint The novel brain-specific tryptophan hydroxylase-2 gene in panic disorder
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Psychopharmacol 20:547-52. 2006
    ..The results of this first study of TPH2 in panic disorder argue against an importance of allelic variation of TPH2 in the pathogenesis of panic disorder with or without agoraphobia...
  14. doi request reprint Reduced cortical thickness in first episode schizophrenia
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Schizophr Res 116:204-9. 2010
    ..In an extension of these earlier studies, we used an entire cortex vertex-wise approach and an automated clustering for the detection and exact quantification of cortical thickness alterations in first episode schizophrenia...
  15. ncbi request reprint White matter abnormalities and brain activation in schizophrenia: a combined DTI and fMRI study
    Ralf G M Schlösser
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University, 07743 Jena, Germany
    Schizophr Res 89:1-11. 2007
    ..It highlights a potential relationship between anatomical changes in a frontal-temporal anatomical circuit and functional alterations in the prefrontal cortex...
  16. doi request reprint Increased parahippocampal and lingual gyrification in first-episode schizophrenia
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Schizophr Res 123:137-44. 2010
    ....
  17. doi request reprint Psychopathological correlates of the entorhinal cortical shape in schizophrenia
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jena, Germany
    Eur Arch Psychiatry Clin Neurosci 260:351-8. 2010
    ..As cortical folding is a stable neuroanatomical parameter terminated in early neonatal stages, our data give reason to assume that the vulnerability to develop psychotic symptoms might be manifest at an early level of brain maturation...
  18. doi request reprint The visual cortex in schizophrenia: alterations of gyrification rather than cortical thickness--a combined cortical shape analysis
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Brain Struct Funct 218:51-8. 2013
    ..The present findings of hypergyria are highly indicative for a disrupted corticogenesis of these visual key regions and might constitute a relevant anatomical basis for visual processing deficits in schizophrenia...
  19. doi request reprint Aberrant anterior cingulate activation in obsessive-compulsive disorder is related to task complexity
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, University Hospital Jena, Philosophenweg 3, 07740 Jena, Germany
    Neuropsychologia 50:958-64. 2012
    ..However, findings regarding the underlying neural substrates are heterogeneous. Moreover, the influence of cognitive demand on the severity of these deficits and associated activation alterations is a matter of debate...
  20. doi request reprint Complex pattern of cortical thinning in schizophrenia: results from an automated surface based analysis of cortical thickness
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, Jena, Germany
    Psychiatry Res 182:134-40. 2010
    ..This pattern is consistent with a disruption of neurofunctional networks previously implicated in the pathophysiology of schizophrenia...
  21. ncbi request reprint Increased prefrontal activation during pain perception in major depression
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller University, Philosophenweg 3, Jena, Germany
    Biol Psychiatry 62:1281-7. 2007
    ....
  22. doi request reprint White matter structure and symptom dimensions in obsessive-compulsive disorder
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, University Hospital Jena, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    J Psychiatr Res 46:264-70. 2012
    ..Hence, different symptom dimensions must be taken into account in order to disentangle the neurobiological underpinnings of OCD...
  23. doi request reprint ADC changes in schizophrenia: a diffusion-weighted imaging study
    Igor Nenadic
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University of Jena, Philosophenweg 3, 07743, Jena, Germany
    Eur Arch Psychiatry Clin Neurosci 261:213-6. 2011
    ..Changes in other parameters like fractional anisotropy (FA) might be a more sensitive indicator of white matter pathology in this disorder...
  24. doi request reprint Altered error-related activity in patients with schizophrenia
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Neuropsychologia 47:2843-9. 2009
    ..Thus, present results clearly indicate that disorder-characteristic activation abnormalities become manifest during dysfunctional executive processing even when the moderating effect of performance is largely eliminated...
  25. ncbi request reprint Frequency domains of resting state default mode network activity in schizophrenia
    Gianluca Mingoia
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, D 07743 Jena, Germany
    Psychiatry Res 214:80-2. 2013
    ..Power spectrum analysis showed a significant diagnosis × frequency interaction and higher power in one frequency band, indicating an alteration of DMN frequency spectrum in schizophrenia...
  26. ncbi request reprint Decreased sensitivity to experimental pain in adjustment disorder
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller University of Jena, Philosophenweg 3, 07743 Jena, Germany
    Eur J Pain 10:467-71. 2006
    ..Although the underlying pathology is elusive it is likely that the mechanisms for reduced pain sensitivity are comparable in MDD and AD...
  27. doi request reprint Default mode network activity in schizophrenia studied at resting state using probabilistic ICA
    Gianluca Mingoia
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany
    Schizophr Res 138:143-9. 2012
    ..These findings suggest that aberrant default mode network connectivity contributes to regional functional pathology in schizophrenia and bears significance for core symptoms...
  28. doi request reprint Neural activation and radial diffusivity in schizophrenia: combined fMRI and diffusion tensor imaging study
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Germany
    Br J Psychiatry 198:223-9. 2011
    ..Most studies have investigated changes in fractional anisotropy, whereas alterations in radial or axial diffusivity have barely been investigated until now...
  29. doi request reprint Disrupted white matter connectivity is associated with reduced cortical thickness in the cingulate cortex in schizophrenia
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Jahnstr 3, Jena, Germany
    Cortex 49:722-9. 2013
    ..Neurodevelopmental models propose a close linkage between gray matter alterations and white matter deficits. However, there are no studies investigating alterations in cortical thickness in relation to white matter connectivity changes...
  30. doi request reprint Altered activation in association with reward-related trial-and-error learning in patients with schizophrenia
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jahnstr, Philosophenweg 3, 07740 Jena, Germany
    Neuroimage 50:223-32. 2010
    ..They moreover suggest that the activation deficits which patients exhibit in association with the processing of reinforcement might constitute the basis for the learning deficits and their accompanying activation alterations...
  31. ncbi request reprint Reduced heat pain thresholds after sad-mood induction are associated with changes in thalamic activity
    Gerd Wagner
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07743 Jena, Germany
    Neuropsychologia 47:980-7. 2009
    ..We present evidence that induced sad affect leads to reduced heat pain thresholds in healthy subjects. This is probably due to altered lateral thalamic activity, which is potentially associated with changed attentional processes...
  32. doi request reprint Age-dependent visuomotor performance and white matter structure: a DTI study
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07743 Jena, Germany
    Brain Struct Funct 218:1075-84. 2013
    ..However, these interindividual variations do not explain the observed association between age and TMT performance. ..
  33. doi request reprint Increased sensitivity to heat pain after sad mood induction in female patients with major depression
    Janneke Terhaar
    Department of Psychiatry and Psychotherapy, University Hospital, Jena, Germany
    Eur J Pain 14:559-63. 2010
    ....
  34. doi request reprint Fronto-cingulate effective connectivity in obsessive compulsive disorder: a study with fMRI and dynamic causal modeling
    Ralf G M Schlösser
    Department of Psychiatry, University of Jena, Germany
    Hum Brain Mapp 31:1834-50. 2010
    ..These findings are consistent with an overactive error control system in OCD subserving suppression of prepotent responses during decision-making...
  35. doi request reprint Association between white matter fiber structure and reward-related reactivity of the ventral striatum
    Kathrin Koch
    Department of Neuroradiology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07743 Jena, Germany
    Hum Brain Mapp 35:1469-76. 2014
    ....
  36. doi request reprint Multimodal functional and structural imaging investigations in psychosis research
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07740 Jena, Germany
    Eur Arch Psychiatry Clin Neurosci 262:S97-106. 2012
    ..Here, investigating the genetic foundations of brain pathology relationships is a major challenge for future multimodal imaging applications in psychosis research...
  37. pmc Reduced cortical thickness is associated with the glutamatergic regulatory gene risk variant DAOA Arg30Lys in schizophrenia
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jena, Germany
    Neuropsychopharmacology 36:1747-53. 2011
    ..Our finding thus underlines the importance of DAOA and related glutamatergic processes as a putative target for therapeutic interventions in schizophrenia...
  38. ncbi request reprint Temporal changes in neural activation during practice of information retrieval from short-term memory: an fMRI study
    Kathrin Koch
    Department of Psychiatry, University of Jena, Philosophenweg 3, 07740 Jena, Germany
    Brain Res 1107:140-50. 2006
    ..The temporal changes in brain activation patterns could be attributed to enhanced efficiency of information processing as a result of cognitive practice...
  39. doi request reprint Assessing the neural basis of uncertainty in perceptual category learning through varying levels of distortion
    Reka Daniel
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University of Jena, Jahnstrasse 3, 07743 Jena, Germany
    J Cogn Neurosci 23:1781-93. 2011
    ..This study characterizes the cortico-striatal network underlying the classification of distorted visual patterns that is directly related to decision uncertainty...
  40. doi request reprint The neural correlates of reward-related trial-and-error learning: an fMRI study with a probabilistic learning task
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jena, Germany
    Learn Mem 15:728-32. 2008
    ..In contrast, learning on the basis of predictable stimulus-outcome associations enables the brain to reduce resources in association with the processes of prediction...
  41. ncbi request reprint ZNF804A and cortical structure in schizophrenia: in vivo and postmortem studies
    Carl Christoph Schultz
    To whom correspondence should be addressed Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07740 Jena, Germany tel 49 3641 9 35665, fax 49 3641 9 35444, E mail
    Schizophr Bull 40:532-41. 2014
    ..In particular, the allele-specific expression profile in patients might constitute a molecular mechanism for the observed protective influence of ZNF804A on cortical thickness and folding and potentially other intermediate phenotypes. ..
  42. doi request reprint Neuropsychological impairments predict the clinical course in schizophrenia
    Wolfgang Wolwer
    Department of Psychiatry and Psychotherapy, Heinrich Heine University Düsseldorf Rhineland State Clinics Düsseldorf, Bergische Landstrasse 2, Dusseldorf, Germany
    Eur Arch Psychiatry Clin Neurosci 258:28-34. 2008
    ....
  43. ncbi request reprint Changes of pain perception, autonomic function, and endocrine parameters during treatment of anorectic adolescents
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller University, Jena, Germany
    J Am Acad Child Adolesc Psychiatry 45:1068-76. 2006
    ..To gain more insight into the pathology, the authors investigated pain perception, autonomic function, and endocrine parameters before and during successful treatment of adolescent AN patients...
  44. ncbi request reprint The influence of major depression and its treatment on heart rate variability and pupillary light reflex parameters
    Karl Jürgen Bär
    Departments of Psychiatry, Friedrich Schiller University of Jena, Philosophenweg 3, 07743 Jena, Germany
    J Affect Disord 82:245-52. 2004
    ..Former studies of autonomic dysfunction in major depression have shown inconclusive results...
  45. ncbi request reprint Pain perception in major depression depends on pain modality
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller University of Jena, Philosophenweg 3, 07743 Jena, Germany
    Pain 117:97-103. 2005
    ..This knowledge may enable us to understand and ultimately treat pain complaints more appropriately in depressed patients...
  46. ncbi request reprint Altered benzodiazepine receptor sensitivity in alcoholism: a study with fMRI and acute lorazepam challenge
    Ralf G M Schlösser
    Department of Psychiatry, University of Jena, Philosophenweg 3, 07740 Jena, Germany
    Psychiatry Res 154:241-51. 2007
    ..Moreover, the results suggest enhanced responsivity to an acute GABAergic challenge in the right cerebellum with disease-related disruption of cerebellar functional integrity...
  47. pmc The influence of negative mood on heart rate complexity measures and baroreflex sensitivity in healthy subjects
    Ralf Köbele
    Department of Psychiatry, Friedrich Schiller University, Jena, Germany
    Indian J Psychiatry 52:42-7. 2010
    ..We have previously shown that the Mood Induction Procedure (MIP) in healthy subjects alters pain perception and thalamic activity during pain perception...
  48. ncbi request reprint Association of a functional 1019C>G 5-HT1A receptor gene polymorphism with panic disorder with agoraphobia
    Claudia Rothe
    Department of Psychiatry, University of Munster, Germany
    Int J Neuropsychopharmacol 7:189-92. 2004
    ..03, n=101). In conclusion, our findings do not support a major contribution of this polymorphism to the pathogenesis of panic disorder, but provide evidence for a possible role in the subgroup with agoraphobia...