Stefan Schulz

Summary

Affiliation: Friedrich Schiller University
Country: Germany

Publications

  1. pmc Reassessment of CXCR4 chemokine receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-2
    Thomas Fischer
    Department of Pharmacology, Julius Maximilians University, Wurzburg, Germany
    PLoS ONE 3:e4069. 2008
  2. doi request reprint Phosphorylation of threonine 333 regulates trafficking of the human sst5 somatostatin receptor
    Aline Petrich
    Department of Pharmacology and Toxicology, Jena University Hospital Friedrich Schiller University Jena, Drackendorfer Strasse 1, D 07749 Jena, Germany
    Mol Endocrinol 27:671-82. 2013
  3. pmc Differentiation of opioid drug effects by hierarchical multi-site phosphorylation
    Sascha Just
    Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University Jena, Drackendorfer Straße 1, D 07747 Jena, Germany
    Mol Pharmacol 83:633-9. 2013
  4. doi request reprint Pasireotide and octreotide stimulate distinct patterns of sst2A somatostatin receptor phosphorylation
    Florian Pöll
    Department of Pharmacology and Toxicology, Friedrich Schiller University, Drackendorfer Strasse 1, D 07747 Jena, Germany
    Mol Endocrinol 24:436-46. 2010
  5. doi request reprint Regional and cellular localization of the CXCl12/SDF-1 chemokine receptor CXCR7 in the developing and adult rat brain
    Bastian Schönemeier
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Comp Neurol 510:207-20. 2008
  6. doi request reprint Real-time monitoring of somatostatin receptor-cAMP signaling in live pituitary
    Stefan Jacobs
    Institute of Pharmacology and Toxicology, University of Wurzburg, 97078 Wurzburg, Germany
    Endocrinology 151:4560-5. 2010
  7. pmc Hierarchical organization of multi-site phosphorylation at the CXCR4 C terminus
    Wiebke Mueller
    Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University, Jena, Germany
    PLoS ONE 8:e64975. 2013
  8. doi request reprint Structural determinants of agonist-selective signaling at the sst(2A) somatostatin receptor
    Falko Nagel
    Department of Pharmacology and Toxicology, University Hospital Jena, Friedrich Schiller University, Drackendorfer Strasse 1, D 07747 Jena, Germany
    Mol Endocrinol 25:859-66. 2011
  9. ncbi request reprint Patterns of SDF-1alpha and SDF-1gamma mRNAs, migration pathways, and phenotypes of CXCR4-expressing neurons in the developing rat telencephalon
    Ralf Stumm
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Comp Neurol 502:382-99. 2007
  10. pmc Rapid dephosphorylation of G protein-coupled receptors by protein phosphatase 1β is required for termination of β-arrestin-dependent signaling
    Florian Pöll
    Institute of Pharmacology and Toxicology, University Hospital, Friedrich Schiller University, D 07747 Jena, Germany
    J Biol Chem 286:32931-6. 2011

Collaborators

Detail Information

Publications36

  1. pmc Reassessment of CXCR4 chemokine receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-2
    Thomas Fischer
    Department of Pharmacology, Julius Maximilians University, Wurzburg, Germany
    PLoS ONE 3:e4069. 2008
    ....
  2. doi request reprint Phosphorylation of threonine 333 regulates trafficking of the human sst5 somatostatin receptor
    Aline Petrich
    Department of Pharmacology and Toxicology, Jena University Hospital Friedrich Schiller University Jena, Drackendorfer Strasse 1, D 07749 Jena, Germany
    Mol Endocrinol 27:671-82. 2013
    ..In addition, we identify G protein-coupled receptor kinase 2-mediated phosphorylation and protein phosphatase 1γ-mediated dephosphorylation of T333 as key regulators of rapid internalization and recycling of the human sst5 receptor...
  3. pmc Differentiation of opioid drug effects by hierarchical multi-site phosphorylation
    Sascha Just
    Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University Jena, Drackendorfer Straße 1, D 07747 Jena, Germany
    Mol Pharmacol 83:633-9. 2013
    ..These results reveal a biochemical mechanism differentiating the endocytic activity of opioid drugs...
  4. doi request reprint Pasireotide and octreotide stimulate distinct patterns of sst2A somatostatin receptor phosphorylation
    Florian Pöll
    Department of Pharmacology and Toxicology, Friedrich Schiller University, Drackendorfer Strasse 1, D 07747 Jena, Germany
    Mol Endocrinol 24:436-46. 2010
    ..Yet, we find that they promote strikingly different patterns of sst(2A) receptor phosphorylation and, hence, stimulate functionally distinct pools of beta-arrestin...
  5. doi request reprint Regional and cellular localization of the CXCl12/SDF-1 chemokine receptor CXCR7 in the developing and adult rat brain
    Bastian Schönemeier
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Comp Neurol 510:207-20. 2008
    ..Thus, CXCR4 and CXCR7 may cooperate or act independently in SDF-1-dependent neuronal development. In mature neurons and blood vessels CXCR7 appears to be the preponderant SDF-1-receptor...
  6. doi request reprint Real-time monitoring of somatostatin receptor-cAMP signaling in live pituitary
    Stefan Jacobs
    Institute of Pharmacology and Toxicology, University of Wurzburg, 97078 Wurzburg, Germany
    Endocrinology 151:4560-5. 2010
    ..This technique can be widely used to assess the contribution of various pituitary receptors, including individual G(i) protein-coupled somatostatin receptors, to the regulation of cAMP levels under physiologically relevant settings...
  7. pmc Hierarchical organization of multi-site phosphorylation at the CXCR4 C terminus
    Wiebke Mueller
    Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University, Jena, Germany
    PLoS ONE 8:e64975. 2013
    ..Hierarchical organization of CXCR4 phosphorylation explains why small deletions at the extreme CXCR4 C terminus typically associated with WHIM syndrome severely alter CXCR4 function...
  8. doi request reprint Structural determinants of agonist-selective signaling at the sst(2A) somatostatin receptor
    Falko Nagel
    Department of Pharmacology and Toxicology, University Hospital Jena, Friedrich Schiller University, Drackendorfer Strasse 1, D 07747 Jena, Germany
    Mol Endocrinol 25:859-66. 2011
    ..Together, these findings suggest that pasireotide activates the sst(2A) receptor via a molecular switch that is structurally and functionally distinct from that turned on during octreotide-driven sst(2A) activation...
  9. ncbi request reprint Patterns of SDF-1alpha and SDF-1gamma mRNAs, migration pathways, and phenotypes of CXCR4-expressing neurons in the developing rat telencephalon
    Ralf Stumm
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Comp Neurol 502:382-99. 2007
    ..We propose that regulated expression of SDF-1 in the intermediate/subventricular zone influences lateromedial tangential migration of CXCR4-expressing GABAergic neurons...
  10. pmc Rapid dephosphorylation of G protein-coupled receptors by protein phosphatase 1β is required for termination of β-arrestin-dependent signaling
    Florian Pöll
    Institute of Pharmacology and Toxicology, University Hospital, Friedrich Schiller University, D 07747 Jena, Germany
    J Biol Chem 286:32931-6. 2011
    ....
  11. doi request reprint Analgesic tolerance to high-efficacy agonists but not to morphine is diminished in phosphorylation-deficient S375A μ-opioid receptor knock-in mice
    Gisela Grecksch
    Institute of Pharmacology and Toxicology, Faculty of Medicine, Otto von Guericke University, D 39120 Magdeburg, Germany
    J Neurosci 31:13890-6. 2011
    ..Whereas tolerance induced by DAMGO or etonitazene requires agonist-driven phosphorylation of S375, the development and maintenance of antinociceptive tolerance to morphine occurs independent of S375 phosphorylation...
  12. doi request reprint UMB-3, a novel rabbit monoclonal antibody, for assessing μ-opioid receptor expression in mouse, rat and human formalin-fixed and paraffin-embedded tissues
    Amelie Lupp
    Department of Pharmacology and Toxicology, University Hospital, Friedrich Schiller University, D 07747 Jena, Germany
    Regul Pept 167:9-13. 2011
    ..Moreover, previous immunohistochemical investigations were restricted to frozen sections from perfusion-fixed rodent brain, largely due to the limited availability of MOR antibodies that effectively stain paraffin-embedded tissues...
  13. pmc A transplantable phosphorylation probe for direct assessment of G protein-coupled receptor activation
    Andrea Kliewer
    Department of Pharmacology and Toxicology, Jena University Hospital Friedrich Schiller University Jena, Jena, Germany
    PLoS ONE 7:e39458. 2012
    ..Together, we propose the application of a phosphorylation probe for direct assessment of G protein-coupled receptor activation and demonstrate its utility in the pharmacological characterization of novel somatostatin analogs...
  14. pmc Deciphering µ-opioid receptor phosphorylation and dephosphorylation in HEK293 cells
    Christian Doll
    Institute of Pharmacology and Toxicology, Jena University Hospital Friedrich Schiller University Jena, Jena, Germany
    Br J Pharmacol 167:1259-70. 2012
    ..In contrast, morphine promotes a selective phosphorylation of Ser(375) without causing rapid receptor internalization...
  15. pmc Agonist-regulated cleavage of the extracellular domain of parathyroid hormone receptor type 1
    Christoph Klenk
    Institute of Pharmacology and Toxicology, Deutsche Forschungsgemeinschaft Research Center for Experimental Biomedicine, University of Wrzburg, 97078 Wurzburg, Germany
    J Biol Chem 285:8665-74. 2010
    ..A processed form of the PTHR was also detected in human kidney. These findings suggest a new model of PTHR processing and regulation of its stability...
  16. ncbi request reprint Carboxyl-terminal multi-site phosphorylation regulates internalization and desensitization of the human sst2 somatostatin receptor
    Andreas Lehmann
    Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University, 07747 Jena, Germany
    Mol Cell Endocrinol 387:44-51. 2014
    ..Together, our findings demonstrate for the first time that agonist-selective sst2 receptor internalization is regulated by multi-site phosphorylation of its carboxyl-terminal tail. ..
  17. doi request reprint Reassessment of sst3 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-5
    Amelie Lupp
    Department of Pharmacology and Toxicology, University Hospital, Friedrich Schiller University Jena, Jena, Germany
    Neuroendocrinology 96:301-10. 2012
    ..Apart from this, very little is known about the clinical relevance of the sst(3) receptor, which may in part be due to the lack of specific monoclonal sst(3) antibodies...
  18. ncbi request reprint Somatostatin receptor 2 is activated in cortical neurons and contributes to neurodegeneration after focal ischemia
    Ralf K Stumm
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Neurosci 24:11404-15. 2004
    ..In summary, we provide direct evidence for activation of SSTR2 by an endogenous ligand after focal ischemia. Activation of functional SSTR2 receptors contributes to increased SSTR2 gene expression and postischemic neurodegeneration...
  19. pmc Agonist-selective patterns of µ-opioid receptor phosphorylation revealed by phosphosite-specific antibodies
    Christian Doll
    Institute of Pharmacology and Toxicology, University Hospital, Friedrich Schiller University, Jena, Germany
    Br J Pharmacol 164:298-307. 2011
    ..However, the detailed molecular events underlying the differential regulation of receptor trafficking by distinct opioid agonists remain incompletely understood...
  20. pmc Rapid uptake and degradation of CXCL12 depend on CXCR7 carboxyl-terminal serine/threonine residues
    Frauke Hoffmann
    Institute of Pharmacology and Toxicology, Jena University Hospital Friedrich Schiller University Jena, Jena, Germany
    J Biol Chem 287:28362-77. 2012
    ..Regulatory pathways targeting CXCR7 C-terminal serine/threonine sites may control the CXCL12 scavenger activity of CXCR7...
  21. ncbi request reprint Gene Regulation Ontology (GRO): design principles and use cases
    Elena Beisswanger
    Jena University Language and Information Engineering JULIE Lab, Jena, Germany
    Stud Health Technol Inform 136:9-14. 2008
    ..The GRO has just been submitted to the OBO library and is currently under review. It is available at http://www.ebi.ac.uk/Rebholz-srv/GRO/GRO.html...
  22. ncbi request reprint A dual role for the SDF-1/CXCR4 chemokine receptor system in adult brain: isoform-selective regulation of SDF-1 expression modulates CXCR4-dependent neuronal plasticity and cerebral leukocyte recruitment after focal ischemia
    Ralf K Stumm
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Neurosci 22:5865-78. 2002
    ..Thus, the isoform-specific regulation of SDF-1 expression modulates neurotransmission and cerebral infiltration via distinct CXCR4-dependent pathways...
  23. ncbi request reprint Intracellular trafficking of somatostatin receptors
    Stefan Jacobs
    Institut fur Pharmakologie und Toxikologie, Universitat Wurzburg, Wurzburg, Germany
    Mol Cell Endocrinol 286:58-62. 2008
    ..This review will focus on the molecular mechanisms of the differential intracellular trafficking of sst(2), sst(3) and sst(5), and discusses our current knowledge on somatostatin receptor interacting proteins...
  24. doi request reprint Carboxyl-terminal receptor domains control the differential dephosphorylation of somatostatin receptors by protein phosphatase 1 isoforms
    Andreas Lehmann
    Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University, Jena, Germany
    PLoS ONE 9:e91526. 2014
    ..This phosphatase specificity has in turn profound consequences for the dephosphorylation dynamics and trafficking patterns of GPCRs. ..
  25. doi request reprint Enhanced expression of the CXCl12/SDF-1 chemokine receptor CXCR7 after cerebral ischemia in the rat brain
    Bastian Schönemeier
    Institute of Pharmacology and Toxicology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    J Neuroimmunol 198:39-45. 2008
    ..These patterns suggest that SDF-1 may influence vascular, astroglial, and neuronal functions via CXCR7 and mediate cell recruitment to ischemic brain areas via CXCR4...
  26. ncbi request reprint Biomedical ontologies: what part-of is and isn't
    Stefan Schulz
    Department of Medical Informatics, University Hospital, Freiburg, Germany
    J Biomed Inform 39:350-61. 2006
    ..We analyze these ambiguities and make suggestions for a standardization of mereological relations in biomedical ontologies...
  27. doi request reprint Fine-tuning somatostatin receptor signalling by agonist-selective phosphorylation and dephosphorylation: IUPHAR Review 5
    Stefan Schulz
    Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University, Jena, Germany
    Br J Pharmacol 171:1591-9. 2014
    ..The recently uncovered differences in phosphorylation and dephosphorylation of these receptors may hence be of physiological significance in mediating responses to acute, persistent or repeated stimuli in a variety of target tissues...
  28. doi request reprint Heterologous regulation of agonist-independent μ-opioid receptor phosphorylation by protein kinase C
    Susann Illing
    Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany
    Br J Pharmacol 171:1330-40. 2014
    ..In the present study, we provide evidence for a selective and dose-dependent phosphorylation of T370 after activation of PKC by phorbol esters...
  29. pmc Potent anti-inflammatory and antinociceptive activity of the endothelin receptor antagonist bosentan in monoarthritic mice
    Anne Katja Imhof
    Institute of Pharmacology and Toxicology, University Hospital, Friedrich Schiller University, Drackendorfer Str 1, 07747 Jena, Germany
    Arthritis Res Ther 13:R97. 2011
    ..We therefore examined the effects of endothelin receptor antagonists on the development of arthritis and inflammatory pain in monoarthritic mice...
  30. pmc CXC chemokine receptor 7 (CXCR7) regulates CXCR4 protein expression and capillary tuft development in mouse kidney
    Sammy Haege
    Institute of Pharmacology and Toxicology, University Hospital Jena, Friedrich Schiller University Jena, Jena, Germany
    PLoS ONE 7:e42814. 2012
    ..Although it is established that CXCR7 regulates heart and brain development in conjunction with CXCL12 and CXCR4, little is known about the influence of CXCR7 on CXCL12 dependent kidney development...
  31. doi request reprint Somatostatin receptors type 2 and 5 expression and localization during human pituitary development
    Stephane Peineau
    Medical Research Council Centre for Synaptic Plasticity S P, University of Bristol, School of Physiology and Pharmacology, Bristol BS8 1TD, United Kingdom Inserm S P, F G, Z C, S J, A F, L S, N d R, P G, S A, P D, U676, 75019 Paris, France University Paris Diderot S P, F G, Z C, S J, A F, L S, N d R, P G, S A, P D, Sorbonne Paris Cité, UMR676, 75019 Paris, France and Institute of Pharmacology and Toxicology S S, Jena University Hospital, Friedrich Schiller University Jena, Germany
    Endocrinology 155:33-9. 2014
    ..Whereas sst2 receptors might play a primary role in the differentiation and regulation of TSH, LH, and FSH cells, sst5 receptors appear to be mainly involved in GH regulation from birth onward. ..
  32. doi request reprint Differential regulation of somatostatin receptor dephosphorylation by β-arrestin1 and β-arrestin2
    Andrea Kliewer
    Department of Pharmacology and Toxicology, Jena University Hospital, Friedrich Schiller University Jena, Drackendorfer Strasse 1, 07747, Jena, Germany
    Naunyn Schmiedebergs Arch Pharmacol 387:263-9. 2014
    ..By contrast, β-arrestin2 is not essential for rapid sst2 receptor dephosphorylation. Together, these findings reveal a novel scaffolding function of β-arrestin1 that facilitates efficient targeting of PP1β to phosphorylated GPCRs. ..
  33. doi request reprint Alterations of phospholamban function can exhibit cardiotoxic effects independent of excessive sarcoplasmic reticulum Ca2+-ATPase inhibition
    Joachim P Schmitt
    Institute of Pharmacology and Toxicology, University of Wurzburg, Wurzburg, Germany
    Circulation 119:436-44. 2009
    ..Here, we investigated whether PLN exhibits cardiotoxic effects via mechanisms other than chronic inhibition of SERCA2a by studying a PLN mutant, PLN(R9C), that triggers cardiac failure in humans and mice...
  34. doi request reprint Reassessment of sst(5) somatostatin receptor expression in normal and neoplastic human tissues using the novel rabbit monoclonal antibody UMB-4
    Amelie Lupp
    Department of Pharmacology and Toxicology, University Hospital, Friedrich Schiller University, Jena, Germany
    Neuroendocrinology 94:255-64. 2011
    ..However, so far highly specific rabbit monoclonal antibodies have been developed for the sst(2) receptor only (clone UMB-1)...
  35. ncbi request reprint Neuronal types expressing mu- and delta-opioid receptor mRNA in the rat hippocampal formation
    Ralf K Stumm
    Department of Pharmacology and Toxicology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Comp Neurol 469:107-18. 2004
    ....
  36. ncbi request reprint Expression of the mu-opioid receptor is induced in dentate gyrus granule cells after focal cerebrocortical ischaemia and stimulation of entorhinal afferents
    Ralf Stumm
    Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
    Eur J Neurosci 22:1032-44. 2005
    ..In activated, MOR-expressing granule cells, inhibitory opioids may counter-regulate glutamatergic excitation by the perforant path...